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1. 发明申请

WO2013106851A2 SYNCOLLIN, PANCREATIC TRIACYLGLYCEROL LIPASE, AND OTHER BIOMARKERS FOR DIABETES 审中-公开
标题翻译： SYNCOLLIN，PANCREATIC TRIACYLGLYCEROL LIPASE和其他生物标志物用于糖尿病
公开(公告)号：WO2013106851A2
公开(公告)日：2013-07-18
申请号：PCT/US2013/021476
申请日：2013-01-14
申请人： EASTERN VIRGINIA MEDICAL SCHOOL
发明人： NADLER, Jerry, L. , GREEN-MITCHELL, Shamina, M. , NYALWIDHE, Julius, O.
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/52
摘要： The present invention provides biomarkers that are useful in determining whether a subject has type 1 diabetes or is at risk for developing type I diabetes. Specifically, syncollin, pancreatic triacylglycerol lipase, as well as fragments and variants of these proteins can be used to diagnose an individual with type I diabetes or one at risk for developing type I diabetes. Additional type I diabetes biomarkers are also provided.
摘要翻译：本发明提供了用于确定受试者是否患有1型糖尿病或处于患I型糖尿病风险中的生物标志物。具体而言，syncollin，胰腺三酰甘油酯脂肪酶以及这些蛋白质的片段和变体可以用于诊断具有I型糖尿病的个体或具有发展为I型糖尿病的风险的个体。还提供了其他I型糖尿病生物标志物。

2. 发明申请

WO2012145349A1 CERCLAGE SUTURE REMOVAL DEVICE 审中-公开
标题翻译：剔除装置
公开(公告)号：WO2012145349A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/034000
申请日：2012-04-18
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , ABUHAMAD, Alfred, Z.
发明人： ABUHAMAD, Alfred, Z.
IPC分类号： A61B17/10
CPC分类号： A61B17/0467 , A61B17/42
摘要： A device for removing a cerclage suture has a shaft sized and shaped to extend from a proximal end outside a vagina to a distal end near a cervix. The shaft also has a blunt end located at the distal end of the shaft and having a taper for allowing the blunt end to pass between a cerclage suture and cervical mucosa without cutting the mucosa and to move the suture away from the mucosa. The device includes a movable cutter at the distal end of the shaft and being movable between an open non-cutting position and a closed cutting position for cutting the suture. The device also includes an actuator for causing the cutter to be moved from the open position to the closed position to cut the suture.
摘要翻译：用于去除环扎缝合线的装置具有尺寸和形状从轴向外的近端延伸到子宫颈附近的轴。该轴还具有位于轴的远端处的钝端，并且具有用于允许钝端在环形缝合线和子宫颈粘膜之间通过而不切割粘膜并使缝合线从粘膜移动的锥形。该装置包括在轴的远端处的可移动切割器，并且可在打开的非切割位置和用于切割缝合线的封闭切割位置之间移动。该装置还包括致动器，用于使切割器从打开位置移动到关闭位置以切割缝合线。

3. 发明申请

WO2010022387A1 METHOD AND APPARATUS FOR CHRONIC DISEASE CONTROL 审中-公开
标题翻译：慢性疾病控制方法与装置
公开(公告)号：WO2010022387A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/054747
申请日：2009-08-24
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , HUBBARD, Thomas, W. , GYURICSKO, Eric , SATIN-SMITH, Marta , SCERBO, Mark, W. , GARCIA, Hector, M. , MCKENZIE, Frederic, D.
发明人： HUBBARD, Thomas, W. , GYURICSKO, Eric , SATIN-SMITH, Marta , SCERBO, Mark, W. , GARCIA, Hector, M. , MCKENZIE, Frederic, D.
IPC分类号： A61B5/00
CPC分类号： A61B5/1112 , A61B5/0002 , A61B5/1118 , A61B5/14532 , A61B2503/06 , A61B2505/07 , A61B2562/0219 , G06F19/00 , G06F19/3481 , G16H50/20
摘要： The invention provides an apparatus and method for measuring the blood glucose level and physical activity of an individual, and providing an individualized prediction of the blood glucose level of the individual over time based upon the measurements. The individualized prediction is updated in a recursive manner as additional measurements are received. Incentives are determined and provided for maintaining a blood glucose level within a threshold of the individualized predicted blood glucose value and for achieving benchmark levels of physical activity and exertion.
摘要翻译：本发明提供了一种用于测量个体的血糖水平和身体活动的装置和方法，并且基于测量提供个体随着时间的血糖水平的个体化预测。当接收到附加测量时，个性化预测以递归方式更新。激励措施被确定并提供用于将血糖水平维持在个体化预测血糖值的阈值内，并用于实现身体活动和运动的基准水平。

4. 发明申请

WO2007145806A2 METHODS FOR REGULATING COMPLEMENT CASCADE PROTEINS USING ASTROVIRUS COAT PROTEIN AND DERIVATIVES THEREOF 审中-公开
标题翻译：使用ASTROVIRUS COAT蛋白及其衍生物调节补体蛋白的方法
公开(公告)号：WO2007145806A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/012617
申请日：2007-05-25
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , KRISHNA, Neel, K. , CUNNION, Kenji
发明人： KRISHNA, Neel, K. , CUNNION, Kenji
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5258 , C12N2770/12022 , C12N2770/12032 , C12N2770/12033
摘要： The present invention provides a method for modulating the complement cascade by depleting the plasma of the functional activity of complement proteins and thereby reducing or eliminating complement-mediated cell lysis. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement-mediated cell lysis and peptide mediators of inflammation. The invention provides a method for the therapeutic use of coat proteins and derivatives thereof from the Astroviradae family of viruses in the treatment of complement- mediated diseases. Methods are described herein where complement cascade, triggered by either the classical or alternative complement pathways, is prevented from effecting cell lysis and inflammation due to inhibition or depletion of one or more complement components in the serum following administration of astrovirus coat proteins or derivatives.
摘要翻译：本发明提供了一种通过消耗补体蛋白的功能活性的血浆以及从而减少或消除补体介导的细胞裂解来调节补体级联的方法。本发明提供了一种用于治疗使用来自Astroviradae病毒的外壳蛋白及其衍生物用于治疗补体介导的细胞裂解和炎症炎症介质的方法。本发明提供了用于治疗使用来自Astroviradae病毒家族的外壳蛋白及其衍生物在治疗补体介导的疾病中的方法。本文描述了方法，其中由经典或替代补体途径触发的补体级联由于在施用星状病毒外壳蛋白或衍生物后在血清中抑制或消耗一种或多种补体成分而被阻止细胞裂解和炎症。

5. 发明申请

WO2007127305A3 SYSTEMS AND METHODS FOR MONITORING AND CONTROLLING INTERNAL PRESSURE OF AN EYE OR BODY PART 审中-公开
公开(公告)号：WO2007127305A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/010138
申请日：2007-04-25
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , DELAHANTY, Thomas, C. , LATTANZIO, Frank, A.
发明人： DELAHANTY, Thomas, C. , LATTANZIO, Frank, A.
IPC分类号： A61B5/00 , B65D81/00 , A61D5/00
摘要： Systems and methods for automatically monitoring and controlling pressure in a body part are disclosed. The systems include an implantable tube with one open end of the tube implanted in the body part, an implantable valve coupled with the tube having at least one open state and a closed state, an implantable sensor for measuring pressure, and an implantable control device coupled with the sensor and the valve. The control device switches the valve between the at least one open state and the closed state, based on pressure information received from the sensor. When the valve is in the at least one open state, the tube drains fluids from the body part due to a difference of pressure between the open ends of the tube. Methods for using the systems to administer drugs and monitor and control fluid pressures in various biological systems are also disclosed.

6. 发明申请

WO2007008924A3 SYSTEM AND METHOD FOR AUTOMATIC DRIVER EVALUATION 审中-公开
公开(公告)号：WO2007008924A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/026942
申请日：2006-07-12
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , FREUND, Barbara , FREUND, Ronald, K.
发明人： FREUND, Barbara , FREUND, Ronald, K.
IPC分类号： G09B19/16 , G09B9/04 , G09B5/00
摘要： Embodiments of the present invention provide a system and method for automatic driver evaluation of a person's driving capabilities and render an outcome of pass or fail without the need for a trained observer to evaluate driver's performance. In one embodiment, the automatic driver evaluation system facilitates the display of a predetermined driving route designed for a predetermined demography, observe simulated driving performance of a user on the predetermined driving route, record errors made by the user while performing the simulated drive, and compare the performance errors to at least one threshold value and generate a score based on the comparison.

7. 发明申请

WO2006020302A2 BIOMARKERS FOR BLADDER CANCER 审中-公开
标题翻译：生物标记用于刮板癌
公开(公告)号：WO2006020302A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/025632
申请日：2005-07-20
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , VLAHOU, Antonia , SEMMES, O. John
发明人： VLAHOU, Antonia , SEMMES, O. John
IPC分类号： C12Q1/68
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying bladder cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as bladder cancer or non-bladder cancer. The biomarkers can be detected by SELDI mass spectrometry.
摘要翻译：本发明提供了可用于限定患者膀胱癌状态的基于蛋白质的生物标志物和生物标志物组合。特别地，本发明的生物标志物可用于将受试者样品分类为膀胱癌或非膀胱癌。生物标志物可以通过SELDI质谱检测。

8. 发明申请

WO2005032646A2 APPARATUS FOR GENERATING ELECTRICAL PULSES AND METHODS OF USING THE SAME 审中-公开
标题翻译：用于产生电脉冲的装置及其使用方法
公开(公告)号：WO2005032646A2
公开(公告)日：2005-04-14
申请号：PCT/US2004/023078
申请日：2004-07-19
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , OLD DOMINION UNIVERSITY , BEEBE, Stephen, J. , SCHOENBACH, Karl, H.
发明人： BEEBE, Stephen, J. , SCHOENBACH, Karl, H.
IPC分类号： A61N
CPC分类号： A61N1/0412 , A61K48/00 , A61N1/327 , C12M35/02 , C12N13/00 , C12N15/87
摘要： A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields ("nsPEF's"). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.
摘要翻译：提供了一种方法和装置，用于通过施加纳秒脉冲电场（“nsPEF”）将试剂输送到电池中。该方法包括用于通过已知方法将试剂递送到细胞中的电路，随后将纳秒脉冲电场施加到所述细胞，以便促进试剂进入细胞核。在优选的实施方案中，本发明涉及增强细胞中基因表达的方法，其包括向所述细胞施加纳秒脉冲电场。还提供了根据本发明的用于产生长脉冲和短脉冲的装置。该装置包括能够产生具有长持续时间和低电压振幅的第一脉冲和具有短持续时间和高电压振幅的第二脉冲的脉冲发生器。

9. 发明申请

WO2003097799A2 HTLV-I TAX INDUCED KILLING OF p53 NULL CANCER CELLS 审中-公开
标题翻译： HTLV-I TAX诱导的p53空位癌细胞的杀伤
公开(公告)号：WO2003097799A2
公开(公告)日：2003-11-27
申请号：PCT/US2003/015280
申请日：2003-05-16
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , SEMMES, Oliver, John, IV , KUPFER, Gary, Michael
发明人： SEMMES, Oliver, John, IV , KUPFER, Gary, Michael
IPC分类号： C12N
CPC分类号： C07K14/005 , A61K48/00 , C12N2740/14022 , C12N2740/14043
摘要： This invention is based on the finding that expression of an exogenous nucleic acid encoding a polypeptide having human T-cell leukemia virus type I (HTLV-1) Tax activity in p53 null cells results in a sensitization of those cells to DNA damaging agents. Therefore, the present invention is directed to a method of inducing cell death in p53 null cells, enhancing susceptibility to such DNA damaging agents, and the selective cell killing of p53 null cells. It has been found that retroviral vectors, and particularly lentiviral vectors, are suitable for the present invention to permit the transient expression of the HTLV-1 Tax protein in the p53 null cells, which sensitizes the cells.
摘要翻译：本发明基于以下发现：编码在p53无细胞中具有人T细胞白血病病毒I型（HTLV-1）Tax活性的多肽的外源核酸的表达导致这些细胞对DNA损伤剂的敏化。因此，本发明涉及在p53无效细胞中诱导细胞死亡，增强对这种DNA损伤剂的易感性，以及p53无效细胞的选择性细胞杀伤的方法。已经发现逆转录病毒载体，特别是慢病毒载体，适用于本发明，以允许HTLV-1 Tax蛋白在p53无效细胞中的瞬时表达，其使细胞敏感。

10. 发明申请

WO2003060467A3 METHOD FOR ANALYZING EFFECTS OF MEDICAL AGENTS 审中-公开
公开(公告)号：WO2003060467A3
公开(公告)日：2003-07-24
申请号：PCT/US2002/040797
申请日：2002-12-20
申请人： EASTERN VIRGINIA MEDICAL SCHOOL , DENG, Yuping
发明人： DENG, Yuping
IPC分类号： G01N33/533
摘要： A method for analyzing the effects of medicinal agents, and more particularly, an ex vivo method of analyzing the effects of medicinal agents on the human immune system is provided.

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