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1. 发明申请

WO2011008853A2 TRANSAPICAL DELIVERRY SYSTEM FOR HEART VALVES 审中-公开
标题翻译：用于心脏瓣膜的通用输送系统
公开(公告)号：WO2011008853A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/041970
申请日：2010-07-14
申请人： EDWARDS LIFESCIENCES CORPORATION , JIMENEZ, Teodoro, S. , LEE, Walter , DEHDASHTIAN, Mark , YEE, Kristopher
发明人： JIMENEZ, Teodoro, S. , LEE, Walter , DEHDASHTIAN, Mark , YEE, Kristopher
IPC分类号： A61M25/10 , A61M25/01 , A61F2/24
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。该系统包括具有其上的转向机构的输送导管，用于通过穿过其顶点进入左心室的导引器以顺行方式将球囊可扩张的假体心脏瓣膜递送至主动脉环。导引器可以具有比近端部分更软的远侧部分，以减少对心脏壁的创伤，同时保持良好的操作场稳定性。输送导管包括刚好靠近远端气囊的偏转部分，以便于在主动脉瓣环内的正确取向中定位假体心脏瓣膜。导管手柄中的触发器可以联接到致动偏转段的偏转线，而手柄中的滑块控制阀推动器的缩回。假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

2. 发明申请

WO2007059252A1 TRANSAPICAL HEART VALVE DELIVERY SYSTEM AND METHOD 审中-公开
标题翻译：通用心脏瓣膜输送系统及方法
公开(公告)号：WO2007059252A1
公开(公告)日：2007-05-24
申请号：PCT/US2006/044422
申请日：2006-11-15
申请人： EDWARDS LIFESCIENCES CORPORATION , DEHDASHTIAN, Mark
发明人： DEHDASHTIAN, Mark
IPC分类号： A61F2/84 , A61F2/24
CPC分类号： A61F2/2436 , A61F2/24 , A61F2/2412 , A61F2/2433 , A61F2002/9583 , A61F2220/0016
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus . The system includes a balloon catheter (54) having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve (50) through an introducer (70) in an antegrade fashion to the aortic annulus . The balloon catheter passes through an introducer that accesses the left ventricle through its apex and a small incision in the chest wall. The balloon catheter includes a deflecting segment (164) just proximal to the distal balloon (52) to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A slider in a deflection handle (154) may be coupled to a deflection wire that actuates the deflecting segment . The method includes using two concentric rings of purse-string sutures (44) around the puncture in the left ventricular apex to maintain a good seal around instruments passed therethrough. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。该系统包括其上具有转向机构的气囊导管（54），用于将气球可扩张的假体心脏瓣膜（50）以顺序的方式通过导引器（70）递送至主动脉环。气囊导管通过导引器，通过其顶点和左胸壁的小切口进入左心室。气囊导管包括刚好靠近远端球囊（52）的偏转部分（164），以便于将主动脉瓣环内的正确定位的假体心脏瓣膜定位。偏转手柄（154）中的滑块可以联接到致动偏转段的偏转线。该方法包括在左心室顶端的穿刺周围使用两个同心环的钱包缝合线（44），以保持穿过其中的器械周围的良好密封。假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

3. 发明申请

WO2011008812A2 TRANSAPICAL DELIVERY SYSTEM FOR HEART VALVES 审中-公开
标题翻译：用于心脏瓣膜的通用输送系统
公开(公告)号：WO2011008812A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/041909
申请日：2010-07-14
申请人： EDWARDS LIFESCIENCES CORPORATION , JIMENEZ, Teodoro, S. , LEE, Walter , DEHDASHTIAN, Mark , YEE, Kristopher
发明人： JIMENEZ, Teodoro, S. , LEE, Walter , DEHDASHTIAN, Mark , YEE, Kristopher
IPC分类号： A61M25/10 , A61M29/02 , A61F2/24
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。该系统包括具有其上的转向机构的输送导管，用于通过穿过其顶点进入左心室的导引器以顺行方式将球囊可扩张的假体心脏瓣膜递送到主动脉瓣环。导引器可以具有比近侧部分更软的远侧部分，以减少对心脏壁的创伤，同时保持良好的操作场稳定性。输送导管包括刚好靠近远侧气囊的偏转部分，以便于将主动脉瓣环内的正确定位的假体心脏瓣膜定位。导管手柄中的触发器可以联接到致动偏转部分的偏转线，而手柄中的滑块控制阀推动器的缩回。假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

4. 发明申请

WO0130270A3 PRE-SHAPED INTRALUMINAL GRAFT 审中-公开
标题翻译：预成形的INTRALUMINAL GRAFT
公开(公告)号：WO0130270A3
公开(公告)日：2001-12-13
申请号：PCT/US0026239
申请日：2000-09-25
申请人： EDWARDS LIFESCIENCES CORP , ENDOGAD RES PTY LTD , DEHDASHTIAN MARK , JIMINEZ THEODORO , WHITE GEOFFREY H , YU WEIYUN
发明人： DEHDASHTIAN MARK , JIMINEZ THEODORO , WHITE GEOFFREY H , YU WEIYUN
IPC分类号： A61F2/07 , A61F2/89 , A61F2/06
CPC分类号： A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/075
摘要： An intraluminal graft having a predetermined substantially a linear configuration is ideally fitted within individuated aneurysmal regions, tortuous or primarily non-linear vessels, and a method of emplacing the same likewise discloses novel aspects.
摘要翻译：具有预定基本线性构型的管腔内移植物理想地装配在个体动脉瘤区域，曲折或主要非线性血管内，并且其放置方法同样公开了新颖方面。

5. 发明申请

WO2011008853A3 TRANSAPICAL DELIVERY SYSTEM FOR HEART VALVES 审中-公开
公开(公告)号：WO2011008853A3
公开(公告)日：2011-06-09
申请号：PCT/US2010041970
申请日：2010-07-14
申请人： EDWARDS LIFESCIENCES CORP , JIMENEZ TEODORO S , LEE WALTER , DEHDASHTIAN MARK , YEE KRISTOPHER
发明人： JIMENEZ TEODORO S , LEE WALTER , DEHDASHTIAN MARK , YEE KRISTOPHER
IPC分类号： A61F2/958 , A61F2/24 , A61M25/01
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.

6. 发明申请

WO2011008853A8 TRANSAPICAL DELIVERY SYSTEM FOR HEART VALVES 审中-公开
公开(公告)号：WO2011008853A8
公开(公告)日：2011-04-21
申请号：PCT/US2010041970
申请日：2010-07-14
申请人： EDWARDS LIFESCIENCES CORP , JIMENEZ TEODORO S , LEE WALTER , DEHDASHTIAN MARK , YEE KRISTOPHER
发明人： JIMENEZ TEODORO S , LEE WALTER , DEHDASHTIAN MARK , YEE KRISTOPHER
IPC分类号： A61F2/958 , A61F2/24 , A61M25/01
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.

7. 发明申请

WO2011008812A3 TRANSAPICAL DELIVERY SYSTEM FOR HEART VALVES 审中-公开
标题翻译：心脏瓣膜的经心传递系统
公开(公告)号：WO2011008812A3
公开(公告)日：2011-04-21
申请号：PCT/US2010041909
申请日：2010-07-14
申请人： EDWARDS LIFESCIENCES CORP , JIMENEZ TEODORO S , LEE WALTER , DEHDASHTIAN MARK , YEE KRISTOPHER
发明人： JIMENEZ TEODORO S , LEE WALTER , DEHDASHTIAN MARK , YEE KRISTOPHER
IPC分类号： A61F2/958 , A61F2/24 , A61M29/02
CPC分类号： A61F2/2427 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/243 , A61F2/2433 , A61F2220/0016 , A61F2220/005 , A61M25/0133 , A61M25/0136 , A61M25/0138 , A61M25/0141 , A61M25/0144 , A61M25/0147 , A61M2025/015
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus. The system includes a delivery catheter having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve to the aortic annulus in an antegrade fashion through an introducer passing into the left ventricle through its apex. The introducer may have a more floppy distal section than a proximal section to reduce trauma to the heart wall while preserving good operating field stability. The delivery catheter includes a deflecting segment just proximal to a distal balloon to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A trigger in a catheter handle may be coupled to a deflection wire that actuates the deflecting segment, while a slider in the handle controls retraction of a valve pusher. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将人工心脏瓣膜输送到主动脉瓣环的输送系统和方法。该系统包括其上具有转向机构的输送导管，用于通过导入器通过其顶端进入左心室以顺行方式将球囊扩张假体心脏瓣膜递送至主动脉瓣环。导引器可以具有比近端部分更软的远端部分以减少对心脏壁的创伤，同时保持良好的手术场稳定性。输送导管包括刚好靠近远端球囊的偏转段，以便于将人造心脏瓣膜定位在主动脉瓣环内的适当取向中。导管手柄中的触发器可联接到致动偏转段的偏转丝上，而手柄中的滑动件控制阀推动器的缩回。假体心脏瓣膜可以安装在现有的钙化小叶上，并且也可以使用预扩张瓣膜成形术程序。

8. 发明申请

WO2007059252A9 TRANSAPICAL HEART VALVE DELIVERY SYSTEM AND METHOD 审中-公开
标题翻译：通用心脏瓣膜输送系统及方法
公开(公告)号：WO2007059252A9
公开(公告)日：2008-08-21
申请号：PCT/US2006044422
申请日：2006-11-15
申请人： EDWARDS LIFESCIENCES CORP , DEHDASHTIAN MARK
发明人： DEHDASHTIAN MARK
IPC分类号： A61F2/84 , A61F2/24
CPC分类号： A61F2/2436 , A61F2/24 , A61F2/2412 , A61F2/2433 , A61F2002/9583 , A61F2220/0016
摘要： A delivery system and method for delivering a prosthetic heart valve to the aortic valve annulus . The system includes a balloon catheter (54) having a steering mechanism thereon for delivering a balloon-expandable prosthetic heart valve (50) through an introducer (70) in an antegrade fashion to the aortic annulus . The balloon catheter passes through an introducer that accesses the left ventricle through its apex and a small incision in the chest wall. The balloon catheter includes a deflecting segment (164) just proximal to the distal balloon (52) to facilitate positioning of the prosthetic heart valve in the proper orientation within the aortic annulus. A slider in a deflection handle (154) may be coupled to a deflection wire that actuates the deflecting segment . The method includes using two concentric rings of purse-string sutures (44) around the puncture in the left ventricular apex to maintain a good seal around instruments passed therethrough. The prosthetic heart valve may be installed over the existing calcified leaflets, and a pre-dilation valvuloplasty procedure may also be utilized.
摘要翻译：用于将假体心脏瓣膜递送到主动脉瓣环的输送系统和方法。该系统包括其上具有转向机构的气囊导管（54），用于将气球可扩张的假体心脏瓣膜（50）以顺序的方式通过导引器（70）递送至主动脉环。气囊导管通过导引器，通过其顶点和左胸壁的小切口进入左心室。气囊导管包括刚好靠近远端球囊（52）的偏转部分（164），以便于将主动脉瓣环内的正确定位的假体心脏瓣膜定位。偏转手柄（154）中的滑块可以联接到致动偏转段的偏转线。该方法包括在左心室顶端的穿刺周围使用两个同心环的钱包缝合线（44），以保持穿过其中的器械周围的良好密封。假体心脏瓣膜可以安装在现有的钙化小叶上，并且还可以使用预扩张瓣膜成形术程序。

9. 发明申请

WO2013016665A1 DELIVERY SYSTEMS FOR PROSTHETIC HEART VALVE 审中-公开
标题翻译：用于人造心脏瓣膜的输送系统
公开(公告)号：WO2013016665A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/048637
申请日：2012-07-27
申请人： EDWARDS LIFESCIENCES CORPORATION , LEE, Walter , DEHDASHTIAN, Mark , JIMENEZ, Teodoro, S. , LEUNG, Gilbert, S. , JANISH, Bryan , VALDEZ, Michael, G. , NGUYEN, Tram , ULRICH, Timothy, C.
发明人： LEE, Walter , DEHDASHTIAN, Mark , JIMENEZ, Teodoro, S. , LEUNG, Gilbert, S. , JANISH, Bryan , VALDEZ, Michael, G. , NGUYEN, Tram , ULRICH, Timothy, C.
IPC分类号： A61F2/76 , A61F2/24 , A61M39/22 , A61M29/02
CPC分类号： A61F2/2433 , A61F2/958 , A61F2002/485 , A61F2002/9517 , A61F2002/9586 , A61F2250/0003 , A61F2250/0021 , A61M25/1002 , A61M25/10184 , A61M2025/1013 , A61M2025/1084
摘要： Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.
摘要翻译：本文描述了将人工装置（例如人造心脏瓣膜）穿过人体并进入心脏以植入其中的系统和方法。与本文公开的输送系统一起递送的假体装置例如可从安装在递送系统上的径向压缩状态径向扩张至径向扩张状态，以使用输送系统的可膨胀气囊进行植入。通过身体并进入心脏的示例性递送途径包括经股动脉途径，经心尖途径和经动脉途径等。

10. 发明申请

WO2006005015A3 PARAVALVULAR LEAK DETECTION, SEALING AND PREVENTION 审中-公开
标题翻译：泄漏检测，密封和预防
公开(公告)号：WO2006005015A3
公开(公告)日：2006-04-27
申请号：PCT/US2005023584
申请日：2005-06-30
申请人： EDWARDS LIFESCIENCES PVT INC , SPENSER BENJAMIN , BENICHOU NETANEL , BASH ASSAF , DEHDASHTIAN MARK
发明人： SPENSER BENJAMIN , BENICHOU NETANEL , BASH ASSAF , DEHDASHTIAN MARK
IPC分类号： A61F2/24 , A61M25/10
CPC分类号： A61F2/2472 , A61F2/2409 , A61F2/2418 , A61F2/2433 , A61F2250/0003 , A61F2250/006 , A61F2250/0069
摘要： The present invention provides a series of new percutaneous concepts of paravalvular repairs including identifying the leak location, several repair techniques and finally built-in means for leak prevention, built on percutaneous valves. A catheter-delivered device (27) locates cavities occurring between a prosthetic valve (20) and the wall of the body vessel where the valve is implanted, the cavities producing paravalvular leaks during diastole, the device comprising at least one of a plurality of flexible wires (28), the wire having attached to it a balloon (29), wherein the balloon is pulled by the leak through the cavity and wherein the wire then serves to mark the cavity location.
摘要翻译：本发明提供了一系列新颖的瓣膜修复的经皮概念，包括识别泄漏位置，几种修复技术，以及最终内置的经皮瓣置入装置。导管输送装置（27）定位在假体瓣膜（20）和植入瓣膜的身体血管壁之间发生的空腔，在舒张期间空腔产生瓣膜旁泄漏，该装置包括多个柔性电线（28），电线已经附接到气球（29），其中气囊被泄漏通过空腔拉动，并且其中电线然后用于标记腔体位置。

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