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1. 发明申请

WO2006094156B1 SYSTEMS AND METHODS FOR TREATING A PATIENT USING GUIDED RADIATION THERAPY OR SURGERY 审中-公开
标题翻译：使用引导辐射治疗或手术治疗患者的系统和方法
公开(公告)号：WO2006094156B1
公开(公告)日：2007-12-21
申请号：PCT/US2006007508
申请日：2006-03-02
申请人： CALYPSO MED TECHNOLOGIES INC , MATE TIMOTHY P , DIMMER STEVEN C , NEWELL LAURENCE J , WRIGHT J NELSON
发明人： MATE TIMOTHY P , DIMMER STEVEN C , NEWELL LAURENCE J , WRIGHT J NELSON
IPC分类号： A61B19/00
CPC分类号： A61B90/16 , A61B34/20 , A61B34/25 , A61B90/14 , A61B90/39 , A61B2034/2051 , A61B2090/101 , A61B2090/363 , A61B2090/374 , A61B2090/3975 , A61B2090/3995
摘要： Systems and methods for locating and tracking a target, i.e., measuring the position and/or rotation of a target during setup and treatment of a patient in guided radiation therapy applications for the head and neck. One embodiment is directed toward a device having a body and markers, such as excitable transponders and/or radiographic fiducials, fixable in or on the body for localizing the body. For example, the body can be a mouthpiece body having a channel configured to receive a patient's teeth such that the mouthpiece is repeatedly and consistently placed in the same relative position in the patient when the patient bites down on the mouthpiece. The transponders can be alternating magnetic transponders and the fiducials can be gold seeds. Other embodiments include a device having a two-piece body, a first piece of the body having excitable transponders and a second piece of the body having radiographic fiducials.
摘要翻译：用于定位和跟踪目标的系统和方法，即在用于头颈部的引导放射治疗应用中，在患者的建立和治疗期间测量目标的位置和/或旋转。一个实施例涉及具有身体和标记的装置，例如可固定在体内或身体上用于定位身体的可兴奋的应答器和/或射线照相基准。例如，身体可以是具有通道的接口管体，该通道被配置为接收患者的牙齿，使得当患者咬在嘴件上时，接口管被重复且一致地放置在患者的相同相对位置。应答器可以是交替磁转发器，基准可以是金种子。其他实施例包括具有两件式主体的装置，具有可兴奋的应答器的本体的第一部分和具有放射照相基准的本体的第二部分。

2. 发明申请

WO2006094156A3 SYSTEMS AND METHODS FOR TREATING A PATIENT USING GUIDED RADIATION THERAPY OR SURGERY 审中-公开
标题翻译：用于使用引导辐射治疗或手术治疗患者的系统和方法
公开(公告)号：WO2006094156A3
公开(公告)日：2007-10-25
申请号：PCT/US2006007508
申请日：2006-03-02
申请人： CALYPSO MED TECHNOLOGIES INC , MATE TIMOTHY P , DIMMER STEVEN C , NEWELL LAURENCE J , WRIGHT J NELSON
发明人： MATE TIMOTHY P , DIMMER STEVEN C , NEWELL LAURENCE J , WRIGHT J NELSON
IPC分类号： A61B19/00
CPC分类号： A61B90/16 , A61B34/20 , A61B34/25 , A61B90/14 , A61B90/39 , A61B2034/2051 , A61B2090/101 , A61B2090/363 , A61B2090/374 , A61B2090/3975 , A61B2090/3995
摘要： Systems and methods for locating and tracking a target, i.e., measuring the position and/or rotation of a target during setup and treatment of a patient in guided radiation therapy applications for the head and neck. One embodiment is directed toward a device having a body and markers, such as excitable transponders and/or radiographic fiducials, fixable in or on the body for localizing the body. For example, the body can be a mouthpiece body having a channel configured to receive a patient's teeth such that the mouthpiece is repeatedly and consistently placed in the same relative position in the patient when the patient bites down on the mouthpiece. The transponders can be alternating magnetic transponders and the fiducials can be gold seeds. Other embodiments include a device having a two-piece body, a first piece of the body having excitable transponders and a second piece of the body having radiographic fiducials.
摘要翻译：用于定位和跟踪目标的系统和方法，即在头部和颈部的引导放射治疗应用中在设置和治疗患者期间测量目标的位置和/或旋转。一个实施例针对一种装置，该装置具有可固定在身体内或身体上以定位身体的身体和标记，诸如可激发的应答器和/或射线照相基准。例如，身体可以是具有构造成接收患者牙齿的通道的牙套主体，使得当患者咬住牙套时，牙套重复且一致地放置在患者中的相同相对位置中。应答器可以是交替的磁转发器，而基准可以是金种子。其他实施例包括具有两件式主体的装置，具有可激发应答器的主体的第一部分和具有射线照相基准点的主体的第二部分。

3. 发明申请

WO2006012631A3 INTEGRATED RADIATION THERAPY SYSTEMS AND METHODS FOR TREATING A TARGET IN A PATIENT 审中-公开
标题翻译：集成辐射疗法系统和方法用于治疗患者的目标
公开(公告)号：WO2006012631A3
公开(公告)日：2006-07-13
申请号：PCT/US2005026447
申请日：2005-07-25
申请人： CALYPSO MED TECHNOLOGIES INC , MEIER ERIC , MATE TIMOTHY P , WRIGHT J NELSON , DIMMER STEVEN C , PURDY LYNN M
发明人： MEIER ERIC , MATE TIMOTHY P , WRIGHT J NELSON , DIMMER STEVEN C , PURDY LYNN M
IPC分类号： A61N5/10
CPC分类号： A61N5/1039 , A61N5/1049 , A61N5/1067 , A61N5/107 , A61N2005/1051
摘要： An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy type to identify the marker that is different than the first energy type.
摘要翻译：集成放射治疗过程包括通过使用定位模式周期性地定位位于患者体内的标记来获取与患者内的目标的参数相关的第一客观目标数据。该方法继续通过周期性地定位标记来获得与目标的参数相关的第二客观目标数据。第一客观目标数据可以在与第二区域分开的第一区域中获取，该第二区域包含用于产生用于治疗患者的电离辐射束的辐射输送装置。本地化模式在第一和第二方面可以是相同的。在其他实施例中，第一客观目标数据可以使用第一定位模式来获取，该第一定位模式使用第一能量类型来识别标记，并且第二客观目标数据可以使用第二定位模式来获得，该第二定位模式使用第二能量类型来识别标记与第一种能量类型不同。

4. 发明申请

WO2006002396A3 RADIATION THERAPY OF THE LUNGS USING LEADLESS MARKERS 审中-公开
标题翻译：使用无铅标记的放射治疗
公开(公告)号：WO2006002396A3
公开(公告)日：2007-05-10
申请号：PCT/US2005022568
申请日：2005-06-24
申请人： CALYPSO MED TECHNOLOGIES INC , VERTATSCHITSCH EDWARD J , DIMMER STEVEN C , MATE TIMOTHY P , MEIER ERIC , SEILER KEITH , WRIGHT J NELSON
发明人： VERTATSCHITSCH EDWARD J , DIMMER STEVEN C , MATE TIMOTHY P , MEIER ERIC , SEILER KEITH , WRIGHT J NELSON
IPC分类号： A61B5/05
CPC分类号： A61N5/1049 , A61B34/25 , A61B34/30 , A61B2034/301 , A61B2090/3958 , A61N5/1067 , A61N5/107 , A61N2005/1051
摘要： Systems and methods for treating a lung of a patient. One embodiment of a method comprises positioning a leadless marker in the lung of the patient relative to the target, and collecting position data of the marker. This method further comprises determining the location of the marker in an external reference frame outside of the patient based on the collected position data, and providing an objective output in the external reference frame that is responsive to movement of the marker. The objective output is provided at a frequency (i.e., periodicity) that results in a clinically acceptable tracking error. In addition, the objective output can also be provided at least substantially contemporaneously with collecting the position data used to determine the location of the marker.
摘要翻译：用于治疗患者肺部的系统和方法。一种方法的一个实施例包括将无引线标记物相对于靶标定位在患者的肺中，以及收集标记物的位置数据。该方法还包括基于所收集的位置数据确定标记在患者外部的外部参考框架中的位置，以及响应于标记的移动而在外部参考框架中提供客观输出。以导致临床上可接受的跟踪误差的频率（即，周期性）提供目标输出。此外，目标输出还可以至少基本同时提供，收集用于确定标记位置的位置数据。

5. 发明申请

WO2009015104A3 IMPLANTABLE DEVICES AND METHODS FOR EXTERNAL BEAM RADIATION TREATMENTS 审中-公开
标题翻译：可植入装置和用于外部束辐射治疗的方法
公开(公告)号：WO2009015104A3
公开(公告)日：2009-08-13
申请号：PCT/US2008070682
申请日：2008-07-21
申请人： CALYPSO MED TECHNOLOGIES INC , NIELSON ERIC D , DIMMER STEVEN C , KRAG DAVID N , MATE TIMOTHY P , PEREZ ROLAND , QUIGLEY FERGUS
发明人： NIELSON ERIC D , DIMMER STEVEN C , KRAG DAVID N , MATE TIMOTHY P , PEREZ ROLAND , QUIGLEY FERGUS
IPC分类号： A61B19/00
CPC分类号： A61N5/1049 , A61N2005/1051
摘要： Implantable devices and methods for external beam radiation treatments are disclosed. One embodiment of an implantable device for guided radiation therapy comprises an active marker configured to be positioned within the patient and to transmit a non-ionizing wireless signal in response to a non-ionizing wirelessly transmitted source energy. The device further includes a fastening unit coupled to the active marker and configured to (a) hold the marker within a desired distance of a target in the tissue and (b) inhibit deformation of tissue from moving the active marker relative to the target.
摘要翻译：公开了用于外部射束辐射处理的可植入装置和方法。用于引导放射治疗的可植入装置的一个实施例包括被配置为定位在患者体内并且响应于非电离无线传输的源能量而传输非电离无线信号的有源标记器。该装置进一步包括紧固单元，该紧固单元联接到有源标记并且被配置为（a）将标记保持在组织中目标的期望距离内，以及（b）抑制组织相对于目标移动有源标记的变形。

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