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1. 发明申请

WO2004005300A1 MICROFINE ZINC-GLYCEROL COMPLEXES 审中-公开
标题翻译： MICROFINE ZINC-GLYCEROL复合物
公开(公告)号：WO2004005300A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021271
申请日：2003-07-09
申请人： PURE PHARMACEUTICALS, INC. , TAYLOR, Reginald , FAIRLIE, David , MOFFITT, Robert
发明人： TAYLOR, Reginald , FAIRLIE, David , MOFFITT, Robert
IPC分类号： C07F3/06
CPC分类号： A61K31/315 , C07C31/225
摘要： The present invention relates in part to a method of manufacturing metal-glycerol complexes and the metal-glycerol complexes so produced, which unexpectedly results in microfine metal-glycerol complex particles which have a mean particle length (i.e., major axis) of less than about 1.0 micron. The metal-glycerol complex particles of the invention also generally maintain a hexoganol crystalline structure, thereby retaining superior lubricity and tactile properties. The invention also provides pharmaceutical and/or therapeutic compositions comprising microfine metal-glycerol complex particles, and methods for using such compositions.
摘要翻译：本发明部分涉及制备金属 - 甘油配合物的方法和如此制备的金属 - 甘油配合物，其意外地导致具有小于约平均粒度（即长轴）的微细金属 - 甘油复合物颗粒 1.0微米。本发明的金属 - 甘油配合物颗粒通常还保持己糖醇晶体结构，从而保持优异的润滑性和触觉性。本发明还提供包含超细金属 - 甘油复合物颗粒的药物和/或治疗组合物，以及使用这些组合物的方法。

2. 发明申请

WO2012012843A1 MODULATORS OF PROTEASE ACTIVATED RECEPTORS 审中-公开
标题翻译：蛋白激活受体的调节剂
公开(公告)号：WO2012012843A1
公开(公告)日：2012-02-02
申请号：PCT/AU2011/000959
申请日：2011-07-28
申请人： THE UNIVERSITY OF QUEENSLAND , FAIRLIE, David Paul , LIU, Ligong , YAU, Mei Kwan , SUEN, Jacky Yung
发明人： FAIRLIE, David Paul , LIU, Ligong , YAU, Mei Kwan , SUEN, Jacky Yung
IPC分类号： C07K5/065 , A61K38/05 , A61K38/06 , A61P1/00 , A61P3/00 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P17/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P37/00 , C07K5/062 , C07K5/078 , C07K5/083
CPC分类号： C07K5/0812 , A61K38/00 , C07K5/00 , C07K5/06034 , C07K5/06078 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0823 , C07K5/0825
摘要： The present invention provides novel compounds of the Formula (1), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for modulating Protease Activated Receptor-2 (PAR2) and for treating a subject at risk of -or susceptible to- a disease or disorder, or having a disease or disorder associated with undesirable PAR2 activity.
摘要翻译：本发明提供了新的式（1）化合物，包含这些化合物的药物组合物和使用这些化合物作为生物学研究的工具的方法，或用于调节蛋白酶活化受体-2（PAR2）的药剂或药物，以及用于治疗受试者风险为 - 易感于疾病或病症，或患有与不良PAR2活性相关的疾病或病症。

3. 发明申请

WO2011153583A1 NOCICEPTIN MIMETICS 审中-公开
公开(公告)号：WO2011153583A1
公开(公告)日：2011-12-15
申请号：PCT/AU2011/000707
申请日：2011-06-07
申请人： THE UNIVERSITY OF QUEENSLAND , FAIRLIE, David , HARRISON, Rosemary Sharon , SHEPHERD, Nicholas Evan
发明人： FAIRLIE, David , HARRISON, Rosemary Sharon , SHEPHERD, Nicholas Evan
IPC分类号： C07K7/08 , A61P9/06 , A61P25/00 , A61K38/10 , A61P9/10 , A61P25/04 , A61P1/00 , A61P9/12 , A61P25/06 , A61P3/00 , A61P11/00 , A61P25/08 , A61P3/04 , A61P11/06 , A61P25/14 , A61P3/10 , A61P25/18 , A61P5/00 , A61P11/16 , A61P25/22 , A61P5/38 , A61P13/00 , A61P25/24 , A61P9/00 , A61P13/02 , A61P25/28 , A61P9/02 , A61P15/00 , A61P25/30 , A61P9/04 , A61P15/10 , A61P25/36
CPC分类号： A61K38/10 , A61K38/00 , A61K38/12 , A61K45/06 , C07K7/08 , C07K7/60 , C07K14/575
摘要： The present invention relates to nociceptin peptide mimetics that have α-helical structures and bind to and modulate the opioid receptor-like-1 (ORL-1) receptor. The peptide mimetics are constrained cyclic nociceptin analogues which have either agonist or antagonist activity. Pharmaceutical compositions comprising the nociceptin peptide mimetics and methods of treating or preventing a disease or condition ameliorated by modulating the ORL-1 receptor are also described.
摘要翻译：本发明涉及具有α-螺旋结构并结合并调节阿片样物质受体-1（ORL-1）受体的伤害感受肽模拟物。肽模拟物是具有激动剂或拮抗剂活性的受约束的环状伤害感受肽类似物。还描述了包含伤害感受肽模拟物的药物组合物和治疗或预防通过调节ORL-1受体改善的疾病或病症的方法。

4. 发明申请

WO2013067579A1 ADIPOSITY-MODULATING MOLECULES AND USES THEREFOR 审中-公开
标题翻译： ADIPOSITY-MODULATING分子及其用途
公开(公告)号：WO2013067579A1
公开(公告)日：2013-05-16
申请号：PCT/AU2012/001365
申请日：2012-11-07
申请人： THE UNIVERSITY OF QUEENSLAND , FAIRLIE, David , LIM, Junxian , IYER, Abishek Venkatasubramanian , BROWN, Lindsay Charles
发明人： FAIRLIE, David , LIM, Junxian , IYER, Abishek Venkatasubramanian , BROWN, Lindsay Charles
IPC分类号： A61K31/192 , A61K31/4406 , A61K31/4402 , A61K31/216 , A61K31/403 , A61K31/404 , A61K31/5377 , A61P3/04 , A61P3/08 , A61P3/10 , A61P9/10 , C07C233/84
CPC分类号： A61K31/195 , A61K31/20 , C07C233/51 , C07C235/12 , C07C2601/08 , C07C2601/14
摘要： Disclosed are methods and compositions for modulating adiposity-related conditions, which utilize inhibitors of phospholipase A 2 , and more particularly phospholipase A 2 Group IIa (PLA2G2A). Representative adiposity-related conditions include obesity, type II diabetes, adipose inflammation, metabolic dysfunction, cardiovascular diseases and more generally, metabolic syndrome.
摘要翻译：公开了利用磷脂酶A2抑制剂，特别是磷脂酶A2组IIa（PLA2G2A）调节肥胖相关病症的方法和组合物。代表性的肥胖相关病症包括肥胖症，II型糖尿病，脂肪炎症，代谢功能障碍，心血管疾病，更一般地，代谢综合征。

5. 发明申请

WO2013013273A1 MODULATORS OF PROTEASE ACTIVATED RECEPTORS 审中-公开
标题翻译：蛋白激活受体的调节剂
公开(公告)号：WO2013013273A1
公开(公告)日：2013-01-31
申请号：PCT/AU2012/000891
申请日：2012-07-27
申请人： THE UNIVERSITY OF QUEENSLAND , FAIRLIE, David Paul , LIU, Ligong , YAU, Mei-Kwan , SUEN, Jacky Yung , REID, Robert , LOHMAN, Rink-Jan , IYER, Abishek Venkatasubramanian , LIM, Junxian , BROWN, Lindsay Charles
发明人： FAIRLIE, David Paul , LIU, Ligong , YAU, Mei-Kwan , SUEN, Jacky Yung , REID, Robert , LOHMAN, Rink-Jan , IYER, Abishek Venkatasubramanian , LIM, Junxian , BROWN, Lindsay Charles
IPC分类号： A61K38/05 , A61K38/06 , C07K5/065 , C07K5/062 , C07K5/078 , C07K5/083 , A61P9/00 , A61P3/04 , A61P5/00
CPC分类号： C07K5/08 , A61K38/05 , C07K5/02 , C07K5/06 , C07K5/06078
摘要： The present invention provides novel compounds of the Formula (I), pharmaceutical compositions comprising such compounds and methods for using such compounds as tools for biological studies or as agents or drugs for therapies such as metabolic syndrome, obesity, type II diabetes, fibrosis and cardiovascular diseases, whether they are used alone or in combination with other treatment modalities.
摘要翻译：本发明提供了新的式（I）化合物，包含这些化合物的药物组合物和使用这些化合物作为生物学研究的工具的方法，或作为代谢综合征，肥胖症，II型糖尿病，纤维化和心血管疾病疾病，无论是单独使用还是与其他治疗方式结合使用。

6. 发明申请

WO1996016950A1 HIV PROTEASE INHIBITORS 审中-公开
标题翻译：艾滋病病毒蛋白酶抑制剂
公开(公告)号：WO1996016950A1
公开(公告)日：1996-06-06
申请号：PCT/AU1995000817
申请日：1995-12-04
申请人： THE UNIVERSITY OF QUEENSLAND , ABBENANTE, John , BERGMAN, Doug , BRINKWORTH, Ross , DANCER, Robert , GARNHAM, Bronwyn , HUNT, Peter , FAIRLIE, David , MARCH, Darren , MARTIN, Jennifer , REID, Robert
发明人： THE UNIVERSITY OF QUEENSLAND
IPC分类号： C07D273/02
CPC分类号： C07D273/00 , A61K38/00 , C07D273/02 , C07D285/00 , C07D291/02 , C07D413/06 , C07K5/021 , C07K5/06139 , C07K5/06165 , C07K14/005 , C12N2740/16122
摘要： A HIV-1 protease inhibitor which includes an N-terminal cycle (A) or a C-terminal cycle (B) or both cycles (A) and (B) wherein Y is selected from side chains of Asn or Ile or Val or Glu and alkyl of 1-6 carbon atoms inclusive of linear or branched chains as well as cycloalkyl; and X is selected from (CH2)n where n = 3-6, -CH(OH)-CH(OH)-CH2-, CH(CO2H)-CH2-CH2, CH2CONHCHR where R = D or L amino acids and alkyl of 1-6 carbon atoms inclusive of linear or branched chains.
摘要翻译：包括N-末端循环（A）或C末端循环（B）或两个循环（A）和（B）的HIV-1蛋白酶抑制剂，其中Y选自Asn或Ile的侧链或Val或Glu 和1-6个碳原子的烷基，包括直链或支链以及环烷基; 并且X选自（CH 2）n，其中n = 3-6，-CH（OH）-CH（OH）-CH 2 - ，CH（CO 2 H）-CH 2 -CH 2，CH 2 CONHCHR其中R = D或L氨基酸，包括1-6个碳原子的直链或支链。

7. 发明申请

WO2005090388A1 ALPHA HELICAL MIMICS, THEIR USES AND METHODS FOR THEIR PRODUCTION 审中-公开
标题翻译： ALPHA HELICAL MIMICS，它们的使用及其生产方法
公开(公告)号：WO2005090388A1
公开(公告)日：2005-09-29
申请号：PCT/AU2005/000400
申请日：2005-03-21
申请人： THE UNIVERSITY OF QUEENSLAND , FAIRLIE, David, P. , SHEPHERD, Nicholas, E.
发明人： FAIRLIE, David, P. , SHEPHERD, Nicholas, E.
IPC分类号： C07K7/50
CPC分类号： C07K7/64 , A61K38/00 , C07K7/56
摘要： This invention discloses short chain peptides that have been constrained to adopt an alpha helical conformation and their use as alpha helical scaffolds for directing amino acid side chains into positions analogous to those found in longer chain alpha helical peptides and for attaching peptidic or non-peptidic appendages in order to mimic side chains of longer alpha helical peptides. More particularly the invention discloses alpha helical cyclic pentapeptides and their use as alpha helical scaffolds or macrocyclic alpha helical modules, either alone, or within longer chain peptides or attached to other macrocyclic peptides or attached to non-peptidic structures, for the purpose of mimicking naturally occurring peptides or proteins, and as agonists or antagonists of the biological activity of naturally-occurring peptides or proteins or for the preparation of new materials.
摘要翻译：本发明公开了已经被限制为采用α螺旋构象的短链肽及其作为用于将氨基酸侧链引导到类似于在较长链α螺旋肽中发现的那些位置并用于连接肽或非肽附属物的α螺旋支架的用途以模拟更长的α螺旋肽的侧链。更具体地，本发明公开了α螺旋环状五肽及其作为α螺旋支架或大环α螺旋模块，单独使用或在更长链肽内或连接于其他大环肽或连接于非肽结构上，用于模拟天然发生的肽或蛋白质，以及作为天然存在的肽或蛋白质的生物活性的激动剂或拮抗剂或用于制备新材料。

8. 发明申请

WO2005051901A1 ANTI-CANCER AGENTS 审中-公开
标题翻译：抗癌药剂
公开(公告)号：WO2005051901A1
公开(公告)日：2005-06-09
申请号：PCT/AU2004/001667
申请日：2004-11-26
申请人： THE UNIVERSITY OF QUEENSLAND , FAIRLIE, David , GLENN, Matthew , KAHNBERG, Pia
发明人： FAIRLIE, David , GLENN, Matthew , KAHNBERG, Pia
IPC分类号： C07C323/47
CPC分类号： C07D235/14 , C04B35/632 , C07C259/06 , C07C271/22 , C07C323/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07C2603/74 , C07D209/12 , C07D209/14 , C07D209/42 , C07D213/40 , C07D213/75 , C07D213/78 , C07D215/40 , C07D231/56 , C07D277/62 , C07D307/68 , C07D401/12
摘要： The present invention provides compounds having the strucutural formula (I) and methods for the treatment of cancer using compounds of formula (I).
摘要翻译：本发明提供具有结构式（I）的化合物和使用式（I）化合物治疗癌症的方法。

9. 发明申请

WO2013067578A1 MODULATORS OF C3A RECEPTORS 审中-公开
标题翻译： C3A受体的调节剂
公开(公告)号：WO2013067578A1
公开(公告)日：2013-05-16
申请号：PCT/AU2012/001364
申请日：2012-11-07
申请人： THE UNIVERSITY OF QUEENSLAND , FAIRLIE, David , REID, Robert C.
发明人： FAIRLIE, David , REID, Robert C.
IPC分类号： C07D263/34 , C07D413/06 , C07D413/12 , C07D277/56 , C07D233/90 , C07D403/12 , C07D401/12 , C07D307/68 , C07D333/38 , C07D271/10 , A61K31/421 , A61K31/422 , A61K31/4725 , A61K31/4439 , A61K31/341 , A61K31/426 , A61K31/381 , A61K31/4174 , A61K31/4245 , A61K31/417 , A61P29/00 , A61P3/04 , A61P3/10 , A61P31/14
CPC分类号： C07D263/34 , A61K39/39 , A61K2039/55511 , C07D233/90 , C07D271/06 , C07D271/10 , C07D277/56 , C07D307/68 , C07D333/38 , C07D401/12 , C07D403/12 , C07D413/06 , C07D413/12
摘要： Heterocyclic compounds that modulate C3a receptors and their use in the treatment or prevention of inflammatory diseases, infectious diseases, cancers, metabolic disorders, obesity, type 2 diabetes, metabolic syndrome and associated cardiovascular diseases are described. The use of the compounds in stimulating or suppressing an immune response is also described together with pharmaceutical compositions comprising the compounds or their pharmaceutically acceptable salts.
摘要翻译：描述了调节C3a受体的杂环化合物及其在治疗或预防炎性疾病，传染病，癌症，代谢紊乱，肥胖症，2型糖尿病，代谢综合征和相关心血管疾病中的用途。化合物在刺激或抑制免疫应答中的用途也与包含该化合物或其药学上可接受的盐的药物组合物一起被描述。

10. 发明申请

WO2007041775A1 CYSTEINE PROTEASE INHIBITORS INCORPORATING AZIDE GROUPS 审中-公开
标题翻译：包含AZIDE组的CYSTEINE PROTEASE INHIBITORS
公开(公告)号：WO2007041775A1
公开(公告)日：2007-04-19
申请号：PCT/AU2006/001478
申请日：2006-10-10
申请人： THE UNIVERSITY OF QUEENSLAND , LE, Giang, Thanh , ABBENANTE, Giovanni , FAIRLIE, David, Paul
发明人： LE, Giang, Thanh , ABBENANTE, Giovanni , FAIRLIE, David, Paul
IPC分类号： C07B43/00 , A61P43/00 , C12N9/99 , A61K31/131 , C07K1/113 , C07C247/04
CPC分类号： C07K5/0202 , A61K31/131 , C07C247/04 , C07C247/12 , C07C271/22 , C07C271/54 , C07C275/24 , C07C2601/14 , C07D209/42 , C07D217/26 , C07D261/18 , C07D307/85 , C07D487/04
摘要： Disclosed is a method of producing a cysteine protease inhibitor, the method comprising incorporating an azide group into an organic molecule. Also disclosed is a cysteine protease inhibitor containing an azide group.
摘要翻译：公开了一种制备半胱氨酸蛋白酶抑制剂的方法，该方法包括将叠氮基掺入有机分子中。还公开了含有叠氮基的半胱氨酸蛋白酶抑制剂。

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