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1. 发明申请

WO2006132530A2 METHODS AND MEANS FOR USE IN DIAGNOSTICS AND TREATMENT OF DIABETES 审中-公开
标题翻译：用于诊断和治疗糖尿病的方法和手段
公开(公告)号：WO2006132530A2
公开(公告)日：2006-12-14
申请号：PCT/NL2006/050017
申请日：2006-01-30
申请人： Leiden University Medical Center , DRIJFHOUT, Jan, Wouter , ROEP, Bart, Otto
发明人： DRIJFHOUT, Jan, Wouter , ROEP, Bart, Otto
IPC分类号： C07K7/06 , C07K14/705 , A61K38/11
CPC分类号： C07K14/62 , C07K14/70535
摘要： The present invention identifies novel epitopes from the insulin B chain which is embodied in methods and means for diagnostics and treatment of type 1 diabetes. The epitopes were found in a peptide comprising a fragment of the human insulin B chain. Using HLA-A2 tetramers having the peptide of the invention cytotoxic T-cells were found in peripheral blood cells samples from healthy individuals. The invention demonstrates that these autoreactive CTL directed against insulin B chain are able to destroy insulin producing beta-cells. Moreover, a significant proportion of cytotoxic T-cells from islet transplant recipients with recurrent autoimmunity and loss of insulin production recognized this peptide or analogue thereof. The peptide has a high affinity for the HLA-A2 allele, in particular HLA-A*0201. Based on the novel epitopes according to the invention, diagnostic and therapeutic methods and medicaments for the prevention or treatment of type 1 diabetes are provided.
摘要翻译：本发明鉴定来自胰岛素B链的新表位，其体现在用于诊断和治疗1型糖尿病的方法和手段中。在包含人胰岛素B链的片段的肽中发现表位。在来自健康个体的外周血细胞样品中发现使用具有本发明的肽细胞毒性T细胞的HLA-A2四聚体。本发明证明这些针对胰岛素B链的自身反应性CTL能够破坏产生胰岛素的β细胞。此外，来自具有复发性自身免疫和胰岛素生成丧失的胰岛移植受体的相当大比例的细胞毒性T细胞识别该肽或其类似物。该肽对HLA-A2等位基因，特别是HLA-A * 0201具有高亲和力。基于本发明的新型表位，提供了用于预防或治疗1型糖尿病的诊断和治疗方法和药物。

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