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1. 发明申请

WO2010064208A2 MSP2 ANTIGENIC PEPTIDES AND THEIR USE 审中-公开
标题翻译： MSP2抗原肽及其使用
公开(公告)号：WO2010064208A2
公开(公告)日：2010-06-10
申请号：PCT/IB2009/055487
申请日：2009-12-03
申请人： UNIVERSITÉ DE LAUSANNE , CORRADIN, Giampietro , FELGER, Ingrid , SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE
发明人： CORRADIN, Giampietro , FELGER, Ingrid
IPC分类号： C07K14/445 , A61K39/015 , C07K16/20 , G01N33/569
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , G01N2469/10 , G01N2469/20 , Y02A50/412
摘要： This invention relates generally to the field of pathogen peptidic antigens and their use, for example, for the preparation of a vaccine against said pathogen. More specifically, the present invention relates to an antigenic peptide derived from the constant part of Plasmodium species sequences, and includes antibodies and methods of producing and using same.
摘要翻译：本发明一般涉及病原体肽抗原领域及其用于制备针对所述病原体的疫苗的用途。更具体地，本发明涉及源自疟原虫种类序列的恒定部分的抗原肽，并且包括抗体及其制备和使用方法。

2. 发明申请

WO2009136373A1 SUB-REGION OF A PLASMODIUM PROTEIN WITH IMPROVED VACCINE POTENTIAL, AND MEDICAL USES THEREOF 审中-公开
标题翻译：具有改善的疫苗潜能的普通蛋白质的亚区域及其医疗用途
公开(公告)号：WO2009136373A1
公开(公告)日：2009-11-12
申请号：PCT/IB2009/051875
申请日：2009-05-07
申请人： INSTITUT PASTEUR , UNIVERSITE DE LAUSANNE , DRUILHE, Pierre , CORRADIN, Giampietro , JAFARSHAD, Ali , ROUSSILLHON, Christian
发明人： DRUILHE, Pierre , CORRADIN, Giampietro , JAFARSHAD, Ali , ROUSSILLHON, Christian
IPC分类号： A61K39/395 , C07K16/20 , C07K14/445 , A61P33/06
CPC分类号： C07K16/205 , A61K39/00 , A61K39/015 , C07K14/445 , C07K2317/21 , Y02A50/412
摘要： The present application relates to a sub-region of a Plasmodium protein, with improved vaccine potential, and to medical uses thereof, notably for treatment or diagnosis of malaria. The present invention notably provides unstructured or unfolded polypeptides deriving from the PFF0165c protein of P. falciparum 3D7. The polypeptides of the invention have a high antigenicity, a high immunogenicity, have a high parasite-killing activity in the ADCI assay, and are strongly associated with clinical protection against malaria, and. The present invention thereby provides a vaccine for the palliative and/or curative treatment of malaria, which is specifically intended for infants, toddlers, children under the age of 5, pregnant women.
摘要翻译：本申请涉及具有改善的疫苗潜力的疟原虫蛋白质的亚区域，以及其医疗用途，特别是用于治疗或诊断疟疾。本发明特别提供源自恶性疟原虫3D7的PFF0165c蛋白质的非结构化或解折叠多肽。本发明的多肽具有高抗原性，高免疫原性，在ADCI测定中具有高寄生虫杀伤活性，并且与抗疟疾的临床保护密切相关。因此，本发明提供了一种用于姑息和/或治疗性疟疾治疗的疫苗，其专门针对婴儿，幼儿，5岁以下的儿童，孕妇。

3. 发明申请

WO2008041050A1 VACUNA CONTRA LA MALARIA, BASADA EN FRAGMENTOS Y COMBINACIONES DE FRAGMENTOS DE LA PROTEÍNA CS DE PLASMODIUM VIVAX 审中-公开
标题翻译：疟原虫疫苗基于片段和组合片段的蛋白质
公开(公告)号：WO2008041050A1
公开(公告)日：2008-04-10
申请号：PCT/IB2006/003263
申请日：2006-10-04
申请人： CENTRO INTERNACIONAL DE VACUNAS , HERRERA VALENCIA, Socrates , AREVALO-HERRERA, Myriam , CORRADIN, Giampietro
发明人： HERRERA VALENCIA, Socrates , AREVALO-HERRERA, Myriam , CORRADIN, Giampietro
IPC分类号： C07K14/445 , A61K39/015
CPC分类号： C07K14/445 , A61K39/00 , A61K39/015 , A61K2039/53 , Y02A50/412
摘要： La presente invención se refiere a un polipéptido sintético o recombinante que se caracteriza porque comprende al menos 3 repeticiones seguidas del nona-péptido A N G A G X1 Q X2 X3, donde X1 es seleccionado entre D y N, X2 es seleccionado entre P y A, y X3 es seleccionado entre G y A. Preferiblemente, el polipéptido de la invención comprende adicionalmente al menos dos (2) repeticiones seguidas de la secuencia GDRADGQPA y en una alternativa aún más deseada el polipéptido incluye una región amino terminal, una región C terminal y/o el fragmento ptt30. También es parte de la invención las vacunas contra la malaria que se caracterizan por comprender dichos péptidos.
摘要翻译：本发明涉及一种重组或合成多肽，其特征在于其包括至少三个连续重复的非肽ANGAG X1 Q X2 X3，其中X1选自D和N，X2选自P，A和X2选自G 本发明的多肽还优选包含序列GDRADGQPA的至少两（2）个连续重复，并且在甚至更优选的实施方案中，多肽包含氨基末端区，C-末端区和/或ptt30片段。本发明还涉及疟疾疫苗，其特征在于它们包括所述肽。

4. 发明申请

WO2007020520A2 ANTIGENIC PEPTIDES AND THEIR USE 审中-公开
标题翻译：抗原肽及其使用
公开(公告)号：WO2007020520A2
公开(公告)日：2007-02-22
申请号：PCT/IB2006/002232
申请日：2006-08-16
申请人： UNIVERSITE DE LAUSANNE , INSTITUT PASTEUR , CORRADIN, Giampietro , KAJAVA, Andrey , DRUILHE, Pierre , JAFARSHAD, Ali
发明人： CORRADIN, Giampietro , KAJAVA, Andrey , DRUILHE, Pierre , JAFARSHAD, Ali
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , Y02A50/412
摘要： This invention relates generally to the field of pathogen peptidic antigens and their use, for example, for the preparation of a vaccine against said pathogen. More specifically, the present invention relates to an antigenic peptide deriving from Plasmodium species sequences, and includes antibodies and methods of producing and using same.
摘要翻译：本发明一般涉及病原体肽抗原领域及其用于制备针对所述病原体的疫苗的用途。更具体地，本发明涉及从疟原虫种类序列衍生的抗原肽，并且包括抗体及其制备和使用方法。

5. 发明申请

WO1995017212A1 CONJUGATES CONSISTING OF PEPTIDIC T CELL ANTIGENS AND CELL BINDING PARTNERS AND THEIR USE FOR THERAPY 审中-公开
标题翻译：临床应用细胞因子抗原和细胞结合合作伙伴及其治疗用途
公开(公告)号：WO1995017212A1
公开(公告)日：1995-06-29
申请号：PCT/EP1994004280
申请日：1994-12-22
申请人： BOEHRINGER MANNHEIM GMBH , MACH, Jean-Pierre , HEALY, Frank , CORRADIN, Giampietro
发明人： BOEHRINGER MANNHEIM GMBH
IPC分类号： A61K47/48
CPC分类号： A61K47/6811
摘要： A conjugate comprising an essentially non-toxic peptide T cell antigen, which is capable of forming a complex with MHC class I or II molecules, and a binding partner for a surface receptor on mammalian target cells, whereby a) the binding partner has a high degree of selectivity for said target cells; by binding to substances which are expressed on the surface of said cells; b) the conjugate comprising the binding partner and the T cell antigen is internalized in said cells after binding of the binding partner to its surface receptor on said cells; c) the T cell antigen is processed from the conjugate and expressed on the cell surface in the form of a complex with MHC molecules, whereby said complex is recognized by the T cell receptor, thereby inducing cytotoxicity of T cells for the aforesaid target cells, is useful to induce specific cytotoxicity of T cells in the treatment of cancer autoimmune diseases, diabetes or allergic reactions.
摘要翻译：一种缀合物，其包含能够与MHC I类或II类分子形成复合物的基本上无毒的T细胞抗原，以及哺乳动物靶细胞上表面受体的结合配偶体，其中a）结合配偶体具有高的对所述靶细胞的选择性程度; 通过结合在所述细胞表面上表达的物质; b）在结合配偶体与所述细胞上的表面受体结合后，包含结合配偶体和T细胞抗原的缀合物在所述细胞内部被内化; c）从缀合物处理T细胞抗原，并以细胞表面形式与MHC分子形成复合体，由此所述复合物被T细胞受体识别，从而诱导T细胞对前述靶细胞的细胞毒性，可用于诱导T细胞特异性细胞毒性治疗癌症自身免疫疾病，糖尿病或过敏反应。

6. 发明申请

WO2007020520A3 ANTIGENIC PEPTIDES AND THEIR USE 审中-公开
标题翻译：抗原肽及其用途
公开(公告)号：WO2007020520A3
公开(公告)日：2007-06-21
申请号：PCT/IB2006002232
申请日：2006-08-16
申请人： UNIV LAUSANNE , PASTEUR INSTITUT , CORRADIN GIAMPIETRO , KAJAVA ANDREY , DRUILHE PIERRE , JAFARSHAD ALI
发明人： CORRADIN GIAMPIETRO , KAJAVA ANDREY , DRUILHE PIERRE , JAFARSHAD ALI
IPC分类号： C07K14/445 , A61K38/00 , A61K39/015 , A61K39/395 , C07K16/20 , C12N15/09
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905
摘要： This invention relates generally to the field of pathogen peptidic antigens and their use, for example, for the preparation of a vaccine against said pathogen. More specifically, the present invention relates to an antigenic peptide deriving from Plasmodium species sequences, and includes antibodies and methods of producing and using same.
摘要翻译：本发明一般涉及病原体肽抗原领域及其用途，例如用于制备针对所述病原体的疫苗。更具体地，本发明涉及源自疟原虫属物种序列的抗原肽，并且包括抗体及其制备和使用方法。

7. 发明申请

WO0250099A2 PROCESS FOR FOLDING CHEMICALLY SYNTHESIZED POLYPEPTIDES 审中-公开
标题翻译：折叠化学合成多肽的方法
公开(公告)号：WO0250099A2
公开(公告)日：2002-06-27
申请号：PCT/EP0114163
申请日：2001-11-27
申请人： RMF DICTAGENE SA , VERDINI ANTONIO , CORRADIN GIAMPIETRO , ROGGERO MARIO
发明人： VERDINI ANTONIO , CORRADIN GIAMPIETRO , ROGGERO MARIO
IPC分类号： C07K1/04 , C07K1/113 , C07K1/14
CPC分类号： C07K1/1133 , C07K1/04
摘要： The present invention relates to a process for folding chemically synthesized polypeptides, comprising treating a polypeptide and/or protein that comprises two or more derivatized cysteine residues with a reducing agent in a folding buffer having a predetermined pH and temperature, wherein the derivatized cysteine residue corresponds to S-butyl-thio-cysteine residue and wherein the reducing agent is cysteine.
摘要翻译：本发明涉及用于折叠化学合成的多肽的方法，包括在具有预定pH和温度的折叠缓冲液中用还原剂处理包含两个或更多个衍生的半胱氨酸残基的多肽和/或蛋白质，其中所述衍生的半胱氨酸残基对应于转化为S-丁基 - 硫代半胱氨酸残基，并且其中还原剂是半胱氨酸。

8. 发明申请

WO1995017167A1 IMMUNOLOGICAL RESPONSE POTENTIATION PROCESS 审中-公开
标题翻译：增效的免疫反应的方法
公开(公告)号：WO1995017167A1
公开(公告)日：1995-06-29
申请号：PCT/CH1994000242
申请日：1994-12-23
申请人： GFF GESELLSCHAFT ZUR FÖRDERUNG DER INDUSTRIEORIENTIERTEN FORSCHUNG , GANDER, Bruno , CORRADIN, Giampietro , MEN, Ying , THOMASIN, Claudio , MERKLE, Hans, Peter
发明人： GFF GESELLSCHAFT ZUR FÖRDERUNG DER INDUSTRIEORIENTIERTEN FORSCHUNG
IPC分类号： A61K09/16
CPC分类号： A61K39/39 , A61K9/1647 , A61K39/015 , A61K39/08 , A61K2039/55555
摘要： An immunological response potentiation process is disclosed for synthetic or genetically engineered antigens having low immunogenicity. The antigen is embedded into biodegradable microparticles, these antigen-loaded microparticles are dispersed in a biodegradable medium which triggers when it is parenterally administered a potentiated antibody, TH-lymphocyte and Tc-lymphocyte response, as compared to an aqueous antigen solution. The extent of immunological potentiation is at least comparable with that attained by IFA compositions. Linear B-TH-cell epitopes, linear Tc-cell epitopes, dimers and multimers of said epitopes, as well as their mixtures, are used as low immunogenicity antigens. The microparticles are based on biodegradable biopolymers such as polyester, polyanhydride, polyorthoester. By mixing microparticles with different wettabilities, swellabilities, release and biodegradation times, the most intense and longest immunological potentiation is achieved. This process is useful for immunising human beings and animals against diseases caused by viruses, bacteria, protozoa or tumour cells.
摘要翻译：中描述了一种方法用于免疫增强弱免疫原性，合成产生或通过基因工程抗原，其嵌入所述抗原到可生物降解的微粒在生物可降解的介质分散这些负载抗原的微粒，和肠胃外给药后，与抗原强化抗体的水溶液，TH淋巴细胞和TC-淋巴细胞反应触发。免疫增强作用的程度是通过IFA制剂幂实现至少相当。作为弱免疫原性抗原的线性B-H细胞表位是线性的Tc-细胞表位，二 - 和这些表位的多聚体，以及它们的混合物。微粒是基于生物可降解的生物聚合物，例如聚酯，聚酐，聚原酸酯，其中，具有不同润湿性的微粒，肿胀，释放和生物降解的原因的在强度和最高和最长在免疫增强的时间过程混合物。该过程在人类和动物抵抗由病毒，细菌，原生动物或肿瘤细胞的疾病的免疫使用。

9. 发明申请

WO2010064208A3 MSP2 ANTIGENIC PEPTIDES AND THEIR USE 审中-公开
标题翻译： MSP2抗原肽及其使用
公开(公告)号：WO2010064208A3
公开(公告)日：2010-07-29
申请号：PCT/IB2009055487
申请日：2009-12-03
申请人： UNIV LAUSANNE , SWISS TROPICAL AND PUBLIC HEAL , CORRADIN GIAMPIETRO , FELGER INGRID
发明人： CORRADIN GIAMPIETRO , FELGER INGRID
IPC分类号： C07K14/445 , A61K39/015 , C07K16/20 , G01N33/569
CPC分类号： C07K14/445 , A61K39/00 , G01N33/56905 , G01N2333/445 , G01N2469/10 , G01N2469/20
摘要： This invention relates generally to the field of P. falciparum antigens and their use, for example, for the preparation of a vaccine against said pathogen. More specifically, the present invention relates to an antigenic peptide derived from the constant part of MSA2, and includes antibodies and methods of producing and using same.
摘要翻译：本发明一般涉及恶性疟原虫抗原的领域及其用于制备针对所述病原体的疫苗的用途。更具体地，本发明涉及源自MSA2的恒定部分的抗原肽，并且包括抗体及其制备和使用方法。

10. 发明申请

WO2002050099A3 PROCESS FOR FOLDING CHEMICALLY SYNTHESIZED POLYPEPTIDES 审中-公开
公开(公告)号：WO2002050099A3
公开(公告)日：2002-06-27
申请号：PCT/EP2001/014163
申请日：2001-11-27
申请人： RMF DICTAGENE S.A. , VERDINI, Antonio , CORRADIN, Giampietro , ROGGERO, Mario
发明人： VERDINI, Antonio , CORRADIN, Giampietro , ROGGERO, Mario
IPC分类号： C07K1/113
摘要： The present invention relates to a process for folding chemically synthesized polypeptides, comprising treating a polypeptide and/or protein that comprises two or more derivatized cysteine residues with a reducing agent in a folding buffer having a predetermined pH and temperature, wherein the derivatized cysteine residue corresponds to S-butyl-thio-cysteine residue and wherein the reducing agent is cysteine.

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