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1. 发明申请

WO2012116765A1 MASS ANALYSER AND METHOD OF MASS ANALYSIS 审中-公开
标题翻译：质量分析仪和质量分析方法
公开(公告)号：WO2012116765A1
公开(公告)日：2012-09-07
申请号：PCT/EP2011/066880
申请日：2011-09-28
申请人： SHIMADZU CORPORATION , DING, Li , SUDAKOV, Mikhail , KUMASHIRO, Sumio
发明人： DING, Li , SUDAKOV, Mikhail , KUMASHIRO, Sumio
IPC分类号： H01J49/42 , H01J49/02
CPC分类号： H01J49/027 , H01J49/0031 , H01J49/061 , H01J49/406 , H01J49/408 , H01J49/4245
摘要： An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.
摘要翻译：用于质量分析的静电离子阱包括第一电极阵列和与第一电极阵列间隔开的第二电极阵列。第一和第二电极阵列可以是由平行条形电极或同心圆形或部分圆形导电环形成的平面阵列。阵列的电极被提供有基本相同的电压图案，由此阵列之间的空间中的电位分布使得在飞行方向上等离子地反射离子，使得它们在空间中经历周期性的振荡运动基本上位于阵列之间。放大器电路用于检测具有与经历周期性振荡运动的离子的质荷比相关的频率分量的图像电流。

2. 发明申请

WO2012078288A3 METHODS OF DETERMINING RISK OF ADVERSE OUTCOMES IN ACUTE MYELOID LEUKEMIA 审中-公开
标题翻译：确定急性脑脊髓灰质炎患者不良事件风险的方法
公开(公告)号：WO2012078288A3
公开(公告)日：2012-08-02
申请号：PCT/US2011059843
申请日：2011-11-08
申请人： UNIV WASHINGTON , LEY TIMOTHY J , WILSON RICHARD K , MARDIS ELAINE K , DING LI , DIPERSIO JOHN K
发明人： LEY TIMOTHY J , WILSON RICHARD K , MARDIS ELAINE K , DING LI , DIPERSIO JOHN K
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/156
摘要： Disclosed are methods of determining risk of adverse outcome in a subject diagnosed with acute myeloid leukemia or myelodysplastic syndrome syndrome. The methods comprise providing a sample comprising bone marrow cells and/or peripheral blood from a subject diagnosed with acute myeloid leukemia or myelodysplastic syndrome syndrome, sequencing at least one exon of DNMT3A comprised by the sample, and identifying mutations, if any, in the DNMT3A gene. The presence of one or more mutations in DNMT3A can indicate that the subject is at high risk for an adverse outcome.
摘要翻译：公开了确定被诊断患有急性骨髓性白血病或骨髓增生异常综合征的受试者的不良结局风险的方法。所述方法包括提供包含来自诊断为急性骨髓性白血病或骨髓增生异常综合征综合征的受试者的骨髓细胞和/或外周血的样品，测序由样品包含的DNMT3A的至少一个外显子，并鉴定DNMT3A中的突变（如果有的话）基因。 DNMT3A中存在一个或多个突变可以表明受试者处于不利结局的高风险。

3. 发明申请

WO2009143054A3 INTRAOCULAR LENS WITH PHOTOSENSITIZER AND METHOD FOR MODIFYING THE REFRACTIVE INDEX OF THE LENS 审中-公开
公开(公告)号：WO2009143054A3
公开(公告)日：2009-11-26
申请号：PCT/US2009/044335
申请日：2009-05-18
申请人： BAUSCH & LOMB INCORPORATED , SMITH, Thomas , KNOX, Wayne, H. , DING, Li , JANI, Dharmendra, M. , LINHARDT, Jrffrey, G.
发明人： SMITH, Thomas , KNOX, Wayne, H. , DING, Li , JANI, Dharmendra, M. , LINHARDT, Jrffrey, G.
IPC分类号： A61F2/16 , A61L27/18
摘要： An intraocular lens comprising an optical, polymeric material with predetermine regions that have been irradiated with light from a laser to form refractive structures. The refractive structures are characterized by a change in refractive index within the irradiated regions of the lens with little or no scattering loss. To facilitate the formation of the refractive structures the optical, polymeric material is prepared from at least one monomer having a photofunctional group, the monomer having a two-photon cross- section of at least 10 GM. The invention is also directed to a method for modifying the refractive index of an intraocular lens prior to the surgical insertion of the lens in a human eye. The described irradiation process is used in a manufacturing environment to create refractive structures in the intraocular lens. The method includes irradiating a solvated intraocular lens at predetermined regions with light from a laser to form refractive structures.

4. 发明申请

WO2004083395A3 TRANSPORTERS AND ION CHANNELS 审中-公开
标题翻译：运输和离子通道
公开(公告)号：WO2004083395A3
公开(公告)日：2009-04-09
申请号：PCT/US2004007967
申请日：2004-03-15
申请人： INCYTE CORP , TANG Y TOM , LEE ERNESTINE A , RICHARDSON THOMAS W , ELLIOTT VICKI S , GRIFFIN JENNIFER A , HAFALIA APRIL J A , DING LI , CHAWLA NARINDER K , YANG JUNMING , BAUGHN MARIAH R , THORNTON MICHAEL B , GIETZEN KIMBERLY J , MARQUIS JOSEPH P , TRIBOULEY CATHERINE M , ISON CRAIG H , RAMKUMAR JAYALAXMI , JIN PEI , CHIEN DAVID , BECHA SHANYA D , WILSON AMY D , HAWKINS PHILLIP R , KHARE REENA , BHATIA UMESH G , BLAKE JULIE J , BURRILL JOHN D , HO ANNE , LEE SALLY , ZHENG WENJIN
发明人： TANG Y TOM , LEE ERNESTINE A , RICHARDSON THOMAS W , ELLIOTT VICKI S , GRIFFIN JENNIFER A , HAFALIA APRIL J A , DING LI , CHAWLA NARINDER K , YANG JUNMING , BAUGHN MARIAH R , THORNTON MICHAEL B , GIETZEN KIMBERLY J , MARQUIS JOSEPH P , TRIBOULEY CATHERINE M , ISON CRAIG H , RAMKUMAR JAYALAXMI , JIN PEI , CHIEN DAVID , BECHA SHANYA D , WILSON AMY D , HAWKINS PHILLIP R , KHARE REENA , BHATIA UMESH G , BLAKE JULIE J , BURRILL JOHN D , HO ANNE , LEE SALLY , ZHENG WENJIN
IPC分类号： C07K14/435 , A61K38/17 , C07K14/705 , C12N20060101
CPC分类号： C07K14/705
摘要： Various embodiments of the invention provide human transporters and ionchannels (TRICH) and polynucleotides which identify and encode TRICH. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.
摘要翻译：本发明的各种实施方案提供了识别和编码TRICH的人转运体和离子通道（TRICH）和多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。其它实施方案提供用于诊断，治疗或预防与TRICH异常表达相关的紊乱的方法。

5. 发明申请

WO2007071991A3 A MASS SPECTROMETER USING A DYNAMIC PRESSURE ION SOURCE 审中-公开
公开(公告)号：WO2007071991A3
公开(公告)日：2007-06-28
申请号：PCT/GB2006/004804
申请日：2006-12-20
申请人： SHIMADZU RESEARCH LABORATIORY (EUROPE) LIMITED , DING, Li
发明人： DING, Li
IPC分类号： H01J49/04 , H01J49/42
摘要： A mass spectrometer has a pulsed ion source, a first ion trap (10) for trapping ions generated by the pulsed ion source and for locating trapped ions for subsequent ejection from the first ion trap. A pulse of cooling gas is introduced into the first ion trap (10) at a peak pressure suitable for enabling the first ion trap (10) to trap ions. A turbomolecular pump (17) reduces the pressure of cooling gas before the trapped ions are ejected from the first ion trap (1) towards a second ion trap (20) for analysis. The pulsed ion source has a sample plate (14) which forms an end wall of the first ion trap (10).

6. 发明申请

WO2006129068A2 METHOD FOR INTRODUCING IONS INTO AN ION TRAP AND AN ION STORAGE APPARATUS 审中-公开
标题翻译：将离子引入离子阱和离子存储装置的方法
公开(公告)号：WO2006129068A2
公开(公告)日：2006-12-07
申请号：PCT/GB2006001938
申请日：2006-05-26
申请人： SHIMADZU RES LAB EUROPE LTD , DING LI , SMITH ALAN JOSEPH
发明人： DING LI , SMITH ALAN JOSEPH
IPC分类号： H01J49/04 , H01J49/06 , H01J49/16 , H01J49/42
CPC分类号： H01J49/4295 , H01J49/0072 , H01J49/0095 , H01J49/062
摘要： A method of introducing ions into an ion trap and an ion storage apparatus are described. Introduction means are used to introduce first ions into an ion trap through an entrance aperture to the ion trap. An operating condition of the introduction means is adjusted to cause second ions, of different polarity to the first ions to be introduced into the ion trap through the same entrance aperture.
摘要翻译：描述了将离子引入离子阱和离子存储装置的方法。引入装置用于通过离子阱的入口将第一离子引入离子阱。引入装置的操作条件被调整以使得与第一离子不同的第二离子通过相同的入口孔引入离子阱。

7. 发明申请

WO2005090609A1 DETERMINATION OF RNA QUALITY 审中-公开
标题翻译： RNA质量的测定
公开(公告)号：WO2005090609A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/009087
申请日：2005-03-18
申请人： ARCTURUS BIOSCIENCE, INC. , ERLANDER, Mark, G. , DING, Li
发明人： ERLANDER, Mark, G. , DING, Li
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/68 , C12Q2545/101 , C12Q2545/114 , C12Q2531/113 , C12Q2525/161
摘要： This invention relates to the determination of RNA quality, or RNA integrity, in a biological sample. The extent of RNA degradation, or retention of RNA integrity, is determined based upon the comparison of the relative amount of two sequences of a representative RNA molecule in the sample. Compositions and methods related to the determination are provided to assess RNA quality.
摘要翻译：本发明涉及生物样品中RNA质量或RNA完整性的确定。基于样品中代表性的RNA分子的两个序列的相对量的比较来确定RNA降解的程度或RNA完整性的保留。提供与测定相关的组合物和方法以评估RNA质量。

8. 发明申请

WO2005083742A2 A TANDEM ION-TRAP TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
标题翻译： TANDEM离子飞行时间质谱仪
公开(公告)号：WO2005083742A2
公开(公告)日：2005-09-09
申请号：PCT/GB2005/000671
申请日：2005-02-23
申请人： SHIMADZU RESEARCH LABORATORY (EUROPE) LIMITED , SUDAKOV, Michael , DING, Li
发明人： SUDAKOV, Michael , DING, Li
IPC分类号： H01J49/42
CPC分类号： H01J49/40 , H01J49/004 , H01J49/423
摘要： A tandem linear ion trap and time-of-flight mass spectrometer, where the ion trap has a straight central axis orthogonal to the flight path of the mass spectrometer. The ion trap comprises a set of electrodes, (401, 403, 402, 404) at least one of the electrodes has a slit for ejecting ions towards the mass spectrometer; a set of DC voltage supplies (+V, -V, V1, V2) to provide discrete DC levels and a number of fast electronic switches (409) for connecting/disconnecting the DC supplies to at least two of the electrodes; a neutral gas filling the ion trap and a digital controller to provide a switching procedure of ion trapping, manipulation with ions, cooling and including a state at which all ions are ejected from the ion trap towards the mass spectrometer.
摘要翻译：串联线性离子阱和飞行时间质谱仪，其中离子阱具有与质谱仪的飞行路径正交的直的中心轴。离子阱包括一组电极（401,403,402,404），至少一个电极具有用于向质谱仪喷射离子的狭缝; 一组直流电压源（+ V，-V，V1，V2）以提供离散DC电平以及用于将DC电源连接/断开至少两个电极的多个快速电子开关（409）填充离子阱的中性气体和数字控制器，以提供离子捕获，用离子的操作，冷却和包括从离子阱向质谱仪喷射所有离子的状态的切换过程。

9. 发明申请

WO0192527A3 REGULATORS OF APOPTOSIS 审中-公开
标题翻译：疫苗调节剂
公开(公告)号：WO0192527A3
公开(公告)日：2003-08-14
申请号：PCT/US0117581
申请日：2001-05-30
申请人： INCYTE GENOMICS INC , TANG Y TOM , AZIMZAI YALDA , YUE HENRY , BURFORD NEIL , DING LI , ELLIOTT VICKI S , ARVIZU CHANDRA S , BAUGHN MARIAH R
发明人： TANG Y TOM , AZIMZAI YALDA , YUE HENRY , BURFORD NEIL , DING LI , ELLIOTT VICKI S , ARVIZU CHANDRA S , BAUGHN MARIAH R
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61K49/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P7/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P17/00 , A61P17/06 , A61P19/00 , A61P19/04 , A61P19/06 , A61P21/00 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/08 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , C12S3/14 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/17 , G01N33/68
CPC分类号： C07K16/18 , A61K38/00 , C07K14/4747 , C12Q1/6876
摘要： The invention provides human apoptosis regulators (APRG) and polynucleotides which identify and encode APRG. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of APRG.
摘要翻译：本发明提供鉴定和编码APRG的人细胞凋亡调节剂（APRG）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与APRG的异常表达相关的紊乱的方法。

10. 发明申请

WO2003060064A3 INTRACELLULAR SIGNALING MOLECULES 审中-公开
公开(公告)号：WO2003060064A3
公开(公告)日：2003-07-24
申请号：PCT/US2002/022379
申请日：2002-07-11
申请人： INCYTE GENOMICS, INC. , BANDMAN, Olga , BAUGHN, Mariah, R. , BECHA, Shanya, D. , CHINN, Anna, M. , COCKS, Benjamin, G. , DING, Li , FORSYTHE, Ian, J. , GIETZEN, Kimberly, J. , GRIFFIN, Jennifer, A. , HAFALIA, April, J.A. , KHAN, Farrah, A. , LAL, Preeti, G. , LEE, Ernestine, A. , LI, Joana, X. , LU, Dyung Aina, M. , RAMKUMAR, Jayalaxmi , RICHARDSON, Thomas, W. , SWARNAKAR, Anita , TANG, Y., Tom , CHAWLA, Narinder, K. , WARREN, Bridget, A. , YANG, Junming , YAO, Monique, G. , YUE, Henry , ZEBARJADIAN, Yeganeh
发明人： BANDMAN, Olga , BAUGHN, Mariah, R. , BECHA, Shanya, D. , CHINN, Anna, M. , COCKS, Benjamin, G. , DING, Li , FORSYTHE, Ian, J. , GIETZEN, Kimberly, J. , GRIFFIN, Jennifer, A. , HAFALIA, April, J.A. , KHAN, Farrah, A. , LAL, Preeti, G. , LEE, Ernestine, A. , LI, Joana, X. , LU, Dyung Aina, M. , RAMKUMAR, Jayalaxmi , RICHARDSON, Thomas, W. , SWARNAKAR, Anita , TANG, Y., Tom , CHAWLA, Narinder, K. , WARREN, Bridget, A. , YANG, Junming , YAO, Monique, G. , YUE, Henry , ZEBARJADIAN, Yeganeh
IPC分类号： C07K1/00
摘要： Various embodiments of the invention provide human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expressionof INTSIG.

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