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1. 发明申请

WO2007076055A9 COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2007076055A9
公开(公告)日：2007-08-30
申请号：PCT/US2006049117
申请日：2006-12-21
申请人： ENTREMED INC , HEMBROUGH TODD A , AGOSTON GREGORY E , TRESTON ANTHONY M , HANSON ARTHUR D
发明人： HEMBROUGH TODD A , AGOSTON GREGORY E , TRESTON ANTHONY M , HANSON ARTHUR D
IPC分类号： A61K31/44
CPC分类号： A61K31/44
摘要： Compositions and methods comprising proteinase activated receptor antagonists are provided. More particularly, the present invention relates to the use of proteins, peptides and molecules that bind to proteinase activated receptor 2, and inhibit the processes associated with the activation of that receptor. More specifically, the present invention provides novel compositions and methods for the treatment of disorders and diseases such as those associated with abnormal cellular proliferation, angiogenesis, inflammation and cancer.

2. 发明申请

WO2006058298A3 A METHOD OF ADMINISTERING ANTI-ANGIOGENIC AGENTS AND A METHOD OF TREATING DISEASE USING SAME 审中-公开
公开(公告)号：WO2006058298A3
公开(公告)日：2006-06-01
申请号：PCT/US2005/042944
申请日：2005-11-29
申请人： ENTREMED, INC. , FOGLER, William, E. , SIDOR, Carolyn, F. , TRESTON, Anthony, M. , VOLKER, Kirk, M.
发明人： FOGLER, William, E. , SIDOR, Carolyn, F. , TRESTON, Anthony, M. , VOLKER, Kirk, M.
IPC分类号： A61K31/56
摘要： A method of administering an anti-angiogenic agent to a human or an animal comprising administering the anti-angiogenic agent such that a plasma concentration of the anti-angiogenic agent in the human or animal is substantially continuously maintained above 1 ng/mL.

3. 发明申请

WO2005030120A3 ANTIANGIOGENIC AGENTS 审中-公开
标题翻译：抗血管生成药物
公开(公告)号：WO2005030120A3
公开(公告)日：2005-12-15
申请号：PCT/US2004016831
申请日：2004-05-28
申请人： ENTREMED INC , AGOSTON GREGORY E , LAVALLEE THERESA M , PRIBLUDA VICTOR S , SHAH JAMSHED H , TRESTON ANTHONY M
发明人： AGOSTON GREGORY E , LAVALLEE THERESA M , PRIBLUDA VICTOR S , SHAH JAMSHED H , TRESTON ANTHONY M
IPC分类号： A61K20060101 , A61K31/56 , C07J1/00 , C07J3/00 , C07J7/00 , C07J31/00 , C07J41/00
CPC分类号： C07J41/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula (I) wherein the variables are defined in the specification.
摘要翻译：通过施用其中变量在说明书中定义的通式（I）的化合物来治疗以不希望的血管生成为特征的哺乳动物疾病的组合物和方法。

4. 发明申请

WO2005030120A2 ANTIANGIOGENIC AGENTS 审中-公开
标题翻译：抗生素代谢物
公开(公告)号：WO2005030120A2
公开(公告)日：2005-04-07
申请号：PCT/US2004/016831
申请日：2004-05-28
申请人： ENTREMED, INC. , AGOSTON, Gregory, E , LAVALLEE, Theresa, M. , PRIBLUDA, Victor, S. , SHAH, Jamshed, H. , TRESTON, Anthony, M.
发明人： AGOSTON, Gregory, E , LAVALLEE, Theresa, M. , PRIBLUDA, Victor, S. , SHAH, Jamshed, H. , TRESTON, Anthony, M.
IPC分类号： A61K
CPC分类号： C07J41/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula (I) wherein the variables are defined in the specification.
摘要翻译：通过施用其中变量在说明书中定义的通式（I）的化合物来治疗特征在于不期望的血管发生的哺乳动物疾病的组合物和方法。

5. 发明申请

WO03063791A2 NON-STEROIDAL ANALOGS OF 2-METHOXYESTRADIOL 审中-公开
标题翻译：非甾体类2-甲氧基雌二醇的类似物
公开(公告)号：WO03063791A2
公开(公告)日：2003-08-07
申请号：PCT/US0302917
申请日：2003-01-30
申请人： ENTREMED INC , AGOSTON GREGORY , SHAH JAMSHED H , HUNSUCKER KIMBERLY A , TRESTON ANTHONY M , PRIBLUDA VICTOR S
发明人： AGOSTON GREGORY , SHAH JAMSHED H , HUNSUCKER KIMBERLY A , TRESTON ANTHONY M , PRIBLUDA VICTOR S
IPC分类号： C07C43/23 , A61K
CPC分类号： C07C43/23 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/26
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis and proliferative activity by administering non-steroidal derivatives of 2-methoxyestradiol of the general formula:(I) wherein the variables are defined in the specification.
摘要翻译：组合物和用于治疗哺乳动物疾病的特征在于不期望的血管发生和增殖活性通过施用通式2-甲氧基雌二醇的非甾体衍生物的方法：其中各变量如说明书中所定义（I）。

6. 发明申请

WO0204010A3 INHIBITION OF TUMOR GROWTH BY A NEMATODE ANTICOAGULANT PROTEIN 审中-公开
标题翻译： NEMATODE抗凝血蛋白抑制肿瘤生长
公开(公告)号：WO0204010A3
公开(公告)日：2003-07-31
申请号：PCT/US0122231
申请日：2001-07-12
申请人： ENTREMED INC , GREEN SHAWN J , HEMBROUGH TODD A
发明人： GREEN SHAWN J , HEMBROUGH TODD A
IPC分类号： A61K35/56 , A61K38/57 , A61P7/02 , A61P35/00 , C12N5/08 , C12N5/06
CPC分类号： A61K38/1767
摘要： The present invention relates to compositions and uses of nematode anticoagulant proteins (NAPs). More specifically, the invention relates to the use of rNAPc2 and rNAP5 for the inhibition of endothelial cell proliferation and the inhibition of angiogenesis. The invention also relates to methods for the treatment of angiogenesis-mediated diseases, such as cancer.
摘要翻译：本发明涉及线虫抗凝蛋白（NAP）的组合物和用途。更具体地，本发明涉及rNAPc2和rNAP5用于抑制内皮细胞增殖和抑制血管发生的用途。本发明还涉及治疗血管生成介导的疾病如癌症的方法。

7. 发明申请

WO0119989A3 METHOD OF PRODUCING AND PURIFYING ENDOSTATIN PROTEIN 审中-公开
标题翻译：生产和纯化内切蛋白TM蛋白的方法
公开(公告)号：WO0119989A3
公开(公告)日：2001-08-09
申请号：PCT/US0025166
申请日：2000-09-14
申请人： ENTREMED INC , LIANG HONG , SIM KIM LEE , CHANG MURAD AMY , ZHOU XINHUA , MADSEN JOHN , BOERNER RENEE J , BERMEJO LOURDES L , MISTRY FIROZ RUSTOM , SHEPARD SCOTT R , SCHRIMSHER JEFFREY L
发明人： LIANG HONG , SIM KIM LEE , CHANG-MURAD AMY , ZHOU XINHUA , MADSEN JOHN , BOERNER RENEE J , BERMEJO LOURDES L , MISTRY FIROZ RUSTOM , SHEPARD SCOTT R , SCHRIMSHER JEFFREY L
IPC分类号： C07K14/78 , C12N15/12 , C07K1/16 , C12N1/16 , C12P21/02
CPC分类号： C07K14/78
摘要： The present invention provides a method for recombinant production, recovery and purification of Endostatin protein. This method may be employed for large scale recovery and purification of recombinantly-produced Endostatin protein.
摘要翻译：本发明提供了内皮抑素TM蛋白质的重组生产，回收和纯化的方法。该方法可用于大规模回收和纯化重组产生的内皮抑素TM蛋白质。

8. 发明申请

WO1996028199A1 FLOW ELECTROPORATION CHAMBER AND METHOD 审中-公开
标题翻译：流动电气室和方法
公开(公告)号：WO1996028199A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003211
申请日：1996-03-11
申请人： ENTREMED, INC.
发明人： ENTREMED, INC. , MESEROL, Peter, M. , PRODELL, Rita, C. , ACKER, Jesse, L.
IPC分类号： A61M01/36
CPC分类号： F25B21/02 , A61K35/18 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M1/36 , A61M1/3607 , A61M1/3687 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2202/0429 , A61M2205/3306 , A61M2205/3368 , A61M2205/3382 , A61M2205/3606 , A61M2205/3673 , C12M35/02 , A61M2202/0092
摘要： The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow, self-contained electroporation system (5) which allows withdrawal of blood from a patient, separation of red blood cells, and optional recombination of blood plasma and the modified red blood cells thereby producing blood with modified biological characteristics. The present invention is particularly suited for use to encapsulate allosteric effectors of hemoglobin, thereby reducing the affinity of erythrocytes for oxygen and improving the release of oxygen from erythrocytes in tissues. The blood is introduced into the system (5) at inlet (11) and mixed with an anticoagulant (27). The blood and anticoagulant mixture is passed through a filter (18) and to a blood separation and wash bowl (44). Plasma and white blood cells are admitted into the plasma reservoir (89) while the red blood cells are retained in the wash bowl (44). The separated red blood cells are pumped out and admixed at junction (67) withan IHP solution from reservoir (50). This mixture is cooled by cooling coil (68) and then pumped to electroporation chamber (72) for treatment.
摘要翻译：本发明涉及用于将生物活性物质包封在红细胞中的方法和装置，其特征在于可选地自动化的连续流动的独立电穿孔系统（5），其允许从患者中取出血液，分离的红细胞，以及血浆和修饰的红细胞的任选重组，从而产生具有改良的生物特征的血液。本发明特别适用于包封血红蛋白的变构效应物，从而降低红细胞对氧的亲和力，改善组织中红细胞释放的氧。将血液在入口（11）处引入系统（5）中并与抗凝剂（27）混合。血液和抗凝血剂混合物通过过滤器（18）和血液分离洗涤碗（44）。等离子体和白细胞进入血浆容器（89），同时红细胞保留在洗涤碗（44）中。将分离的红细胞泵出并在接合处（67）与储存器（50）的IHP溶液混合。将该混合物通过冷却盘管（68）冷却，然后泵送到电穿孔室（72）进行处理。

9. 发明申请

WO2007070372A3 COMPOSITIONS AND METHODS FOR INHIBITING CELLULAR PROLIFERATION 审中-公开
标题翻译：用于抑制细胞增殖的组合物和方法
公开(公告)号：WO2007070372A3
公开(公告)日：2008-07-10
申请号：PCT/US2006046846
申请日：2006-12-08
申请人： ENTREMED INC , AFFYMAX INC , HEMBROUGH TODD A , HOLMES CHRISTOPHER P , YIN QUN , ZEMEDE GENET H , ANGELL YVONNE M , FREDERICK BRIAN T , XU CAIDING
发明人： HEMBROUGH TODD A , HOLMES CHRISTOPHER P , YIN QUN , ZEMEDE GENET H , ANGELL YVONNE M , FREDERICK BRIAN T , XU CAIDING
IPC分类号： C07K7/00 , C07K14/00
CPC分类号： A61K38/08 , A61K38/10 , A61K47/55 , A61K47/60 , A61K47/62 , C07K7/08 , C07K14/001
摘要： Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.
摘要翻译：提供了有效抑制异常或不期望的细胞增殖，特别是与新生血管形成和肿瘤生长相关的内皮细胞增殖和血管发生的组合物和方法。组合物包含肽分子，任选地含有一个或多个共价连接并且任选地用聚乙二醇（PEG）修饰的单个肽链。所述方法包括以足以抑制细胞增殖，特别是内皮细胞增殖的剂量向人或动物施用本文所述的组合物。该方法可用于治疗由不期望的和不受控制的细胞增殖如癌症介导的疾病和过程，特别是通过抑制血管发生。将组合物给予具有血运重建的转移性肿瘤的人或动物可用于预防这些肿瘤的生长或扩张。

10. 发明申请

WO2004002418A3 COMPOSITIONS AND METHODS COMPRISING PROTEIN ACTIVATED RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2004002418A3
公开(公告)日：2004-01-08
申请号：PCT/US2003/020366
申请日：2003-06-26
申请人： ENTREMED, INC , HEMBROUGH, Todd , PRIBLUDA, Victor
发明人： HEMBROUGH, Todd , PRIBLUDA, Victor
IPC分类号： A61K38/00
摘要： Compositions and methods comprising protein activated receptor antagonists are provided. More particularly, the present invention relates to the use of proteins, peptides and biomolecules that bind to protein activated receptor 2, and inhibit the processes associated with the activation of that receptor. More specifically, the present invention provides novel compositions and methods for the treatment of disorders and diseases such as those associated with abnormal cellular proliferation, angiogenesis, inflammation and cancer.

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