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1. 发明申请

WO2014200737A1 MULTI-LUMEN-CATHETER RETRACTOR SYSTEM FOR A MINIMALLY-INVASIVE, OPERATIVE GASTROINTESTINAL TREATMENT 审中-公开
标题翻译：用于微型入路，手术胃肠道治疗的多用途导管系统
公开(公告)号：WO2014200737A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/040429
申请日：2014-06-01
申请人： MACROPLATA INC. , PISKUN, Gregory , TO, John , FABRO, Mariel , TANG, Brian , KANTSEVOY, Sergey
发明人： PISKUN, Gregory , TO, John , FABRO, Mariel , TANG, Brian , KANTSEVOY, Sergey
IPC分类号： A61B1/00 , A61B1/018 , A61B17/02 , A61B17/34 , A61B1/31 , A61B1/32 , A61B17/00
CPC分类号： A61B17/0218 , A61B17/00234 , A61B2017/00331 , A61B2017/00557 , A61B2017/0225 , A61B2017/345
摘要： A system for performing minimally invasive procedures in a body lumen of a patient including a flexible catheter having a first lumen configured and dimensioned to receive an endoscope therethrough and a second lumen configured and dimensioned to receive a first flexible tube therethrough. The first flexible tube is movable through the second lumen and has a distal portion including a first curve extending in a first direction with respect to the longitudinal axis and a second curve extending in a second different direction with respect to the longitudinal axis. A retractor system is positioned at a distal portion of the catheter and is movable from a non-expanded insertion position to an expanded position forming an expanded cage to form a larger working space. The distal portion of the first flexible tube is movable within the expanded cage.
摘要翻译：一种用于在患者的体腔中执行微创手术的系统，包括柔性导管，所述柔性导管具有构造和尺寸以便容纳内窥镜的第一腔，以及构造和尺寸设计成容纳穿过其中的第一柔性管的第二腔。第一柔性管可移动穿过第二内腔，并且具有包括相对于纵向轴线在第一方向上延伸的第一曲线的远侧部分和相对于纵向轴线沿第二不同方向延伸的第二曲线。牵开器系统定位在导管的远端部分处，并且可从非扩张插入位置移动到扩展位置，形成扩张笼以形成更大的工作空间。第一柔性管的远侧部分可在扩展的笼内移动。

2. 发明申请

WO2013192116A1 MULTI-LUMEN-CATHETER RETRACTOR SYSTEM FOR A MINIMALLY-INVASIVE, OPERATIVE GASTROINTESTINAL TREATMENT 审中-公开
标题翻译：用于微型入路，手术胃肠道治疗的多用途导管系统
公开(公告)号：WO2013192116A1
公开(公告)日：2013-12-27
申请号：PCT/US2013/046200
申请日：2013-06-17
申请人： MACROPLATA INC. , PISKUN, Gregory , TO, John , FABRO, Mariel , TANG, Brian , KANTSEVOY, Sergey
发明人： PISKUN, Gregory , TO, John , FABRO, Mariel , TANG, Brian , KANTSEVOY, Sergey
IPC分类号： A61B1/00 , A61B1/018 , A61B17/02 , A61B17/34
CPC分类号： A61B1/00087 , A61B1/00135 , A61B1/00154 , A61B1/31 , A61B17/0218 , A61B17/083 , A61B17/122 , A61B17/1285 , A61B17/3421 , A61B2017/00278 , A61B2017/00287 , A61B2017/00296 , A61B2017/00323 , A61B2017/00336 , A61B2017/00818 , A61B2017/00902 , A61B2017/2212 , A61B2017/2905 , A61B2017/3445 , A61B2017/3447 , A61B2017/345 , A61B2090/08021 , F04C2270/041
摘要： Improved methods and devices for performing an endoscopic surgery are provided. Systems are taught for operatively treating gastrointestinal disorders endoscopically in a stable, yet dynamic operative environment, and in a minimally-invasive manner. Such systems include, for example, an endoscopic surgical suite. The surgical suite can have a reversibly-expandable retractor that expands to provide a stable, operative environment within a subject. The expansion can be asymmetric around a stabilizer subsystem to maximize space for a tool and an endoscope to each be maneuvered independently to visualize a target tissue and treat the target tissue from outside the patient in a minimally invasive manner.
摘要翻译：提供了用于进行内窥镜手术的改进的方法和装置。所述系统被教导用于在稳定而又动态的手术环境中以微创方式内窥镜治疗胃肠道疾病。这样的系统包括例如内窥镜手术套件。外科手术套件可以具有可逆扩张的收缩器，其扩张以在受试者内提供稳定的手术环境。扩张可以在稳定器子系统周围是不对称的，以最大化工具和内窥镜的空间，每个人都可以独立地操纵以使目标组织可视化并且以微创方式从患者外部治疗目标组织。

3. 发明申请

WO2008048626A2 METHODS AND DEVICES FOR CATHETER ADVANCEMENT AND DELIVERY OF SUBSTANCES THERETHROUGH 审中-公开
标题翻译：用于导管推进和递送物质的方法和设备
公开(公告)号：WO2008048626A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/022122
申请日：2007-10-16
申请人： GUIDED DELIVERY SYSTEMS, INC. , STARKSEN, Niel, F. , IM, Karl, S. , FABRO, Mariel , MEIER, Stephen , SERINA, Eugene
发明人： STARKSEN, Niel, F. , IM, Karl, S. , FABRO, Mariel , MEIER, Stephen , SERINA, Eugene
IPC分类号： A61M31/00
CPC分类号： A61M25/01 , A61B17/0401 , A61B17/0485 , A61B17/0644 , A61B17/068 , A61B17/3468 , A61B2017/00243 , A61B2017/00783 , A61B2017/0496 , A61B2017/06019 , A61F2/2466
摘要： Methods and devices for successively advancing a plurality of catheters over a guide element to a body tissue are described. In some of the methods, the guide element may be attached to the body tissue, which may be accessible minimally invasively. In certain variations, the guide element may not be detached from the body tissue after the catheters have been advanced over the guide element. The methods may further comprise deploying at least one implant from at least one of the plurality of catheters. In some variations, a method may comprise advancing a first delivery catheter to a first region of a body tissue, deploying a first anchor from the first delivery catheter, where the first anchor is attached to a guide element, proximally withdrawing the first delivery catheter, advancing a second delivery catheter over the guide element, and deploying a second anchor from the second delivery catheter.
摘要翻译：描述了用于将多个导管连续地在引导元件上推进到身体组织的方法和装置。在一些方法中，引导元件可以附接到身体组织，该身体组织可以微创地进入。在某些变型中，在导管已经在导引元件上行进之后，导引元件不会从身体组织上脱离。该方法可以进一步包括从多个导管中的至少一个部署至少一个植入物。在一些变型中，一种方法可以包括：使第一输送导管前进到身体组织的第一区域;从第一输送导管展开第一锚定件，其中第一锚定件附接到引导元件;近侧地撤回第一输送导管; 在引导元件上推进第二输送导管，并从第二输送导管展开第二锚定件。

4. 发明申请

WO2010085456A1 ANCHOR DEPLOYMENT DEVICES AND RELATED METHODS 审中-公开
标题翻译：锚固部署装置及相关方法
公开(公告)号：WO2010085456A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021437
申请日：2010-01-19
申请人： GUIDED DELIVERY SYSTEMS INC. , SERINA, Eugene , MEIER, Stephen, C. , YUAN, Shih-Hsiung Albert , FABRO, Mariel
发明人： SERINA, Eugene , MEIER, Stephen, C. , YUAN, Shih-Hsiung Albert , FABRO, Mariel
IPC分类号： A61M31/00
CPC分类号： A61M25/0043 , A61B1/00078 , A61B1/3137 , A61B6/12 , A61B6/481 , A61B6/485 , A61B8/12 , A61B17/00234 , A61B17/0057 , A61B17/320016 , A61B17/7208 , A61B2017/00243 , A61M25/0041 , A61M25/04 , A61M2210/127
摘要： Described here are devices, methods, and kits for the deployment of tissue anchors. In some variations, the devices may comprise a shaft defining a lumen for housing at least one anchor therein and a mechanism for deploying the anchor distally from the lumen. In certain variations, the devices may comprise one or more stop elements. For example, a device may comprise a stop element that limits the advancement of the device through an opening in a wall portion or at the distal end of another device.
摘要翻译：这里描述了用于部署组织锚的装置，方法和试剂盒。在一些变型中，装置可以包括限定用于容纳至少一个锚固件的内腔的轴和用于将锚固件从腔内向远侧展开的机构。在某些变型中，装置可以包括一个或多个停止元件。例如，装置可以包括限制装置通过壁部分中的开口或另一装置的远端的开口的止挡元件。

5. 发明申请

WO2010042845A1 TERMINATION DEVICES AND RELATED METHODS 审中-公开
标题翻译：终止设备及相关方法
公开(公告)号：WO2010042845A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060202
申请日：2009-10-09
申请人： GUIDED DELIVERY SYSTEMS INC. , MEIER, Stephen, C. , SERINA, Eugene , ADAM, Charles, J. , FABRO, Mariel , CALHOUN, Tenny, C. , TAM, Tammy, Y. , LUNSFORD, John, P. , TANG, Brian , OLSON, Stephen
发明人： MEIER, Stephen, C. , SERINA, Eugene , ADAM, Charles, J. , FABRO, Mariel , CALHOUN, Tenny, C. , TAM, Tammy, Y. , LUNSFORD, John, P. , TANG, Brian , OLSON, Stephen
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0485 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B17/10 , A61B2017/00243 , A61B2017/00783 , A61B2017/045 , A61B2017/0451 , A61B2017/0488 , A61B2017/0496 , A61B2017/320052
摘要： Devices and methods for locking and/or cutting tethers during a tissue modification procedure are described. In some variations, a tether may be used to tighten tissue by bringing two pieces or sections of the tissue together. The tether, which may be under tension, may be locked to maintain the tension, and excess tether may be severed, using one or more of the devices and/or methods. The devices and/or methods may be used, for example, in minimally invasive procedures.
摘要翻译：描述了在组织修改过程中锁定和/或切割系绳的装置和方法。在一些变型中，系绳可以用于通过将组织的两个片段或部分组合在一起来收紧组织。可能处于紧张状态的系绳可以被锁定以保持张力，并且可以使用一种或多种装置和/或方法来切断多余的系绳。装置和/或方法可以用于例如微创手术。

6. 发明申请

WO2012036798A1 DEVICES, METHODS AND KITS FOR HEART VALVE REPLACEMENT 审中-公开
标题翻译：用于心瓣膜替换的装置，方法和工具
公开(公告)号：WO2012036798A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/046462
申请日：2011-08-03
申请人： GUIDED DELIVERY SYSTEMS INC. , STARKSEN, Niel, F. , FABRO, Mariel
发明人： STARKSEN, Niel, F. , FABRO, Mariel
IPC分类号： A61B17/88
CPC分类号： A61F2/2412 , A61F2/2409 , A61F2/2427 , A61F2220/0008 , A61F2230/0013
摘要： Heart valve replacement devices, methods and kits are described here. A method may comprise advancing a first catheter into the left ventricle of a heart so that the first catheter is positioned beneath the mitral valve of the heart, advancing a replacement valve from the first catheter while the first catheter is in its position beneath the mitral valve of the heart, such that the replacement valve passes between the mitral valve leaflets and up into the left atrium of the heart, and coupling the replacement valve to tissue in the vicinity of the mitral valve. Replacement valves may be coupled to tissue using, for example, one or more anchors. The anchors may be coupled to each other with a tensioning member which may be tensioned to provide a cinching effect that results in radial contraction of tissue in the vicinity of the replacement and/or native valve.
摘要翻译：此处介绍心脏瓣膜置换装置，方法和试剂盒。一种方法可以包括将第一导管推入心脏的左心室，使得第一导管位于心脏的二尖瓣下方，从第一导管推进更换瓣膜，同时第一导管位于二尖瓣下方的位置使得更换瓣膜通过二尖瓣小叶之间并进入心脏的左心房，并将置换瓣膜连接到二尖瓣附近的组织。替代阀可以使用例如一个或多个锚固件联接到组织。锚固件可以用张紧构件彼此联接，张紧构件可以被张紧以提供紧固效应，其导致在更换和/或自然瓣膜附近的组织的径向收缩。

7. 发明申请

WO2009052427A1 SYSTEMS AND METHODS FOR CARDIAC REMODELING 审中-公开
标题翻译：心脏重塑的系统与方法
公开(公告)号：WO2009052427A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/080368
申请日：2008-10-17
申请人： GUIDED DELIVERY SYSTEMS INC. , LOULMET, Didier , FABRO, Mariel , SERINA, Eugene , STARKSEN, Niel, F.
发明人： LOULMET, Didier , FABRO, Mariel , SERINA, Eugene , STARKSEN, Niel, F.
IPC分类号： A61B17/00 , A61B17/04 , A61B17/064
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B2017/00243 , A61B2017/00783 , A61B2017/0414 , A61B2017/0496 , A61F2/2445 , A61F2/2481 , A61F2/2487
摘要： Described herein are devices and methods for improving the hemodynamic function of a patient. In particular, a first device adapted to reshape an atrio-ventricular valve is used in combination with a second device configured to further alter the blood flow through the valve. The first device is typically an implant positioned in the subvalvular space of a ventricle. The second device may be an annuloplasty implant, a non-annulus valve apparatus implant, a ventriculoplasty implant, or a cardiac rhythm management device.
摘要翻译：本文描述了用于改善患者的血液动力学功能的装置和方法。特别地，适于重新形成心室瓣膜的第一装置与被配置为进一步改变通过所述瓣膜的血液流动的第二装置组合使用。第一装置通常是定位在心室的瓣膜下空间的植入物。第二装置可以是瓣环成形植入物，非环形瓣膜装置植入物，心室成形术植入物或心律管理装置。

8. 发明申请

WO2005025644A3 DELIVERY DEVICES AND MEHODS FOR HEART VALVE REPAIR 审中-公开
标题翻译：输送装置和心脏瓣膜修复
公开(公告)号：WO2005025644A3
公开(公告)日：2007-05-03
申请号：PCT/US2004028431
申请日：2004-09-01
申请人： GUIDED DELIVERY SYSTEMS INC , STARKSEN NIEL F , TO JOHN , FABRO MARIEL , WEI MICHAEL F , MORALES RODOLFO A
发明人： STARKSEN NIEL F , TO JOHN , FABRO MARIEL , WEI MICHAEL F , MORALES RODOLFO A
IPC分类号： A61B17/04 , A61B17/00 , A61B17/06 , A61B17/064 , A61B17/068 , A61B17/10 , A61B17/12 , A61F2/24 , A61M20060101
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.
摘要翻译：装置，系统和方法便于心脏瓣膜环空处理装置的定位，从而增强环空处理。方法通常涉及将锚定器输送装置通过患者的脉管系统推进到心脏中的位置以处理瓣膜环，使锚定器输送装置与一段长度的瓣膜环接触，将多个联接的锚定器从锚定器输送装置输送到将锚固件固定到环形空间，并将锚固件拉紧在一起以周向地紧固阀环。装置通常包括具有至少一个张紧构件和至少一个张紧致动器的细长导管，用于使导管的远端部分变形以帮助其符合瓣膜环。导管装置可用于导航二尖瓣下方的子宫下空间，以便锚定器输送装置的定位。

9. 发明申请

WO2007021834A1 DEVICES AND METHODS FOR ANCHORING TISSUE 审中-公开
标题翻译：用于锚固组织的装置和方法
公开(公告)号：WO2007021834A1
公开(公告)日：2007-02-22
申请号：PCT/US2006/031190
申请日：2006-08-10
申请人： GUIDED DELIVERY SYSTEMS, INC. , TO, John , STARKSEN, Niel, F. , FABRO, Mariel , PLIAM, Nathan, B. , IM, Karl, S.
发明人： TO, John , STARKSEN, Niel, F. , FABRO, Mariel , PLIAM, Nathan, B. , IM, Karl, S.
IPC分类号： A61B17/064 , A61B17/00 , A61F2/24
CPC分类号： A61F2/2445 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61F2/0811
摘要： Anchors, anchoring systems, anchor delivery devices, and method of using anchors are described. An anchor may be a flexible anchor having two curved legs that cross in a single turning direction to form a loop, wherein the legs are adapted to penetrate tissue. The ends of the curved legs may be blunt or sharp. The anchor can assume different configurations such as a deployed configuration and a delivery configuration, and the anchor may switch between these different configurations. In operation, the anchor may be inserted into tissue by releasing the anchor from a delivery configuration so that the anchor self-expands into the deployed configuration, so that the legs of the anchor may penetrate the tissue in a curved pathway.
摘要翻译：描述了锚，锚固系统，锚固装置以及使用锚的方法。锚可以是具有两个弯曲腿的柔性锚，所述两个弯曲的腿在单个转动方向上交叉以形成环，其中所述腿适于穿透组织。弯曲的腿的端部可以是钝的或尖锐的。锚可以采取不同的配置，例如部署的配置和传送配置，并且锚可以在这些不同的配置之间切换。在操作中，锚可以通过从输送构型释放锚而插入到组织中，使得锚固体自膨胀成展开构型，使得锚的腿可以以弯曲的路径穿透组织。

10. 发明申请

WO2005025644A2 DELIVERY DEVICES AND MEHODS FOR HEART VALVE REPAIR 审中-公开
标题翻译：输送装置和心脏瓣膜修复
公开(公告)号：WO2005025644A2
公开(公告)日：2005-03-24
申请号：PCT/US2004/028431
申请日：2004-09-01
申请人： GUIDED DELIVERY SYSTEMS, INC. , STARKSEN, Niel, F. , TO, John , FABRO, Mariel , WEI, Michael, F. , MORALES, Rodolfo, A.
发明人： STARKSEN, Niel, F. , TO, John , FABRO, Mariel , WEI, Michael, F. , MORALES, Rodolfo, A.
IPC分类号： A61M
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.
摘要翻译：装置，系统和方法便于心脏瓣膜环空处理装置的定位，从而增强环空处理。方法通常涉及将锚定器输送装置通过患者的脉管系统推进到心脏中的位置以处理瓣膜环，使锚定器输送装置与一段长度的瓣膜环接触，将多个联接的锚定器从锚定器输送装置输送到将锚固件固定到环形空间，并将锚固件拉紧在一起以周向地紧固阀环。装置通常包括具有至少一个张紧构件和至少一个张紧致动器的细长导管，用于使导管的远端部分变形以帮助其符合瓣膜环。导管装置可用于导航二尖瓣下方的子宫下空间，以便锚定器输送装置的定位。

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