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1. 发明申请

WO0012760A3 TOXICOLOGICAL RESPONSE MARKERS 审中-公开
标题翻译：毒理学反应标记
公开(公告)号：WO0012760A3
公开(公告)日：2000-08-03
申请号：PCT/US9919768
申请日：1999-08-27
申请人： INCYTE PHARMA INC , CUNNINGHAM MARY JANE , ZWEIGER GARY B , PANZER SCOTT R , SEILHAMER JEFFREY J
发明人： CUNNINGHAM MARY JANE , ZWEIGER GARY B , PANZER SCOTT R , SEILHAMER JEFFREY J
IPC分类号： G01N33/50 , C12N15/09 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6809
摘要： The present invention relates to a composition comprising a plurality of nucleic acid molecules. The composition can be used as hybridizable array elements in a microarray. The present invention also relates to methods for screening compounds and therapeutics for metabolic responses indicative of a toxic compound.
摘要翻译：本发明涉及包含多个核酸分子的组合物。该组合物可用作微阵列中的可杂交阵列元件。本发明还涉及用于筛选化合物和治疗剂用于指示有毒化合物的代谢反应的方法。

2. 发明申请

WO0177389A3 GENES EXPRESSED IN FOAM CELL DIFFERENTIATION 审中-公开
标题翻译：基因表达在泡沫细胞分化中
公开(公告)号：WO0177389A3
公开(公告)日：2003-04-24
申请号：PCT/US0111128
申请日：2001-04-04
申请人： INCYTE GENOMICS INC , SHIFFMAN DOV , SOMOGYI ROLAND , LAWN RICHARD , SEILHAMER JEFFREY J , PORTER GORDON J , MIKITA THOMAS , TAI JULIE
发明人： SHIFFMAN DOV , SOMOGYI ROLAND , LAWN RICHARD , SEILHAMER JEFFREY J , PORTER GORDON J , MIKITA THOMAS , TAI JULIE
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P9/10 , C07K14/47 , C07K16/18 , C12M1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q2600/158
摘要： The present invention relates to purified polynucleotides and compositions comprising pluralities of polynucleotides that are differentially expressed during foam cell development and are associated with atherosclerosis. The present invention presents the use of the compositions as elements on a substrate, and provides methods for using the compositions and polynucleotides.
摘要翻译：本发明涉及纯化的多核苷酸和包含多个多核苷酸的组合物，其在泡沫细胞发育过程中差异表达并与动脉粥样硬化相关。本发明提供了组合物作为底物上的元素的用途，并提供了使用组合物和多核苷酸的方法。

3. 发明申请

WO1997030157A1 NOVEL HUMAN MYELOID TERMINAL DIFFERENTIATION RESPONSE GENE 审中-公开
标题翻译：新型人牙ID ID AL AL ATION SE SE SE SE。。。。
公开(公告)号：WO1997030157A1
公开(公告)日：1997-08-21
申请号：PCT/US1997002458
申请日：1997-02-14
申请人： INCYTE PHARMACEUTICALS, INC. , COCKS, Benjamin, Graeme , AU-YOUNG, Janice , SEILHAMER, Jeffrey, J.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/19
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention provides polynucleotide and amino acid sequences which encode and identify a novel human myeloid terminal differentiation response gene designated MYD118. The present invention also provides for MYD118 antisense molecules. The invention further provides genetically engineered expression vectors and host cells for the production of purified MYD118 polypeptide; antibodies, antagonists and inhibitors of MYD118 polypeptide; and pharmaceutical compositions and methods of treatment based on polynucleotide sequences encoding MYD118 polypeptide. The invention specifically provides for use of the MYD118 polynucleotide sequences as a diagnostic composition for the detection of myeloproliferative diseases and leukemias. The invention also relates to therapeutic methods and compositions based upon the nucleotide and amino acid sequences for MYD118. The invention further provides antibodies which specifically bind to MYD118.
摘要翻译：本发明提供编码和鉴定指定为MYD118的新型人骨髓末端分化应答基因的多核苷酸和氨基酸序列。本发明还提供MYD118反义分子。本发明进一步提供用于产生纯化的MYD118多肽的遗传工程表达载体和宿主细胞; 抗体，拮抗剂和MYD118多肽的抑制剂; 以及基于编码MYD118多肽的多核苷酸序列的药物组合物和治疗方法。本发明特别提供MYD118多核苷酸序列用作检测骨髓增生性疾病和白血病的诊断组合物。本发明还涉及基于MYD118的核苷酸和氨基酸序列的治疗方法和组合物。本发明进一步提供特异性结合MYD118的抗体。

4. 发明申请

WO1996022374A1 A NEW CHEMOKINE EXPRESSED IN FETAL SPLEEN, ITS PRODUCTION AND USES 审中-公开
标题翻译：一个新的CHEMOKINE表达在田间，它的生产和用途
公开(公告)号：WO1996022374A1
公开(公告)日：1996-07-25
申请号：PCT/US1996000920
申请日：1996-01-19
申请人： INCYTE PHARMACEUTICALS, INC. , COLEMAN, Roger , WILDE, Craig, G. , SEILHAMER, Jeffrey, J.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12N15/19
CPC分类号： C07K14/523 , C07K2319/00 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel chemokine (FSEC) initially found in human fetal spleen cells. The present invention also provides for antisense molecules to the nucleotide sequences which encode FSEC, expression vectors for the production of purified FSEC, antibodies capable of binding specifically to FSEC, hybridization probes or oligonucleotides for the detection of FSEC-encoding nucleotide sequences, genetically engineered host cells for the expression of FSEC, diagnostic tests for chemokine activation based on FSEC-encoding nucleic acid molecules and antibodies capable of binding specifically to FSEC.
摘要翻译：本发明提供鉴定和编码最初在人胎儿脾细胞中发现的新趋化因子（FSEC）的核苷酸和氨基酸序列。本发明还提供编码FSEC的核苷酸序列的反义分子，用于产生纯化的FSEC的表达载体，能够特异性结合FSEC的抗体，用于检测编码FSEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达FSEC的细胞，基于编码FSEC的核酸分子和能够特异性结合FSEC的抗体的趋化因子激活的诊断试验。

5. 发明申请

WO0132927A3 TISSUE SPECIFIC GENES OF DIAGNOSTIC IMPORT 审中-公开
标题翻译：诊断进口组织特异性基因
公开(公告)号：WO0132927A3
公开(公告)日：2002-08-15
申请号：PCT/US0030396
申请日：2000-11-02
申请人： INCYTE GENOMICS INC , SORNASSE THIERRY , SEILHAMER JEFFREY J , WATSON GEORGE A
发明人： SORNASSE THIERRY , SEILHAMER JEFFREY J , WATSON GEORGE A
IPC分类号： G01N33/50 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to a composition comprising a plurality of polynucleotides which are cell and/or tissue specific and which may be used in their entirety or in part as references in producing an expression profile that defines a metabolic or developmental process, treatment, condition, disease, or disorder.
摘要翻译：本发明涉及一种组合物，其包含多个多核苷酸，其是细胞和/或组织特异性的，并且可以全部或部分地用作产生限定代谢或发育过程，治疗，病症，疾病或障碍。

6. 发明申请

WO0136684A2 MAMMALIAN TOXICOLOGICAL RESPONSE MARKERS 审中-公开
标题翻译：妈妈毒理学反应标记
公开(公告)号：WO0136684A2
公开(公告)日：2001-05-25
申请号：PCT/US0031743
申请日：2000-11-16
申请人： INCYTE GENOMICS INC , CUNNINGHAM MARY JANE , ZWEIGER GARY B , KASER MATTHEW R , PANZER SCOTT R , SEILHAMER JEFFREY J , YUE HENRY , BAUGHN MARIAH R , AZIMZAI YALDA , LAL PREETI
发明人： CUNNINGHAM MARY JANE , ZWEIGER GARY B , KASER MATTHEW R , PANZER SCOTT R , SEILHAMER JEFFREY J , YUE HENRY , BAUGHN MARIAH R , AZIMZAI YALDA , LAL PREETI
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/16 , A61P3/06 , A61P13/12 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： C12Q1/6883 , C12Q1/6876 , C12Q2600/158
摘要： The present invention relates to mammalian nucleic acid and protein molecules comprising a plurality of nucleic acid and protein molecules. The mammalian nucleic acid molecules can be used as hybridizable array elements in a microarray in diagnostic and therapeutic applications including detecting metabolic and toxicological responses, and in monitoring drug mechanism of action. The protein molecules can be used in a pharmaceutical composition. The present invention also relates to methods for screening compounds and therapeutics for metabolic responses indicative of a toxic compound or molecule.
摘要翻译：本发明涉及包含多个核酸和蛋白质分子的哺乳动物核酸和蛋白质分子。哺乳动物核酸分子可以在诊断和治疗应用中用作微阵列中的可杂交阵列元件，包括检测代谢和毒理反应，以及监测药物作用机制。蛋白质分子可以用于药物组合物中。本发明还涉及用于筛选指示有毒化合物或分子的代谢反应的化合物和治疗剂的方法。

7. 发明申请

WO9808535A3 Method of causing selective immunosuppression using HL-60-related lectins 审中-公开
标题翻译：使用HL-60相关凝集素引起选择性免疫抑制的方法
公开(公告)号：WO9808535A3
公开(公告)日：1998-05-28
申请号：PCT/US9715016
申请日：1997-08-26
申请人： INCYTE PHARMA INC , UNIV CALIFORNIA , BAUM LINDA G , PERILLO NANCY L , SEILHAMER JEFFREY J
发明人： BAUM LINDA G , PERILLO NANCY L , SEILHAMER JEFFREY J
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , A61K39/395
CPC分类号： C07K14/4726 , A61K38/1709 , A61K2300/00
摘要： The invention provides methods of treating a neoplastic disease characterized by proliferation of lymphocytes by administering pharmaceutical compositions comprising a soluble lectin having a molecular weight of about 14 kilodaltons. In addition, methods of treating a lectin-producing tumor by administering an effective amount of an antibody that specifically binds the lectin, lectin antagonists, inhibitory saccharides, or glycosylation inhibitors in order to prevent lectin-induced apoptosis of tumor-infiltrating T cells.

8. 发明申请

WO0177174A3 HUMAN TRANSPORTERS AND ION CHANNELS 审中-公开
标题翻译：人类运输和离子通道
公开(公告)号：WO0177174A3
公开(公告)日：2002-10-10
申请号：PCT/US0111206
申请日：2001-04-06
申请人： INCYTE GENOMICS INC , REDDY ROOPA , THORNTON MICHAEL , BOROWSKY MARK L , TANG Y TOM , KHAN FARRAH A , TRIBOULEY CATHERINE M , GANDHI AMEENA R , YAO MONIQUE G , SANJANWALA MADHU S , BAUGHN MARIAH R , NGUYEN DANNIEL B , POLICKY JENNIFER L , YUE HENRY , SEILHAMER JEFFREY J , WALIA NARINDER K , LAL PREETI , KEARNEY LIAM , WALSH RODERICK T , LU DYUNG AINA M , LU YAN , GREENE BARRIE D , RAUMANN BRIGITTE E , PATTERSON CHANDRA
发明人： REDDY ROOPA , THORNTON MICHAEL , BOROWSKY MARK L , TANG Y TOM , KHAN FARRAH A , TRIBOULEY CATHERINE M , GANDHI AMEENA R , YAO MONIQUE G , SANJANWALA MADHU S , BAUGHN MARIAH R , NGUYEN DANNIEL B , POLICKY JENNIFER L , YUE HENRY , SEILHAMER JEFFREY J , WALIA NARINDER K , LAL PREETI , KEARNEY LIAM , WALSH RODERICK T , LU DYUNG AINA M , LU YAN , GREENE BARRIE D , RAUMANN BRIGITTE E , PATTERSON CHANDRA
IPC分类号： G01N33/50 , A61K38/00 , A61K45/00 , A61K49/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/06 , A61P3/08 , A61P3/10 , A61P3/12 , A61P5/14 , A61P5/38 , A61P7/00 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/06 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/12 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/46 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A01K67/027 , A61K38/16 , A61K39/00 , C12N15/12
CPC分类号： C07K14/705
摘要： The invention provides human transporters and ion channels (TRICH) and polynucleotides which identify and encode TRICH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of TRICH.
摘要翻译：本发明提供了识别和编码TRICH的人转运体和离子通道（TRICH）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与TRICH异常表达相关的紊乱的方法。

9. 发明申请

WO9735989A3 Cyclic nucleotide phosphodiesterase 审中-公开
标题翻译：环核苷酸磷酸二酯酶
公开(公告)号：WO9735989A3
公开(公告)日：1997-10-30
申请号：PCT/US9704717
申请日：1997-03-20
申请人： INCYTE PHARMA INC , AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , COLEMAN ROGER , SEILHAMER JEFFREY J
发明人： AU-YOUNG JANICE , COCKS BENJAMIN GRAEME , COLEMAN ROGER , SEILHAMER JEFFREY J
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K45/00 , A61P29/00 , C07K16/40 , C12N9/16 , C12N15/12 , C12N15/55 , C12Q1/44 , C12Q1/68 , A61K35/00 , C12N15/63
CPC分类号： C12N9/16 , A61K38/00
摘要： The present invention relates to a family of cyclic nucleotide phosphodiesterases (CN PCD8) and provides specific polynucleotide and amino acid sequences which encode and identify CN PDE8 family members designated herein as CN PDE8A and CN PDE8B. The present invention also relates to the use of proteins, peptides and organic molecules capable of modulating CN PDE8 activity to inhibit or enhance phosphodiesterase activity associated with disease. The present invention further relates to the use of CN PDE8 and genetically engineered host cells that express CN PDE8 to evaluate and screen for substances and compounds that modulate cyclic nucleotide phosphodiesterase activity. The present invention also provides for cn pde8 antisense molecules. The invention provides genetically engineered expression vectors and host cells for the production of purified CN PDE8 polypeptide. The present invention further provides pharmaceutical compositions and methods of treatment based on the identification of agonist, antagonists and inhibitors of CN PDE8. The invention specifically provides for use of the cn pde8 polynucleotide sequences as a diagnostic composition for the detection of disease.

10. 发明申请

WO1996023078A1 COMPUTER SYSTEM STORING AND ANALYZING MICROBIOLOGICAL DATA 审中-公开
标题翻译：计算机系统存储和分析微生物数据
公开(公告)号：WO1996023078A1
公开(公告)日：1996-08-01
申请号：PCT/US1995012429
申请日：1995-09-06
申请人： INCYTE PHARMACEUTICALS, INC. , SEILHAMER, Jeffrey, J. , DELEGEANE, Angelo , SCOTT, Randal, W.
发明人： INCYTE PHARMACEUTICALS, INC.
IPC分类号： C12Q01/68
CPC分类号： G06F19/28
摘要： A relational database (1) for the storage of microbiological information. The database contains cDNA sequencing data (290, 300) and coresponding match logs (510, 515) indicating a correlation between presently identified cDNA sequences and previously known sequences. In addition, a variety of the tables that make up the database are used to store historical data related to the identification of a particular cDNA sequence. Such tables include biological source data (130); cell culture and treatment data (140); mRNA preparation data (150); cDNA construction data (170); and clone preparation data. The clone preparation data further includes tables containing data relevant to inoculation (200), preparation (210), excision (190), and a fluorometer (220, 230, 240). The interrelated information in the database allows various queries to be used to extract data for scientific analysis and other applications. For example an abundance analysis may be performed by using the database of the preferred embodiment to determine the frequency a particular RNA transcript appears in a certain source tissue.
摘要翻译：用于存储微生物信息的关系数据库（1）。数据库包含cDNA测序数据（290,300）和相应的匹配记录（510,515），表明当前鉴定的cDNA序列与先前已知序列之间的相关性。此外，构成数据库的各种表用于存储与特定cDNA序列的鉴定有关的历史数据。这些表包括生物源数据（130）; 细胞培养和治疗数据（140）; mRNA制备数据（150）; cDNA构建数据（170）; 并克隆准备数据。克隆制备数据还包括含有与接种（200），制备（210），切除（190）和荧光计（220,230,240）相关的数据的表。数据库中的相关信息允许使用各种查询来提取科学分析和其他应用程序的数据。例如，可以通过使用优选实施方案的数据库来确定特定RNA转录物出现在某个来源组织中的频率来进行丰度分析。

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