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    • 3. 发明申请
    • PROCESS FOR EXTRACTION OF PECTIN
    • 提取PECTIN的方法
    • WO2012167963A1
    • 2012-12-13
    • PCT/EP2012/055425
    • 2012-03-27
    • CP Kelco ApSJENSEN, Søren VodstrupSØRENSEN, Susanne OxenbøllROLIN, Claus
    • JENSEN, Søren VodstrupSØRENSEN, Susanne OxenbøllROLIN, Claus
    • C08B37/00
    • C08B37/0045
    • Embodiments of the processes provided herein allow for extraction of high quality pectins from pectin-containing plant materials using oxalic acid for extraction of the pectin containing material. Generally described, the process for extracting pectin having a high degree of polymerization includes preparing an aqueous suspension of a pectin-containing plant material; adding oxalic acid and/or a water-soluble oxalate to the aqueous suspension in an amount sufficient to provide a mixture having a pH of between 3.0 and 3.6 and a total molarity of oxalate greater than a total molarity of calcium(II); heating the mixture to a temperature from about 50 to about 80°C for a time sufficient to extract pectin from the pectin-containing plant material; and separating the extracted pectin from the mixture. The extracted pectin desirably is characterized as having a degree of esterification (DE) of at least 72 and a high degree of polymerization, the degree of polymerization being characterized by an intrinsic viscosity of greater than about 6.5 dL/g.
    • 本文提供的方法的实施方案允许使用草酸从含果胶的植物材料中提取高质量的果胶,以提取含果胶物质。 通常描述,提取具有高聚合度的果胶的方法包括制备含有果胶的植物材料的水性悬浮液; 向水性悬浮液中加入草酸和/或水溶性草酸盐,其量足以提供pH为3.0至3.6的混合物,并且草酸盐的总摩尔浓度大于钙(II)的总摩尔浓度; 将混合物加热到约50至约80℃的温度足以从含果胶的植物材料中提取果胶的时间; 并从混合物中分离提取的果胶。 提取的果胶的特征在于具有至少72的酯化度(DE)和高聚合度,聚合度的特征在于特性粘度大于约6.5dL / g。
    • 6. 发明申请
    • TABLET COATINGS MADE FROM MODIFIED CARBOXYMETHYLCELLULOSE MATERIALS
    • 改性羧甲基纤维素材料制成的片剂涂料
    • WO2009031039A3
    • 2009-08-20
    • PCT/IB2008003018
    • 2008-05-02
    • CP KELCO APSBOEKEMA REGINA HELENA ALIDAVAESSEN-VAN HOVEN HENRICA WILHELMINA CORNELIAPETRONELLA ANJA MARIA CHRISTINA
    • BOEKEMA REGINA HELENA ALIDAVAESSEN-VAN HOVEN HENRICA WILHELMINA CORNELIAPETRONELLA ANJA MARIA CHRISTINA
    • A61K9/36
    • A61K9/2893A61K9/2866A61K31/717
    • Coated tablets for the delivery of active ingredients to a user are provided. Such tablets include particular molecular weight-modified carboxymethylcellulose (CMC) coating materials either alone or in combination with other types of hydrocolloids, biogums, cellulose ethers, and the like. The utilization of such modified CMC products aids in the production of such coatings through the availability of larger amounts of base materials with lower amounts of water requiring evaporation therefrom. In such a manner, not only may dimensionally stable, non-tacky, salt tolerant, and quick dissolving edible coatings be produced, but the amount of time required for such manufacture is minimal when compared with traditional methods of production with cellulose-based materials. Furthermore, such novel edible non-digestible tablet coatings exhibit delayed dissolution beyond a user 's oral cavity for tastemasking purposes, as well as protection of the tablet from environmental conditions and low tackiness properties to prevent adhesion to the user's palate. The novel method of tablet coating manufacture as well as the ultimate coated tablets exhibiting such physical characteristics are also encompassed within this invention.
    • 提供了用于向用户传送活性成分的涂层片剂。 这样的片剂包括单独的或与其它类型的水胶体,生物胶,纤维素醚等组合的特定分子量改性的羧甲基纤维素(CMC)涂层材料。 这种改性CMC产品的利用有助于生产这种涂料,因为可用量较多的基料,需要较少量的水需要蒸发。 以这种方式,不仅可以制造尺寸稳定,非粘性,耐盐性和快速溶解的可食用涂层,而且与使用纤维素基材料的传统生产方法相比,这种制造所需的时间量是最小的。 此外,这种新型可食用的不消化片剂涂料表现出延迟溶解超过用户口腔的目的,以及保护片剂免受环境条件和低粘性特性,以防止粘附到使用者的腭上。 片剂包衣制造的新方法以及展示这种物理特性的最终的包衣片剂也包括在本发明中。
    • 7. 发明申请
    • IMPROVED PROCESS FOR TREATING PECTIN CONTAINING PLANT MATERIAL
    • 改进的处理含果胶植物材料的方法
    • WO2004020472A3
    • 2004-04-01
    • PCT/DK0300570
    • 2003-09-02
    • CP KELCO APSCHRISTENSEN JAN AA STAUNSTRUP
    • CHRISTENSEN JAN AA STAUNSTRUP
    • C08B37/06A23L29/231C08B37/00
    • C08B37/0045
    • The present invention discloses a method for treating pectin containing plant material. The fresh plant material is adjusted to a pH between 3.2 and 3.9 at a temperature below 90°C to render the native pectin esterase in the plant material inactive. Thus, minimal deesterification takes place during transportation of the plant material, nor during subsequent washing and/or conventional drying of the plant material. Since the enzyme remains inactivated, the activity of the enzyme can be reestablished at a later point by increasing the Ph to above about 4.0. Pectin made from such treated plant material has a higher molecular weight and a lower calcium sensitivity than pectin made from the same plant material, which has not been subjected to said treatment.
    • 本发明公开了一种处理含果胶植物材料的方法。 在低于90℃的温度下将新鲜植物材料调节至3.2至3.9之间的pH,以使植物材料中的天然果胶酯酶失活。 因此,在植物材料的运输过程中发生最少的去酯化反应,也不会在随后的植物材料的洗涤和/或常规干燥过程中发生。 由于酶保持失活,酶的活性可通过将Ph增加至约4.0以上在稍后的时间重新建立。 由这种处理的植物材料制成的果胶比由未经过所述处理的相同植物材料制成的果胶具有更高的分子量和更低的钙敏感性。