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1. 发明申请

WO2011075839A1 INTERVENTIONAL INSTRUMENT TRACKING DEVICE IMAGEABLE WITH MAGNETIC RESONANCE IMAGING AND METHOD FOR USE THEREOF 审中-公开
标题翻译：具有磁共振成像的传统仪器跟踪装置及其使用方法
公开(公告)号：WO2011075839A1
公开(公告)日：2011-06-30
申请号：PCT/CA2010/002041
申请日：2010-12-22
申请人： SUNNYBROOK HEALTH SCIENCES CENTRE , CUNNINGHAM, Charles, H. , DOMINQUEZ-VIQUEIRA, William
发明人： CUNNINGHAM, Charles, H. , DOMINQUEZ-VIQUEIRA, William
IPC分类号： A61M25/095 , A61B19/00 , A61B5/055
CPC分类号： A61B5/055 , A61B5/062 , A61B34/20 , A61B2034/2046 , A61B2090/3954 , A61B2090/3958 , A61M25/0127 , G01R33/287
摘要： A tracking device configured to be coupled to an interventional instrument and tracked by a magnetic resonance imaging system is provided. The tracking device includes, for example, paramagnetic and diamagnetic components that form first and second tracking members. When the tracking device is adjusted into a first arrangement, the tracking device will produce a local magnetic field in the presence of the magnetic field of an MRI system that is measurable by the MRI system. However, when the tracking device is adjusted into a second arrangement, the local magnetic field produced by the tracking device is reduced relative to the first arrangement, wherein the reduced local magnetic field produces substantially no magnetic field disturbances detectable by the MRI system. Images may be acquired of a patient in which the tracking device has been introduced and, using a numerical fitting method, an accurate location of the tracking device can be determined.
摘要翻译：提供了一种被配置为耦合到介入仪器并由磁共振成像系统跟踪的跟踪装置。跟踪装置包括例如形成第一和第二跟踪构件的顺磁性和抗磁性成分。当跟踪装置被调整为第一布置时，跟踪装置将在可由MRI系统测量的MRI系统的磁场的存在下产生局部磁场。然而，当跟踪装置被调整为第二布置时，相对于第一布置，由跟踪装置产生的局部磁场减小，其中减小的局部磁场基本上不产生由MRI系统可检测的磁场干扰。可以获取其中已经引入了跟踪装置的患者的图像，并且可以使用数值拟合方法来确定跟踪装置的精确位置。

2. 发明申请

WO2012142715A1 NMR SIGNALS SPATIAL ENCODING USING MAGNETIC SUSCEPTIBILITY MARKERS 审中-公开
标题翻译： NMR信号使用磁性可辨认标记进行空间编码
公开(公告)号：WO2012142715A1
公开(公告)日：2012-10-26
申请号：PCT/CA2012/050258
申请日：2012-04-23
申请人： SUNNYBROOK HEALTH SCIENCES CENTRE , CUNNINGHAM, Charles H. , KARIMI, Hirad
发明人： CUNNINGHAM, Charles H. , KARIMI, Hirad
IPC分类号： G01R33/56 , G01R33/28
CPC分类号： G01R33/385 , G01R33/285 , G01R33/34084 , G01R33/56509
摘要： A device for spatially encoding nuclear magnetic resonance signals is provided. The device includes a plurality of spatial-encoding elements configured to produce a spatial-encoding magnetic field in the presence of an external magnetic field, such as the main magnetic field of a magnetic resonance imaging ("MRI"} system. The spatial- encoding elements include paramagnetic and diamagnetic spatial-encoding elements. The device further includes a support configured to hold the plurality of spatial- encoding elements in a fixed arrangement. By adjusting the orientation of the device, the spatial-encoding elements are moved relative to each other and thereby produce a plurality of different spatial-encoding magnetic fields. These spatial-encoding magnetic fields are used to spatially encode nuclear magnetic resonance signals emanating from spins in a volume-of-interest adjacent the device. An image reconstruction method for reconstructing images from signals spatially-encoded with the device is also provided.
摘要翻译：提供了用于空间编码核磁共振信号的装置。该装置包括多个空间编码元件，被配置为在诸如磁共振成像（“MRI”）系统的主磁场的外部磁场的存在下产生空间编码磁场，空间编码元件包括顺磁和反磁性空间编码元件，该装置还包括配置成以固定布置保持多个空间编码元件的支撑件，通过调整装置的取向，空间编码元件相对于彼此移动从而产生多个不同的空间编码磁场，这些空间编码磁场用于空间编码与设备相邻的感兴趣体积中的旋转发出的核磁共振信号，用于重建图像的图像重建方法，还提供了用该设备进行空间编码的信号。

3. 发明申请

WO2005112754A2 POSITIVE CONTRAST MRI OF MAGNETICALLY TAGGED CELLS, OBJECTS, TISSUES 审中-公开
标题翻译：磁性标记细胞，对象，组织的正对比MRI
公开(公告)号：WO2005112754A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017689
申请日：2005-05-18
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CONOLLY, Steven M. , CUNNINGHAM, Charles, H.
发明人： CONOLLY, Steven M. , CUNNINGHAM, Charles, H.
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/055 , G01R33/5601
摘要： Contrast agents incorporating super-paramagnetic iron-oxide (SPIO) nanoparticles have shown promise as a means to visualize labeled cells using MRI. Labeled cells cause significant signal dephasing due to the magnetic field inhomogeneity induced in water molecules near the cell. With the resulting signal void as the means for detection, the particles are behaving as a negative contrast agent, which can suffer from partial-volume effects. Disclosed is a new method for imaging labeled cells with positive contrast. Spectrally-selective RF pulses are used to excite and refocus the off-resonance water surrounding the labeled cells so that only the fluid and tissue immediately adjacent to the labeled cells are visible in the image. Phantom, in vitro, and in vivo experiments show the feasibility of the new method. A significant linear correlation (r = 0.87, p
摘要翻译：结合超顺磁性氧化铁（SPIO）纳米颗粒的造影剂已经显示出希望作为使用MRI可视化标记细胞的手段。标记的细胞由于在细胞附近的水分子中诱导的磁场不均匀性而导致显着的信号去相位。由于产生的信号为空白，作为检测手段，颗粒表现为负面造影剂，可能会受到部分体积的影响。公开了一种用于成像具有正对比度的标记细胞的新方法。使用光谱选择性RF脉冲来激发和重新聚焦标记细胞周围的非共振水，使得只有紧邻标记细胞的流体和组织在图像中是可见的。 Phantom，体外和体内实验显示了新方法的可行性。已经观察到估计的细胞数和信号之间的显着的线性相关性（r = 0.87，p <0.005）。

4. 发明申请

WO2005112754A3 POSITIVE CONTRAST MRI OF MAGNETICALLY TAGGED CELLS, OBJECTS, TISSUES 审中-公开
标题翻译：磁性标记细胞的正对比MRI，目标，组织
公开(公告)号：WO2005112754A3
公开(公告)日：2007-04-19
申请号：PCT/US2005017689
申请日：2005-05-18
申请人： UNIV LELAND STANFORD JUNIOR , CONOLLY STEVEN M , CUNNINGHAM CHARLES H
发明人： CONOLLY STEVEN M , CUNNINGHAM CHARLES H
IPC分类号： A61B5/055 , A61B5/05 , A61B5/06
CPC分类号： A61B5/06 , A61B5/055 , G01R33/5601
摘要： Contrast agents incorporating super-paramagnetic iron-oxide (SPIO) nanoparticles have shown promise as a means to visualize labeled cells using MRI. Labeled cells cause significant signal dephasing due to the magnetic field inhomogeneity induced in water molecules near the cell. With the resulting signal void as the means for detection, the particles are behaving as a negative contrast agent, which can suffer from partial-volume effects. Disclosed is a new method for imaging labeled cells with positive contrast. Spectrally-selective RF pulses are used to excite and refocus the off-resonance water surrounding the labeled cells so that only the fluid and tissue immediately adjacent to the labeled cells are visible in the image. Phantom, in vitro, and in vivo experiments show the feasibility of the new method. A significant linear correlation (r = 0.87, p
摘要翻译：结合超顺磁性氧化铁（SPIO）纳米颗粒的造影剂已经显示出希望作为使用MRI可视化标记细胞的手段。标记的细胞由于在细胞附近的水分子中诱导的磁场不均匀性而导致显着的信号去相位。由于产生的信号为空白，作为检测手段，颗粒表现为负性造影剂，可能会受到部分体积的影响。公开了用于对具有正对比度的标记细胞进行成像的新方法。使用光谱选择性RF脉冲来激发和重新聚焦标记细胞周围的非共振水，使得只有紧邻标记细胞的流体和组织在图像中是可见的。 Phantom，体外和体内实验显示了新方法的可行性。已经观察到估计的细胞数和信号之间的显着的线性相关性（r = 0.87，p <0.005）。

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