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1. 发明申请

WO9855510A3 CYCLIN RELATED PROTEINS 审中-公开
标题翻译： CYCLIN相关蛋白
公开(公告)号：WO9855510A3
公开(公告)日：1999-03-18
申请号：PCT/US9811735
申请日：1998-06-05
申请人： INCYTE PHARMA INC , HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARN J , COCKS BENJAMIN GRAEME , SHAH PURVI
发明人： HILLMAN JENNIFER L , CORLEY NEIL C , GUEGLER KARN J , COCKS BENJAMIN GRAEME , SHAH PURVI
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K45/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12P21/02 , C12Q1/68 , C07K14/00
CPC分类号： C12N9/93 , A61K38/00 , C07K14/4738
摘要： The invention provides two human proteins, involved in the cyclin-mediated regulatory pathway; a cyclin B-like protein, designated HCRP-2, and a ubiquitin conjugating enzyme E2-like protein, allegedly specifically involved in the degradation of mitotic cyclins, designated HCRP-1.

2. 发明申请

WO1997035989A2 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 审中-公开
标题翻译：循环核酸磷酸酯酶
公开(公告)号：WO1997035989A2
公开(公告)日：1997-10-02
申请号：PCT/US1997004717
申请日：1997-03-20
申请人： INCYTE PHARMACEUTICALS, INC. , AU-YOUNG, Janice , COCKS, Benjamin, Graeme , COLEMAN, Roger , SEILHAMER, Jeffrey, J.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/55
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention relates to a family of cyclic nucleotide phosphodiesterases (CN PCD8) and provides specific polynucleotide and amino acid sequences which encode and identify CN PDE8 family members designated herein as CN PDE8A and CN PDE8B. The present invention also relates to the use of proteins, peptides and organic molecules capable of modulating CN PDE8 activity to inhibit or enhance phosphodiesterase activity associated with disease. The present invention further relates to the use of CN PDE8 and genetically engineered host cells that express CN PDE8 to evaluate and screen for substances and compounds that modulate cyclic nucleotide phosphodiesterase activity. The present invention also provides for cn pde8 antisense molecules. The invention provides genetically engineered expression vectors and host cells for the production of purified CN PDE8 polypeptide. The present invention further provides pharmaceutical compositions and methods of treatment based on the identification of agonist, antagonists and inhibitors of CN PDE8. The invention specifically provides for use of the cn pde8 polynucleotide sequences as a diagnostic composition for the detection of disease.
摘要翻译：本发明涉及一种环状核苷酸磷酸二酯酶（CN PCD8），并提供编码和鉴定CN PDE8家族成员CN PDE8A和CN PDE8B的特异性多核苷酸和氨基酸序列。本发明还涉及能够调节CN PDE8活性以抑制或增强与疾病相关的磷酸二酯酶活性的蛋白质，肽和有机分子的用途。本发明还涉及CN PDE8和表达CN PDE8的遗传工程宿主细胞的用途，以评估和筛选调节环核苷酸磷酸二酯酶活性的物质和化合物。本发明还提供了cn pde8反义分子。本发明提供用于产生纯化的CN PDE8多肽的遗传工程表达载体和宿主细胞。本发明还提供了基于鉴定CN PDE8的激动剂，拮抗剂和抑制剂的药物组合物和治疗方法。本发明特别提供了使用cn pde8多核苷酸序列作为疾病检测的诊断组合物。

3. 发明申请

WO2011060490A1 ANGIOGENIN EXPRESSION IN PLANTS 审中-公开
标题翻译： ANGIOGENIN在植物中的表达
公开(公告)号：WO2011060490A1
公开(公告)日：2011-05-26
申请号：PCT/AU2010/001543
申请日：2010-11-18
申请人： AGRICULTURE VICTORIA SERVICES PTY LTD , SPANGENBERG, German , MOURADOV, Aidyn , WANG, Jianghui , COCKS, Benjamin Graeme , KNIGHT, Matthew , MCDONAGH, Matthew
发明人： SPANGENBERG, German , MOURADOV, Aidyn , WANG, Jianghui , COCKS, Benjamin Graeme , KNIGHT, Matthew , MCDONAGH, Matthew
IPC分类号： A01H4/00 , C07K4/10 , A01H5/00 , C12N15/05
CPC分类号： C12N9/22 , C12N15/8257
摘要： The present invention relates to plant-produced angiogenins, to related plant cells, plant calli, plants, seeds and other plant parts and products derived therefrom and to uses of plant-produced angiogenins. The present invention also relates to expression of angiogenin genes in plants and to related nucleic acids, constructs and methods.
摘要翻译：本发明涉及植物产生的血管生成素，相关植物细胞，植物愈伤组织，植物，种子和其它植物部分以及由其衍生的产品以及植物产生的血管生成素的用途。本发明还涉及血管生成素基因在植物中以及相关核酸，构建体和方法中的表达。

4. 发明申请

WO1997024441A1 NUCLEIC ACIDS ENCODING INTERFERON GAMMA INDUCING FACTOR-2 审中-公开
标题翻译：核酸编码干扰素诱导因子-2
公开(公告)号：WO1997024441A1
公开(公告)日：1997-07-10
申请号：PCT/US1996020432
申请日：1996-12-20
申请人： INCYTE PHARMACEUTICALS, INC. , COLEMAN, Roger , COCKS, Benjamin, Graeme , HAWKINS, Phillip, R.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/19
CPC分类号： C07K14/54 , A61K48/00
摘要： The present invention provides a polynucleotide (igif-2) which identifies and encodes a novel interferon gamma inducing factor-2 (IGIF-2) which was expressed in adenoid, brain, kidney, liver, lung, skin, synovium, and T-lymphocytes. The present invention also provides for antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified IGIF-2; antibodies, antagonists and inhibitors; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, antagonists and inhibitors. The invention specifically provides for use of the polypeptide as therapeutic for immuno-compromised individuals and as a positive control in diagnostic assays for the detection of aberrant IGIF-2 expression or altered leukocyte or lymphocyte activity.
摘要翻译：本发明提供了鉴定和编码在腺样体，脑，肾，肝，肺，皮肤，滑膜和T淋巴细胞中表达的新型干扰素γ诱导因子-2（IGIF-2）的多核苷酸（igif-2）。本发明还提供了反义分子。本发明进一步提供用于产生纯化的IGIF-2的遗传工程表达载体和宿主细胞; 抗体，拮抗剂和抑制剂; 以及基于多肽，其抗体，拮抗剂和抑制剂的药物组合物和治疗方法。本发明特别提供多肽作为免疫受损个体的治疗剂的用途，以及用于检测异常IGIF-2表达或改变的白细胞或淋巴细胞活性的诊断测定中的阳性对照。

5. 发明申请

WO9735989A3 Cyclic nucleotide phosphodiesterase 审中-公开
标题翻译：环核苷酸磷酸二酯酶
公开(公告)号：WO9735989A3
公开(公告)日：1997-10-30
申请号：PCT/US9704717
申请日：1997-03-20
申请人： INCYTE PHARMA INC , AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , COLEMAN ROGER , SEILHAMER JEFFREY J
发明人： AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , COLEMAN ROGER , SEILHAMER JEFFREY J
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K45/00 , A61P29/00 , C07K16/40 , C12N9/16 , C12N15/12 , C12N15/55 , C12Q1/44 , C12Q1/68 , A61K35/00 , C12N15/63
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention relates to a family of cyclic nucleotide phosphodiesterases (CN PCD8) and provides specific polynucleotide and amino acid sequences which encode and identify CN PDE8 family members designated herein as CN PDE8A and CN PDE8B. The present invention also relates to the use of proteins, peptides and organic molecules capable of modulating CN PDE8 activity to inhibit or enhance phosphodiesterase activity associated with disease. The present invention further relates to the use of CN PDE8 and genetically engineered host cells that express CN PDE8 to evaluate and screen for substances and compounds that modulate cyclic nucleotide phosphodiesterase activity. The present invention also provides for cn pde8 antisense molecules. The invention provides genetically engineered expression vectors and host cells for the production of purified CN PDE8 polypeptide. The present invention further provides pharmaceutical compositions and methods of treatment based on the identification of agonist, antagonists and inhibitors of CN PDE8. The invention specifically provides for use of the cn pde8 polynucleotide sequences as a diagnostic composition for the detection of disease.

6. 发明申请

WO9802456A3 HUMAN C-TYPE LECTIN 审中-公开
标题翻译：人C型LECTIN
公开(公告)号：WO9802456A3
公开(公告)日：2002-10-17
申请号：PCT/US9712342
申请日：1997-07-15
申请人： INCYTE PHARMA INC , AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , GOLI SURYA K , HILLMAN JENNIFER L
发明人： AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , GOLI SURYA K , HILLMAN JENNIFER L
IPC分类号： A61K38/00 , C07K14/47 , C12N15/54 , C12N1/21 , C12N9/12 , C12N15/70
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides a polynucleotide (mctl) which identifies and encodes a novel human C-type lectin (MCTL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding MCTL. The invention also provides for the use of substantially purified MCTL and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of MCTL. Additionally, the invention provides for the use of antisense molecules to mctl in pharmaceutical compositions for treatment of diseases associated with the expression of MCTL. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of mctl. The present invention also relates to anti-MCTL antibodies which specifically bind to MCTL.
摘要翻译：本发明提供鉴定和编码新型人C型凝集素（MCTL）的多核苷酸（mct1）。本发明提供了包含编码MCTL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在商业生产重组蛋白质和用于治疗与MCTL表达相关的疾病的药物组合物中使用基本上纯化的MCTL及其激动剂。另外，本发明提供了用于治疗与MCTL表达相关的疾病的药物组合物中的mct1的反义分子的用途。本发明还描述了使用包含与mct1的基因组序列或转录物杂交的多核苷酸，其片段或其互补体的诊断组合物的诊断测定法。本发明还涉及特异性结合MCTL的抗MCTL抗体。

7. 发明申请

WO1998014619A1 METHODS FOR GENERATING AND ANALYZING TRANSCRIPT MARKERS 审中-公开
标题翻译：生成和分析转录标记的方法
公开(公告)号：WO1998014619A1
公开(公告)日：1998-04-09
申请号：PCT/US1997018344
申请日：1997-10-03
申请人： INCYTE PHARMACEUTICALS, INC. , WANG, Bruce, B. , CHUNG, Alicia , GUEGLER, Karl, J. , YANG, Zhi , COCKS, Benjamin, Graeme , STUART, Susan, G.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12Q01/68
CPC分类号： C12N15/66 , C12N15/1096
摘要： The present invention relates generally to the field of molecular biology and specifically to rapid, high-throughput gene discovery methods that facilitate genome closure and to methods for analyzing gene expression patterns. The present invention provides methods and vectors useful for constructing libraries of transcript markers. The present invention also provides sequence specific methods for extending the nucleotide sequence of partial transcripts in a high-throughput manner using polymerase chain reaction.
摘要翻译：本发明一般涉及分子生物学领域，特别涉及促进基因组闭合的快速，高通量基因发现方法和用于分析基因表达模式的方法。本发明提供了用于构建转录物标记库的方法和载体。本发明还提供了使用聚合酶链反应以高通量方式扩展部分转录物的核苷酸序列的序列特异性方法。

8. 发明申请

WO1997030157A1 NOVEL HUMAN MYELOID TERMINAL DIFFERENTIATION RESPONSE GENE 审中-公开
标题翻译：新型人牙ID ID AL AL ATION SE SE SE SE。。。。
公开(公告)号：WO1997030157A1
公开(公告)日：1997-08-21
申请号：PCT/US1997002458
申请日：1997-02-14
申请人： INCYTE PHARMACEUTICALS, INC. , COCKS, Benjamin, Graeme , AU-YOUNG, Janice , SEILHAMER, Jeffrey, J.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/19
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for MYD118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 polypeptide. The invention specifically provides for use of the MYD118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide and amino acid sequences for MYD118. The invention further provides antibodies which specifically bind to MYD118.
摘要翻译：本发明提供编码和鉴定指定为MYD118的新型人骨髓末端分化应答基因的多核苷酸和氨基酸序列。本发明还提供MYD118反义分子。本发明进一步提供用于产生纯化的MYD118多肽的遗传工程表达载体和宿主细胞; 抗体，拮抗剂和MYD118多肽的抑制剂; 以及基于编码MYD118多肽的多核苷酸序列的药物组合物和治疗方法。本发明特别提供MYD118多核苷酸序列用作检测骨髓增生性疾病和白血病的诊断组合物。本发明还涉及基于MYD118的核苷酸和氨基酸序列的治疗方法和组合物。本发明进一步提供特异性结合MYD118的抗体。

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