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2. 发明申请

WO2004023973A2 MOLECULES FOR DIAGNOSTICS AND THERAPEUTICS 审中-公开
标题翻译：分子诊断和治疗
公开(公告)号：WO2004023973A2
公开(公告)日：2004-03-25
申请号：PCT/US2003/028227
申请日：2003-09-12
申请人： INCYTE CORPORATION , SCHMIDT, Jeanette, P. , WRIGHT, Rachel, J. , BRUNS, Christopher, M. , MARJANOVIC, Mirjana, M. , SHEN, Fan , HARTHSHORNE, Toinette, A. , SUCHOROLSKI, Martin, T. , ALTUS, Christina, M. , PITTS, Steven, J. , ELDER, Linda, V. , MOONEY, Elizabeth, M. , DELEGEANE, Angelo, M. , PANESAR, Iqbal, S. , BANVILLE, Steven, C. , REDDY, Thirupathi, P. , STEVENS, Kristian, A. , BLANCHARD, John, L. , PANZER, Scott, R. , WANG, Xinhao , AU, Alan, P. , GERSTIN, JR., Edward, H. , PERALTA, Careyna, H. , ANDERSON, Scott, B. , RIOUX, Pierre , SHEN, Edward, J. , WU, Mingham, C. , STUVE, Laura, L. , LAGACE, Robert, E. , SPIRO, Peter, A. , STEWART, Elizabeth, A. , WINGROVE, James , VITT, Ursula, A. , KIRTON, Edward, S. , XU, Yuming , KWONG, Mary , POLICKY, Jennifer, L. , HURWITZ, Bonnie, L. , MA, Yan , JACKSON, Jennifer, L. , GIETZEN, Darryl , PATURY, Srikanth , SHI, Xiaobing , SUAREZ, Charlyn, J.
发明人： SCHMIDT, Jeanette, P. , WRIGHT, Rachel, J. , BRUNS, Christopher, M. , MARJANOVIC, Mirjana, M. , SHEN, Fan , HARTHSHORNE, Toinette, A. , SUCHOROLSKI, Martin, T. , ALTUS, Christina, M. , PITTS, Steven, J. , ELDER, Linda, V. , MOONEY, Elizabeth, M. , DELEGEANE, Angelo, M. , PANESAR, Iqbal, S. , BANVILLE, Steven, C. , REDDY, Thirupathi, P. , STEVENS, Kristian, A. , BLANCHARD, John, L. , PANZER, Scott, R. , WANG, Xinhao , AU, Alan, P. , GERSTIN, JR., Edward, H. , PERALTA, Careyna, H. , ANDERSON, Scott, B. , RIOUX, Pierre , SHEN, Edward, J. , WU, Mingham, C. , STUVE, Laura, L. , LAGACE, Robert, E. , SPIRO, Peter, A. , STEWART, Elizabeth, A. , WINGROVE, James , VITT, Ursula, A. , KIRTON, Edward, S. , XU, Yuming , KWONG, Mary , POLICKY, Jennifer, L. , HURWITZ, Bonnie, L. , MA, Yan , JACKSON, Jennifer, L. , GIETZEN, Darryl , PATURY, Srikanth , SHI, Xiaobing , SUAREZ, Charlyn, J.
IPC分类号： A61B
CPC分类号： C12Q1/6876 , C07K14/47 , C12Q2600/136 , C12Q2600/142 , C12Q2600/158
摘要： The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing ditph for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.
摘要翻译：本发明提供了用于诊断和治疗的纯化的人多核苷酸（dithp）。还包括由dithp编码的多肽（DITHP）。本发明还提供了在诊断测定中使用寡核苷酸，寡核苷酸或其片段。本发明进一步提供了用于表达DITHP的包含ditph的载体和宿主细胞。本发明另外提供了使用分离和纯化的DITHP诱导抗体并筛选化合物文库和抗DITHP抗体在诊断测定中的用途。还提供含有dithp和使用方法的微阵列。

3. 发明申请

WO2002060942A3 PROTEIN MODIFICATION AND MAINTENANCE MOLECULES 审中-公开
公开(公告)号：WO2002060942A3
公开(公告)日：2002-08-08
申请号：PCT/US2002/002813
申请日：2002-01-30
申请人： INCYTE GENOMICS, INC. , WARREN, Bridget, A. , HONCHELL, Cynthia, D. , LU, Yan , CHAWLA, Narinder, K. , BURFORD, Neil , DELEGEANE, Angelo, M. , GANDHI, Ameena, R. , BAUGHN, Mariah, R. , GRIFFIN, Jennifer, A. , GIETZEN, Kimberly, J. , LU, Dyung, Aina, M. , ISON, Craig, H. , RAMKUMAR, Jayalaxmi , TANG, Tom, Y. , LAL, Preeti., G. , BOROWSKI, Mark, L. , DUGGAN, Brendan, M. , HAFALIA, April, J., A. , ARVIZU, Chandra , THANGAVELU, Kavitha , YAO, Monique, G. , ELLIOTT, Vicki, S. , DING, Li , YUE, Henry , LEE, Sally , SWARNAKAR, Anita , TRAN, Uyen, K. , XU, Yuming
发明人： WARREN, Bridget, A. , HONCHELL, Cynthia, D. , LU, Yan , CHAWLA, Narinder, K. , BURFORD, Neil , DELEGEANE, Angelo, M. , GANDHI, Ameena, R. , BAUGHN, Mariah, R. , GRIFFIN, Jennifer, A. , GIETZEN, Kimberly, J. , LU, Dyung, Aina, M. , ISON, Craig, H. , RAMKUMAR, Jayalaxmi , TANG, Tom, Y. , LAL, Preeti., G. , BOROWSKI, Mark, L. , DUGGAN, Brendan, M. , HAFALIA, April, J., A. , ARVIZU, Chandra , THANGAVELU, Kavitha , YAO, Monique, G. , ELLIOTT, Vicki, S. , DING, Li , YUE, Henry , LEE, Sally , SWARNAKAR, Anita , TRAN, Uyen, K. , XU, Yuming
IPC分类号： C12N9/64
摘要： The invention provides human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMMM.

4. 发明申请

WO2002012467A3 DRUG METABOLIZING ENZYMES 审中-公开
公开(公告)号：WO2002012467A3
公开(公告)日：2002-02-14
申请号：PCT/US2001/024382
申请日：2001-08-03
申请人： INCYTE GENOMICS, INC. , BAUGHN, Mariah, R. , BRUNS, Christopher, M. , DAS, Debopriya , DELEGEANE, Angelo, M. , DING, Li , ELLIOT, Vicki, S. , GANDHI, Ameena, R. , GRIFFIN, Jennifer, A. , HAFALIA, April, J., A. , KHAN, Farrah, A. , LAL, Preeti , LEE, Sally , LU, Dyung, Aina, M. , LU, Yan , PATTERSON, Chandra , RAMKUMAR, Jayalaxmi , RING, Huijun, Z. , SANJANWALA, Madhu, S. , TANG, Y., Tom , THANGAVELU, Kavitha , THORNTON, Michael , TRIBOULEY, Catherine, M. , WALIA, Narinder, K. , WARREN, Bridget, A. , YANG, Junming , YAO, Monique, G. , YUE, Henry
发明人： BAUGHN, Mariah, R. , BRUNS, Christopher, M. , DAS, Debopriya , DELEGEANE, Angelo, M. , DING, Li , ELLIOT, Vicki, S. , GANDHI, Ameena, R. , GRIFFIN, Jennifer, A. , HAFALIA, April, J., A. , KHAN, Farrah, A. , LAL, Preeti , LEE, Sally , LU, Dyung, Aina, M. , LU, Yan , PATTERSON, Chandra , RAMKUMAR, Jayalaxmi , RING, Huijun, Z. , SANJANWALA, Madhu, S. , TANG, Y., Tom , THANGAVELU, Kavitha , THORNTON, Michael , TRIBOULEY, Catherine, M. , WALIA, Narinder, K. , WARREN, Bridget, A. , YANG, Junming , YAO, Monique, G. , YUE, Henry
IPC分类号： C12N15/53
摘要： The invention provides human drug metabolizing enzymes (DME) and polynucleotides which identify and encode DME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of DME.

5. 发明申请

WO1996038569A1 HUMAN ICE HOMOLOG 审中-公开
标题翻译：人类冰岛人类学
公开(公告)号：WO1996038569A1
公开(公告)日：1996-12-05
申请号：PCT/US1996008150
申请日：1996-05-30
申请人： INCYTE PHARMACEUTICALS, INC. , BRAXTON, Scott, Michael , DELEGEANE, Angelo, M. , DIEP, Dinh
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/57
CPC分类号： C12N9/6475
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a new human interleukin-1 converting enzyme homolog (ICEY). The present invention also provides for antisense molecules to the nucleotide sequences which encode ICEY, expression vectors for the production of purified ICEY, antibodies capable of binding specifically to ICEY, hybridization probes or oligonucleotides for the detection of ICEY-encoding nucleotide sequences, genetically engineered host cells for the expression of ICEY, diagnostic tests for activation of monocyte/macrophages based on ICEY-encoding nucleic acid molecules, and use of the protein to produce antibodies capable of binding specifically to the protein and use of the protein to screen for inhibitors.
摘要翻译：本发明提供鉴定和编码新的人白细胞介素-1转换酶同源物（ICEY）的核苷酸和氨基酸序列。本发明还提供编码ICEY的核苷酸序列的反义分子，用于产生纯化的ICEY的表达载体，能够特异性结合ICEY的抗体，用于检测ICEY编码核苷酸序列的杂交探针或寡核苷酸，遗传工程化宿主用于表达ICEY的细胞，基于编码ICEY编码核酸分子的单核细胞/巨噬细胞活化的诊断试验，以及使用该蛋白质产生能够特异性结合该蛋白质的抗体和使用蛋白质筛选抑制剂。

6. 发明申请

WO2003047526A3 CELL ADHESION AND EXTRACELLULAR MATRIX PROTEINS 审中-公开
公开(公告)号：WO2003047526A3
公开(公告)日：2003-06-12
申请号：PCT/US2002/038437
申请日：2002-11-26
申请人： INCYTE GENOMICS, INC. , BAUGHN, Mariah, R. , BECHA, Shanya, D. , BHATIA, Umesh , BLAKE, Julie, J. , BOROWSKY, Mark, L. , BURRILL, John, D. , DELEGEANE, Angelo, M. , ELLIOTT, Vicki, S. , GANDHI, Ameena, R. , GIETZEN, Kimberly, J. , GORVAD, Ann, E. , GRIFFIN, Jennifer, A. , HO, Anne , JIN, Pei , KABLE, Amy, E. , LAL, Preeti, G. , LEE, Ernestine, A. , LEE, Sally , LEE, Soo, Yeun , MARQUIS, Joseph, P. , LEHR-MASON, Patricia, M. , RAMKUMAR, Jayalaxmi , RICHARDSON, Thomas, W. , SPRAGUE, William, W. , SWARNAKAR, Anita , TANG, Tom, Y. , TRAN, Bao , TRAN, Uyen, K. , CHAWLA, Narinder, K. , WARREN, Bridget, A. , XU, Yuming , YUE, Henry , ZHENG, Wenjin
发明人： BAUGHN, Mariah, R. , BECHA, Shanya, D. , BHATIA, Umesh , BLAKE, Julie, J. , BOROWSKY, Mark, L. , BURRILL, John, D. , DELEGEANE, Angelo, M. , ELLIOTT, Vicki, S. , GANDHI, Ameena, R. , GIETZEN, Kimberly, J. , GORVAD, Ann, E. , GRIFFIN, Jennifer, A. , HO, Anne , JIN, Pei , KABLE, Amy, E. , LAL, Preeti, G. , LEE, Ernestine, A. , LEE, Sally , LEE, Soo, Yeun , MARQUIS, Joseph, P. , LEHR-MASON, Patricia, M. , RAMKUMAR, Jayalaxmi , RICHARDSON, Thomas, W. , SPRAGUE, William, W. , SWARNAKAR, Anita , TANG, Tom, Y. , TRAN, Bao , TRAN, Uyen, K. , CHAWLA, Narinder, K. , WARREN, Bridget, A. , XU, Yuming , YUE, Henry , ZHENG, Wenjin
IPC分类号： C12N1/21
摘要： Various embodiments of the invention provide human cell adhesion and extracellular matrix proteins (CADECM) and polynucleotides which identify and encode CADECM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CADECM.

7. 发明申请

WO0208396A3 HUMAN PROTEASES 审中-公开
标题翻译：人类保护
公开(公告)号：WO0208396A3
公开(公告)日：2003-04-10
申请号：PCT/US0122397
申请日：2001-07-17
申请人： INCYTE GENOMICS INC , DELEGEANE ANGELO M , GANDHI AMEENA R , HAFALIA APRIL J A , LU DYUNG AINA M , PATTERSON CHANDRA , TRIBOULEY CATHERINE M , DAS DEBOPRIYA , KALLICK DEBORAH A , NGUYEN DANNIEL B , LEE ERNESTINE A
发明人： DELEGEANE ANGELO M , GANDHI AMEENA R , HAFALIA APRIL J A , LU DYUNG AINA M , PATTERSON CHANDRA , TRIBOULEY CATHERINE M , DAS DEBOPRIYA , KALLICK DEBORAH A , NGUYEN DANNIEL B , LEE ERNESTINE A
IPC分类号： G01N33/50 , A61K38/00 , A61K38/46 , A61K45/00 , A61K49/00 , A61P1/04 , A61P1/08 , A61P1/10 , A61P1/12 , A61P1/14 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/00 , A61P5/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P7/08 , A61P7/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/08 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/14 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08 , A61P17/14 , A61P17/16 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/00 , A61P33/02 , A61P33/10 , A61P35/00 , A61P35/04 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/42 , C07K16/40 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/02 , C12N15/09 , C12N15/55 , C12P21/08 , C12Q1/02 , C12Q1/37 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/573 , A01K67/027 , A61K31/00 , A61K38/43 , A61K39/00
CPC分类号： C12N9/64
摘要： The invention provides human proteases (PRTS) and polynucleotides which identify and encode PRTS. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PRTS.
摘要翻译：本发明提供鉴定和编码PRTS的人类蛋白酶（PRTS）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供诊断，治疗或预防与PRTS异常表达相关的疾病的方法。

8. 发明申请

WO2003002610A1 EXTRACELLULAR MESSENGERS 审中-公开
公开(公告)号：WO2003002610A1
公开(公告)日：2003-01-09
申请号：PCT/US2002/020430
申请日：2002-06-26
申请人： INCYTE GENOMICS, INC. , DELEGEANE, Angelo, M. , BOROWSKY, Mark, L. , KHAN, Farrah, A. , KEARNEY, Liam , RAMKUMAR, Jayalaxmi , WALIA, Narinder, K. , LU, Yan , HONCHELL, Cynthia, D. , KALLICK, Deborah, A. , EMERLING, Brooke, M. , GORVAD, Ann, E. , GRIFFIN, Jennifer, A. , WARREN, Bridget, A. , YUE, Henry , THANGAVELU, Kavitha , SPRAGUE, William, W. , ISON, Craig, H. , ELLIOTT, Vicki, S. , MASON, Patricia, M. , RICHARDSON, Thomas, W. , TRAN, Uyen, K. , SWARNAKAR, Anita , JIN, Pei , KABLE, Amy, E.
发明人： DELEGEANE, Angelo, M. , BOROWSKY, Mark, L. , KHAN, Farrah, A. , KEARNEY, Liam , RAMKUMAR, Jayalaxmi , WALIA, Narinder, K. , LU, Yan , HONCHELL, Cynthia, D. , KALLICK, Deborah, A. , EMERLING, Brooke, M. , GORVAD, Ann, E. , GRIFFIN, Jennifer, A. , WARREN, Bridget, A. , YUE, Henry , THANGAVELU, Kavitha , SPRAGUE, William, W. , ISON, Craig, H. , ELLIOTT, Vicki, S. , MASON, Patricia, M. , RICHARDSON, Thomas, W. , TRAN, Uyen, K. , SWARNAKAR, Anita , JIN, Pei , KABLE, Amy, E.
IPC分类号： C07K17/00
CPC分类号： C07K14/47 , A61K38/00
摘要： Various embodiments of the invention provide human extracellular messengers (EXMES) and polynucleotides which identify and encode EXMES. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of EXMES.

9. 发明申请

WO0202603A3 PROTEIN MODIFICATION AND MAINTENANCE MOLECULES 审中-公开
标题翻译：蛋白质修饰和维持分子
公开(公告)号：WO0202603A3
公开(公告)日：2003-01-03
申请号：PCT/US0120925
申请日：2001-06-29
申请人： INCYTE GENOMICS INC , YUE HENRY , LAL PREETI , TANG Y TOM , LU DYUNG AINA M , YAO MONIQUE G , NGUYEN DANNIEL B , HAFALIA APRIL J A , PATTERSON CHANDRA , DELEGEANE ANGELO M , BURFORD NEIL , POLICKY JENNIFER L , GANDHI AMEENA R , RAMKUMAR JAYALAXMI , KHAN FARRAH A , THANGAVELU KAVITHA , XU YUMING , GIETZEN KIMBERLY J
发明人： YUE HENRY , LAL PREETI , TANG Y TOM , LU DYUNG AINA M , YAO MONIQUE G , NGUYEN DANNIEL B , HAFALIA APRIL J A , PATTERSON CHANDRA , DELEGEANE ANGELO M , BURFORD NEIL , POLICKY JENNIFER L , GANDHI AMEENA R , RAMKUMAR JAYALAXMI , KHAN FARRAH A , THANGAVELU KAVITHA , XU YUMING , GIETZEN KIMBERLY J
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61K49/00 , A61P1/04 , A61P1/06 , A61P1/12 , A61P1/14 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/24 , A61P7/00 , A61P7/04 , A61P7/06 , A61P7/08 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/14 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/12 , A61P17/14 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/12 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/00 , A61P33/02 , A61P33/10 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P41/00 , A61P43/00 , C07K14/47 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A01K67/027 , A61K38/17 , G01N33/577 , G01N33/68
CPC分类号： C07K14/47
摘要： The invention provides human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMM.
摘要翻译：本发明提供了鉴定和编码PMMM的人蛋白质修饰和维持分子（PMMM）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明提供了用于诊断，治疗或预防与PMM异常表达相关的紊乱的方法。

10. 发明申请

WO02081636A2 PROTEIN MODIFICATION AND MAINTENANCE MOLECULES 审中-公开
标题翻译：蛋白质修饰和维持分子
公开(公告)号：WO02081636A2
公开(公告)日：2002-10-17
申请号：PCT/US0210812
申请日：2002-04-05
申请人： INCYTE GENOMICS INC , GANDHI AMEENA R , DELEGEANE ANGELO M , SWARNAKAR ANITA , HAFALIA APRIL J A , DUGGAN BRENDAN M , WARREN BRIDGET A
发明人： GANDHI AMEENA R , DELEGEANE ANGELO M , SWARNAKAR ANITA , HAFALIA APRIL J A , DUGGAN BRENDAN M , WARREN BRIDGET A
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61K49/00 , A61P1/00 , A61P9/00 , A61P15/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07K14/47 , C07K16/18 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N37/00 , C12N
CPC分类号： C12N9/6421 , A01K2217/05 , A61K38/00
摘要： The invention provides human protein modification and maintenance molecules (PMOD) and polynucleotides which identify and encode PMOD. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMOD.
摘要翻译：本发明提供了鉴定和编码PMOD的人蛋白质修饰和维持分子（PMOD）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与PMOD异常表达相关的紊乱的方法。

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