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1. 发明申请

WO2013082208A3 SAMPLE HOLDER WITH PLUNGER AND METHOD FOR EXPELLING SAMPLE 审中-公开
标题翻译：带样品的样品瓶和样品的方法
公开(公告)号：WO2013082208A3
公开(公告)日：2013-10-24
申请号：PCT/US2012066936
申请日：2012-11-29
申请人： COVARIS INC
发明人： LAUGHARN JAMES A , TSINTERIS ION A
IPC分类号： G01N1/08 , A61B10/00 , A61B10/02 , G01N1/42
CPC分类号： G01N1/08 , A61B10/0096 , B01L3/508 , B01L3/5082 , B01L3/5635 , B01L2200/0657 , B01L2300/042 , B01L2300/0851 , B01L2400/0478 , G01N1/42 , G01N2001/2866
摘要： Method and apparatus for holding and/or transferring a sample material into a second holder. The sample holder may comprise a shoulder arranged on the outer surface to engage a second holder and to position a top opening of the sample holder for communication with the second holder. A sample may be expelled from a sample holder using a piston that moves from a lower portion to an upper portion of the sample holder.
摘要翻译：用于将样品材料保持和/或转移到第二保持器中的方法和装置。样品保持器可以包括布置在外表面上的肩部以接合第二保持器并且定位用于与第二保持器连通的样品保持器的顶部开口。可以使用从样品保持器的下部移动到上部的活塞将样品从样品保持器排出。

2. 发明申请

WO2012125911A9 ACOUSTIC TREATMENT VESSEL AND METHOD FOR ACOUSTIC TREATMENT 审中-公开
公开(公告)号：WO2012125911A9
公开(公告)日：2012-09-20
申请号：PCT/US2012/029404
申请日：2012-03-16
申请人： COVARIS, INC. , LAUGHARN, James, A. , BECKETT, Carl
发明人： LAUGHARN, James, A. , BECKETT, Carl
IPC分类号： B01F11/02 , B06B1/00 , A61N7/00
摘要： Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window and/or a chamber wall which may comprise an acoustically reflective material or a gas/wall interface that serves to reflect acoustic energy to form one or more secondary focal zones. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.

3. 发明申请

WO2012125911A1 ACOUSTIC TREATMENT VESSEL AND METHOD FOR ACOUSTIC TREATMENT 审中-公开
标题翻译：声学治疗血管和呼吸治疗方法
公开(公告)号：WO2012125911A1
公开(公告)日：2012-09-20
申请号：PCT/US2012029404
申请日：2012-03-16
申请人： COVARIS INC , LAUGHARN JAMES A , BECKETT CARL
发明人： LAUGHARN JAMES A , BECKETT CARL
IPC分类号： B01F11/02 , A61N7/00 , B06B1/00
CPC分类号： A61B8/00 , B01F11/0258 , G10K11/28
摘要： Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window and/or a chamber wall which may comprise an acoustically reflective material or a gas/wall interface that serves to reflect acoustic energy to form one or more secondary focal zones. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
摘要翻译：使用连续方法来声学处理材料的方法和系统，其中可以使材料以连续或间歇的方式流入/离开材料暴露于聚焦声能的声学处理室。方法和系统可以被布置成允许在较长时间内连续处理，同时声能源以相对高的功率输出操作。处理室可以包括诸如声窗和/或室壁的特征，其可以包括声反射材料或气体/壁界面，其用于反射声能以形成一个或多个次焦点区域。提供了与处理室相对于声源和耦合介质，材料流动路径等的布置相关的处理系统配置。

4. 发明申请

WO2012040571A2 METHOD AND APPARATUS FOR FRAGMENTING NUCLEIC ACIDS 审中-公开
标题翻译：碎化核酸的方法和设备
公开(公告)号：WO2012040571A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052959
申请日：2011-09-23
申请人： COVARIS, INC. , DURIN, Guillaume , LAUGHARN, James, A., Jr.
发明人： DURIN, Guillaume , LAUGHARN, James, A., Jr.
IPC分类号： C12M1/00 , C12N1/24 , C12N15/10 , C12Q1/68
CPC分类号： B01L3/50215 , B01L3/5021 , B01L3/50255 , B01L2200/0631 , B01L2200/0663 , B01L2200/141 , B01L2300/042 , B01L2300/0681 , B01L2300/0838 , B01L2300/0841 , B01L2300/0854 , B01L2400/0409 , B01L2400/0463 , B01L2400/086 , C12N15/10 , C12Q1/6806 , G01N1/28 , Y10T436/25
摘要： Systems and methods include processing devices used to fragment nucleic acids to average nucleic acid sizes ranging from between about 5 kbp and about 20 kbp. A processing device may include an inlet portion and a channel upstream from a shearing region arranged so that a relatively constant pressure is established and maintained (e.g., a pressure that changes by less than about 40%) at an entrance of the shearing region during a majority of sample flow through the shearing region. In some embodiments, after forcing the sample through the shearing region once, the processing device may be taken out of the centrifuge, inverted and placed back into the centrifuge so that the sample is forced through the shearing region again.
摘要翻译：系统和方法包括用于片段化核酸的处理装置，以平均范围在约5kbp和约20kbp之间的核酸大小。处理装置可包括入口部分和剪切区域上游的通道，所述剪切区域布置成使得在剪切区域的入口处建立并保持相对恒定的压力（例如，变化小于约40％的压力）大部分样品流过剪切区域。在一些实施例中，在迫使样品通过剪切区域一次之后，可以将处理装置从离心机中取出，倒置并放回到离心机中，使得样品再次被迫通过剪切区域。

5. 发明申请

WO2008016691A2 METHODS AND APPARATUS FOR TREATING SAMPLES WITH ACOUSTIC ENERGY 审中-公开
标题翻译：用声学能量处理样品的方法和装置
公开(公告)号：WO2008016691A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/017281
申请日：2007-08-01
申请人： COVARIS, INC. , LAUGHARN, James, A. , GARRISON, Brevard, S. , YATES, Douglas, A.
发明人： LAUGHARN, James, A. , GARRISON, Brevard, S. , YATES, Douglas, A.
CPC分类号： C12Q1/6806 , B01F11/0283 , B01F2215/0454 , B01J2219/00486 , B01L99/00 , C01B25/327 , G01N1/28 , G01N1/286 , G01N2001/2866 , G01N2035/00554 , Y10T436/25
摘要： This invention relates to systems and methods for applying acoustic energy to a sample. According to one aspect of the invention, a system comprises a housing, a chamber for receiving the sample, an acoustic energy source for providing a focused acoustic field to the sample according to a treatment protocol, a processor for determining the treatment protocol, a sensor for detecting information about the sample, and a user interface for communicating with a user. According to another aspect of the invention, a focused acoustic field may be applied to a pressurized sample.
摘要翻译：本发明涉及向样品施加声能的系统和方法。根据本发明的一个方面，一种系统包括壳体，用于接收样品的腔室，用于根据治疗方案向样品提供聚焦声场的声能源，用于确定治疗方案的处理器，传感器用于检测关于样本的信息，以及用于与用户通信的用户界面。根据本发明的另一方面，聚焦的声场可以应用于加压样品。

6. 发明申请

WO2017173039A1 EXTRACTION OF CFDNA FROM BIOLOGICAL SAMPLES 审中-公开
标题翻译：从生物样品中提取CFDNA
公开(公告)号：WO2017173039A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/024944
申请日：2017-03-30
申请人： COVARIS, INC.
发明人： KHOJA, Hamid , THOMANN, Hans-Ulrich , LAUGHARN, James, A., Jr.
IPC分类号： C12N15/10
CPC分类号： C12N15/1003 , C12N13/00 , C12Q2523/301
摘要： Focused acoustic treatment of samples including a target biomolecule, such as cfDNA, may aid in the recovery of the biomolecule from a sample. cfDNA in a sample, whether chemically stabilized or not, may be linked or otherwise bound to histones or other proteins, e.g., by hydrogen bonds of histones or chaperone proteins to DNA and/or covalent crosslinks of such proteins to the DNA. Focused acoustic energy may remove or disrupt such links, aiding in isolation of the cfDNA from the sample.
摘要翻译：包括目标生物分子如cfDNA的样品的集中声学处理可帮助从样品中回收生物分子。无论是否化学稳定，样品中的cfDNA可以与组蛋白或其他蛋白质连接或以其他方式结合，例如通过组蛋白或分子伴侣蛋白质与DNA的氢键和/或这种蛋白质与DNA的共价交联。集中的声能可以消除或破坏这种联系，帮助从样本中分离cfDNA。

7. 发明申请

WO2016061098A8 ACOUSTIC ENERGY MEDIATION OF GENETIC FRAGMENTATION 审中-公开
标题翻译：声学能量介导遗传碎片
公开(公告)号：WO2016061098A8
公开(公告)日：2016-06-23
申请号：PCT/US2015055319
申请日：2015-10-13
申请人： COVARIS INC
发明人： LAUGHARN JAMES A JR , KHOJA HAMID
IPC分类号： B01F11/02 , G01N1/28 , G01N35/00
CPC分类号： C12P19/34 , B01F11/0283 , B01F13/0052 , B01L3/5082 , C12Q1/6806 , G01N1/286 , C12Q2523/301 , C12Q2525/301 , C12Q2535/122
摘要： Method and apparatus for controlling acoustic treatment of a sample to mediate a tagmentation process used on double stranded DNA.
摘要翻译：用于控制样品的声学处理以介导在双链DNA上使用的标签化过程的方法和设备。

8. 发明申请

WO2013078194A2 SAMPLE HOLDER AND METHOD FOR FRAGMENTING SAMPLE MATERIAL 审中-公开
标题翻译：样品容器和碎片化样品材料的方法
公开(公告)号：WO2013078194A2
公开(公告)日：2013-05-30
申请号：PCT/US2012066043
申请日：2012-11-20
申请人： COVARIS INC
发明人： LAUGHARN JAMES A JR , TSINTERIS ION A
IPC分类号： G01N1/28
CPC分类号： G01N1/28 , G01N1/286 , G01N1/42 , G01N2001/2866
摘要： Method and apparatus for holding and/or treating a sample material. A sample may be positioned in a vessel and a crushing force may be applied to the sample material while in the vessel, e.g., by a plunger that is part of a cap to pulverize the sample at cryogenic temperatures. The sample holder may include an acoustic window arranged to admit acoustic energy into the vessel for acoustic treatment of the sample. A flexible film may be used at a portion of the vessel, e.g., at the acoustic window, to cooperate with a plunger for crushing a sample.
摘要翻译：用于保存和/或处理样本材料的方法和设备。样品可以放置在容器中，并且可以在容器中施加压碎力，例如通过作为盖的一部分的柱塞在低温下粉碎样品。样品架可以包括声学窗口，该声学窗口布置成将声能引入容器中以对样品进行声学处理。可在容器的一部分处（例如在声窗处）使用柔性膜以与柱塞配合以压碎样品。

9. 发明申请

WO2013010066A1 SYSTEMS AND METHODS FOR PREPARING NANOCRYSTALLINE COMPOSITIONS USING FOCUSED ACOUSTICS 审中-公开
标题翻译：使用聚焦声学制备纳米晶体组合物的系统和方法
公开(公告)号：WO2013010066A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/046636
申请日：2012-07-13
申请人： COVARIS, INC. , BECKETT, Carl , LAUGHARN, James, A., Jr. , KAKUMANU, Srikanth
发明人： BECKETT, Carl , LAUGHARN, James, A., Jr. , KAKUMANU, Srikanth
IPC分类号： C30B7/00 , C30B29/60 , B01F11/02
CPC分类号： C30B7/00 , B01F11/0241 , B01F11/0283 , B01F2215/0454 , C30B29/60
摘要： Methods and systems for preparing nanocrystalline compositions using focused acoustic processing to cause and/or enhance crystal growth. A flow through system may be employed to expose sample material having a volume of greater or less than 30 mL to focused acoustic energy while flowing through a process chamber at a rate of at least 0.1 mL/min. Sample material may be processed by a suitable focused acoustic field in a cyclic fashion and/or with adjustment of processing parameters based on monitored characteristics of the sample, such as level of crystallinity. Nanocrystalline particles within the sample may have a tight particle size distribution with an average particle size between 10 nm and 1 micron. Stable nanocrystalline compositions may be reproducibly prepared using focused acoustics to have controllable morphologies and dimensions.
摘要翻译：使用聚焦声学处理制备纳米晶体组合物以引起和/或增强晶体生长的方法和系统。可以使用流通系统来将具有大于或小于30mL的体积的样品材料暴露于聚焦的声能，同时以至少0.1mL / min的速率流过处理室。样品材料可以通过合适的聚焦声场以循环方式和/或基于监测的样品特性（例如结晶度水平）调整处理参数来处理。样品内的纳米晶体颗粒可以具有紧密的粒度分布，平均粒度在10nm和1微米之间。稳定的纳米晶体组合物可以使用聚焦声学重复地制备以具有可控的形态和尺寸。

10. 发明申请

WO2012094374A3 SAMPLE HOLDER AND METHOD FOR TREATING SAMPLE MATERIAL 审中-公开
标题翻译：样品架和处理样品材料的方法
公开(公告)号：WO2012094374A3
公开(公告)日：2012-08-30
申请号：PCT/US2012020149
申请日：2012-01-04
申请人： COVARIS INC , LAUGHARN JAMES A
发明人： LAUGHARN JAMES A
IPC分类号： G01N1/28
CPC分类号： G01N1/286 , G01N2001/2866
摘要： Method and apparatus for holding and/or treating a sample material. A sample material may be positioned in a vessel between top and bottom flexible films where the flexible films are connected together by a substantially rigid support structure that surrounds the sample material. A crushing force may be applied to the sample material via the top and bottom flexible films, e.g., to pulverize the sample at cryogenic temperatures. A sample holder may have two vessels, one arranged for applying a crushing force to a first sample and another for holding a sample for other processing, such as a histology analysis.
摘要翻译：用于保存和/或处理样本材料的方法和设备。样品材料可以放置在顶部柔性膜和底部柔性膜之间的容器中，其中柔性膜通过围绕样品材料的基本上刚性的支撑结构连接在一起。粉碎力可以通过顶部和底部柔性膜施加到样品材料上，例如在低温下粉碎样品。样品架可以具有两个容器，一个容器用于向第一样品施加压碎力，另一个容纳样品用于其他处理，例如组织学分析。

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