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1. 发明申请

WO2008031064A1 HYD1 PEPTIDES AS ANTI-CANCER AGENTS 审中-公开
标题翻译： HYD1肽作为抗癌剂
公开(公告)号：WO2008031064A1
公开(公告)日：2008-03-13
申请号：PCT/US2007/077927
申请日：2007-09-07
申请人： UNIVERSITY OF SOUTH FLORIDA , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HAZLEHURST, Lori, Anne , DALTON, William, S. , CRESS, Anne, E. , LAM, Kit
发明人： HAZLEHURST, Lori, Anne , DALTON, William, S. , CRESS, Anne, E. , LAM, Kit
IPC分类号： C07K7/00
CPC分类号： G01N33/5011 , C07K7/06
摘要： The present invention concerns fragments and variants of the HYD1 peptide; polynucleotides encoding the peptides; host cells genetically modified with the polynucleotides; vectors comprising the polynucleotides; compositions containing these peptides, polynucleotides, vectors, or host cells; and methods of using the peptides, polynucleotides, vectors, and host cells as inhibitors of aberrant cell growth in vitro or in vivo , e.g. , as anti-cancer agents for treatment of cancer, such as myeloma. The present invention further includes a method of increasing the efficacy of chemotherapy and radiation therapy, comprising administering an agent that binds β1 integrin to a patient in need thereof. In one embodiment, the β1 integrin binding agent is the HYD1 peptide, or a functional fragment or variant thereof. In another aspect, the invention pertains to a composition (an adhesion trap) comprising a substrate (also referred to as a surface or support) with a HYD1 peptide, or fragment or variant thereof, immobilized to the substrate, and a method of removing circulating tumor cells (CTC) from blood by contacting a subject's blood with the immobilized peptide. Another aspect of the invention concerns a method of identifying modulators of peptide binding. Another aspect of the invention concerns a method for detecting CTC.
摘要翻译：本发明涉及HYD1肽的片段和变体; 编码肽的多核苷酸; 用多核苷酸遗传修饰的宿主细胞; 包含多核苷酸的载体; 含有这些肽，多核苷酸，载体或宿主细胞的组合物; 以及使用肽，多核苷酸，载体和宿主细胞作为体外或体内异常细胞生长的抑制剂的方法，例如用作治疗癌症如骨髓瘤的抗癌剂。本发明还包括增加化学疗法和放射疗法的功效的方法，其包括向有需要的患者施用结合β1整联蛋白的药剂。在一个实施方案中，β1整联蛋白结合剂是HYD1肽或其功能片段或变体。另一方面，本发明涉及一种组合物（粘附陷阱），其包含固定在基底上的具有HYD1肽或其片段或变体的底物（也称为表面或载体）和除去循环的方法通过使受试者的血液与固定的肽接触，从血液中获得肿瘤细胞（CTC）。本发明的另一方面涉及鉴定肽结合调节剂的方法。本发明的另一方面涉及一种检测CTC的方法。

2. 发明申请

WO2003079974A2 INTEGRIN LIGAND 审中-公开
公开(公告)号：WO2003079974A2
公开(公告)日：2003-10-02
申请号：PCT/US2003/006610
申请日：2003-03-06
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , DYAX CORPORATION , CRESS, Anne, E. , EDGE, Albert
发明人： CRESS, Anne, E. , EDGE, Albert
IPC分类号： A61K
CPC分类号： C40B30/04 , A61K31/155 , A61K31/353 , A61K31/381 , A61K31/4965 , G01N33/574 , G01N33/6884 , G01N33/6893 , G01N2333/70546 , G01N2500/00
摘要： The invention includes ligands (and methods for identifying the ligands) that bind specifically to a naturally occurring variant of a cell surface molecule, such as a naturally occurring variant of an integrin. The invention includes ligands that bind a naturally occurring variant of an alpha 6 integrin, called alpha 6 p. The invention also includes methods of diagnosis and/or treatment using the ligands. Preferred ligands bind to the naturally occurring variant of the cell surface molecule with a higher affinity than to the unmodified cell surface molecule.
摘要翻译：本发明包括与细胞表面分子的天然存在的变体例如整联蛋白的天然存在的变体特异性结合的配体（和鉴定配体的方法）。本发明包括结合称为α6p的α6整联蛋白的天然存在的变体的配体。本发明还包括使用配体进行诊断和/或治疗的方法。优选的配体以比未修饰的细胞表面分子更高的亲和力结合细胞表面分子的天然存在的变体。

3. 发明申请

WO2003079974A3 INTEGRIN LIGAND 审中-公开
公开(公告)号：WO2003079974A3
公开(公告)日：2003-10-02
申请号：PCT/US2003/006610
申请日：2003-03-06
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , DYAX CORPORATION , CRESS, Anne, E. , EDGE, Albert
发明人： CRESS, Anne, E. , EDGE, Albert
IPC分类号： G01N33/53
摘要： The invention includes ligands (and methods for identifying the ligands) that bind specifically to a naturally occurring variant of a cell surface molecule, such as a naturally occurring variant of an integrin. The invention includes ligands that bind a naturally occurring variant of an alpha 6 integrin, called alpha 6 p. The invention also includes methods of diagnosis and/or treatment using the ligands. Preferred ligands bind to the naturally occurring variant of the cell surface molecule with a higher affinity than to the unmodified cell surface molecule.

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