专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997024441A1 NUCLEIC ACIDS ENCODING INTERFERON GAMMA INDUCING FACTOR-2 审中-公开
标题翻译：核酸编码干扰素诱导因子-2
公开(公告)号：WO1997024441A1
公开(公告)日：1997-07-10
申请号：PCT/US1996020432
申请日：1996-12-20
申请人： INCYTE PHARMACEUTICALS, INC. , COLEMAN, Roger , COCKS, Benjamin, Graeme , HAWKINS, Phillip, R.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/19
CPC分类号： C07K14/54 , A61K48/00
摘要： The present invention provides a polynucleotide (igif-2) which identifies and encodes a novel interferon gamma inducing factor-2 (IGIF-2) which was expressed in adenoid, brain, kidney, liver, lung, skin, synovium, and T-lymphocytes. The present invention also provides for antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified IGIF-2; antibodies, antagonists and inhibitors; and pharmaceutical compositions and methods of treatment based on the polypeptide, its antibodies, antagonists and inhibitors. The invention specifically provides for use of the polypeptide as therapeutic for immuno-compromised individuals and as a positive control in diagnostic assays for the detection of aberrant IGIF-2 expression or altered leukocyte or lymphocyte activity.
摘要翻译：本发明提供了鉴定和编码在腺样体，脑，肾，肝，肺，皮肤，滑膜和T淋巴细胞中表达的新型干扰素γ诱导因子-2（IGIF-2）的多核苷酸（igif-2）。本发明还提供了反义分子。本发明进一步提供用于产生纯化的IGIF-2的遗传工程表达载体和宿主细胞; 抗体，拮抗剂和抑制剂; 以及基于多肽，其抗体，拮抗剂和抑制剂的药物组合物和治疗方法。本发明特别提供多肽作为免疫受损个体的治疗剂的用途，以及用于检测异常IGIF-2表达或改变的白细胞或淋巴细胞活性的诊断测定中的阳性对照。

2. 发明申请

WO1997035989A2 CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 审中-公开
标题翻译：循环核酸磷酸酯酶
公开(公告)号：WO1997035989A2
公开(公告)日：1997-10-02
申请号：PCT/US1997004717
申请日：1997-03-20
申请人： INCYTE PHARMACEUTICALS, INC. , AU-YOUNG, Janice , COCKS, Benjamin, Graeme , COLEMAN, Roger , SEILHAMER, Jeffrey, J.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/55
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention relates to a family of cyclic nucleotide phosphodiesterases (CN PCD8) and provides specific polynucleotide and amino acid sequences which encode and identify CN PDE8 family members designated herein as CN PDE8A and CN PDE8B. The present invention also relates to the use of proteins, peptides and organic molecules capable of modulating CN PDE8 activity to inhibit or enhance phosphodiesterase activity associated with disease. The present invention further relates to the use of CN PDE8 and genetically engineered host cells that express CN PDE8 to evaluate and screen for substances and compounds that modulate cyclic nucleotide phosphodiesterase activity. The present invention also provides for cn pde8 antisense molecules. The invention provides genetically engineered expression vectors and host cells for the production of purified CN PDE8 polypeptide. The present invention further provides pharmaceutical compositions and methods of treatment based on the identification of agonist, antagonists and inhibitors of CN PDE8. The invention specifically provides for use of the cn pde8 polynucleotide sequences as a diagnostic composition for the detection of disease.
摘要翻译：本发明涉及一种环状核苷酸磷酸二酯酶（CN PCD8），并提供编码和鉴定CN PDE8家族成员CN PDE8A和CN PDE8B的特异性多核苷酸和氨基酸序列。本发明还涉及能够调节CN PDE8活性以抑制或增强与疾病相关的磷酸二酯酶活性的蛋白质，肽和有机分子的用途。本发明还涉及CN PDE8和表达CN PDE8的遗传工程宿主细胞的用途，以评估和筛选调节环核苷酸磷酸二酯酶活性的物质和化合物。本发明还提供了cn pde8反义分子。本发明提供用于产生纯化的CN PDE8多肽的遗传工程表达载体和宿主细胞。本发明还提供了基于鉴定CN PDE8的激动剂，拮抗剂和抑制剂的药物组合物和治疗方法。本发明特别提供了使用cn pde8多核苷酸序列作为疾病检测的诊断组合物。

3. 发明申请

WO1998014619A1 METHODS FOR GENERATING AND ANALYZING TRANSCRIPT MARKERS 审中-公开
标题翻译：生成和分析转录标记的方法
公开(公告)号：WO1998014619A1
公开(公告)日：1998-04-09
申请号：PCT/US1997018344
申请日：1997-10-03
申请人： INCYTE PHARMACEUTICALS, INC. , WANG, Bruce, B. , CHUNG, Alicia , GUEGLER, Karl, J. , YANG, Zhi , COCKS, Benjamin, Graeme , STUART, Susan, G.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12Q01/68
CPC分类号： C12N15/66 , C12N15/1096
摘要： The present invention relates generally to the field of molecular biology and specifically to rapid, high-throughput gene discovery methods that facilitate genome closure and to methods for analyzing gene expression patterns. The present invention provides methods and vectors useful for constructing libraries of transcript markers. The present invention also provides sequence specific methods for extending the nucleotide sequence of partial transcripts in a high-throughput manner using polymerase chain reaction.
摘要翻译：本发明一般涉及分子生物学领域，特别涉及促进基因组闭合的快速，高通量基因发现方法和用于分析基因表达模式的方法。本发明提供了用于构建转录物标记库的方法和载体。本发明还提供了使用聚合酶链反应以高通量方式扩展部分转录物的核苷酸序列的序列特异性方法。

4. 发明申请

WO1997030157A1 NOVEL HUMAN MYELOID TERMINAL DIFFERENTIATION RESPONSE GENE 审中-公开
标题翻译：新型人牙ID ID AL AL ATION SE SE SE SE。。。。
公开(公告)号：WO1997030157A1
公开(公告)日：1997-08-21
申请号：PCT/US1997002458
申请日：1997-02-14
申请人： INCYTE PHARMACEUTICALS, INC. , COCKS, Benjamin, Graeme , AU-YOUNG, Janice , SEILHAMER, Jeffrey, J.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/19
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for MYD118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 polypeptide. The invention specifically provides for use of the MYD118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide and amino acid sequences for MYD118. The invention further provides antibodies which specifically bind to MYD118.
摘要翻译：本发明提供编码和鉴定指定为MYD118的新型人骨髓末端分化应答基因的多核苷酸和氨基酸序列。本发明还提供MYD118反义分子。本发明进一步提供用于产生纯化的MYD118多肽的遗传工程表达载体和宿主细胞; 抗体，拮抗剂和MYD118多肽的抑制剂; 以及基于编码MYD118多肽的多核苷酸序列的药物组合物和治疗方法。本发明特别提供MYD118多核苷酸序列用作检测骨髓增生性疾病和白血病的诊断组合物。本发明还涉及基于MYD118的核苷酸和氨基酸序列的治疗方法和组合物。本发明进一步提供特异性结合MYD118的抗体。

5. 发明申请

WO1998025956A2 NOVEL HUMAN GTP-BINDING PROTEINS 审中-公开
标题翻译：新型人GTP结合蛋白
公开(公告)号：WO1998025956A2
公开(公告)日：1998-06-18
申请号：PCT/US1997022317
申请日：1997-12-08
申请人： INCYTE PHARMACEUTICALS, INC. , HILLMAN, Jennifer, L. , BANDMAN, Olga , HAWKINS, Phillip, R. , GOLI, Surya, K.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C07K14/00
CPC分类号： C07K14/4722 , A61K38/00
摘要： The present invention provides three novel GTP-binding proteins (designated individually as BND-1, BND-2, and BND-3, and collectively as BND) and polynucleotides which identify and encode BND. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding BND and a method for producing BND. The invention also provides for use of BND and agonists, antibodies, or antagonists specifically binding BND, in the prevention and treatment of diseases associated with expression of BND. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding BND for the treatment of diseases associated with the expression of BND. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding BND.
摘要翻译：本发明提供了三种新型GTP结合蛋白（分别命名为BND-1，BND-2和BND-3，共同为BND）和鉴定和编码BND的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码BND的核酸序列和生产BND的方法。本发明还提供使用BND和特异性结合BND的激动剂，抗体或拮抗剂来预防和治疗与BND表达相关的疾病。另外，本发明提供反义分子用于编码BND的多核苷酸用于治疗与BND表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合BND的抗体的诊断测定法。

6. 发明申请

WO1998011232A2 HUMAN NM23-LIKE PROTEIN 审中-公开
标题翻译：人类NM23样蛋白
公开(公告)号：WO1998011232A2
公开(公告)日：1998-03-19
申请号：PCT/US1997016173
申请日：1997-09-12
申请人： INCYTE PHARMACEUTICALS, INC. , BANDMAN, Olga , HAWKINS, Phillip, R.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/52
CPC分类号： C12N9/12 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and for a method for producing the protein. The invention also provides for the use of substantially purified H-nm23 for the treatment of diseases associated with the expression of H-nm23. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding H-nm23 and antibodies which specifically bind to the protein.
摘要翻译：鉴定和编码一种新的nm23型人类蛋白质（H-nm23）的多核苷酸。包含编码感兴趣蛋白质的核苷酸序列的表达载体和重组宿主细胞，以及制备该蛋白质的方法。还描述了基本上纯化的H-nm23蛋白用于治疗与该蛋白表达相关的疾病的用途。描述了使用诊断组合物的诊断测试，所述诊断组合物包括能够与编码H-nm23蛋白质的天然序列杂交的多核苷酸，以及此外特异性结合蛋白质的抗体。

7. 发明申请

WO1998006846A1 HUMAN INDUCED TUMOR PROTEIN 审中-公开
标题翻译：人类诱导的肿瘤蛋白
公开(公告)号：WO1998006846A1
公开(公告)日：1998-02-19
申请号：PCT/US1997014378
申请日：1997-08-14
申请人： INCYTE PHARMACEUTICALS, INC. , AU-YOUNG, Janice , HAWKINS, Phillip, R.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/12
CPC分类号： C07K14/4702 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a human induced tumor protein (HITP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HITP. The invention also provides for the production and use of substantially purified HITP in pharmaceutical compositions to force differentiation and to stop cell division in cancerous cells. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HITP and the anti-HITP antibodies which specifically bind to HITP.
摘要翻译：本发明提供鉴定和编码人诱导的肿瘤蛋白（HITP）的多核苷酸。本发明提供了包含编码HITP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供在药物组合物中生产和使用基本上纯化的HITP以强制分化并停止癌细胞中的细胞分裂。本发明还描述了利用多核苷酸与编码HITP的转录物和特异性结合HITP的抗HITP抗体杂交的诊断测定法。

8. 发明申请

WO1997039126A1 NOVEL RANTES HOMOLOG FROM PROSTATE 审中-公开
标题翻译：新兴的RANTES HOMOLOG从PROSTATE
公开(公告)号：WO1997039126A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006249
申请日：1997-04-14
申请人： INCYTE PHARMACEUTICALS, INC. , HAWKINS, Phillip, R. , BANDMAN, Olga , MURRY, Lynn, E.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/19
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog (PTEC). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多核苷酸（PTEC），该文库鉴定并编码新的人类群同系物（PTEC）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

9. 发明申请

WO1996016979A1 EXPRESSED CHEMOKINES, THEIR PRODUCTION AND USES 审中-公开
标题翻译：表现的化学品，其生产和用途
公开(公告)号：WO1996016979A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015484
申请日：1995-11-29
申请人： INCYTE PHARMACEUTICALS, INC. , WILDE, Craig, G. , HAWKINS, Phillip, R. , BANDMAN, Olga , SEILHAMER, Jeffrey, J. , NEOTE, Kuldeep, Singh
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C07K01/00
CPC分类号： C07K14/715 , C07K14/523 , C07K16/24 , C07K2319/00 , C12N2799/026 , C12Q1/6876 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also provides for antisense molecules to the nucleotide sequences which encode ECs, expression vectors for the production of purified ECs, antibodies capable of binding specifically to ECs, hybridization probes or oligonucleotides for the detection of EC-encoding nucleotide sequences, genetically engineered host cells for the expression of ECs, diagnostic tests for inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs, pharmaceutical compositions to treat inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs.
摘要翻译：本发明提供鉴定和编码来自肝脏和垂体腺组织的新型表达趋化因子（EC）的核苷酸和氨基酸序列。本发明还提供编码EC的核苷酸序列的反义分子，用于产生纯化的EC的表达载体，能够特异性结合EC的抗体，用于检测编码EC编码的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达EC的细胞，基于EC编码核酸分子或能够特异性结合EC的抗体的炎症或疾病的诊断性测试，基于EC编码核酸分子或能够结合的抗体治疗炎症或疾病的药物组合物特别是EC。

10. 发明申请

WO1998006840A1 NOVEL HUMAN GLYCOPROTEIN 审中-公开
标题翻译：新型人造蛋白
公开(公告)号：WO1998006840A1
公开(公告)日：1998-02-19
申请号：PCT/US1997013078
申请日：1997-07-22
申请人： INCYTE PHARMACEUTICALS, INC. , BANDMAN, Olga , AU-YOUNG, Janice , HAWKINS, Phillip, R. , HILLMAN, Jennifer, L.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/12
CPC分类号： C07K14/705 , A61K38/00 , Y02A50/465
摘要： The present invention provides polynucleotides which identify and encode a novel human glycoprotein (SC2H). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding SC2H. The invention also provides for the use of substantially purified SC2H and its agonists in the commercial production of recombinant proteins for the treatment of diseases associated with the expression of SC2H. Additionally, the invention provides for the use of antisense molecules to SC2H in the treatment of diseases associated with the expression of SC2H. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotides which hybridize with naturally occurring sequences encoding SC2H and antibodies which specifically bind to the protein.
摘要翻译：本发明提供鉴定和编码新型人糖蛋白（SC2H）的多核苷酸。本发明提供了包含编码SC2H的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了在商业生产重组蛋白质中用于治疗与SC2H表达相关的疾病的基本纯化的SC2H及其激动剂的用途。另外，本发明提供了用于治疗与SC2H表达相关的疾病的SC2H反义分子的用途。本发明还描述了利用包含与编码SC2H的天然存在的序列和特异性结合蛋白质的抗体杂交的多核苷酸的诊断组合物的诊断测定法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式