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    • 2. 发明申请
    • ROTARY CAM VALVE
    • 旋转凸轮阀
    • WO2006052652A2
    • 2006-05-18
    • PCT/US2005/039786
    • 2005-11-04
    • WELCH ALLYN, INC.DANNA, DominickSCINTA, Wendy, MarieKRAUTER, Allan, I.NEWMAN, Richard, W.KUGLER, Andrew, Jay
    • DANNA, DominickSCINTA, Wendy, MarieKRAUTER, Allan, I.NEWMAN, Richard, W.KUGLER, Andrew, Jay
    • C12Q1/70C12Q1/68
    • B01L3/502715B01L3/50273B01L3/565B01L2200/027B01L2200/10B01L2200/16B01L2300/024B01L2300/0816B01L2300/0867B01L2300/087B01L2400/0481B01L2400/0487B01L2400/0633G01N33/56944G01N33/56983G01N33/56994G01N2035/00158
    • Disclosed is a rapid and easy to use diagnostic tool that a point-of-care practitioner can use to specifically identify the cause of a disease, such as the upper respiratory infection (URI) pharyngitis. Such a disease has multiple potential causative pathogens and has a number of combined clinical manifestations. The diagnostic tool is rapid in order to provide the busy point- of-care practitioner with an assay result within a time that does not affect patient flow. The time usually available to such a practitioner is optimally less than 10 minutes, so that an assay that detects multiple pathogens rapidly is regarded as one that does so in less than 10 minutes. The diagnostic tool can be operated with minimal training and within the confines of said practitioner's environment. The diagnostic tool has specificity and sensitivity above those of the prior art devices. The tool is self-contained, which thereby helps to control the spread of infection and eases the burden of disposal of used equipment. The tool includes a diagnostic card configured to enable a plurality of nucleic acid diagnostic assays for rapidly detecting the presence or absence of multiple pathogens at the point-of-care. The tool includes a device that interacts with the card and that contains assay analysis means.
    • 公开了一种快速和易于使用的诊断工具,一个点护理人员可以用来专门识别疾病的原因,例如上呼吸道感染(URI)咽炎。 这种疾病具有多种潜在的致病病原体,并具有多种组合的临床表现。 诊断工具是快速的,以便在不影响患者流量的时间内向繁忙的护理人员提供测定结果。 这种实践者通常可获得的时间最好不到10分钟,所以快速检测多种病原体的检测方法被认为是在不到10分钟内这样做的检测方法。 诊断工具可以在最少的培训下进行,并且在所述从业者的环境的范围内。 诊断工具的特性和灵敏度高于现有技术装置。 该工具是独立的,从而有助于控制感染的传播,并减轻二手设备的处置负担。 该工具包括诊断卡,其被配置为使得能够在护理点处快速检测多种病原体的存在或不存在的多个核酸诊断测定。 该工具包括与卡相互作用并且包含测定分析手段的装置。
    • 6. 发明申请
    • MICROFLUIDIC DEVICE WITH ELASTOMERIC SEAL
    • 具有弹性密封的微流体装置
    • WO2009002334A1
    • 2008-12-31
    • PCT/US2007/066319
    • 2007-06-26
    • WELCH ALLYN, INC.DANNA, Dominick
    • DANNA, Dominick
    • F16K31/00
    • F16K15/188B01J19/0093B01J2219/00813B01L3/502715B01L2200/027B01L2300/044B01L2300/0672B01L2300/0816
    • The invention comprises a low cost method of scaling and resealing a micro fluidic device before, during, and after communication of fluids into the microfluidic device. The invention includes a microfluidic device with fluid introduction ports substantially hermetically sealed with elastomeric plugs, wherein the plugs can be penetrated by hollow needles to introduce fluids such as air, water, ethanol, or other chemical or biological reagents into the device while maintaining a substantially hermetic seal. The invention includes a method for introducing fluids into a microfluidic device from an external source. The method comprises the steps of penetrating fluid introduction ports substantially hermetically sealed with elastomeric plugs with hollow needles connected to a fluid source, pumping fluid into the device, and removing the hollow needle from the plug, whereupon plug self-reseals to form a substantially hermetic seal.
    • 本发明包括在流体进入微流体装置之前,期间和之后将微流体装置缩放和重新密封的低成本方法。 本发明包括具有基本上用弹性体塞密封的流体引入端口的微流体装置,其中塞子可被空心针穿透,以将诸如空气,水,乙醇或其他化学或生物试剂的流体引入装置中,同时保持基本上 气密封。 本发明包括从外部源将流体引入微流体装置的方法。 该方法包括以下步骤:将具有弹性体塞的基本上气密密封的流体引入口穿过,所述弹性体塞具有连接到流体源的中空针,将流体泵送到所述装置中,以及从所述塞子中移出所述空心针,由此插头自发地形成基本上密封的 密封。
    • 7. 发明申请
    • ROTARY CAM VALVE
    • 旋转凸轮阀
    • WO2006052652A3
    • 2008-09-12
    • PCT/US2005039786
    • 2005-11-04
    • WELCH ALLYN INCDANNA DOMINICKSCINTA WENDY MARIEKRAUTER ALLAN INEWMAN RICHARD WKUGLER ANDREW JAY
    • DANNA DOMINICKSCINTA WENDY MARIEKRAUTER ALLAN INEWMAN RICHARD WKUGLER ANDREW JAY
    • C12Q1/68C12M1/00C12M1/34C12P19/34
    • B01L3/502715B01L3/50273B01L3/565B01L2200/027B01L2200/10B01L2200/16B01L2300/024B01L2300/0816B01L2300/0867B01L2300/087B01L2400/0481B01L2400/0487B01L2400/0633G01N33/56944G01N33/56983G01N33/56994G01N2035/00158
    • Disclosed is a rapid and easy to use diagnostic tool that a point-of-care practitioner can use to specifically identify the cause of a disease, such as the upper respiratory infection (URI) pharyngitis. Such a disease has multiple potential causative pathogens and has a number of combined clinical manifestations. The diagnostic tool is rapid in order to provide the busy point- of-care practitioner with an assay result within a time that does not affect patient flow. The time usually available to such a practitioner is optimally less than 10 minutes, so that an assay that detects multiple pathogens rapidly is regarded as one that does so in less than 10 minutes. The diagnostic tool can be operated with minimal training and within the confines of said practitioner's environment. The diagnostic tool has specificity and sensitivity above those of the prior art devices. The tool is self-contained, which thereby helps to control the spread of infection and eases the burden of disposal of used equipment. The tool includes a diagnostic card configured to enable a plurality of nucleic acid diagnostic assays for rapidly detecting the presence or absence of multiple pathogens at the point-of-care. The tool includes a device that interacts with the card and that contains assay analysis means.
    • 公开了一种快速和易于使用的诊断工具,一个点护理人员可以用来专门识别疾病的原因,例如上呼吸道感染(URI)咽炎。 这种疾病具有多种潜在的致病病原体,并具有多种组合的临床表现。 诊断工具是快速的,以便在不影响患者流量的时间内向繁忙的护理人员提供测定结果。 这种实践者通常可获得的时间最好不到10分钟,所以快速检测多种病原体的检测方法被认为是在不到10分钟内这样做的检测方法。 诊断工具可以在最少的培训下进行,并且在所述从业者的环境的范围内。 诊断工具的特性和灵敏度高于现有技术装置。 该工具是独立的,从而有助于控制感染的传播,并减轻二手设备的处置负担。 该工具包括诊断卡,其被配置为使得能够在护理点处快速检测多种病原体的存在或不存在的多个核酸诊断测定。 该工具包括与卡相互作用并且包含测定分析手段的装置。