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1. 发明申请

WO2005091777A3 METHODS AND MATERIALS RELATING TO INSULIN GROWTH FACTOR-LIKE (IGFL) POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开
标题翻译：与胰岛素生长因子（IGFL）多肽和多核苷酸相关的方法和材料
公开(公告)号：WO2005091777A3
公开(公告)日：2007-04-26
申请号：PCT/US2005003374
申请日：2005-02-02
申请人： NUVELO INC , EMTAGE PETER C R , HU TIANHUA , TANG Y TOM
发明人： EMTAGE PETER C R , HU TIANHUA , TANG Y TOM
IPC分类号： A61K8/18 , A61K38/30 , A61Q13/00 , C07H21/04 , C07K14/65 , C12N5/02 , C12N15/00 , C12N15/09 , C12P21/06 , C12Q1/68
CPC分类号： C07K14/65 , A61K38/00 , C07H21/04
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel insulin growth factor-like (IGFL) polypeptides. Other aspects of the invention include vectors containing processes for producing novel IGFL polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新型胰岛素生长因子样（IGFL）多肽的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。本发明的其它方面包括含有生产新型IGFL多肽的方法的载体和对这些多肽具有特异性的抗体。

2. 发明申请

WO2004001005A3 INTRACELLULAR SIGNALING PROTEINS 审中-公开
标题翻译：细胞信号蛋白
公开(公告)号：WO2004001005A3
公开(公告)日：2006-01-05
申请号：PCT/US0319589
申请日：2003-06-18
申请人： INCYTE CORP , LI JOANA X , CHAWLA NARINDER K , GIETZEN KIMBERLY J , RICHARDSON THOMAS W , KABLE AMY E , RAMKUMAR JAYALAXMI , ELLIOTT VICKI S , KHARE REENA , ISON CRAIG H , BULLOCH SEAN A , YANG JUNMING , WILSON AMY D , GRIFFIN JENNIFER A , YANG YONGHONG G , SPRAGUE WILLIAM W , TANG Y TOM
发明人： LI JOANA X , CHAWLA NARINDER K , GIETZEN KIMBERLY J , RICHARDSON THOMAS W , KABLE AMY E , RAMKUMAR JAYALAXMI , ELLIOTT VICKI S , KHARE REENA , ISON CRAIG H , BULLOCH SEAN A , YANG JUNMING , WILSON AMY D , GRIFFIN JENNIFER A , YANG YONGHONG G , SPRAGUE WILLIAM W , TANG Y TOM
IPC分类号： A61K38/00 , C07K14/47 , A61K38/17 , C12P21/02
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00
摘要： Various embodiments of the invention provide human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of INTSIG.
摘要翻译：本发明的各种实施方案提供了识别和编码INTSIG的人细胞内信号分子（INTSIG）和多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。其他实施方案提供用于诊断，治疗或预防与INTSIG的异常表达相关的紊乱的方法。

3. 发明申请

WO2004087874A3 NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：新型核酸和多糖
公开(公告)号：WO2004087874A3
公开(公告)日：2005-12-22
申请号：PCT/US2004009202
申请日：2004-03-24
申请人： NUVELO INC , TANG Y TOM , ZHOU PING , WANG JIAN-RUI , WANG ZHI WEI , HU TIANHUA , DRMANAC RADOJE T
发明人： TANG Y TOM , ZHOU PING , WANG JIAN-RUI , WANG ZHI WEI , HU TIANHUA
IPC分类号： C07K14/47 , C12N20060101 , C12N15/11
CPC分类号： C07K14/47
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences enclosed by these nucleic acids and uses thereof.
摘要翻译：本发明提供新的核酸，由这些核酸包围的新的多肽序列及其用途。

4. 发明申请

WO2004099390A2 MOLECULES FOR DISEASE DETECTION AND TREATMENT 审中-公开
标题翻译：疾病检测和治疗分子
公开(公告)号：WO2004099390A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/009299
申请日：2004-03-26
申请人： INCYTE CORPORATION , SWARNAKAR, Anita , MARQUIS, Joseph, P. , HAFALIA, April, J., A. , CHAWLA, Narinder, K. , BECHA, Shanya, D. , YUE, Henry , NGUYEN, Danniel, B. , WARREN, Bridget, A. , LEE, Soo Yeun , BAUGHN, Mariah, R. , TANG, Y., Tom , EMERLING, Brooke, M. , ISON, Craig, H.
发明人： SWARNAKAR, Anita , MARQUIS, Joseph, P. , HAFALIA, April, J., A. , CHAWLA, Narinder, K. , BECHA, Shanya, D. , YUE, Henry , NGUYEN, Danniel, B. , WARREN, Bridget, A. , LEE, Soo Yeun , BAUGHN, Mariah, R. , TANG, Y., Tom , EMERLING, Brooke, M. , ISON, Craig, H.
IPC分类号： C12N
CPC分类号： C07K14/47
摘要： Various embodiments of the invention provide human molecules for disease detection and treatment (MDDT) and polynucleotides which identify and encode MDDT. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of MDDT.
摘要翻译：本发明的各种实施方案提供用于疾病检测和治疗（MDDT）的人分子和鉴定和编码MDDT的多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。其他实施方案提供用于诊断，治疗或预防与MDDT异常表达相关的紊乱的方法。

5. 发明申请

WO0218424A9 NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：核酸和多糖
公开(公告)号：WO0218424A9
公开(公告)日：2004-04-15
申请号：PCT/US0127093
申请日：2001-08-31
申请人： HYSEQ INC , TANG Y TOM , ASUNDI VINOD , ZHOU PING , XUE AIDONG J , REN FEIYAN , ZHANG JIE , WANG JIAN-RUI , ZHAO QING A , WANG DUNRUI , LIU CHENGHUA , DRMANAC RADOJE T , WEHRMAN TOM
发明人： TANG Y TOM , ASUNDI VINOD , ZHOU PING , XUE AIDONG J , REN FEIYAN , ZHANG JIE , WANG JIAN-RUI , ZHAO QING A , WANG DUNRUI , LIU CHENGHUA , DRMANAC RADOJE T , WEHRMAN TOM
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译：本发明提供新的核酸，由这些核酸编码的新的多肽序列及其用途。

6. 发明申请

WO2004015078A2 METHODS AND MATERIALS RELATING TO NOVEL GROWTH REGULATORY-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开
标题翻译：与新兴增长相关的多肽和多核苷酸的方法和材料
公开(公告)号：WO2004015078A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/024922
申请日：2003-08-06
申请人： NUVELO, INC. , MIZE, Nancy, K. , BOYLE, Bryan , FORD, John, E. , ARTERBURN, Matthew, C. , TANG, Y., Tom , LIU, Chenghua , DRMANAC, Radoje, T. , SONG, Yong , SJAASTAD, Michael
发明人： MIZE, Nancy, K. , BOYLE, Bryan , FORD, John, E. , ARTERBURN, Matthew, C. , TANG, Y., Tom , LIU, Chenghua , DRMANAC, Radoje, T. , SONG, Yong , SJAASTAD, Michael
IPC分类号： C12N
CPC分类号： C07K14/78 , A61K38/00 , C07K14/4702
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human growth regulatory-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human thymus. Other aspects of the invention include vectors containing processes for producing novel human growth regulatory-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供由对应于新的人生长调节样多肽的这样的多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。这些多核苷酸包含从人胸腺cDNA文库中分离的核酸序列。本发明的其它方面包括含有生产新的人类生长调节样多肽的方法的载体和对这些多肽特异性的抗体。

7. 发明申请

WO0222780A8 METHODS AND MATERIALS RELATING TO NEUROPILIN-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开
标题翻译：与神经营养样多聚体和多核苷酸相关的方法和材料
公开(公告)号：WO0222780A8
公开(公告)日：2003-12-11
申请号：PCT/US0128590
申请日：2001-09-11
申请人： HYSEQ INC , TANG Y TOM
发明人： TANG Y TOM
IPC分类号： C07K14/71 , C07H21/04 , C12N15/11
CPC分类号： C07K14/71
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human neuropilin-like polypeptides including Neuropilin-Hyl and Neuropilin-Hy2. Polynucleotide of the invention comprises of nucleic acid sequence isolated from cDNA library prepared from human fetal liver-spleen (Columbia University) mRNA (SEQ ID NO:1) for Neuropilin-Hyl. Polynucleotide of the invention also comprises of nucleic acid sequence isolated from cDNA library prepared from human bone marrow (Clontech) mRNA (SEQ ID NO: 5) for Neuropilin-Hy2. Other aspects of the invention include vectors containing processes for producing novel human neuropilin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供了由这样的多核苷酸和突变体或其变体编码的新型多核苷酸和多肽，其对应于新型人类神经丝氨酸样多肽，包括Neuropilin-Hyl和Neuropilin-Hy2。本发明的多核苷酸包含从用于Neuropilin-Hyl的人胎肝脾（哥伦比亚大学）mRNA（SEQ ID NO：1）制备的cDNA文库中分离的核酸序列。本发明的多核苷酸还包含从用于Neuropilin-Hy2的人骨髓（Clontech）mRNA（SEQ ID NO：5）制备的cDNA文库中分离的核酸序列。本发明的其它方面包括含有生产新型人类神经丝氨酸样多肽的方法的载体和对这些多肽具有特异性的抗体。

8. 发明申请

WO2003093439A3 ENZYMES 审中-公开
公开(公告)号：WO2003093439A3
公开(公告)日：2003-11-13
申请号：PCT/US2003/013821
申请日：2003-04-29
申请人： INCYTE CORPORATION , KHARE, Reena , KABLE, Amy, E. , LEE, Soo, Yeun , HAFALIA, April, J., A. , CHAWLA, Narinder, K. , MARQUIS, Joseph, P. , RAMKUMAR, Jayalaxmi , WILSON, Amy, D. , JIN, Pei , HAWKINS, Phillip, R. , BULLOCH, Sean, A. , SWARNAKAR, Anita , ELLIOTT, Vicki, S. , RICHARDSON, Thomas, W. , MASON, Patricia, M. , BAUGHN, Mariah, R. , YUE, Henry , BECHA, Shanya, D. , TANG, Y., Tom , BATRA, Sajeev , LU, Dyung Aina, M. , BHATIA, Umesh, G. , BURRILL, John, D. , LEE, Sally , BLAKE, Julie, J. , HO, Anne , ZHENG, Wenjin , GAO, Jing
发明人： KHARE, Reena , KABLE, Amy, E. , LEE, Soo, Yeun , HAFALIA, April, J., A. , CHAWLA, Narinder, K. , MARQUIS, Joseph, P. , RAMKUMAR, Jayalaxmi , WILSON, Amy, D. , JIN, Pei , HAWKINS, Phillip, R. , BULLOCH, Sean, A. , SWARNAKAR, Anita , ELLIOTT, Vicki, S. , RICHARDSON, Thomas, W. , MASON, Patricia, M. , BAUGHN, Mariah, R. , YUE, Henry , BECHA, Shanya, D. , TANG, Y., Tom , BATRA, Sajeev , LU, Dyung Aina, M. , BHATIA, Umesh, G. , BURRILL, John, D. , LEE, Sally , BLAKE, Julie, J. , HO, Anne , ZHENG, Wenjin , GAO, Jing
IPC分类号： C12N9/00
摘要： Various embodiments of the invention provide human enzymes (ENZM) and polynucleotides which identify and encode ENZM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ENZM.

10. 发明申请

WO2003068935A3 METHODS OF THERAPY AND DIAGNOSIS 审中-公开
公开(公告)号：WO2003068935A3
公开(公告)日：2003-08-21
申请号：PCT/US2003/004515
申请日：2003-02-14
申请人： NUVELO, INC. , EMTAGE, Peter , DEDERA, Douglas, A. , BOYLE, Bryan, J. , WANG, Jian-Rui , CHEN, Huang-Tsu , WAN, Ching-Yi , YAMAZAKI, Victoria , ASUNDI, Vinod , LIU, Chenghua , TANG, Y., Tom , DRMANAC, Radoje, T.
发明人： EMTAGE, Peter , DEDERA, Douglas, A. , BOYLE, Bryan, J. , WANG, Jian-Rui , CHEN, Huang-Tsu , WAN, Ching-Yi , YAMAZAKI, Victoria , ASUNDI, Vinod , LIU, Chenghua , TANG, Y., Tom , DRMANAC, Radoje, T.
IPC分类号： C12Q1/68
摘要： Certain cells, including types of cancer cells such as B-cell lymphoma, T-cell lymphoma, T-cell leukemia, multiple myeloma, and Hodgkin's Disease, are capable of expressing cell surface antigen RNA and proteins. Targeting using cell surface antigen polypeptides, nucleic acids encoding for cell surface antigen polypeptides, antibodies specific for cell surface antigens, and small molecules and peptides that bind to or recognize said cell surface antigens, provides a method of killing or inhibiting that growth of cells that express the cell surface antigen protein. Methods of therapy and diagnosis of disorders associated with cell surface protein-expressing cells are described.

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