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1. 发明申请

WO2003055527A2 NOVEL IMMUNOCONJUGATES USEFUL FOR TREATMENT OF TUMOURS 审中-公开
标题翻译：新型免疫球蛋白适用于治疗肿瘤
公开(公告)号：WO2003055527A2
公开(公告)日：2003-07-10
申请号：PCT/EP2002/014842
申请日：2002-12-23
申请人： VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW , REVETS, Hilde , CORTEZ-RETAMOZO, Virna , MUYLDERMANS, Serge , DE BAETSELIER, Patrick
发明人： REVETS, Hilde , CORTEZ-RETAMOZO, Virna , MUYLDERMANS, Serge , DE BAETSELIER, Patrick
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/6853 , A61K47/6899
摘要： The present invention relates to novel immunoconjugates that are devoid of light chains and comprise at least one variable domain of a heavy chain antibody. The immunoconjugates of the present invention can be used for the preparation of a medicament to treat tumours.
摘要翻译：本发明涉及不含轻链的新型免疫偶联物，并且包含至少一个可变结构域的重链抗体。本发明的免疫偶联物可用于制备治疗肿瘤的药物。

2. 发明申请

WO2008148858A1 THE NOVEL ADIPOCYTOKINE VISFATIN/PBEF1 IS AN APOPTOSIS ASSOCIATED FACTOR INDUCED IN MONOCYTES DURING IN VIVO HIV-1 INFECTION 审中-公开
标题翻译：新型ADIPOCYTOKINE VISFATIN / PBEF1是在HIV感染中感染单核细胞诱导的相关因子
公开(公告)号：WO2008148858A1
公开(公告)日：2008-12-11
申请号：PCT/EP2008/057025
申请日：2008-06-05
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , INSTITUUT VOOR TROPISCHE GENEESKUNDE , RAES, Geert , DE BAETSELIER, Patrick , VAN DEN BERGH, Rafaël , VANHAM, Guido
发明人： RAES, Geert , DE BAETSELIER, Patrick , VAN DEN BERGH, Rafaël , VANHAM, Guido
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/56972 , G01N33/56988
摘要： The present invention relates to the use of monocyte markers for diagnostic, prognostic or theranostic applications during diseases and syndromes caused by HIV infection. More specifically, it relates to a method, comprising isolation of monocytes and determining gene expression, preferably PBEF1 gene expression. Said method is useful to determine the evolution of the disease or can be used to evaluate the efficacy of a treatment.
摘要翻译：本发明涉及单核细胞标志物在由HIV感染引起的疾病和综合征期间用于诊断，预后或应用的应用。更具体地，本发明涉及一种方法，其包括分离单核细胞并确定基因表达，优选PBEF1基因表达。所述方法可用于确定疾病的进展或可用于评估治疗的功效。

3. 发明申请

WO2007033959A2 USE OF P-SELECTIN GLYCOPROTEIN LIGAND 1 IN MODULATION OF HEMATOGENOUS METASTASIS OF LYMPHOMAS 审中-公开
标题翻译： P-选择素GLYCOPROTEIN LIGAND 1在淋巴细胞的HEMATOGENOUS METASTASIS的调制中的应用
公开(公告)号：WO2007033959A2
公开(公告)日：2007-03-29
申请号：PCT/EP2006066490
申请日：2006-09-19
申请人： VIB VZW , UNIV BRUXELLES , DE BAETSELIER PATRICK , RAES GEERT , HASSANZADEH GHASSABEH GHOLAMRE
发明人： DE BAETSELIER PATRICK , RAES GEERT , HASSANZADEH GHASSABEH GHOLAMRE
CPC分类号： A61K38/177 , A61K38/178 , A61K38/4886
摘要： The present invention relates to the use of P-selectin ligand 1 for the modulation of hematogenous metastasis of lymphomas. More specifically, it relates to the use of P-selectin glycoprotein ligan-1 and of molecules that impair the binding of P-selectin ligand in preventing metastasis, preferably metastasis in liver and spleen.
摘要翻译：本发明涉及P-选择蛋白配体1用于调节淋巴瘤血源性转移的用途。更具体地说，本发明涉及P-选择蛋白糖蛋白连接蛋白-1以及损害P-选择蛋白配体结合预防转移，优选肝脏和脾脏转移的分子的用途。

4. 发明申请

WO2003055527A3 IMMUNOCONJUGATES USEFUL FOR TREATMENT OF TUMOURS 审中-公开
公开(公告)号：WO2003055527A3
公开(公告)日：2003-07-10
申请号：PCT/EP2002/014842
申请日：2002-12-23
申请人： VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW , REVETS, Hilde , CORTEZ-RETAMOZO, Virna , MUYLDERMANS, Serge , DE BAETSELIER, Patrick
发明人： REVETS, Hilde , CORTEZ-RETAMOZO, Virna , MUYLDERMANS, Serge , DE BAETSELIER, Patrick
IPC分类号： A61K47/48
摘要： The present invention relates to novel immunoconjugates that are devoid of light chains and comprise at least one variable domain of a heavy chain antibody. The immunoconjugates of the present invention can be used for the preparation of a medicament to treat tumours.

5. 发明申请

WO2005024418A2 NOVEL MARKERS FOR ALTERNATIVELY ACTIVATED MACROPHAGES 审中-公开
标题翻译：用于激活的宏观活性的新标志物
公开(公告)号：WO2005024418A2
公开(公告)日：2005-03-17
申请号：PCT/EP2004/052076
申请日：2004-09-07
申请人： VIB VZM , VRIJE UNIVERSITEIT BRUSSEL , RAES, Geert , HASSANZADEH GHASSABEH, Gholamreza , DE BAETSELIER, Patrick
发明人： RAES, Geert , HASSANZADEH GHASSABEH, Gholamreza , DE BAETSELIER, Patrick
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , G01N33/5094 , G01N2333/705
摘要： The present invention relates to novel markers for alternatively activated macrophages. More specifically, the present invention relates to the use of galactose-type C-type lectins as surface markers, that allows rapid identification and sorting of the alternative macrophages. Such identifications can be useful in diseases where there is an imbalance between proinflammatory and anti-inflammatory immune reactions.
摘要翻译：本发明涉及用于交替活化的巨噬细胞的新标记物。更具体地说，本发明涉及使用半乳糖型C型凝集素作为表面标记，其允许快速鉴定和分选替代巨噬细胞。这种鉴定可用于促炎症和抗炎症免疫反应之间不平衡的疾病。

6. 发明申请

WO1994018325A1 TNF-ALPHA MUTEINS AND A PROCESS FOR PREPARING THEM 审中-公开
标题翻译： TNF-ALPHA MUTEINS及其制备方法
公开(公告)号：WO1994018325A1
公开(公告)日：1994-08-18
申请号：PCT/EP1994000286
申请日：1994-02-02
申请人： N.V. INNOGENETICS S.A. , LUCAS, Rudolph , DE BAETSELIER, Patrick , FRANSEN, Lucie , SABLON, Erwin
发明人： N.V. INNOGENETICS S.A.
IPC分类号： C12N15/28
CPC分类号： C07K14/525 , A61K38/00
摘要： The invention relates to a tumor necrosis factor mutein characterized in that the TNF- alpha amino acid sequence is mutated, or deleted totally or partially, in the region extending from amino acid position at 101 to 116 in such a way that: either the lectin-like activities are modulated with respect to TNF- alpha , and/or the toxic activity is reduced with respect to TNF- alpha , and/or the inflammatory cytokines inducing capacities are modulated with respect to TNF- alpha , and/or the adhesion molecules inducing capacities are modulated with respect to TNF- alpha , and/or the metastasis promoting activity is reduced with respect to TNF- alpha , and/or the half life time is increased with respect to TNF- alpha and with said muteins being characterized in that they have retained the aforementioned activities; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及肿瘤坏死因子突变蛋白，其特征在于TNF-α氨基酸序列在从101到116的氨基酸位置延伸的区域中全部或部分突变或缺失，使得：相对于TNF-α调节相似的活性，和/或相对于TNF-α降低毒性活性，和/或相对于TNF-α调节炎症细胞因子诱导能力，和/或诱导粘附分子相对于TNF-α调节能力，和/或相对于TNF-α降低转移促进活性，和/或相对于TNF-α增加半衰期，并且所述突变蛋白的特征在于它们保留上述活动; 或其药学上可接受的盐。

7. 发明申请

WO2007039645A1 AFRICAN TRYPANOSOMIASIS THERAPY WITH A NANOBODY-CONJUGATED HUMAN TRYPANOLYTIC FACTOR 审中-公开
标题翻译：非人类TRYPANOSOMIASIS治疗与纳米结合人类TRYPANOLYTIC因子
公开(公告)号：WO2007039645A1
公开(公告)日：2007-04-12
申请号：PCT/EP2006/067149
申请日：2006-10-06
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , DE BAETSELIER, Patrick , MUYLDERMANS, Serge , MAGEZ, Stefan
发明人： DE BAETSELIER, Patrick , MUYLDERMANS, Serge , MAGEZ, Stefan
IPC分类号： C12N15/62 , A61K47/48
CPC分类号： C07K14/775 , A61K47/6811 , A61K47/6849
摘要： The present invention relates to the treatment of trypanosomiasis using a nanobody- conjugated trypanolytic factor. More specifically, it relates to a therapy with nanobody- conjugated human apo-L1, whereby said apo-L1 is preferably truncated at the C-terminal end to avoid neutralization by the trypanosomes.
摘要翻译：本发明涉及使用纳米体系共混的锥虫溶解因子治疗锥虫病。更具体地说，本发明涉及具有纳米体系共轭人apo-L1的疗法，其中所述apo-L1优选在C末端截短以避免锥虫体中和。

8. 发明申请

WO2007033959A3 USE OF P-SELECTIN GLYCOPROTEIN LIGAND 1 IN MODULATION OF HEMATOGENOUS METASTASIS OF LYMPHOMAS 审中-公开
公开(公告)号：WO2007033959A3
公开(公告)日：2007-03-29
申请号：PCT/EP2006/066490
申请日：2006-09-19
申请人： VIB VZW , VRIJE UNIVERSITEIT BRUSSEL , DE BAETSELIER, Patrick , RAES, Geert , HASSANZADEH GHASSABEH, Gholamreza
发明人： DE BAETSELIER, Patrick , RAES, Geert , HASSANZADEH GHASSABEH, Gholamreza
IPC分类号： A61K38/17 , A61P35/00
摘要： The present invention relates to the use of P-selectin ligand 1 for the modulation of hematogenous metastasis of lymphomas. More specifically, it relates to the use of P-selectin glycoprotein ligan-1 and of molecules that impair the binding of P-selectin ligand in preventing metastasis, preferably metastasis in liver and spleen.

9. 发明申请

WO2004098626A2 THE USE OF A POLYPEPTIDE DOMAIN TO MODULATE THE TUMORIGENIC AND METASTATIC POTENTIAL OF CANCER CELLS 审中-公开
标题翻译：使用SLPI的多肽域来调节癌细胞的肿瘤发生和分化潜能
公开(公告)号：WO2004098626A2
公开(公告)日：2004-11-18
申请号：PCT/EP2004/050627
申请日：2004-04-28
申请人： VIB vzw , REVETS, Hilde , DE BAETSELIER, Patrick , DEVOOGDT, Nick , HASSANZADEH, Gholamreza
发明人： REVETS, Hilde , DE BAETSELIER, Patrick , DEVOOGDT, Nick , HASSANZADEH, Gholamreza
IPC分类号： A61K38/08
CPC分类号： A61K38/57
摘要： The present invention relates to the use of a polypeptide domain to modulate the tumorigenic and metastatic potential of cancer cells. More specifically, the present invention relates to a domain of a Secretory Leukocyte Protease Inhibitor (SLPI) to modulate tumor invasiveness and/or metastasis. It further relates to compounds, such as antibodies, that interact with said domain and repress the tumor invasiveness and/or the metastasis.
摘要翻译：本发明涉及多肽结构域用于调节癌细胞的致瘤和转移潜力的用途。更具体地，本发明涉及调节肿瘤侵袭和/或转移的分泌性白细胞蛋白酶抑制剂（SLPI）的结构域。它还涉及与所述结构域相互作用并抑制肿瘤侵袭和/或转移的化合物，例如抗体。

10. 发明申请

WO2004056853A3 AN IMMUNOMODULATORY PROTEIN DERIVED FROM TRYPANOSOMES AND USES THEREOF 审中-公开
公开(公告)号：WO2004056853A3
公开(公告)日：2004-07-08
申请号：PCT/EP2003/051082
申请日：2003-12-19
申请人： VIB VZW , DE BAETSELIER, Patrick , BESCHIN, Alain
发明人： DE BAETSELIER, Patrick , BESCHIN, Alain
IPC分类号： C07K14/44
摘要： The present invention relates to the field of immunomodulation. More particularly, the present invention relates to the identification and isolation of a polypeptide derived from Trypanosomes which can be used to modulate the immune response in mammals.

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