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1. 发明申请

WO2011060359A3 SELECTIVELY ACTUATING WIRELESS, PASSIVE IMPLANTABLE SENSOR 审中-公开
标题翻译：选择性地启动无线，被动植入式传感器
公开(公告)号：WO2011060359A3
公开(公告)日：2011-05-19
申请号：PCT/US2010/056709
申请日：2010-11-15
申请人： CARDIOMEMS, INC. , CROS, Florent
发明人： CROS, Florent
IPC分类号： A61B5/053 , A61B5/04
摘要： A wireless sensor having a primary passive electrical resonant circuit that has an intrinsic electrical property that is variable in response to a characteristic of a patient and a secondary passive electrical resonant circuit. In one aspect, the primary passive resonant circuit can be positioned into a tuned position in response to the actuation of the secondary passive electrical resonant circuit. In a further aspect, in the tuned position, the primary passive electrical resonant circuit, in response to an energizing signal produced by an ex- vivo source of RF energy, is configured to generate a sensor signal characterized by a resonant frequency that is indicative of the characteristic.
摘要翻译：具有主无源电谐振电路的无线传感器具有响应于患者和次级无源电谐振电路的特性而可变的固有电特性。在一个方面中，响应于次级无源电谐振电路的致动，初级无源谐振电路可以被定位在调谐位置中。在另一方面，在调谐位置，主无源电谐振电路响应于由射频能量的离体源产生的激励信号而被配置为产生传感器信号，该传感器信号的特征在于表示谐振频率特点。

2. 发明申请

WO2008051907A1 METHOD AND APPARATUS FOR MEASURING PRESSURE INSIDE A FLUID SYSTEM 审中-公开
标题翻译：用于测量流体内部压力的方法和装置
公开(公告)号：WO2008051907A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/082092
申请日：2007-10-22
申请人： CardioMEMS, Inc. , CROS, Florent , CORCORAN, Kevin , BERR, Miguel Luis
发明人： CROS, Florent , CORCORAN, Kevin , BERR, Miguel Luis
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/07
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/0215
摘要： A disclosed method determines fluid pressure inside a vessel without compromising the integrity of the vessel. A sensor is positioned in operative communication with the external wall of the vessel such that expansion of the external wall of the vessel exerts a force against the sensor that is directed substantially radially outward with respect to the vessel. A substantially radially inward force is caused to be directed against the sensor in response to the substantially radially outward force exerted by the external vessel wall. The sensor can thus be used to detect the magnitude of the substantially radially outward force. A disclosed apparatus determines fluid pressure inside a vessel without compromising the integrity of the vessel. The apparatus includes a sensor and a band operatively associated with the sensor and configured to at least partially encircle the vessel so as to retain the sensor in operative communication against the external wall of the vessel.
摘要翻译：所公开的方法确定容器内的流体压力而不损害容器的完整性。传感器被定位成与容器的外壁可操作地连通，使得容器的外壁的膨胀对传感器施加相对于容器大致径向向外的力。响应于由外部血管壁施加的基本径向向外的力，基本上径向向内的力被引导抵靠传感器。因此，传感器可用于检测基本径向向外的力的大小。所公开的装置确定容器内的流体压力而不损害容器的完整性。该装置包括传感器和与传感器可操作地相关联的带，并被配置为至少部分地环绕容器，以便将传感器保持在与血管的外壁有效连通的位置。

3. 发明申请

WO2006086114A2 METHOD OF MANUFACTURING A HERMETIC CHAMBER WITH ELECTRICAL FEEDTHROUGHS 审中-公开
标题翻译：用电气制造方法
公开(公告)号：WO2006086114A2
公开(公告)日：2006-08-17
申请号：PCT/US2006001101
申请日：2006-01-13
申请人： CARDIOMEMS INC , O'BRIAN DAVID , CROS FLORENT , PARK JIN WOO , FONSECA MICHAEL , YOU LIANG , ALLEN MARK
发明人： O'BRIAN DAVID , CROS FLORENT , PARK JIN WOO , FONSECA MICHAEL , YOU LIANG , ALLEN MARK
IPC分类号： G01L7/00
CPC分类号： G01L9/0075 , A61B5/03 , A61B2562/0247 , B81B7/007 , B81B2201/0264 , B81B2201/06 , B81B2207/096 , B81C1/00301 , G01L9/0073
摘要： A method of manufacturing a hermetically-sealed chamber with an electrical feedthrough includes the step of hermetically fixing an electrode to a substrate in a predetermined location on the substrate. A passage is formed through the substrate through the predetermined location such that at least a portion of the electrode is exposed to the passage. The passage is then at least partially filled with an electrically conductive material. A housing is then formed including the substrate such that the housing defines a chamber, with the electrode being disposed within the housing and the chamber being hermetically sealed. The electrode within the chamber can be placed in electrical communication with an exterior electrical component by way of the electrically conductive material in the passage.
摘要翻译：制造具有电馈通的气密密封室的方法包括将电极气密地固定在基板上的预定位置上的步骤。通过基板穿过预定位置形成通道，使得电极的至少一部分暴露于通道。然后通道至少部分地填充有导电材料。然后形成包括基板的壳体，使得壳体限定室，其中电极设置在壳体内，并且室被气密地密封。室内的电极可以通过通道中的导电材料与外部电气部件电连接。

4. 发明申请

WO2022246170A2 SYSTEMS AND METHODS FOR MICROBOT-MEDIATED THERAPEUTIC DELIVERY 审中-公开
公开(公告)号：WO2022246170A2
公开(公告)日：2022-11-24
申请号：PCT/US2022/030213
申请日：2022-05-20
申请人： BIONAUT LABS LTD. , CHO, Suehyun , CROS, Florent , KISELYOV, Alex , SHPIGELMACHER, Michael
发明人： CHO, Suehyun , CROS, Florent , KISELYOV, Alex , SHPIGELMACHER, Michael
IPC分类号： A61K9/50 , A61M31/00 , C07K14/28 , G06F30/38
摘要： Provided are systems and miniature devices configured to navigate within a patient to a location therewithin for delivering to induce a localized therapeutic effect. Specifically, the present disclosure provides miniature devices configured to be remotely maneuvered along a path within the patient, where the miniature device is configured to selectively: (i) release a guide substance; (ii) release a payload that induces a physiological response; and/or (iii) produce a microtrauma at locations along the path. Further provided are various methods of treatment using such systems and devices.

5. 发明申请

WO2021092076A1 A SYSTEM AND MINIATURE DEVICES FOR DELIVERING A THERAPEUTIC COMPONENT TO A TREATMENT SITE IN A PATIENT 审中-公开
公开(公告)号：WO2021092076A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/058964
申请日：2020-11-04
申请人： BIONAUT LABS LTD. , SHPIGELMACHER, Michael , KISELYOV, Alex , CROS, Florent , HARRINGTON, Darrell , CHO, Suehyun , CAPUTO, John
发明人： SHPIGELMACHER, Michael , KISELYOV, Alex , CROS, Florent , HARRINGTON, Darrell , CHO, Suehyun , CAPUTO, John
IPC分类号： A61M31/00 , A61K47/69 , A61K9/51 , A61K9/50
摘要： A miniature device is provided for use in a system configured to deliver a therapeutic component to a treatment site in a patient. The miniature device comprises at least one steering portion comprising a magnetic material, and at least one carrier portion affixed to the steering portion and comprising the therapeutic component. The carrier portion is configured to at least partially dissipate under one or more predetermined conditions at the treatment site, thereby releasing the therapeutic component. Further provided is a system comprising one or more such miniature devices and a magnetic inducing apparatus configured to be operated to generate a varying magnetic field, thereby remotely controlling motion of the miniature device.

6. 发明申请

WO2009146089A3 SYSTEM AND APPARATUS FOR IN-VIVO ASSESSMENT OF RELATIVE POSITION OF AN IMPLANT 审中-公开
标题翻译：用于内生植入物相对位置的体内评估的系统和装置
公开(公告)号：WO2009146089A3
公开(公告)日：2010-01-21
申请号：PCT/US2009039220
申请日：2009-04-01
申请人： CARDIOMEMS INC , KROH JASON , CROS FLORENT , COURCIMAULT CHRISTOPHE
发明人： KROH JASON , CROS FLORENT , COURCIMAULT CHRISTOPHE
IPC分类号： A61B17/70 , A61B18/18 , A61F2/44
CPC分类号： G01L9/0073 , A61B5/0031 , A61B5/076 , A61B5/1116 , A61B5/4504 , A61B5/686 , A61B17/7002 , A61B2017/00221 , A61B2560/0219 , A61B2560/0223 , A61B2562/0261 , G01F15/066 , G01L1/14 , H01Q7/00
摘要： A system and apparatus for providing an in- vivo assessment of relative movement of an implant that is positioned in a living being is provided that comprises a first assembly and a second assembly that are positioned within the living being. The first assembly comprises a passive electrical resonant circuit that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and, in response to the electromagnetic coupling, generates an output signal characterized by a frequency that is dependent upon a distance between the first assembly and the second assembly at the time of the electromagnetic coupling.
摘要翻译：提供了一种系统和装置，其用于提供定位在生命体内的植入物的相对运动的体内评估，该植入物包括位于生物体内的第一组件和第二组件。第一组件包括被动电谐振电路，其被配置为选择性地电磁耦合到离体RF能量源，并且响应于电磁耦合，产生以由频率决定的频率的输出信号，该频率取决于第一组件和第二组件在电磁耦合时。

7. 发明申请

WO2023022966A1 TETHER-FREE ROBOTIC SYSTEM TO PERFORM A REMOTE MICROSURGERY IN THE CENTRAL NERVOUS SYSTEM (CNS) 审中-公开
公开(公告)号：WO2023022966A1
公开(公告)日：2023-02-23
申请号：PCT/US2022/040303
申请日：2022-08-15
申请人： BIONAUT LABS LTD. , CROS, Florent , SHPIGELMACHER, Michael , KONDABATNI, Kishore Kumar , KISELYOV, Alex
发明人： CROS, Florent , SHPIGELMACHER, Michael , KONDABATNI, Kishore Kumar , KISELYOV, Alex
IPC分类号： A61B1/00 , A61B34/30
摘要： The present disclosure relates to systems that comprise a millimeter size tetherless object powered by an external magnetic field, and an interactive hardware-software platform separate from the miniature device that generates, modulates and controls magnetic fields in a defined three-dimensional operational volume to propel, navigate the miniature device to a specific anatomical target to complete a (micro surgical) mission or task, as well as using such systems to perform microsurgery in the central nervous system (CNS).

8. 发明申请

WO2021126905A1 MAGNETIC MINIATURE DEVICE AND SYSTEM FOR REMOTELY MANEUVERING IT 审中-公开
公开(公告)号：WO2021126905A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065207
申请日：2020-12-16
申请人： BIONAUT LABS LTD. , CROS, Florent , SHPIGELMACHER, Michael , KISELYOV, Alex , HARRINGTON, Darrell , CHO, Suehyun , SARGSYAN, Hovhannes
发明人： CROS, Florent , SHPIGELMACHER, Michael , KISELYOV, Alex , HARRINGTON, Darrell , CHO, Suehyun , SARGSYAN, Hovhannes
IPC分类号： A61K9/00 , A61K47/69 , A61M5/145 , A61M31/00 , A61K9/51 , A61K9/50 , A61K49/18
摘要： A miniature device configured to be maneuvered within a patient under manipulation by an external magnetic field and to selectively perform a predefined function is provided. The miniature device comprises a shell defining therewithin an internal cavity, and a magnetic arrangement disposed within the cavity. The miniature device is configured such that the magnetic arrangement, within a rotating magnetic field, effects one of performance of the function and propulsion of the miniature device within the patient, and, within a magnetic field gradient, effects the other of performance of the function and propulsion of the miniature device within the patient.

9. 发明申请

WO2011011104A1 VENTRICULAR SHUNT SYSTEM AND METHOD 审中-公开
标题翻译：通气管系统及方法
公开(公告)号：WO2011011104A1
公开(公告)日：2011-01-27
申请号：PCT/US2010/033396
申请日：2010-05-03
申请人： CARDIOMEMS, INC. , YADEV, Jay, S. , CROS, Florent
发明人： YADEV, Jay, S. , CROS, Florent
IPC分类号： A61M25/088 , A61B5/027 , A61M39/22
CPC分类号： G01F15/066 , A61B5/0031 , A61B5/031 , A61B5/05 , A61B5/076 , A61B5/6846 , A61B2560/0219 , A61B2560/0223 , A61M27/006 , G01R23/12 , G01R23/145 , H01Q7/00
摘要： A ventricular shunt systems and methods of preventing hydrocephalus are described herein. In one aspect, the ventricular shunt system has at least one pressure sensor that is configured to be selectively electromagnetically coupled to an ex-vivo source of RF energy and is variable in response to the pressure in a patient's ventricle.
摘要翻译：本文描述了心室分流系统和预防脑积水的方法。在一个方面，心室分流系统具有至少一个压力传感器，其被配置为选择性地电磁耦合到离体RF能量源，并且响应于患者心室中的压力是可变的。

10. 发明申请

WO2022246174A2 SYSTEM AND METHOD FOR LOCALIZED THERAPEUTIC TREATMENT 审中-公开
公开(公告)号：WO2022246174A2
公开(公告)日：2022-11-24
申请号：PCT/US2022/030221
申请日：2022-05-20
申请人： BIONAUT LABS LTD. , CHO, Suehyun , CROS, Florent , KISELYOV, Alex , SHPIGELMACHER, Michael
发明人： CHO, Suehyun , CROS, Florent , KISELYOV, Alex , SHPIGELMACHER, Michael
IPC分类号： A61K9/50 , A61M31/00 , A61K39/395 , C07K14/28 , G06F30/38
摘要： Provided are systems and miniature devices configured to navigate within a patient to a location therewithin for delivering to induce a localized therapeutic effect, such as the delivery of catalyzing energy and/or for the conversion of a prodrug to a pharmaceutically active drug. Further provided are various methods of treatment using such systems and devices.

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