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1. 发明申请

WO2008011046A2 COMPUTER SYSTEMS AND METHODS FOR SELECTING SUBJECTS FOR CLINICAL TRIALS 审中-公开
标题翻译：计算机系统和选择临床试验对象的方法
公开(公告)号：WO2008011046A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/016239
申请日：2007-07-16
申请人： THE H.LEE MOFFITT CANCER AND RESEARCH INSTITUTE, INC. , THE UNIVERSITY OF SOUTH FLORIDA , YEATMAN, Timothy , DALTON, William, S.
发明人： YEATMAN, Timothy , DALTON, William, S.
IPC分类号： G06F19/00
CPC分类号： G06Q50/24 , G06F19/00 , G06Q50/22 , G16H10/20 , G16H10/60
摘要： Computers, computer program products, and methods for identifying a plurality of subjects for a clinical trial are provided. A candidate set of molecular profiles in a stored plurality of molecular profiles are identified. Each such profile has measurements for a discriminating set of cellular constituents that match the measurements of corresponding cellular constituents in a responder set of biological samples, thereby identifying the plurality of subjects for the trial from those subjects from which the candidate set of molecular profiles were derived. Each respective molecular profile in the stored plurality of profiles has measurements of a plurality of cellular constituents from a respective biological sample in a plurality of samples obtained from a first plurality of subjects. The discriminating set of cellular constituents is identified from those cellular constituents in the plurality of cellular constituents whose measurement values discriminates between the responder and nonresponder sets of biological samples.
摘要翻译：提供了用于识别临床试验的多个受试者的计算机，计算机程序产品和方法。识别存储的多个分子谱中的一组候选分子谱。每个这样的概况都具有用于识别一组细胞成分的测量结果，该组细胞成分匹配生物样本的响应组中的对应细胞成分的测量结果，从而从衍生出候选分子谱集的那些受试者识别用于试验的多个受试者。所存储的多个分布图中的每个相应的分子图谱具有对从第一多个受试者获得的多个样品中来自各个生物样品的多个细胞成分的测量结果。从其多个细胞成分中的那些细胞成分中鉴别出一组细胞成分，其测量值区分响应者组和无响应者组的生物样品。

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