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1. 发明申请

WO2009106641A3 COMPOSITIONS AND METHODS FOR AUGMENTATION AND REGENERATION OF LIVING TISSUE IN A SUBJECT 审中-公开
标题翻译：用于补充和再生一个主体的生活组织的组合物和方法
公开(公告)号：WO2009106641A3
公开(公告)日：2010-08-05
申请号：PCT/EP2009052431
申请日：2009-03-02
申请人： COLOPLAST AS , EVERLAND HANNE , SAMUELSEN PETER , VANGE JAKOB , CLAUSEN CHRISTIAN , GALLEGO MONICA RAMOS
发明人： EVERLAND HANNE , SAMUELSEN PETER , VANGE JAKOB , CLAUSEN CHRISTIAN , GALLEGO MONICA RAMOS
IPC分类号： A61L27/18 , A61K9/14 , A61K9/16 , A61K9/50 , A61L27/38 , A61L27/56 , A61L27/58
CPC分类号： A61L27/3604 , A61L27/18 , A61L27/38 , A61L27/56 , A61L2400/06 , Y10T428/2982 , C08L67/04
摘要： The present invention provides for a composition, for augmentation and regeneration of living tissue in a subject, comprising a population of porous microparticles of a biodegradable polymer, one or more mammalian cell populations, and optionally, a biocompatible adhesive.
摘要翻译：本发明提供用于增加和再生受试者中的活组织的组合物，其包含生物可降解聚合物，一种或多种哺乳动物细胞群和任选的生物相容性粘合剂的多孔微粒群。

2. 发明申请

WO2008107484A2 FISTULA PLUG COMPRISING ECM 审中-公开
标题翻译：包含ECM的FISTULA插管
公开(公告)号：WO2008107484A2
公开(公告)日：2008-09-12
申请号：PCT/EP2008/052783
申请日：2008-03-07
申请人： COLOPLAST A/S , NIELSEN, Lene Feldskov , TRUELSEN, Jens Hoeg , EVERLAND, Hanne
发明人： NIELSEN, Lene Feldskov , TRUELSEN, Jens Hoeg , EVERLAND, Hanne
IPC分类号： A61L31/00 , A61L31/04 , A61L31/14
CPC分类号： A61L31/148 , A61L27/3633 , A61L27/3641 , A61L27/48 , A61L27/58 , A61L31/005 , A61L31/129
摘要： The present invention relates to a temporary composite scaffold comprising discrete ECM particles formed as a fistula plug. We demonstrate that when using scaffolds containing ECM material, higher concentrations of ECM surprisingly do not give better cell morphology. Concentrations lower than 60%(w/w) are sufficient to obtain the best cell morphology and distribution.
摘要翻译：本发明涉及一种临时复合支架，其包括形成为瘘塞的离散的ECM颗粒。我们证明当使用含有ECM材料的支架时，较高浓度的ECM令人惊讶地不能提供更好的细胞形态。浓度低于60％（w / w）足以获得最佳的细胞形态和分布。

3. 发明申请

WO2007048831A2 BIODEGRADABLE SCAFFOLD WITH ECM MATERIAL 审中-公开
标题翻译：具有ECM材料的生物可降解SCAFFOLD
公开(公告)号：WO2007048831A2
公开(公告)日：2007-05-03
申请号：PCT/EP2006/067837
申请日：2006-10-26
申请人： COLOPLAST A/S , NIELSEN, Peter Sylvest , NIELSEN, Brian , JESPERSEN, Lene Karin , EVERLAND, Hanne , NIELSEN, Lene Feldskov
发明人： NIELSEN, Peter Sylvest , NIELSEN, Brian , JESPERSEN, Lene Karin , EVERLAND, Hanne , NIELSEN, Lene Feldskov
IPC分类号： A61L15/00
CPC分类号： A61L27/3633 , A61L27/56 , A61L27/58
摘要： We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the reconstructive properties of the ECM. The optimal amount of discrete ECM material for each application is disclosed and this concentration is equally distributed in the dressing hence avoiding unnecessary high concentrations of ECM. In addition to the effect of the ECM, the porous structure of the base material provides the cells with a structure for in-growth.
摘要翻译：我们将Extra Cellular Matrix（ECM）的不连续区域添加到可生物降解的支架中。因此，可以组合脚手架可以提供的物理范围与ECM的重建性质。公开了每种应用的离散ECM材料的最佳量，并且该浓度均匀分布在敷料中，从而避免不必要的高浓度的ECM。除了ECM的作用之外，基体材料的多孔结构为细胞提供了用于生长的结构。

4. 发明申请

WO2008107483A2 MESH COMPRISING ECM 审中-公开
标题翻译：包含ECM的MESH
公开(公告)号：WO2008107483A2
公开(公告)日：2008-09-12
申请号：PCT/EP2008/052782
申请日：2008-03-07
申请人： COLOPLAST A/S , NIELSEN, Lene Feldskov , TRUELSEN, Jens Hoeg , EVERLAND, Hanne
发明人： NIELSEN, Lene Feldskov , TRUELSEN, Jens Hoeg , EVERLAND, Hanne
IPC分类号： A61L31/00 , A61L31/04 , A61L31/10
CPC分类号： A61L31/10 , A61L27/34 , A61L27/3633 , A61L27/3641 , A61L27/48 , A61L27/56 , A61L27/58 , A61L31/005 , A61L31/129 , A61L31/146 , A61L31/148
摘要： Herein is disclosed the utility of discontinuous regions of Extraceullar Matrix Proteins (ECM) in promoting cell growth in a Mesh. When the described scaffolds are applied on top of inert materials, cell in-growth is promoted and the attachment of the mesh is properly secured. In one aspect, the mesh has a side with reduced cellular in-growth and a side with enhanced in-growth. Combining inert materials with cell attractive materials such as ECM can do this. This is particularly advantageous for use as hernia implant. Here, the mesh should adhere only to the abdominal wall (on one side of the mesh) without adhering to the intestines. In one aspect of the invention, the inert material is elongated and coated on both ends. This is particularly advantageous for use as slings. Here, the mesh will adhere to the anchorage points in the ends of the sling, and still allow urethral redistribution as a consequence of bladder emptying.
摘要翻译：本文公开了Extraceullar Matrix Proteins（ECM）的不连续区域在促进网状细胞生长中的用途。当将所述支架应用于惰性材料的顶部时，促进细胞生长并适当地固定网状物的附着。在一个方面，网状物具有减少的细胞生长中的侧面和具有增强的生长增长的一侧。将惰性材料与细胞吸引材料如ECM结合可以实现。这对于用作疝植入物是特别有利的。这里，网状物只能粘附于腹壁（网状物的一侧）而不粘附在肠上。在本发明的一个方面，惰性材料是细长的并涂覆在两端。这对于用作吊索是特别有利的。在这里，网状物将粘附在吊索末端的锚固点上，并且由于膀胱排空仍然允许尿道再分布。

5. 发明申请

WO2007122232A2 GELATIN NON-WOVEN STRUCTURES PRODUCED BY A NON-TOXIC DRY SOLVENT SPINNING PROCESS 审中-公开
标题翻译：非溶剂干燥纺丝工艺生产的不凝胶结构
公开(公告)号：WO2007122232A2
公开(公告)日：2007-11-01
申请号：PCT/EP2007/053989
申请日：2007-04-24
申请人： COLOPLAST A/S , VANGE, Jakob , EVERLAND, Hanne , HASSINGBOE, Jens
发明人： HASSINGBOE, Jens
IPC分类号： D01F4/00 , D04H3/04 , A61L15/32 , A61L27/22
CPC分类号： A61L15/32 , A61L15/42 , A61L27/222 , B29C47/0004 , B29K2089/00 , D01D5/04 , D01D5/14 , D01F4/00 , D04H1/42 , D04H1/4374 , D04H1/4382 , D04H3/00 , D04H3/073 , D04H3/12 , D04H3/16 , D04H13/00 , Y10T428/2927 , Y10T428/2933 , Y10T442/60
摘要： The present application discloses an alternative method for the formation of non-woven with fibers in the 1 to 200µm range. Using an aqueous solution of gelatin (optionally with
摘要翻译：本申请公开了用于在1至200μm范围内用纤维形成无纺布的替代方法。使用明胶水溶液（任选地含有<30％的低分子量醇），使用从喷嘴发出的加压空气和直接从发射的细纤维形成的无纺布喷射纤维。明胶非织造织物可以通过热处理或化学交联进行交联，无纺布是通过体外成纤维细胞生长和体内伤口愈合测定的生物相容性的。

6. 发明申请

WO2007101443A1 DEGRADABLE HYDROPHILIC BLOCK COPOLYMERS WITH IMPROVED BIOCOM PATIBILΠ FOR SOFT TISSUE REGENERATION 审中-公开
标题翻译：具有改进的生物体肥料的可降解的亲水性嵌段共聚物？用于软组织再生
公开(公告)号：WO2007101443A1
公开(公告)日：2007-09-13
申请号：PCT/DK2007/000115
申请日：2007-03-07
申请人： COLOPLAST A/S , VANGE, Jakob , SCHWACH-ABDELLAOUI, Khadija , EVERLAND, Hanne , NIELSEN, Peter, Sylvest , NIELSEN, Brian , JESPERSEN, Lene, Karin , NIELSEN, Lene, Feldskov
发明人： VANGE, Jakob , SCHWACH-ABDELLAOUI, Khadija , EVERLAND, Hanne , NIELSEN, Peter, Sylvest , NIELSEN, Brian , JESPERSEN, Lene, Karin , NIELSEN, Lene, Feldskov
IPC分类号： C08G63/664 , C08G81/00 , C08J9/00 , C08J9/28 , A61L27/18 , A61L15/26 , A61L27/56
CPC分类号： C08G63/664 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , C08G2261/126 , C08J9/28 , C08J2201/0482 , C08J2201/0484 , C08J2367/04 , C12N5/0068 , C12N2533/30 , C12N2533/40 , Y10T428/249958 , C08L67/04
摘要： The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O-(CHR 1 CHR 2 O) n -B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [-CH(CH 3 )-COO-] and (ii) glycolide units [-CH 2 -COO-] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C 1-6 -alkyl or hydroxy protecting groups, one of R 1 and R 2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR 1 CHR 2 O)-] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.
摘要翻译：本申请公开了可生物降解的聚合物，包括这种聚合物的多孔和其它材料，以及这种材料的各种医学用途，包括用作支撑细胞粘附的支架或用于组织再生的生长中的用途。该聚合物具有下式：其中A是聚（丙交酯 - 共 - 乙交酯），其中A是聚（丙交酯 - 共 - 乙交酯））残基，（i）丙交酯单元[-CH（CH 3） - COO-]的摩尔比和（ii）乙交酯单元[-CH 2 -COO- ]在聚（丙交酯 - 共 - 乙交酯）残基中的比例在80:20至10:90的范围内，B是聚（丙交酯 - 共 - 乙交酯）残基或氢，C 1-6 - N 1 - 烷基或羟基保护基，R 1和R 2之一是氢或甲基，另一个是氢，n是10-1000，摩尔比的（iii）聚亚烷基二醇单元[ - （CHR 1 CH 2 O） - ]与（i）丙交酯单元和（ii）乙二醇单元的组合聚（丙交酯 - 共 - 乙交酯）残基最多为14:86，共聚物的分子量至少为20,000g / mol。

7. 发明申请

WO2007028169A2 A METHOD FOR CELL IMPLANTATION 审中-公开
标题翻译：一种细胞植入方法
公开(公告)号：WO2007028169A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034673
申请日：2006-09-05
申请人： INTERFACE BIOTECH A/S , EVERLAND, Hanne , CLAUSEN, Christian , OSTHER, Kurt
发明人： EVERLAND, Hanne , CLAUSEN, Christian , OSTHER, Kurt
IPC分类号： A61K35/12
CPC分类号： A61K38/4833 , A61K35/32 , A61K38/363 , A61L27/3843 , A61K2300/00
摘要： The present invention provides for a method for tissue engineering by cell implantation that involves the use of a scaffold in situ at the site of a defect, where the therapeutic cells are fixed in place into the scaffold only once the scaffold is inserted at the site of the tissue defect, thereby locking not only the cells to the scaffold, but also the scaffold to the tissue defect. The invention also provides a kit of parts suitable for performing the method of the invention.
摘要翻译：本发明提供了一种通过细胞移植进行组织工程的方法，该方法涉及在缺损部位的原位使用支架，其中一旦将支架插入到位于组织缺陷，从而不仅将细胞锁定到支架，而且将支架锁定到组织缺损。本发明还提供适用于执行本发明方法的一组零件。

8. 发明申请

WO2008107484A3 FISTULA PLUG COMPRISING ECM 审中-公开
标题翻译：包含ECM的FISTULA插管
公开(公告)号：WO2008107484A3
公开(公告)日：2009-09-03
申请号：PCT/EP2008052783
申请日：2008-03-07
申请人： COLOPLAST AS , NIELSEN LENE FELDSKOV , TRUELSEN JENS HOEG , EVERLAND HANNE
发明人： NIELSEN LENE FELDSKOV , TRUELSEN JENS HOEG , EVERLAND HANNE
IPC分类号： A61L27/36 , A61L27/48 , A61L27/58 , A61L31/00 , A61L31/12 , A61L31/14
CPC分类号： A61L31/148 , A61L27/3633 , A61L27/3641 , A61L27/48 , A61L27/58 , A61L31/005 , A61L31/129
摘要： The present invention relates to a temporary composite scaffold comprising discrete ECM particles formed as a fistula plug. We demonstrate that when using scaffolds containing ECM material, higher concentrations of ECM surprisingly do not give better cell morphology. Concentrations lower than 60%(w/w) are sufficient to obtain the best cell morphology and distribution.
摘要翻译：本发明涉及一种临时复合支架，其包括形成为瘘塞的离散的ECM颗粒。我们证明当使用含有ECM材料的支架时，较高浓度的ECM令人惊讶地不能提供更好的细胞形态。浓度低于60％（w / w）足以获得最佳的细胞形态和分布。

9. 发明申请

WO2008128546A1 MULTI COMPONENT NON-WOVEN 审中-公开
标题翻译：多元件非织造布
公开(公告)号：WO2008128546A1
公开(公告)日：2008-10-30
申请号：PCT/DK2008/050090
申请日：2008-04-17
申请人： COLOPLAST A/S , HASSINGBOE, Jens , VANGE, Jacob , EVERLAND, Hanne , WEIMIN, Rong
发明人： HASSINGBOE, Jens , VANGE, Jacob , EVERLAND, Hanne , WEIMIN, Rong
IPC分类号： A61L15/32
CPC分类号： A61F13/00987 , A61L15/32
摘要： The formation of a non-woven, free from organic solvent, formed through parallel formation of fibers on a collection device is disclosed. As the individual fibers are dry prior to contact with other fibers, the different contents of the various fiber types do not interact. However, when wetted, the fibers will start to be dissolved, or swell, and the different contents will be released and then interact. For the example of thrombin and fibrinogen, the interaction will initiate the formation of a fibrin coagulum by the cleavage of fibrinogen through the action of thrombin to form fibrin monomers that spontaneously polymerize to form a three dimensional network of fibrin.
摘要翻译：公开了通过在收集装置上平行形成纤维而形成无机织物，无机溶剂。由于单个纤维在与其他纤维接触之前是干燥的，所以各种纤维类型的不同内容不相互作用。然而，当润湿时，纤维将开始溶解或膨胀，并且不同的内容物将被释放并且然后相互作用。对于凝血酶和纤维蛋白原的实例，相互作用将通过凝血酶的作用通过纤维蛋白原的切割引发纤维蛋白凝结物的形成，从而形成自发聚合以形成纤维蛋白的三维网络的纤维蛋白单体。

10. 发明申请

WO2008107482A1 SCAFFOLDS FOR THE REGENERATION OF CARTILAGE 审中-公开
标题翻译：用于再生卡片的药物
公开(公告)号：WO2008107482A1
公开(公告)日：2008-09-12
申请号：PCT/EP2008/052781
申请日：2008-03-07
申请人： COLOPLAST A/S , EVERLAND, Hanne , VANGE, Jacob , CLAUSEN, Christian , NIELSEN, Lene Feldskov
发明人： EVERLAND, Hanne , VANGE, Jacob , CLAUSEN, Christian , NIELSEN, Lene Feldskov
IPC分类号： A61L27/48 , A61L27/56 , A61L27/58
CPC分类号： A61L27/56 , A61L27/48 , A61L27/58 , A61L2430/06 , C08L5/08 , C08L71/02 , C08L67/04
摘要： The present application discloses that incorporation of dermatan sulfate and/or HA in composite scaffolds of certain polymers gives rise to a chondrogenic effect on chondrocytes resulting in formation of cartilage that resembles the natural ECM. This effect with dermatan sulfate as the primary additive has not previously been seen. The composites are formed by incorporation of dermatan sulfate finely dispersed particles optionally nanoparticles or as molecular dissolutions in a polymer matrix with no bonding between the DS and the matrix, providing the DS to the chondrocytes in an accessible non-crosslinked form.
摘要翻译：本申请公开了在某些聚合物的复合支架中掺入硫酸皮肤素和/或HA导致对软骨细胞的软骨形成作用，导致形成类似于天然ECM的软骨。以前没有看到这种硫酸皮肤素作为主要添加剂的效果。通过将硫酸皮肤素精细分散的颗粒任选地纳入纳米颗粒或作为分子溶解在聚合物基质中，在DS和基质之间没有结合形成复合物，以可接近的非交联形式向软骨细胞提供DS。

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