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    • 10. 发明申请
    • PALBOCICLIB SALTS
    • WO2017072543A1
    • 2017-05-04
    • PCT/HU2016/050050
    • 2016-10-26
    • EGIS GYÓGYSZERGYÁR ZRT.
    • LUKÁCS, GyulaMÁRVÁNYOS, Ede LászlóBERECZ, GáborHÉDER, János LeventeMILEN, MátyásPEREGI, BalázsGUDOR, RóbertVOLK, BalázsTÓTHNÉ LAURITZ, Mária
    • C07D401/14A61K31/519A61P35/00
    • C07D471/04
    • The subject of the invention relates to various new salts of palbociclib, furthermore to their hydrate and solvate forms, such as the palbociclib hydrogen bromide (1:1) salt, the palbociclib hydrogen bromide (1:2) dihydrate salt, the palbociclib hydrogen chloride (1:1) salt Form E, the palbociclib sulphate (2:1) dihydrate salt, the palbociclib camsylate (1:1) salt, the palbociclib napsylate (1:1) salt, the palbociclib napsylate (1:2) dihydrate salt, the palbociclib tosylate (1:1) salt, the palbociclib citrate (1:1) monohydrate salt, the palbociclib maleate (1:1) salt Form I, the palbociclib maleate (1:1) salt Form II and the palbociclib oxalate (1:1) salt. The subject of the invention also relates to the production of the above palbociclib salts, medicinal preparations containing these and the medical use of the above forms.
    • 本发明的主题涉及palbociclib的各种新盐,此外还涉及它们的水合物和溶剂合物形式,例如palbociclib溴化氢(1:1)盐,palbociclib溴化氢(1:2) )二水合物盐,palbociclib氯化氢(1:1)盐形式E,palbociclib硫酸盐(2:1)二水合物盐,palbociclib樟脑磺酸盐(1:1)盐,palbociclib萘磺酸盐(1:1)盐,palbociclib 萘磺酸盐(1:2)二水合物盐,palbociclib甲苯磺酸盐(1:1)盐,palbociclib柠檬酸盐(1:1)一水合物盐,palbociclib马来酸盐(1:1)盐,palbociclib马来酸盐(1:1) 盐II型和palbociclib草酸盐(1:1)盐。 本发明的主题还涉及上述palbociclib盐的生产,含有这些的药物制剂以及上述形式的医学用途。