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1. 发明申请

WO0250099A2 PROCESS FOR FOLDING CHEMICALLY SYNTHESIZED POLYPEPTIDES 审中-公开
标题翻译：折叠化学合成多肽的方法
公开(公告)号：WO0250099A2
公开(公告)日：2002-06-27
申请号：PCT/EP0114163
申请日：2001-11-27
申请人： RMF DICTAGENE SA , VERDINI ANTONIO , CORRADIN GIAMPIETRO , ROGGERO MARIO
发明人： VERDINI ANTONIO , CORRADIN GIAMPIETRO , ROGGERO MARIO
IPC分类号： C07K1/04 , C07K1/113 , C07K1/14
CPC分类号： C07K1/1133 , C07K1/04
摘要： The present invention relates to a process for folding chemically synthesized polypeptides, comprising treating a polypeptide and/or protein that comprises two or more derivatized cysteine residues with a reducing agent in a folding buffer having a predetermined pH and temperature, wherein the derivatized cysteine residue corresponds to S-butyl-thio-cysteine residue and wherein the reducing agent is cysteine.
摘要翻译：本发明涉及用于折叠化学合成的多肽的方法，包括在具有预定pH和温度的折叠缓冲液中用还原剂处理包含两个或更多个衍生的半胱氨酸残基的多肽和/或蛋白质，其中所述衍生的半胱氨酸残基对应于转化为S-丁基 - 硫代半胱氨酸残基，并且其中还原剂是半胱氨酸。

2. 发明申请

WO0107469A3 POLYPEPTIDE DENDRIMERS AS UNIMOLECULAR CARRIERS OF DIAGNOSTIC IMAGING CONTRAST AGENTS, BIOACTIVE SUBSTANCES AND DRUGS 审中-公开
标题翻译：作为诊断成像造影剂，生物活性物质和药物的单分子载体的多肽DENDRIMERS
公开(公告)号：WO0107469A3
公开(公告)日：2001-05-10
申请号：PCT/EP0007022
申请日：2000-07-21
申请人： VERDINI ANTONIO
发明人： VERDINI ANTONIO
IPC分类号： A61K45/00 , A61K47/48 , A61K48/00 , A61P31/04 , A61P31/12 , A61P35/00 , C07K1/02 , C07K14/00
CPC分类号： C07K14/001 , A61K47/641
摘要： The invention describes new polypeptide dendrimers and processes for the synthesis of the same. The polypeptide dendrimers of the invention have a structure which consists of a multifunctional core moiety from which highly branched polypeptide chains, formed by short peptide branching units, extend radially outwards. The outermost branches surround a lower density space with hollows and channels into which bioactive substances employed in diagnosis and therapy can be entrapped or covalently linked. For these properties the said polypeptide dendrimers are particularly useful in a number of areas in biology and medicine as carriers for the delivery of bioactive substances, including drugs, or as carriers of bacterial, viral and parasite antigens, gene-therapy compounds and diagnostic imaging contrast agents.
摘要翻译：本发明描述了新的多肽树枝状聚合物及其合成方法。本发明的多肽树枝状聚合物具有由多功能核心部分组成的结构，由短肽分支单元形成的高度分支的多肽链径向向外延伸。最外面的分支围绕具有空腔和通道的较低密度空间，诊断和治疗中使用的生物活性物质可以被包埋或共价连接到该空间和通道中。对于这些性质，所述多肽树枝状大分子在生物学和医学的许多领域中特别有用，作为递送生物活性物质（包括药物）或作为细菌，病毒和寄生虫抗原，基因治疗化合物和诊断成像对比代理商。

3. 发明申请

WO1993021208A1 PARTIALLY MODIFIED AND RETRO-INVERTED TETRAPEPTIDES ANALOGUES OF C-REACTIVE PROTEIN FRAGMENTS 审中-公开
标题翻译：部分修饰和逆转反应的C-反应蛋白片段的模拟物
公开(公告)号：WO1993021208A1
公开(公告)日：1993-10-28
申请号：PCT/EP1993000825
申请日：1993-04-02
申请人： ITALFARMACO S.P.A. , VERDINI, Antonio, Silvio , PINORI, Massimo , CAPPELLETTI, Silvana , GAZERRO, Laura , LEONI, Flavio
发明人： ITALFARMACO S.P.A.
IPC分类号： C07K05/02
CPC分类号： C07K5/0212
摘要： Retro-inverted tetrapeptides analogues of C-reactive protein fragments endowed with immuno-modulating activity.
摘要翻译： C反应蛋白片段的逆转四肽类似物具有免疫调节活性。

4. 发明申请

WO2004073728A3 COMPOSITIONS COMPRISING FETAL HEMOGLOBIN AND BACTERIAL ENDOTOXIN AND OPTIONALLY ADDITIONAL FETAL LIVER COMPONENTS 审中-公开
标题翻译：包含天门冬氨酸和细菌内毒素和可选择性添加剂的组合物
公开(公告)号：WO2004073728A3
公开(公告)日：2004-10-07
申请号：PCT/EP2004001553
申请日：2004-02-18
申请人： CLINIQUE LA PRAIRIE RES SA , WESTPHAL OTTO , WAELLI THIERRY , GORCZYNSKI REGINALD , MUELLER SILKE , MACH JEAN-PIERRE , HARTMANN ALFRED , BESSLER WOLFGANG , HOFMANN PETRA , ZAEHRINGER ULRICH , ALEXANDER CHRISTIAN , VOR DEM ESCHE ULRICH , ULMER ARTUR J , VERDINI ANTONIO
发明人： WESTPHAL OTTO , WAELLI THIERRY , GORCZYNSKI REGINALD , MUELLER SILKE , MACH JEAN-PIERRE , HARTMANN ALFRED , BESSLER WOLFGANG , HOFMANN PETRA , ZAEHRINGER ULRICH , ALEXANDER CHRISTIAN , VOR DEM ESCHE ULRICH , ULMER ARTUR J , VERDINI ANTONIO
IPC分类号： A61K35/407 , A61K35/74 , A61K38/00 , A61K38/17 , A61K38/42 , A61K39/02 , A61P35/00 , A61P37/00
CPC分类号： A61K35/407 , A23L33/10 , A61K35/74 , A61K38/42 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the gamma-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition. The composition of the invention finds a variety of applications which have in common the stimulation of the immune system and the reversion in polarization of cytokines and chemokines from a Th2-directed response to a Th1-type response. The proposed applications would therefore include the treatment of allergic conditions, malignancies, chronic infections, autoimmune phenomena and age-related imbalances.
摘要翻译：本发明涉及代表包含细菌内毒素，胎儿血红蛋白或更特别是不含血红素的衍生物或其γ链，以及除了HbF之外存在于胎肝中的成分的新的免疫调节原理的药物组合物。组合物以药学上可接受的载体和/或稀释剂递送给人。根据本发明，惊奇地发现内毒素和胎儿血红蛋白部分结构显示出明显的协同生物医学活性。胎儿血红蛋白及其部分结构的生物医学效应令人惊讶地不是基于作为氧转运蛋白的经典血红蛋白功能，而是与内毒素介导的生物活性的调节有关。在口服施用组合物后，也观察到该生物医学活性。本发明的组合物发现各种各样的应用，其具有共同的刺激免疫系统和从Th2导向的Th1型反应的细胞因子和趋化因子的极化反转。因此，所提出的申请将包括治疗过敏性疾病，恶性肿瘤，慢性感染，自身免疫现象和年龄相关的不平衡。

5. 发明申请

WO2004073728A2 COMPOSITIONS COMPRISING FETAL HEMOGLOBIN AND BACTERIAL ENDOTOXIN AND OPTIONALLY ADDITIONAL FETAL LIVER COMPONENTS 审中-公开
标题翻译：包含胎儿血红蛋白和细菌内毒素以及任选附加的胎儿肝组分的组合物
公开(公告)号：WO2004073728A2
公开(公告)日：2004-09-02
申请号：PCT/EP2004/001553
申请日：2004-02-18
申请人： CLINIQUE LA PRAIRIE RESEARCH SA , WESTPHAL, Otto , WÄLLI, Thierry , GORCZYNSKI, Reginald , MÜLLER, Silke , MACH, Jean-Pierre , HARTMANN, Alfred , BESSLER, Wolfgang , HOFMANN, Petra , ZÄHRINGER, Ulrich , ALEXANDER, Christian , VOR DEM ESCHE, Ulrich , ULMER, Artur, J. , VERDINI, Antonio
发明人： WESTPHAL, Otto , WÄLLI, Thierry , GORCZYNSKI, Reginald , MÜLLER, Silke , MACH, Jean-Pierre , HARTMANN, Alfred , BESSLER, Wolfgang , HOFMANN, Petra , ZÄHRINGER, Ulrich , ALEXANDER, Christian , VOR DEM ESCHE, Ulrich , ULMER, Artur, J. , VERDINI, Antonio
IPC分类号： A61K38/00
CPC分类号： A61K35/407 , A23L33/10 , A61K35/74 , A61K38/42 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition representing a novel immunomodulating principle comprising bacterial endotoxin, fetal hemoglobin or more particularly a heme-free derivative or the γ-chain thereof, and optionally, components which are present in the fetal liver in addition to HbF. The composition is delivered to humans in a pharmaceutically acceptable carrier and/or diluent. In accordance with the present invention it was surprisingly found that endotoxin and fetal hemoglobin partial structures display a pronounced synergistic biomedical activity. The biomedical effect of fetal hemoglobin and its partial structures is surprisingly not based on a classical hemoglobin function as an oxygen transporter but related to a modulation of endotoxin-mediated bioactivity. This biomedical activity is surprisingly also observed after oral application of the composition. The composition of the invention finds a variety of applications which have in common the stimulation of the immune system and the reversion in polarization of cytokines and chemokines from a Th2-directed response to a Th1-type response. The proposed applications would therefore include the treatment of allergic conditions, malignancies, chronic infections, autoimmune phenomena and age-related imbalances.
摘要翻译：本发明涉及代表新型免疫调节原理的药物组合物，其包含细菌内毒素，胎儿血红蛋白或更具体地是不含血红素的衍生物或其γ链，以及任选存在于胎儿肝脏除了HbF。该组合物在药学上可接受的载体和/或稀释剂中递送给人。根据本发明，令人惊讶地发现内毒素和胎儿血红蛋白部分结构显示显着的协同生物医学活性。胎儿血红蛋白及其部分结构的生物医学效应令人惊讶地不基于经典血红蛋白功能作为氧转运体，而是与内毒素介导的生物活性的调节有关。在口服该组合物之后，还惊奇地发现了这种生物医学活性。本发明的组合物找到了各种应用，其共同具有免疫系统的刺激以及细胞因子和趋化因子从Th2型定向的Th1型应答反应中的极化复归。因此，拟议的应用将包括治疗过敏性疾病，恶性肿瘤，慢性感染，自身免疫现象和与年龄有关的失衡。

6. 发明申请

WO2002050099A3 PROCESS FOR FOLDING CHEMICALLY SYNTHESIZED POLYPEPTIDES 审中-公开
公开(公告)号：WO2002050099A3
公开(公告)日：2002-06-27
申请号：PCT/EP2001/014163
申请日：2001-11-27
申请人： RMF DICTAGENE S.A. , VERDINI, Antonio , CORRADIN, Giampietro , ROGGERO, Mario
发明人： VERDINI, Antonio , CORRADIN, Giampietro , ROGGERO, Mario
IPC分类号： C07K1/113
摘要： The present invention relates to a process for folding chemically synthesized polypeptides, comprising treating a polypeptide and/or protein that comprises two or more derivatized cysteine residues with a reducing agent in a folding buffer having a predetermined pH and temperature, wherein the derivatized cysteine residue corresponds to S-butyl-thio-cysteine residue and wherein the reducing agent is cysteine.

7. 发明申请

WO8603495A3 DERIVATIVES OF SUBSTANCES P AND OF FRAGMENTS THEREOF 审中-公开
标题翻译：物质P及其片段的衍生物
公开(公告)号：WO8603495A3
公开(公告)日：1986-07-31
申请号：PCT/EP8500667
申请日：1985-12-05
申请人： ENICHEM SPA , BONELLI FABIO , FARINA ATONIO , PESSI ANTONELLO , SQUADRINI FABIO , VERDINI ANTONIO SILVIO , VISCOMI GIUSEPPE CLAUDIO
发明人： BONELLI FABIO , FARINA ANTONIO , PESSI ANTONELLO , SQUADRINI FABIO , VERDINI ANTONIO SILVIO , VISCOMI GIUSEPPE CLAUDIO
IPC分类号： C07C69/96 , A61K38/00 , C07B31/00 , C07B51/00 , C07C67/00 , C07K7/06 , C07K14/575
CPC分类号： C07K14/575 , A61K38/00
摘要： Derivatives of substance P and of fragments thereof, wherein at least an aminoacid residue bears chemically bonded a methoxy-(ethoxy)n ethyl group.

8. 发明申请

WO1986003495A1 DERIVATIVES OF SUBSTANCES P AND OF FRAGMENTS THEREOF 审中-公开
标题翻译：物质P及其碎片的衍生物
公开(公告)号：WO1986003495A1
公开(公告)日：1986-06-19
申请号：PCT/EP1985000667
申请日：1985-12-05
申请人： ENICHEM S.P.A. , BONELLI, Fabio , FARINA, Antonio , PESSI, Antonello , SQUADRINI, Fabio , VERDINI, Antonio, Silvio , VISCOMI, Giuseppe, Claudio
发明人： ENICHEM S.P.A.
IPC分类号： C07K07/06

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