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1. 发明申请

WO2006011792A2 ANTIMICROBIAL PEPTIDES 审中-公开
标题翻译：抗菌肽
公开(公告)号：WO2006011792A2
公开(公告)日：2006-02-02
申请号：PCT/NL2005/000545
申请日：2005-07-26
申请人： OctoPlus Technologies B.V. , GROTE, Johannes Jakobus , DRIJFHOUT, Jan Wouter
发明人： GROTE, Johannes Jakobus , DRIJFHOUT, Jan Wouter
IPC分类号： A61K38/17
CPC分类号： A61K38/17
摘要： The present invention relates to a group of peptidic compounds which have antimicrobial activity. The compounds also have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. The compounds can be used to manufacture medicaments useful for the treatment of bacterial or fungal infections. The medicaments may be administered systemically or locally.
摘要翻译：本发明涉及具有抗微生物活性的一组肽化合物。该化合物还对毒素特别是对细菌毒素如脂多糖或脂磷壁酸具有亲和力。该化合物可用于制备可用于治疗细菌或真菌感染的药物。药物可以全身或局部施用。

2. 发明申请

WO2004067563A1 PEPTIDE INHIBITORS OF TOXINS DERIVED FROM LL-37 审中-公开
标题翻译：来自LL-37的毒素的肽抑制剂
公开(公告)号：WO2004067563A1
公开(公告)日：2004-08-12
申请号：PCT/NL2004/000060
申请日：2004-01-27
申请人： OCTOPLUS TECHNOLOGIES B.V. , GROTE, Johannes, Jakobus , DRIJFHOUT, Jan, Wouter
发明人： GROTE, Johannes, Jakobus , DRIJFHOUT, Jan, Wouter
IPC分类号： C07K14/47
CPC分类号： C07K14/4723 , A61K38/00 , A61K48/00
摘要： The present invention relates to a group of peptidic compounds which have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. These compounds can inhibit or neutralize the toxins. In addition, the present invention relates to the use of these compounds as therapeutic or diagnostic agents.
摘要翻译：本发明涉及对毒素特别是对细菌毒素如脂多糖或脂磷壁酸具有亲和力的一组肽类化合物。这些化合物可以抑制或中和毒素。另外，本发明涉及这些化合物作为治疗剂或诊断剂的用途。

3. 发明申请

WO2010005293A1 PEPTIDYLARGININE DEIMINASE (PAD) INHIBITORS 审中-公开
标题翻译：哌啶脱乙酰胺（PAD）抑制剂
公开(公告)号：WO2010005293A1
公开(公告)日：2010-01-14
申请号：PCT/NL2009/050340
申请日：2009-06-15
申请人： CHIRALIX B.V. , MODIQUEST B.V. , ACADEMISCH ZIEKENHUIS LEIDEN H.O.D.N. LUMC , BLAAUW, Richard Hendrik , PRUIJN, Gerardus Jozef Maria , RAATS, Jozef Maria Hendrik , RUTJES, Floris Petrus Johannes Theodorus , DRIJFHOUT, Jan Wouter
发明人： BLAAUW, Richard Hendrik , PRUIJN, Gerardus Jozef Maria , RAATS, Jozef Maria Hendrik , RUTJES, Floris Petrus Johannes Theodorus , DRIJFHOUT, Jan Wouter
IPC分类号： C07K7/06 , C07K7/08 , C07K14/47 , A61K38/08 , A61K38/10 , A61K38/17
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/47 , C07K14/4713
摘要： The invention relates to PAD inhibitors that are suitable to be used as a medicament against an autoimmune disease such as RA.
摘要翻译：本发明涉及适合用作抗自身免疫疾病如RA的药物的PAD抑制剂。

4. 发明申请

WO2007055578A1 CYCLIC ANTIMICROBIAL PEPTIDES DERIVED FROM LACTOFERRIN 审中-公开
标题翻译：从LACTOFERRIN衍生的循环抗微生物肽
公开(公告)号：WO2007055578A1
公开(公告)日：2007-05-18
申请号：PCT/NL2006/050284
申请日：2006-11-10
申请人： LEIDS UNIVERSITAIR MEDISCH CENTRUM , FEITSMA, Rolf Ide Johannes , NIBBERING, Peter Hendricus , DRIJFHOUT, Jan Wouter
发明人： FEITSMA, Rolf Ide Johannes , NIBBERING, Peter Hendricus , DRIJFHOUT, Jan Wouter
IPC分类号： C07K7/64 , A61K38/12 , A61P31/04
CPC分类号： C07K5/0815 , C07K5/0817 , C07K5/1019 , C07K14/79
摘要： The present invention relates to cyclic compounds, preferably cyclic peptides, that at least comprise a stretch of positively charged amino acids, at some distance thereof an aromatic amino acid. The aromatic amino acid may be immediately followed by an amino acid with a thiol-group in the side chain. The cyclic compounds show a dramatic increase in antimicrobial activity as compared linear versions having the same amino acid sequence, in particular under physiological salt conditions. The cyclic compounds show antimicrobial activity against a broad spectrum of microbes and may be used in both prophylactic and therapeutic methods against infectious diseases.
摘要翻译：本发明涉及环状化合物，优选环状肽，其至少包含一段带正电荷的氨基酸，其一定距离处为芳族氨基酸。芳族氨基酸可以紧接着在侧链中具有硫醇基的氨基酸。与具有相同氨基酸序列的线性形式相比，特别是在生理盐条件下，环状化合物显示出抗微生物活性的显着增加。环状化合物显示对广谱微生物的抗微生物活性，并可用于预防和治疗传染病的方法。

5. 发明申请

WO2006011792A3 ANTIMICROBIAL PEPTIDES DERIVED FROM CAP18 审中-公开
标题翻译：来自CAP18的抗真菌肽
公开(公告)号：WO2006011792A3
公开(公告)日：2006-09-14
申请号：PCT/NL2005000545
申请日：2005-07-26
申请人： OCTOPLUS TECHNOLOGIES B V , ACADEMISCH ZIEKENHUIS LEIDEN , GROTE JOHANNES J , DRIJFHOUT JAN WOUTER , HIEMSTRA PIETER SICCO , NELL MAARTJE JOHANNA , VONK MARCEL JAN , BLOEMBERG GUIDO VINCENT
发明人： GROTE JOHANNES JAKOBUS , DRIJFHOUT JAN WOUTER , HIEMSTRA PIETER SICCO , NELL MAARTJE JOHANNA , VONK MARCEL JAN , BLOEMBERG GUIDO VINCENT
IPC分类号： A61K38/17 , A61K31/04 , A61P31/10
CPC分类号： A61K38/17
摘要： The present invention relates to a group of peptidic compounds which have antimicrobial activity. The compounds also have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. The compounds can be used to manufacture medicaments useful for the treatment of bacterial or fungal infections. The medicaments may be administered systemically or locally.
摘要翻译：本发明涉及具有抗微生物活性的一组肽化合物。该化合物还对毒素特别是对细菌毒素如脂多糖或脂磷壁酸具有亲和力。该化合物可用于制备可用于治疗细菌或真菌感染的药物。药物可以全身或局部施用。

6. 发明申请

WO2006004394A2 METHOD FOR DETECTING GLUTEN 审中-公开
标题翻译：检测谷氨酰胺的方法
公开(公告)号：WO2006004394A2
公开(公告)日：2006-01-12
申请号：PCT/NL2005/000400
申请日：2005-06-01
申请人： ACADEMISCH ZIEKENHUIS LEIDEN , DRIJFHOUT, Jan, Wouter , KONING, Frits , SPAENIJ-DEKKING, Elisabeth, Hermine, Adriane
发明人： DRIJFHOUT, Jan, Wouter , KONING, Frits , SPAENIJ-DEKKING, Elisabeth, Hermine, Adriane
IPC分类号： G01N33/564
CPC分类号： G01N33/564
摘要： Provided is a mAb-based method for the detection of T cell stimulatory epitopes known to be involved in CD. The method has many advantages compared to the existing methods for the detection of gluten since it is the first method that can; (i) detect T cell stimulatory epitopes of gluten; (ii) detect the epitopes separately, (iii) detect T cell stimulatory epitopes present on gliadin and glutenin homologues present in other cereals also known to be involved in CD; and (iv) detect T cell stimulatory epitopes on both intact proteins and small protein fragments. The new method is a valuable tool in the screening of basic ingredients, semi manufactured ingredients and food products that are intended to be used in the gluten free diet of CD patients. Moreover the new method can also be used for the screening of cereals and different wheat varieties for the level of toxicity for CD patients. Thereby the method can help in the selection of cereals and wheat varieties with low toxicity which might form the basis for future breeding programs. In the future these cereals will be used for the production of safe food for CD patients.
摘要翻译：提供了用于检测已知参与CD的T细胞刺激性表位的基于mAb的方法。与现有的麸质检测方法相比，该方法具有许多优点，因为它是第一种方法; （i）检测谷蛋白的T细胞刺激性表位; （ii）分别检测表位，（iii）检测存在于已知参与CD的其他谷物中的麦醇溶蛋白和谷蛋白同源物上存在的T细胞刺激性表位; 和（iv）检测完整蛋白质和小蛋白质片段上的T细胞刺激性表位。这种新方法是筛选旨在用于CD患者无麸质饮食的基本成分，半成品成分和食品的有用工具。此外，该新方法还可用于筛选谷类和不同小麦品种的CD病毒毒性水平。因此，该方法可以帮助选择低毒的谷类和小麦品种，这可能构成未来育种计划的基础。未来这些谷物将用于为CD患者生产安全食品。

7. 发明申请

WO03050542A2 METHOD OF DETECTING AUTOANTIBODIES FROM PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS, A PEPTIDE AND AN ASSAYKIT 审中-公开
标题翻译：从患有炎热性疾病的患者中检测自身抗体的方法，肽和测定试剂
公开(公告)号：WO03050542A2
公开(公告)日：2003-06-19
申请号：PCT/NL0200815
申请日：2002-12-11
申请人： STICHTING TECH WETENSCHAPP , VAN VENROOIJ WALTHERUS JACOBUS , DRIJFHOUT JAN WOUTER , VAN BOEKEL MARTINUS ADRIANUS M , PRUIJN GERARDUS JOZEF MARIA
发明人： VAN VENROOIJ WALTHERUS JACOBUS , DRIJFHOUT JAN WOUTER , VAN BOEKEL MARTINUS ADRIANUS M , PRUIJN GERARDUS JOZEF MARIA
IPC分类号： C07K7/06 , C07K7/08 , C07K7/54 , C07K14/47 , G01N33/53 , G01N33/564 , G01N33/68
CPC分类号： G01N33/564 , C07K7/08 , C07K7/52 , C07K7/64 , C07K14/4713 , G01N2410/00 , G01N2800/102 , Y10S435/973 , Y10S435/975 , Y10S530/806
摘要： The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glycine.
摘要翻译：本发明涉及从患有类风湿性关节炎的患者中检测自身抗体的方法。为此，根据本发明，使用至少两个肽单元，其中至少一个肽单元包含不衍生自（pro）填充蛋白，纤维蛋白，纤维蛋白原，波形蛋白，细胞角蛋白1和细胞角蛋白9的部分，哪个肽单元包含基序XG和包含基序XnonG的肽单元，其中X是瓜氨酸或其类似物，而nonG是除甘氨酸以外的氨基酸。

8. 发明申请

WO2007105954A1 METHODS FOR IDENTIFYING T-CELL EPITOPES ASSOCIATED WITH IMPAIRED PEPTIDE PROCESSING AND APPLICATIONS OF THE IDENTIFIED EPITOPES 审中-公开
标题翻译：用于鉴定与缺陷肽加工相关的T细胞外膜的方法和鉴定的抗原决定簇的应用
公开(公告)号：WO2007105954A1
公开(公告)日：2007-09-20
申请号：PCT/NL2007/050105
申请日：2007-03-16
申请人： LEIDEN UNIVERSITY MEDICAL CENTER , VAN HALL, Thorbald , WEINZIERL, Andreas Oliver , VAN VEELEN, Petrus Antonius , DRIJFHOUT, Jan Wouter , MELIEF, Cornelis Johannes Maria , OFFRINGA, Rienk
发明人： VAN HALL, Thorbald , WEINZIERL, Andreas Oliver , VAN VEELEN, Petrus Antonius , DRIJFHOUT, Jan Wouter , MELIEF, Cornelis Johannes Maria , OFFRINGA, Rienk
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/56977 , G01N33/505 , G01N2333/70539
摘要： The current invention provides methods for the identification of antigens and/or epitopes that are differentially displayed on TAP deficient or TAP impaired cells and are not detectably displayed on normal or TAP proficient cells. The identification and applications of these differentially presented antigens, which in this specification are referred to as TEIPP, T cell Epitopes associated with Impaired Peptide Processing, is a prime object of this invention. The invention also provides peptides comprising a TEIPP epitope obtained from the methods of the invention, which may be applied in medicaments and methods of treatment raising a T cell response against TAP deficient tumor cells or virally infected cells.
摘要翻译：本发明提供用于鉴定在TAP缺陷型或TAP受损细胞上差异显示并且不可检测地显示在正常或TAP精通细胞上的抗原和/或表位的方法。在本说明书中将这些差异表达的抗原的鉴定和应用称为TEIPP，与受损肽加工相关的T细胞表位，是本发明的主要目的。本发明还提供了包含可用于药物的本发明方法获得的TEIPP表位的肽，以及提高针对TAP缺陷型肿瘤细胞或病毒感染细胞的T细胞应答的治疗方法。

9. 发明申请

WO2006132530A3 METHODS AND MEANS FOR USE IN DIAGNOSTICS AND TREATMENT OF DIABETES 审中-公开
标题翻译：用于诊断和治疗糖尿病的方法和手段
公开(公告)号：WO2006132530A3
公开(公告)日：2007-02-01
申请号：PCT/NL2006050017
申请日：2006-01-30
申请人： UNIV LEIDEN MEDICAL CT , DRIJFHOUT JAN WOUTER , ROEP BART OTTO
发明人： DRIJFHOUT JAN WOUTER , ROEP BART OTTO
IPC分类号： C07K7/06 , A61K38/11 , C07K14/705
CPC分类号： C07K14/62 , C07K14/70535
摘要： The present invention identifies novel epitopes from the insulin B chain which is embodied in methods and means for diagnostics and treatment of type 1 diabetes. The epitopes were found in a peptide comprising a fragment of the human insulin B chain. Using HLA-A2 tetramers having the peptide of the invention cytotoxic T-cells were found in peripheral blood cells samples from healthy individuals. The invention demonstrates that these autoreactive CTL directed against insulin B chain are able to destroy insulin producing beta-cells. Moreover, a significant proportion of cytotoxic T-cells from islet transplant recipients with recurrent autoimmunity and loss of insulin production recognized this peptide or analogue thereof. The peptide has a high affinity for the HLA-A2 allele, in particular HLA-A*0201. Based on the novel epitopes according to the invention, diagnostic and therapeutic methods and medicaments for the prevention or treatment of type 1 diabetes are provided.
摘要翻译：本发明鉴定来自胰岛素B链的新表位，其体现在用于诊断和治疗1型糖尿病的方法和手段中。在包含人胰岛素B链的片段的肽中发现表位。在来自健康个体的外周血细胞样品中发现使用具有本发明的肽细胞毒性T细胞的HLA-A2四聚体。本发明证明这些针对胰岛素B链的自身反应性CTL能够破坏产生胰岛素的β细胞。此外，来自具有复发性自身免疫和胰岛素生成丧失的胰岛移植受体的相当大比例的细胞毒性T细胞识别该肽或其类似物。该肽对HLA-A2等位基因，特别是HLA-A * 0201具有高亲和力。基于本发明的新型表位，提供了用于预防或治疗1型糖尿病的诊断和治疗方法和药物。

10. 发明申请

WO2006132530A2 METHODS AND MEANS FOR USE IN DIAGNOSTICS AND TREATMENT OF DIABETES 审中-公开
标题翻译：用于诊断和治疗糖尿病的方法和手段
公开(公告)号：WO2006132530A2
公开(公告)日：2006-12-14
申请号：PCT/NL2006/050017
申请日：2006-01-30
申请人： Leiden University Medical Center , DRIJFHOUT, Jan, Wouter , ROEP, Bart, Otto
发明人： DRIJFHOUT, Jan, Wouter , ROEP, Bart, Otto
IPC分类号： C07K7/06 , C07K14/705 , A61K38/11
CPC分类号： C07K14/62 , C07K14/70535
摘要： The present invention identifies novel epitopes from the insulin B chain which is embodied in methods and means for diagnostics and treatment of type 1 diabetes. The epitopes were found in a peptide comprising a fragment of the human insulin B chain. Using HLA-A2 tetramers having the peptide of the invention cytotoxic T-cells were found in peripheral blood cells samples from healthy individuals. The invention demonstrates that these autoreactive CTL directed against insulin B chain are able to destroy insulin producing beta-cells. Moreover, a significant proportion of cytotoxic T-cells from islet transplant recipients with recurrent autoimmunity and loss of insulin production recognized this peptide or analogue thereof. The peptide has a high affinity for the HLA-A2 allele, in particular HLA-A*0201. Based on the novel epitopes according to the invention, diagnostic and therapeutic methods and medicaments for the prevention or treatment of type 1 diabetes are provided.
摘要翻译：本发明鉴定来自胰岛素B链的新表位，其体现在用于诊断和治疗1型糖尿病的方法和手段中。在包含人胰岛素B链的片段的肽中发现表位。在来自健康个体的外周血细胞样品中发现使用具有本发明的肽细胞毒性T细胞的HLA-A2四聚体。本发明证明这些针对胰岛素B链的自身反应性CTL能够破坏产生胰岛素的β细胞。此外，来自具有复发性自身免疫和胰岛素生成丧失的胰岛移植受体的相当大比例的细胞毒性T细胞识别该肽或其类似物。该肽对HLA-A2等位基因，特别是HLA-A * 0201具有高亲和力。基于本发明的新型表位，提供了用于预防或治疗1型糖尿病的诊断和治疗方法和药物。

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