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    • 7. 发明申请
    • METHODS AND MATERIALS RELATING TO NEUROPILIN-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES
    • 与神经营养样多聚体和多核苷酸相关的方法和材料
    • WO0222780A8
    • 2003-12-11
    • PCT/US0128590
    • 2001-09-11
    • HYSEQ INCTANG Y TOM
    • TANG Y TOM
    • C07K14/71C07H21/04C12N15/11
    • C07K14/71
    • The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human neuropilin-like polypeptides including Neuropilin-Hyl and Neuropilin-Hy2. Polynucleotide of the invention comprises of nucleic acid sequence isolated from cDNA library prepared from human fetal liver-spleen (Columbia University) mRNA (SEQ ID NO:1) for Neuropilin-Hyl. Polynucleotide of the invention also comprises of nucleic acid sequence isolated from cDNA library prepared from human bone marrow (Clontech) mRNA (SEQ ID NO: 5) for Neuropilin-Hy2. Other aspects of the invention include vectors containing processes for producing novel human neuropilin-like polypeptides, and antibodies specific for such polypeptides.
    • 本发明提供了由这样的多核苷酸和突变体或其变体编码的新型多核苷酸和多肽,其对应于新型人类神经丝氨酸样多肽,包括Neuropilin-Hyl和Neuropilin-Hy2。 本发明的多核苷酸包含从用于Neuropilin-Hyl的人胎肝脾(哥伦比亚大学)mRNA(SEQ ID NO:1)制备的cDNA文库中分离的核酸序列。 本发明的多核苷酸还包含从用于Neuropilin-Hy2的人骨髓(Clontech)mRNA(SEQ ID NO:5)制备的cDNA文库中分离的核酸序列。 本发明的其它方面包括含有生产新型人类神经丝氨酸样多肽的方法的载体和对这些多肽具有特异性的抗体。