专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011115688A3 INTEGRIN INTERACTION INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2011115688A3
公开(公告)日：2011-09-22
申请号：PCT/US2011/000512
申请日：2011-03-21
申请人： H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE , UNIVERSITY OF SOUTH FLORIDA , HAZLEHURST, Lori , MCLAUGHLIN, Mark , JAIN, Priyesh , DALTON, William, S.
发明人： HAZLEHURST, Lori , MCLAUGHLIN, Mark , JAIN, Priyesh , DALTON, William, S.
IPC分类号： C07K7/64 , A61K38/12 , A61P35/00
摘要： Integrin interaction inhibitors using a beta-turn promoter are described herein. These peptides are useful in treating cancer, such as multiple myeloma, by administering a therapeutically effective amount of the integrin interaction inhibitor. Data show that integrin interaction inhibitors act synergistically or additively interacts with anti-proliferative agents such as doxorubicin, SAHA, arsenic trioxide, and etopside.

2. 发明申请

WO2008011046A2 COMPUTER SYSTEMS AND METHODS FOR SELECTING SUBJECTS FOR CLINICAL TRIALS 审中-公开
标题翻译：计算机系统和选择临床试验对象的方法
公开(公告)号：WO2008011046A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/016239
申请日：2007-07-16
申请人： THE H.LEE MOFFITT CANCER AND RESEARCH INSTITUTE, INC. , THE UNIVERSITY OF SOUTH FLORIDA , YEATMAN, Timothy , DALTON, William, S.
发明人： YEATMAN, Timothy , DALTON, William, S.
IPC分类号： G06F19/00
CPC分类号： G06Q50/24 , G06F19/00 , G06Q50/22 , G16H10/20 , G16H10/60
摘要： Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discriminating set of cellular constituents that match the measurements of corresponding cellular constituents in a responder set of biological samples, thereby identifying the plurality of subjects for the trial from those subjects from which the candidate set of molecular profiles were derived. Each respective molecular profile in the stored plurality of profiles has measurements of a plurality of cellular constituents from a respective biological sample in a plurality of samples obtained from a first plurality of subjects. The discriminating set of cellular constituents is identified from those cellular constituents in the plurality of cellular constituents whose measurement values discriminates between the responder and nonresponder sets of biological samples.
摘要翻译：提供了用于识别临床试验的多个受试者的计算机，计算机程序产品和方法。识别存储的多个分子谱中的一组候选分子谱。每个这样的概况都具有用于识别一组细胞成分的测量结果，该组细胞成分匹配生物样本的响应组中的对应细胞成分的测量结果，从而从衍生出候选分子谱集的那些受试者识别用于试验的多个受试者。所存储的多个分布图中的每个相应的分子图谱具有对从第一多个受试者获得的多个样品中来自各个生物样品的多个细胞成分的测量结果。从其多个细胞成分中的那些细胞成分中鉴别出一组细胞成分，其测量值区分响应者组和无响应者组的生物样品。

3. 发明申请

WO2004092568A2 CONSTANT BYPASS FLOW CONTROLLER FOR A VARIABLE DISPLACEMENT PUMP 审中-公开
标题翻译：用于可变位移泵的恒定旁路流量控制器
公开(公告)号：WO2004092568A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011368
申请日：2004-04-13
申请人： GOODRICH PUMP & ENGINE CONTROL SYSTEMS, INC. , BENNETT, George, L. , DALTON, William , ZAGRANSKI, Raymond
发明人： BENNETT, George, L. , DALTON, William , ZAGRANSKI, Raymond
IPC分类号： F02M
CPC分类号： F02M37/045
摘要： A fuel metering unit for controlling a variable displacement pump including a main metering valve in fluid communication with the pump for metering an output of the pump, a pressure regulator in fluid communication with the metering valve to create a spill return and a control valve in fluid communication with the pressure regulator and the pump for regulating the spill return flow so the spill return flow is maintained substantially constant at a low level to minimize the heat generated by recirculation by setting a displacement of the pump.
摘要翻译：一种用于控制可变排量泵的燃料计量单元，其包括与所述泵流体连通的主计量阀，用于计量所述泵的输出;压力调节器，其与所述计量阀流体连通以产生溢流回流;以及流体控制阀与压力调节器和泵的通信，用于调节溢流回流，使得溢流回流保持基本上恒定在低水平，以通过设定泵的位移来最小化通过再循环产生的热量。

4. 发明申请

WO2008073887A9 METHOD FOR TREATING METALLIC SURFACES WITH AN ALTERNATING ELECTRICAL CURRENT 审中-公开
公开(公告)号：WO2008073887A9
公开(公告)日：2008-09-12
申请号：PCT/US2007086970
申请日：2007-12-10
申请人： ELISHA HOLDING LLC , SOUCIE WAYNE , WINN DENNIS , DALTON WILLIAM
发明人： SOUCIE WAYNE , WINN DENNIS , DALTON WILLIAM
IPC分类号： B21D39/00
CPC分类号： C25D9/04
摘要： A method for providing enhanced corrosion protection of metallic components and surfaces when exposing the metallic component to a silicate medium while applying an AC (Alternating Current) current.

5. 发明申请

WO0220032A9 STAT3 AGONISTS AND ANTAGONISTS AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： STAT3激动剂及其拮抗剂及其治疗用途
公开(公告)号：WO0220032A9
公开(公告)日：2003-03-20
申请号：PCT/US0128254
申请日：2001-09-10
申请人： UNIV JOHNS HOPKINS , UNIV SOUTH FLORIDA , YU HUA , PARDOLL DREW , JOVE RICHARD , DALTON WILLIAM
发明人： YU HUA , PARDOLL DREW , JOVE RICHARD , DALTON WILLIAM
IPC分类号： A61K31/00 , A61K38/00 , A61K38/17 , A61K38/20 , A61K48/00 , C07K14/47 , G01N33/50 , A61K31/70 , A61K39/395 , A61K45/00 , G01N33/53
CPC分类号： G01N33/5005 , A61K31/00 , A61K38/1709 , A61K38/204 , A61K48/00 , C07K14/4705
摘要： The present invention relates to methods of modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the immune response for treatment and/or prevention of inflammation, infection, inflammation, immune disorders, and ischemia.
摘要翻译：本发明涉及调节，即激动或拮抗Stat3（Transcription3的信号转导和激活因子）用于基因治疗的信号传导活性的方法。 Stat3信号传导的抑制和/或激活是调节血管生成和用于治疗和/或预防炎症，感染，炎症，免疫疾病和缺血的免疫应答的有效方法。

6. 发明申请

WO2008011046A3 COMPUTER SYSTEMS AND METHODS FOR SELECTING SUBJECTS FOR CLINICAL TRIALS 审中-公开
标题翻译：计算机系统和选择临床试验项目的方法
公开(公告)号：WO2008011046A3
公开(公告)日：2008-10-02
申请号：PCT/US2007016239
申请日：2007-07-16
申请人： H LEE MOFFITT CANCER AND RES I , UNIV SOUTH FLORIDA , YEATMAN TIMOTHY , DALTON WILLIAM S
发明人： YEATMAN TIMOTHY , DALTON WILLIAM S
IPC分类号： G01N33/48 , G06G7/48
CPC分类号： G06Q50/24 , G06Q50/22 , G16H10/20 , G16H10/60
摘要： Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discriminating set of cellular constituents that match the measurements of corresponding cellular constituents in a responder set of biological samples, thereby identifying the plurality of subjects for the trial from those subjects from which the candidate set of molecular profiles were derived. Each respective molecular profile in the stored plurality of profiles has measurements of a plurality of cellular constituents from a respective biological sample in a plurality of samples obtained from a first plurality of subjects. The discriminating set of cellular constituents is identified from those cellular constituents in the plurality of cellular constituents whose measurement values discriminates between the responder and nonresponder sets of biological samples.
摘要翻译：提供了计算机，计算机程序产品和用于识别用于临床试验的多个对象的方法。鉴定存储的多个分子谱中的候选分子谱集。每个这样的简档具有与生物样本的响应者组中的相应细胞成分的测量相匹配的细胞成分鉴别组的测量结果，从而从衍生出候选分子谱的集合的那些受试者中鉴定出试验的多个受试者。存储的多个轮廓中的每个相应分子轮廓具有来自从第一组多个受试者获得的多个样本中的相应生物样品的多个细胞组分的测量。从多个细胞组分中的细胞成分鉴别细胞组分的鉴别集，其测量值区分应答者和生物样品的无应答组。

7. 发明申请

WO2008031064A1 HYD1 PEPTIDES AS ANTI-CANCER AGENTS 审中-公开
标题翻译： HYD1肽作为抗癌剂
公开(公告)号：WO2008031064A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/077927
申请日：2007-09-07
申请人： UNIVERSITY OF SOUTH FLORIDA , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HAZLEHURST, Lori, Anne , DALTON, William, S. , CRESS, Anne, E. , LAM, Kit
发明人： HAZLEHURST, Lori, Anne , DALTON, William, S. , CRESS, Anne, E. , LAM, Kit
IPC分类号： C07K7/00
CPC分类号： G01N33/5011 , C07K7/06
摘要： The present invention concerns fragments and variants of the HYD1 peptide; polynucleotides encoding the peptides; host cells genetically modified with the polynucleotides; vectors comprising the polynucleotides; compositions containing these peptides, polynucleotides, vectors, or host cells; and methods of using the peptides, polynucleotides, vectors, and host cells as inhibitors of aberrant cell growth in vitro or in vivo , e.g. , as anti-cancer agents for treatment of cancer, such as myeloma. The present invention further includes a method of increasing the efficacy of chemotherapy and radiation therapy, comprising administering an agent that binds β1 integrin to a patient in need thereof. In one embodiment, the β1 integrin binding agent is the HYD1 peptide, or a functional fragment or variant thereof. In another aspect, the invention pertains to a composition (an adhesion trap) comprising a substrate (also referred to as a surface or support) with a HYD1 peptide, or fragment or variant thereof, immobilized to the substrate, and a method of removing circulating tumor cells (CTC) from blood by contacting a subject's blood with the immobilized peptide. Another aspect of the invention concerns a method of identifying modulators of peptide binding. Another aspect of the invention concerns a method for detecting CTC.
摘要翻译：本发明涉及HYD1肽的片段和变体; 编码肽的多核苷酸; 用多核苷酸遗传修饰的宿主细胞; 包含多核苷酸的载体; 含有这些肽，多核苷酸，载体或宿主细胞的组合物; 以及使用肽，多核苷酸，载体和宿主细胞作为体外或体内异常细胞生长的抑制剂的方法，例如用作治疗癌症如骨髓瘤的抗癌剂。本发明还包括增加化学疗法和放射疗法的功效的方法，其包括向有需要的患者施用结合β1整联蛋白的药剂。在一个实施方案中，β1整联蛋白结合剂是HYD1肽或其功能片段或变体。另一方面，本发明涉及一种组合物（粘附陷阱），其包含固定在基底上的具有HYD1肽或其片段或变体的底物（也称为表面或载体）和除去循环的方法通过使受试者的血液与固定的肽接触，从血液中获得肿瘤细胞（CTC）。本发明的另一方面涉及鉴定肽结合调节剂的方法。本发明的另一方面涉及一种检测CTC的方法。

8. 发明申请

WO2004092568A3 CONSTANT BYPASS FLOW CONTROLLER FOR A VARIABLE DISPLACEMENT PUMP 审中-公开
标题翻译：用于可变位移泵的恒定旁路流量控制器
公开(公告)号：WO2004092568A3
公开(公告)日：2005-03-24
申请号：PCT/US2004011368
申请日：2004-04-13
申请人： GOODRICH PUMP & ENGINE CONTROL , BENNETT GEORGE L , DALTON WILLIAM , ZAGRANSKI RAYMOND
发明人： BENNETT GEORGE L , DALTON WILLIAM , ZAGRANSKI RAYMOND
IPC分类号： B67D7/66 , F02M37/04 , F02M1/00
CPC分类号： F02M37/045
摘要： A fuel metering unit for controlling a variable displacement pump including a main metering valve in fluid communication with the pump for metering an output of the pump, a pressure regulator in fluid communication with the metering valve to create a spill return and a control valve in fluid communication with the pressure regulator and the pump for regulating the spill return flow so the spill return flow is maintained substantially constant at a low level to minimize the heat generated by recirculation by setting a displacement of the pump.
摘要翻译：一种用于控制可变排量泵的燃料计量单元，其包括与所述泵流体连通的主计量阀，用于计量所述泵的输出;压力调节器，其与所述计量阀流体连通以产生溢流回流;以及流体控制阀与压力调节器和泵的通信，用于调节溢流回流，使得溢流回流保持基本上恒定在低水平，以通过设定泵的位移来最小化通过再循环产生的热量。

9. 发明申请

WO2012129335A3 HYD1 PEPTIDES FOR RELAPSED CANCER 审中-公开
标题翻译： HYD1用于相关癌症的肽
公开(公告)号：WO2012129335A3
公开(公告)日：2012-12-27
申请号：PCT/US2012029993
申请日：2012-03-21
申请人： H LEE MOFFITT CANCER CT & RES , UNIV SOUTH FLORIDA , HAZLEHURST LORI ANNE , DALTON WILLIAM S , EMMONS MICHAEL , GEBHARD ANTHONY W
发明人： HAZLEHURST LORI ANNE , DALTON WILLIAM S , EMMONS MICHAEL , GEBHARD ANTHONY W
IPC分类号： A61K38/08 , A61K38/10 , A61K39/395 , A61K48/00 , A61P35/00
CPC分类号： A61K38/08 , A61K31/00 , A61K39/395 , A61K45/06 , C07K7/06 , G01N33/50 , G01N33/5011 , G01N33/57492 , G01N2333/70546 , G01N2333/7055 , G01N2333/70585 , G01N2800/52
摘要： The subject invention pertains to compositions and methods for treatment of malignancies and inhibiting the growth of cancer cells, such as multiple myeloma and other hematologic malignancies, using HYDl peptides. Other aspects of the invention are directed to methods for selection of agents useful in the treatment of malignancies and inhibiting the growth of cancer cells. Further aspects of the invention include methods for determining whether a cancer is sensitive or resistant to treatment with HYDl peptides based on the presence of certain biomarkers, such as a4 integrin and CD44 expression.
摘要翻译：本发明涉及用HYD1肽治疗恶性肿瘤和抑制癌细胞如多发性骨髓瘤和其他血液恶性肿瘤的生长的组合物和方法。本发明的其它方面涉及用于选择可用于治疗恶性肿瘤并抑制癌细胞生长的药剂的方法。本发明的其它方面包括用于基于某些生物标记（例如α4整联蛋白和CD44表达）的存在来确定癌症是否敏感或抗HYD1肽治疗的方法。

10. 发明申请

WO2012129335A2 HYD1 PEPTIDES FOR RELAPSED CANCER 审中-公开
标题翻译： HYD1肽用于复发的癌症
公开(公告)号：WO2012129335A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/029993
申请日：2012-03-21
申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC , UNIVERSITY OF SOUTH FLORIDA , HAZLEHURST, Lori, Anne , DALTON, William, S. , EMMONS, Michael , GEBHARD, Anthony, W.
发明人： HAZLEHURST, Lori, Anne , DALTON, William, S. , EMMONS, Michael , GEBHARD, Anthony, W.
IPC分类号： A61K38/08 , A61K38/10 , A61K39/395 , A61K48/00 , A61P35/00
CPC分类号： A61K38/08 , A61K31/00 , A61K39/395 , A61K45/06 , C07K7/06 , G01N33/50 , G01N33/5011 , G01N33/57492 , G01N2333/70546 , G01N2333/7055 , G01N2333/70585 , G01N2800/52
摘要： The subject invention pertains to compositions and methods for treatment of malignancies and inhibiting the growth of cancer cells, such as multiple myeloma and other hematologic malignancies, using HYDl peptides. Other aspects of the invention are directed to methods for selection of agents useful in the treatment of malignancies and inhibiting the growth of cancer cells. Further aspects of the invention include methods for determining whether a cancer is sensitive or resistant to treatment with HYDl peptides based on the presence of certain biomarkers, such as α4 integrin and CD44 expression.
摘要翻译：本发明涉及使用HYD1肽治疗恶性肿瘤和抑制癌细胞如多发性骨髓瘤和其他血液恶性肿瘤生长的组合物和方法。本发明的其他方面涉及选择用于治疗恶性肿瘤和抑制癌细胞生长的药剂的方法。本发明的其他方面包括基于某些生物标志物（例如α4整联蛋白和CD44表达）的存在来确定癌症是否对用HYD1肽治疗敏感或抗性的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式