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    • 4. 发明申请
    • APPARATUS AND METHOD FOR ABLATING TISSUE
    • 装置和方法,用于剥离组织
    • WO2007149970A2
    • 2007-12-27
    • PCT/US2007/071762
    • 2007-06-21
    • ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.CROWE, John E.PODMORE, Jonathan L.HOLZBAUR, Michael
    • CROWE, John E.PODMORE, Jonathan L.HOLZBAUR, Michael
    • A61N1/00
    • A61B18/1492A61B2018/0016A61B2018/00363A61B2018/00577
    • A device for ablating cardiac tissue includes a plurality of ablation elements substantially aligned along a common axis and adjustable between first and second predetermined positions. In the first predetermined position, the plurality of ablation elements form a curved contact surface. In the second predetermined position, the plurality of ablation elements form a substantially straight insertion configuration. At least one hinge (27) may connect adjacent ones of the plurality of ablation elements (26). Each of the plurality of ablation elements may be located within a housing (29), which may have at least a portion of a hinge integrally formed therewith to connect adjacent ablation elements. Alternatively, a strand of superelastic material (38), such as a Nitinol wire, may interconnect ablation elements. The superelastic material may bias the plurality of ablation elements into at least one of the first and second predetermined positions.
    • 用于消融心脏组织的装置包括多个消融元件,其基本上沿公共轴线对准并且可在第一和第二预定位置之间调节。 在第一预定位置,多个消融元件形成弯曲的接触表面。 在第二预定位置,多个消融元件形成基本上直的插入构造。 至少一个铰链(27)可以连接多个消融元件(26)中的相邻的一个。 多个消融元件中的每一个可以位于壳体(29)内,壳体(29)可以具有与其一体形成的铰链的至少一部分以连接相邻的消融元件。 或者,一种超弹性材料(38),例如镍钛诺丝,可以互连消融元件。 超弹性材料可以将多个消融元件偏置到第一和第二预定位置中的至少一个中。
    • 5. 发明申请
    • THERAPEUTIC PLATELETS AND METHODS
    • 治疗药片及方法
    • WO2005020893A3
    • 2007-04-19
    • PCT/US2004025653
    • 2004-08-06
    • UNIV CALIFORNIACROWE JOHN HTABLIN FERNWOLKERS WILLEM FWALKER NAOMI JAUH JOONG-HYUCKTANG MINKELOOPER SHERI
    • CROWE JOHN HTABLIN FERNWOLKERS WILLEM FWALKER NAOMI JAUH JOONG-HYUCKTANG MINKELOOPER SHERI
    • A01N1/00A01N1/02A61K20060101C12N5/02C12N5/08
    • A01N1/0221A01N1/02
    • The invention provides methods for loading a preservative into blood platelets comprising providing a preservative solution having a preservative, water and protein, and loading blood platelets with the preservative solution to produce preservative-loaded blood platelets having the preservative solution generally including higher glass transition temperatures than glass transition temperatures for a preservative solution having the preservative, water and no protein. A process for processing blood platelets comprising suspending blood platelets in a preservative solution at a concentration greater than about 108 platelets per ml. of preservative solution to produce preservative-loaded blood platelets, freeze-drying the preservative-loaded blood platelets, and recovering at least 75% of the freeze-dried platelets. A platelet composition comprising blood platelets loaded with a preservative solution having a preservative, water, and protein, and generally further having higher glass transition temperatures than glass transition temperatures for blood platelets loaded with the preservative, water, but no protein.
    • 本发明提供了将防腐剂装载到血小板中的方法,其包括提供具有防腐剂,水和蛋白质的防腐剂溶液,并将血小板与防腐剂溶液加载以产生具有防腐剂溶液的血小板,所述血小板具有通常包含较高玻璃化转变温度 具有防腐剂,水和无蛋白质的防腐溶液的玻璃化转变温度。 一种处理血小板的方法,包括以大于约108个血小板/ ml的浓度将血小板悬浮在防腐溶液中。 的防腐溶液以产生防腐剂血小板,冷冻干燥载有防腐剂的血小板,并回收至少75%的冻干血小板。 一种血小板组合物,其包含负载有防腐剂,水和蛋白质的防腐溶液的血小板,并且通常进一步具有比装有防腐剂,水但不含蛋白质的血小板的玻璃化转变温度更高的玻璃化转变温度。