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1. 发明申请

WO2012125911A1 ACOUSTIC TREATMENT VESSEL AND METHOD FOR ACOUSTIC TREATMENT 审中-公开
标题翻译：声学治疗血管和呼吸治疗方法
公开(公告)号：WO2012125911A1
公开(公告)日：2012-09-20
申请号：PCT/US2012029404
申请日：2012-03-16
申请人： COVARIS INC , LAUGHARN JAMES A , BECKETT CARL
发明人： LAUGHARN JAMES A , BECKETT CARL
IPC分类号： B01F11/02 , A61N7/00 , B06B1/00
CPC分类号： A61B8/00 , B01F11/0258 , G10K11/28
摘要： Methods and systems for acoustically treating material using a continuous process in which material may be caused to flow in a continuous or intermittent fashion into/out of an acoustic treatment chamber where the material is exposed to focused acoustic energy. The methods and systems may be arranged to permit continuous processing for extended periods while an acoustic energy source operates at a relatively high power output. Treatment chambers may include features such as an acoustic window and/or a chamber wall which may comprise an acoustically reflective material or a gas/wall interface that serves to reflect acoustic energy to form one or more secondary focal zones. Treatment system configurations relating to arrangements of a treatment chamber relative to an acoustic source and coupling medium, material flow paths, and others are provided.
摘要翻译：使用连续方法来声学处理材料的方法和系统，其中可以使材料以连续或间歇的方式流入/离开材料暴露于聚焦声能的声学处理室。方法和系统可以被布置成允许在较长时间内连续处理，同时声能源以相对高的功率输出操作。处理室可以包括诸如声窗和/或室壁的特征，其可以包括声反射材料或气体/壁界面，其用于反射声能以形成一个或多个次焦点区域。提供了与处理室相对于声源和耦合介质，材料流动路径等的布置相关的处理系统配置。

2. 发明申请

WO2012003003A2 COMPOSITIONS AND METHODS FOR PREPARING NANOFORMULATIONS AND SYSTEMS FOR NANO-DELIVERY USING FOCUSED ACOUSTICS 审中-公开
标题翻译：使用焦点声学处理纳米交付纳米生成和系统的组合物和方法
公开(公告)号：WO2012003003A2
公开(公告)日：2012-01-05
申请号：PCT/US2011001171
申请日：2011-07-01
申请人： COVARIS INC , BECKETT CARL , LAUGHARN JAMES A JR , KAKUMANU SRIKANTH
发明人： BECKETT CARL , LAUGHARN JAMES A JR , KAKUMANU SRIKANTH
IPC分类号： B01F11/02 , B01J2/18 , B01J19/10
CPC分类号： B01F11/0283 , B01F3/0807 , B01F2215/0431 , B01F2215/0454 , B01F2215/0477 , B01J2/18 , B01J2219/00932
摘要： Focused ultrasonic acoustic processing is used to prepare formulations particles ranging between approximately 10 nm and approximately 50 microns (e.g., between 1 micron and 20 microns), or between approximately 10 nm approximately 400 nm (e.g., between 10 nm and 100 nm). Formulations (e.g., nanoformulations) may include a suspension (e.g., nanosuspension), an emulsion (e.g., nanoemulsion) or another small particle system. Formulations may be used as delivery systems for therapeutic agents. A formulation may also include a suspension of micron or submicron sized particles dispersed within a solvent. Or, a formulation may include a bioactive agent and a carrier compound such as a surfactant that encapsulates the bioactive agent (e.g., liposome/micelle containing a pharmaceutical, polynucleotide, etc.). In some cases, the polydispersity index of the particle size distribution in a formulation is less than 0.1. Formulations may be suitably prepared using focused acoustic energy that results in a reduction of the average particle size of a mixture. Alternatively, suitable formulations may be prepared using focused acoustics in a manner that does not reduce the average particle size of the mixture.
摘要翻译：聚焦超音波处理用于制备约10nm至约50微米（例如，1微米至20微米）之间或约10nm约400nm（例如，10nm至100nm）之间的制剂颗粒。制剂（例如，纳米制剂）可以包括悬浮液（例如纳米悬浮液），乳剂（例如纳米乳剂）或另一小颗粒系统。制剂可用作治疗剂的递送系统。制剂还可以包括分散在溶剂中的微米或亚微米级颗粒的悬浮液。或者，制剂可以包括生物活性剂和载体化合物，例如包封生物活性剂的表面活性剂（例如含有药物，多核苷酸等的脂质体/胶束）。在一些情况下，制剂中粒度分布的多分散指数小于0.1。可以使用导致混合物的平均粒度的降低的聚焦声能适当地制备制剂。或者，可以以不降低混合物的平均粒度的方式使用聚焦声学制备合适的制剂。

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