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1. 发明申请

WO2009005790A3 STERILE THIOL-DERIVATIZED HYALURONIC ACID POLYMER COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2009005790A3
公开(公告)日：2009-01-08
申请号：PCT/US2008/008157
申请日：2008-06-30
申请人： CARBYLAN BIOSURGERY, INC. , DANILOFF, George, Y. , SPIRO, Robert, C. , GRAVETT, David, M. , HILLAS, Patrick, J. , HE, Pingren
发明人： DANILOFF, George, Y. , SPIRO, Robert, C. , GRAVETT, David, M. , HILLAS, Patrick, J. , HE, Pingren
IPC分类号： A61L27/20 , A61P41/00
摘要： The present application provides sterile hyaluronic polymer compositions than are useful, e.g., as medical devices, biomedical adhesives, and sealants. Generally, provided are sterile dry compositions comprising a soluble thiol-derivatized hyaluronic acid and one or more stabilizing excipients. Also provided are related kits and methods. The compositions described herein are particularly robust to sterilizing irradiation, and substantially maintain both their molecular weight and gelation parameters such as gelation time after sterilization, such that such sterile compositions are cabable of hydrogel formation.

2. 发明申请

WO2006002332A1 METHODS AND CROSSLINKED POLYMER COMPOSITIONS FOR CARTILAGE REPAIR 审中-公开
标题翻译：用于修复的方法和交联聚合物组合物
公开(公告)号：WO2006002332A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/022343
申请日：2005-06-23
申请人： ANGIOTECH BIOMATERIALS CORPORATION , DANILOFF, George, Y. , TOLEIKIS, Philip, M. , HUNTER, William, L. , AVELAR, Rui
发明人： DANILOFF, George, Y. , TOLEIKIS, Philip, M. , HUNTER, William, L. , AVELAR, Rui
IPC分类号： A61L27/24
CPC分类号： A61L27/26 , A61L2430/06
摘要： A method of repairing damaged cartilage and soft tissue in a patient is provided using a biocompatible, non-immunogenic composition. The composition comprises a hydrophilic polymer and a plurality of crosslinkable components having reactive functional groups. The composition used in the method may be loaded with biologically active agents for delivery to the damaged tissues. Kits for use in carrying out the method of the invention are also provided.
摘要翻译：使用生物相容性，非免疫原性组合物提供修复患者中受损软骨和软组织的方法。组合物包含亲水性聚合物和具有反应性官能团的多个可交联组分。用于该方法的组合物可以装载用于递送至受损组织的生物活性剂。还提供了用于实施本发明的方法的试剂盒。

3. 发明申请

WO2004094495A3 COMPOSITIONS AND METHODS OF USING A TRANSIENT COLORANT 审中-公开
标题翻译：使用瞬态色素的组合物和方法
公开(公告)号：WO2004094495A3
公开(公告)日：2005-04-21
申请号：PCT/US2004004153
申请日：2004-02-10
申请人： COHESION TECH INC , DANILOFF GEORGE Y , DANIELS JOHN R
发明人： DANILOFF GEORGE Y , DANIELS JOHN R
IPC分类号： A61L27/50 , A61L31/14 , A61Q19/00 , C08F2/46 , C08F2/50 , C08G63/08 , C08G67/00
CPC分类号： A61L31/14 , A61L27/50
摘要： This invention relates generally to compositions and systems for forming biomaterials containing a transient colorant for visualizing tissue or surgical materials coated with such biomaterials, to methods of using such compositions as bioadhesives, for tissue augmentation, in the prevention of surgical adhesions, for coating surfaces of synthetic implants, as drug delivery matrices, for ophthalmic applications, and in other applications.
摘要翻译：本发明一般涉及用于形成生物材料的组合物和系统，所述组合物和系统包含用于可视化涂覆有这种生物材料的组织或手术材料的临时着色剂，使用这些组合物作为生物粘合剂，用于组织增强，防止手术粘连，合成植入物，作为药物递送基质，用于眼科应用和其它应用。

4. 发明申请

WO2004094495A2 COMPOSITIONS AND METHODS OF USING A TRANSIENT COLORANT 审中-公开
标题翻译：使用瞬态色素的组合物和方法
公开(公告)号：WO2004094495A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/004153
申请日：2004-02-10
申请人： COHESION TECHNOLOGIES, INC. , DANILOFF, George, Y. , DANIELS, John, R.
发明人： DANILOFF, George, Y. , DANIELS, John, R.
IPC分类号： C08G
CPC分类号： A61L31/14 , A61L27/50
摘要： This invention relates generally to compositions and systems for forming biomaterials containing a transient colorant for visualizing tissue or surgical materials coated with such biomaterials, to methods of using such compositions as bioadhesives, for tissue augmentation, in the prevention of surgical adhesions, for coating surfaces of synthetic implants, as drug delivery matrices, for ophthalmic applications, and in other applications.
摘要翻译：本发明一般涉及用于形成生物材料的组合物和系统，所述组合物和系统包含用于可视化涂覆有这种生物材料的组织或手术材料的临时着色剂，使用这些组合物作为生物粘合剂，用于组织增强，防止手术粘连，合成植入物，作为药物递送基质，用于眼科应用和其它应用。

5. 发明申请

WO2007033353A2 CHEMICAL TARGET-BINDING COMPOSITIONS 审中-公开
标题翻译：化学目标结合组合物
公开(公告)号：WO2007033353A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/035968
申请日：2006-09-14
申请人： THERABIT, INC. , DANILOFF, George, Y.
发明人： DANILOFF, George, Y.
IPC分类号： A61K48/00 , A61K9/14
CPC分类号： A61K9/1635 , A61K9/0024 , A61K9/5073
摘要： Herein in described compositions and methods for modulating and regulating the concentration of a chemical target in an organism or in an ecosystem. In one embodiment, the concentration is regulated such that it is maintained below or above a certain threshold, thus avoiding toxic or harmful effects of the chemical target. The described compositions may, for example, be implanted in a human body or placed in the ecosystem. The compositions comprise binding moieties that reversibly bind to a chemical target in the organism or ecosystem. The binding capacity and the binding constants for a chemical target are designed such that the composition maintains the concentration of the chemical target substantially within a beneficial range of concentration.
摘要翻译：在此描述了用于调节和调节生物体或生态系统中化学靶浓度的组合物和方法。在一个实施方案中，调节浓度以使其保持低于或高于特定阈值，从而避免化学目标的毒性或有害影响。所描述的组合物可以例如植入人体或置于生态系统中。该组合物包含可逆地结合生物体或生态系统中的化学靶标的结合部分。化学靶的结合容量和结合常数被设计成使得组合物将化学靶的浓度基本保持在有利的浓度范围内。

6. 发明申请

WO2006078282A3 COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND ASSOCIATED METHODS OF PREPARATION AND USE 审中-公开
标题翻译：用于形成交联生物材料的组合物和系统及其制备和使用的相关方法
公开(公告)号：WO2006078282A3
公开(公告)日：2007-01-18
申请号：PCT/US2005015036
申请日：2005-04-28
申请人： ANGIOTECH BIOMATERIALS CORP , DANILOFF GEORGE Y , SEHL LOUIS C , TROLLSAS OLOF MIKAEL , SCHROEDER JACQUELINE , GRAVETT DAVID M , TOLEIKIS PHILIP M
发明人： DANILOFF GEORGE Y , SEHL LOUIS C , TROLLSAS OLOF MIKAEL , SCHROEDER JACQUELINE , GRAVETT DAVID M , TOLEIKIS PHILIP M
IPC分类号： A61L27/50 , A61K9/107 , A61K9/14 , A61K9/16 , A61K9/51 , A61K47/34 , A61L24/04 , A61L27/16 , A61L27/26 , A61L31/04
CPC分类号： A61L31/041 , A61K9/1075 , A61K9/1647 , A61K9/5153 , A61K47/34 , A61L24/043 , A61L27/16 , A61L27/26 , A61L27/50
摘要： Crosslinkable compositions are provided that readily crosslinkin situ to provide crosslinked biomaterials. The composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. In one embodiment, a first component has nucleophilic groups and a second component has electrophilic groups. Additional components may have nucleophilic or electrophilic groups. Methods for preparing and using the compositions are also provided as are kits for delivery of the compositions. Exemplary uses for the crosslinked compositions include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
摘要翻译：提供可交联原位以提供交联生物材料的可交联组合物。所述组合物含有至少两种在其上具有反应性基团的生物相容性，非免疫原性组分，所述官能团被选择以使组分之间的相互反应即交联。在一个实施方案中，第一组分具有亲核基团，第二组分具有亲电基团。另外的组分可以具有亲核或亲电基团。制备和使用组合物的方法也提供用于递送组合物的试剂盒。交联组合物的示例性用途包括组织增加，生物活性剂递送，生物粘附和防止手术或损伤后的粘连。

7. 发明申请

WO2006034128A2 MULTIFUNCTIONAL COMPOUNDS FOR FORMING CROSSLINKED BIOMATERIALS AND METHODS OF PREPARATION AND USE 审中-公开
标题翻译：用于形成交联生物材料的多功能化合物及其制备和使用方法
公开(公告)号：WO2006034128A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/033367
申请日：2005-09-19
申请人： ANGIOTECH BIOMATERIALS CORPORATION , DANILOFF, George, Y. , NGO, Michael, Huy , TROLLSAS, Olof, Mikael , GRAVETT, David, M , TOLEIKIS, Philip, M.
发明人： DANILOFF, George, Y. , NGO, Michael, Huy , TROLLSAS, Olof, Mikael , GRAVETT, David, M , TOLEIKIS, Philip, M.
IPC分类号： A61F2/44 , A61K38/00
CPC分类号： C08G65/005 , A61F2/44 , A61F2002/30677 , A61K9/0024 , A61K9/0048 , A61K9/1641 , A61K38/00 , A61L27/54 , A61L31/16 , C08G65/332 , C08G65/3342 , C08G2210/00 , C08G2650/32 , C08L71/02 , C08L2203/02
摘要： Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.
摘要翻译：提供了易于交联的多官能化合物

8. 发明申请

WO1994003814A2 METHOD AND KIT FOR PYRIDINIUM CROSSLINK ASSAY 审中-公开
标题翻译：吡啶类交联测定方法和试剂盒
公开(公告)号：WO1994003814A2
公开(公告)日：1994-02-17
申请号：PCT/US1993007203
申请日：1993-07-30
申请人： METRA BIOSYSTEMS, INC. , CERELLI, Mary, J. , DANILOFF, George, Y. , KUNG, Viola, T. , ZUK, Robert, F. , JU, Hsin-Shan, Julia , EVANS, Brian, Jeffrey , HE, Pingren
发明人： METRA BIOSYSTEMS, INC.
IPC分类号： G01N33/682
CPC分类号： G01N33/5308 , C07K16/44 , G01N33/6887
摘要： A method of assaying bone collagen degradation activity in a human subject. In the method, a human urine sample is reacted with a monoclonal antibody which (i) is capable of reacting immunospecifically with pyridinium crosslinks selected from the group consisting of native free pyridinoline and native free deoxypyridinoline, and (ii) has a ratio of reactivity toward the selected pyridinium crosslinks and urinary pyridinium peptides larger than 1,000 daltons in molecular weight, of greater than about 5:1. An immunocomplex forms between the antibody reagent and the selected pyridinium crosslinks which are present in the sample, and the amount of immunocomplex is measured. Also disclosed are antibody reagents and kits which can be used in the method.
摘要翻译：测定人类受试者骨胶原降解活性的方法。在该方法中，人尿样品与单克隆抗体反应，（i）能够与选自天然游离吡啶啉和天然游离的脱氧吡啶啉的吡啶鎓交联物进行免疫特异性反应，和（ii）具有反应性比所选择的吡啶鎓交联剂和大于1,000道尔顿的尿吡啶肽分子量大于约5:1。在抗体试剂和存在于样品中的所选择的吡啶鎓交联之间形成免疫复合物，并测量免疫复合物的量。还公开了可用于该方法的抗体试剂和试剂盒。

9. 发明申请

WO2011014432A1 MODIFIED HYALURONIC ACID POLYMER COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：改性羟丙酸聚合物组合物及相关方法
公开(公告)号：WO2011014432A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/043108
申请日：2010-07-23
申请人： CARBYLAN BIOSURGERY, INC. , HE, Pingren , GRAVETT, David, M. , DANILOFF, George, Y.
发明人： HE, Pingren , GRAVETT, David, M. , DANILOFF, George, Y.
IPC分类号： A61L27/20 , C08B37/00 , A61L27/52 , C08J3/075
CPC分类号： A61K31/58 , A61K9/0019 , A61K9/06 , A61K9/10 , A61K9/14 , A61K31/573 , A61K35/00 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/36 , A61L27/26 , A61L27/52 , A61L2430/24 , C08B37/0072 , C08J3/075 , C08J2305/08 , C08L5/08 , C08L71/02
摘要： The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, and hydrogel precursor compositions and the resulting hydrogels. The compositions are lightly cross-linked and possess low pro-inflammatory properties when injected in vivo, and can be used as, for example, medical devices, biomedical adhesives and sealants, and for localized delivery of bioactive agents, among other uses.
摘要翻译：本申请提供了包含具有低水平的官能团改性的透明质酸的组合物，通过这种轻度改性的透明质酸与合适的二官能或多官能交联剂的受控反应形成的混合物，以及水凝胶前体组合物和所得的水凝胶。组合物轻度交联并且在体内注射时具有低促炎特性，并且可以用作例如医疗装置，生物医学粘合剂和密封剂，以及用于生物活性剂的局部递送以及其它用途。

10. 发明申请

WO2009005790A2 STERILE HYALURONIC ACID POLYMER COMPOSITIONS AND RELATED METHODS 审中-公开
标题翻译：非甾体酸性聚合物组合物及相关方法
公开(公告)号：WO2009005790A2
公开(公告)日：2009-01-08
申请号：PCT/US2008008157
申请日：2008-06-30
申请人： CARBYLAN BIOSURGERY INC , DANILOFF GEORGE Y , SPIRO ROBERT C , GRAVETT DAVID M , HILLAS PATRICK J , HE PINGREN
发明人： DANILOFF GEORGE Y , SPIRO ROBERT C , GRAVETT DAVID M , HILLAS PATRICK J , HE PINGREN
IPC分类号： A61L27/20 , A61P41/00
CPC分类号： A61L27/52 , A61L27/20 , A61L27/50 , C08L5/08
摘要： The present application provides sterile hyaluronic polymer compositions than are useful, e.g., as medical devices, biomedical adhesives, and sealants. Generally, provided are sterile dry compositions comprising a thiol-derivatized hyaluronic acid and one or more stabilizing excipients. Also provided are related kits and methods. The compositions described herein are particularly robust to sterilizing irradiation, and substantially maintain both their molecular weight and gelation parameters such as gelation time after sterilization, such that such sterile compositions are cabable of hydrogel formation.
摘要翻译：本申请提供无菌透明质酸聚合物组合物，例如作为医疗装置，生物医学粘合剂和密封剂是有用的。通常，提供包含硫醇衍生的透明质酸和一种或多种稳定赋形剂的无菌干组合物。还提供了相关的工具包和方法。本文所述的组合物对灭菌辐射特别有效，并且基本上保持其分子量和凝胶化参数两者，例如灭菌后的凝胶化时间，使得这种无菌组合物能够形成水凝胶。

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