专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007144637A1 2 -OXYHETEROARYLAMIDE DERIVATIVES AS PARP INHIBITORS 审中-公开
标题翻译：作为PARP抑制剂的2-异烟酰胺衍生物
公开(公告)号：WO2007144637A1
公开(公告)日：2007-12-21
申请号：PCT/GB2007/002229
申请日：2007-06-15
申请人： KUDOS PHARMACEUTICALS LIMITED , JAVAID, Muhammad Hashim , COCKCROFT, Xiao-Ling Fan , MENEAR, Keith Allan , MARTIN, Niall Morrison Barr
发明人： JAVAID, Muhammad Hashim , COCKCROFT, Xiao-Ling Fan , MENEAR, Keith Allan , MARTIN, Niall Morrison Barr
IPC分类号： C07D333/38 , C07D409/12 , A61K31/381
CPC分类号： C07D333/38 , C07D409/12
摘要： A compound of the formula (I): and pharmaceutically acceptable salts thereof, wherein: HetA is a C 5 arylene group, wherein the two substituent groups are on adjacent ring atoms, and where the group is further optionally substituted by one halo, amino or C 1-7 alkoxy group; Y is -CR C1 R C2 -(CH 2 ) m -, where m is 0 or 1, R C1 is selected from H, CH 3 and CF 3 , and R C2 is selected from H and CH 3 , or R C1 and R C2 together with the carbon atom to which they are attached form the 1,1-cyclopropylene group formula (A): R N1 and R N2 are independently selected from H and R, where R is optionally substituted C 1-10 alkyl, C 3-20 heterocyclyl and C 5-20 aryl; or R N1 and R N2 , together with the nitrogen atom to which they are attached form an optionally substituted 5-7 membered, nitrogen containing, heterocylic ring; HetB is selected from: (i), where Y 1 and Y 3 are independently selected from CH and N, Y 2 is selected from CX and N and X is H, Cl or F; and (ii), (aa), (bb) Q is O or S.
摘要翻译：式（I）的化合物及其药学上可接受的盐，其中：HetA是C 5亚芳基，其中两个取代基在相邻的环原子上，并且其中该基团进一步任选地被一个卤素，氨基或C 1-7烷氧基取代; 其中m是0或1，其中m是0,1或2，其中m是0或1， R C1选自H，CH 3和CF 3，R C2选自H和CH 或者它们所连接的碳原子一起形成1,1-亚环丙基基团的式（A ）：R N1和R N2独立地选自H和R，其中R是任选取代的C 1-10烷基，C _{3-20个杂环基和C 5-20-20芳基; 或R N1和R N2，以及它们所连接的氮原子一起形成任选取代的5-7元含氮杂环; HetB选自：（i）其中Y 1和Y 3独立地选自CH和N，Y 2选自CX N和X是H，Cl或F; 和（ii），（aa），（bb）Q是O或S.}

2. 发明申请

WO2006067472A1 PARP INHIBITORS 审中-公开
标题翻译： PARP抑制剂
公开(公告)号：WO2006067472A1
公开(公告)日：2006-06-29
申请号：PCT/GB2005/005017
申请日：2005-12-22
申请人： KUDOS PHARMACEUTICALS LIMITED , JAVAID, Muhammad, Hashim , SMITH, Graeme, Cameron, Murray , MARTIN, Niall, Morrison, Barr , GOMEZ, Sylvie , LOH, Vincent, Junior, Ming, Lai , COCKCROFT, Xiao-ling, Fan , MENEAR, Keith, Allan
发明人： JAVAID, Muhammad, Hashim , SMITH, Graeme, Cameron, Murray , MARTIN, Niall, Morrison, Barr , GOMEZ, Sylvie , LOH, Vincent, Junior, Ming, Lai , COCKCROFT, Xiao-ling, Fan , MENEAR, Keith, Allan
IPC分类号： C07D207/09 , C07D211/38 , C07D215/36 , C07D231/14 , C07D231/18 , C07D231/20 , C07C235/58 , C07D241/44 , C07D261/10 , A61K31/166 , A61K31/341 , A61K31/401 , A61P7/04 , A61P9/00 , A61P29/00
CPC分类号： C07C235/60 , C07C2601/08 , C07C2601/14 , C07D207/08 , C07D215/36 , C07D231/14 , C07D231/18 , C07D231/20 , C07D241/44 , C07D261/10 , C07D261/18 , C07D263/32 , C07D271/12 , C07D277/18 , C07D295/14 , C07D295/18 , C07D295/26 , C07D307/14 , C07D307/52 , C07D317/68 , C07D333/34 , C07D333/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D495/04
摘要： A compound of the formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of H, C 1-7 alkoxy, amino, halo or hydroxy; n is 1 or 2; R N1 and R N2 are independently selected from H and R, where R is optionally substituted C 1-10 alkyl, C 3-20 heterocyclyl and C 5-20 aryl; or R N1 and R N2 , together with the nitrogen atom to which they are attached form an optionally substituted 5-7 membered, nitrogen containing, heterocylic ring; Het is selected from: (i) where Y 1 and Y 3 are independently selected from CH and N, Y 2 is selected from CX and N and X is H, Cl or F; and (ii) where Q is O or S. In particular, the present invention relates to the use of these compounds to inhibit the activity of the enzyme poly (ADP-ribose)polymerase, also known as poly(ADP-ribose)synthase and poly ADP-ribosyltransferase, and commonly referred to as PARP.
摘要翻译：式（I）的化合物及其异构体，盐，溶剂化物，化学保护形式及其前药，其中：R 2，R 3，R 4 R 5和R 5独立地选自H，C 1-7烷氧基，氨基，卤素或羟基; n为1或2; R N1和R N2独立地选自H和R，其中R是任选取代的C 1-10烷基，C 3 -20个杂环基和C 5-20-20芳基; 或R N1和R N2，以及它们所连接的氮原子一起形成任选取代的5-7元含氮杂环; Het选自：（i）其中Y 1和Y 3独立地选自CH和N，Y 2选自CX和 N和X是H，Cl或F; 特别地，本发明涉及这些化合物用于抑制聚（ADP-核糖）聚合酶，也称为聚（ADP-核糖）合酶的活性的用途，聚ADP-核糖基转移酶，通常称为PARP。

3. 发明申请

WO2006021801A1 4-HETEROARYLMETHYL SUBSTITUTED PHTHALAZINONE DERIVATIVES 审中-公开
标题翻译： 4-取代甲基取代的苯乙酮衍生物
公开(公告)号：WO2006021801A1
公开(公告)日：2006-03-02
申请号：PCT/GB2005/003343
申请日：2005-08-26
申请人： KUDOS PHARMACEUTICALS LIMITED , JAVAID, Muhammad, Hashim , SMITH, Graeme, Cameron. Murray , MARTIN, Niall, Morrison, Barr , GOMEZ, Sylvie , LOH, Vincent, Junior, Ming, Lai , COCKCROFT, Xiao-Ling, Fan , FORTE, Stefano , MENEAR, Keith, Allan , MATTHEWS, Ian, Timothy, William
发明人： JAVAID, Muhammad, Hashim , SMITH, Graeme, Cameron. Murray , MARTIN, Niall, Morrison, Barr , GOMEZ, Sylvie , LOH, Vincent, Junior, Ming, Lai , COCKCROFT, Xiao-Ling, Fan , FORTE, Stefano , MENEAR, Keith, Allan , MATTHEWS, Ian, Timothy, William
IPC分类号： C07D401/06
CPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/14
摘要： A compound of formula (I): for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NR x or CR x R y ; if X=NR x then n is 1 or 2 and if X=CR x R y then n is 1; R x is selected from the group consisting of H, optionally substituted C 1-20 alkyl, C 5-20 aryl, C 3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; R y is selected from H, hydroxy, amino; or R x and R y may together form a spiro-C 3-7 cycloalkyl or heterocyclyl group; R C1 and R C2 are independently selected from the group consisting of hydrogen and C 1-4 alkyl, or when X is CR x R y , R C1 , R C2 , R x and R y , together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R 1 is selected from H and halo; and Het is selected from: (i) formula (i), where Y 1 is selected from CH and N, Y 2 is selected from CH and N, Y 3 is selected from CH, CF and N, where only one or two of Y 1 , Y 2 and Y 3 can be N; and (ii) formula (ii), where Q is O or S.
摘要翻译：式（I）的化合物：用于治疗通过抑制PARP而改善的癌症或其它疾病，其中：A和B一起表示任选取代的稠合芳环; X可以是NR 或CR x 如果X = NR ，那么n是1或2，如果X = CR x R y，那么n是1; R“X”选自H，任选取代的C 1-20烷基，C 5-20芳基，C 1-4烷基，酰基，磺酰基，酰基和磺酰基; R y选自H，羟基，氨基; 或R x和R y可以一起形成螺C 3-7环烷基或杂环基; R C1和R C2独立地选自氢和C 1-4烷基，或当X是CR 1时， R 1，X 2，R 2，...，R 2，R 2，...，与它们所连接的碳原子一起可以形成任选取代的稠合芳环; R 1选自H和卤素; Het选自：（i）式（i），其中Y 1选自CH，N，Y 2选自CH和N，Y ^{3 选自CH，CF和N，其中只有Y 1，Y 2和Y 3中的一个或者两个，可以N; 和（ii）式（ii），其中Q是O或S.}

4. 发明申请

WO2006109081A1 DNA-PK INHIBITORS 审中-公开
标题翻译： DNA-PK抑制剂
公开(公告)号：WO2006109081A1
公开(公告)日：2006-10-19
申请号：PCT/GB2006/001369
申请日：2006-04-13
申请人： KUDOS PHARMACEUTICALS LIMITED , CANCER RESEARCH TECHNOLOGY LIMITED , SMITH, Graeme, Cameron, Murray , MARTIN, Niall, Morrison, Barr , HUMMERSONE, Marc, Geoffrey , MENEAR, Keith, Allan , COCKCROFT, Xiao-Ling, Fan , FRIGERIO, Mark , GRIFFIN, Roger, John , GOLDING, Bernard, Thomas , HARDCASTLE, Ian, Robert , NEWELL, David, Richard , CALVERT, Hilary, Alan , CURTIN, Nicola, Jane , SARAVANAN, Kappusamy , DESAGE-EL MURR, Marine
发明人： SMITH, Graeme, Cameron, Murray , MARTIN, Niall, Morrison, Barr , HUMMERSONE, Marc, Geoffrey , MENEAR, Keith, Allan , COCKCROFT, Xiao-Ling, Fan , FRIGERIO, Mark , GRIFFIN, Roger, John , GOLDING, Bernard, Thomas , HARDCASTLE, Ian, Robert , NEWELL, David, Richard , CALVERT, Hilary, Alan , CURTIN, Nicola, Jane , SARAVANAN, Kappusamy , DESAGE-EL MURR, Marine
IPC分类号： C07D405/04 , C07D407/12 , C07D407/04 , C07D409/04 , C07D409/12 , C07D471/04 , A61P35/00 , A61K31/353 , A61K31/4709 , A61K31/517
CPC分类号： C07D413/00 , C07D401/14 , C07D405/04 , C07D407/04 , C07D407/14 , C07D409/04 , C07D471/04
摘要： Compounds of formula: (I) wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(=O), CH 2 and NH are disclosed for use in inhibiting DNA-PK.
摘要翻译：式（I）化合物其中A，B和D分别选自：（i）CH，NH，C; （ii）CH，N，N; 和（iii）CH，O，C; 虚线表示适当位置的两个双键; 并且其中Z选自S，O，C（= O），CH 2 N和NH，用于抑制DNA-PK。

5. 发明申请

WO2007144652A3 PARP INHIBITORS 审中-公开
标题翻译： PARP抑制剂
公开(公告)号：WO2007144652A3
公开(公告)日：2008-04-10
申请号：PCT/GB2007002247
申请日：2007-06-15
申请人： KUDOS PHARM LTD , JAVAID MUHAMMAD HASHIM , GOMEZ SYLVIE , COCKCROFT XIAO-LING FAN , MENEAR KEITH ALLAN , MARTIN NIALL MORRISON BARR
发明人： JAVAID MUHAMMAD HASHIM , GOMEZ SYLVIE , COCKCROFT XIAO-LING FAN , MENEAR KEITH ALLAN , MARTIN NIALL MORRISON BARR
IPC分类号： C07D211/08 , A61K31/166 , A61K31/4015 , A61K31/435 , A61K31/45 , A61K31/497 , A61K31/55 , C07C235/60 , C07D211/34 , C07D211/70 , C07D217/02 , C07D225/02 , C07D241/04 , C07D243/08 , C07D405/02
CPC分类号： C07D211/34 , C07C235/60 , C07D211/08 , C07D211/70 , C07D217/02 , C07D225/02 , C07D241/04 , C07D243/08 , C07D405/02
摘要： A compound of the formula (I), and pharmaceutically acceptable salts thereof, wherein: R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of H, C 1-7 alkoxy, amino, halo or hydroxy; Y is -CR C1 R C2 -(CH 2 ) m -, where m is 0 or 1, R ci is selected from CH 3
摘要翻译：式（I）化合物及其药学上可接受的盐，其中：R 2，R 3，R 4和R 3 > 5 独立地选自H，C 1-7烷氧基，氨基，卤素或羟基; Y是-CR C 1 -C 2 - （CH 2）m - ，其中m是0或1， R 3选自CH 3 3

6. 发明申请

WO2007144652A2 PARP INHIBITORS 审中-公开
标题翻译： PARP抑制剂
公开(公告)号：WO2007144652A2
公开(公告)日：2007-12-21
申请号：PCT/GB2007/002247
申请日：2007-06-15
申请人： KUDOS PHARMACEUTICALS LIMITED , JAVAID, Muhammad Hashim , GOMEZ, Sylvie , COCKCROFT, Xiao-Ling Fan , MENEAR, Keith Allan , MARTIN, Niall Morrison Barr
发明人： JAVAID, Muhammad Hashim , GOMEZ, Sylvie , COCKCROFT, Xiao-Ling Fan , MENEAR, Keith Allan , MARTIN, Niall Morrison Barr
CPC分类号： C07D211/34 , C07C235/60 , C07D211/08 , C07D211/70 , C07D217/02 , C07D225/02 , C07D241/04 , C07D243/08 , C07D405/02
摘要： A compound of the formula (I), and pharmaceutically acceptable salts thereof, wherein: R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of H, C 1-7 alkoxy, amino, halo or hydroxy; Y is -CR C1 R C2 -(CH 2 ) m -, where m is 0 or 1, R ci is selected from CH 3 and CF 3 , and R c2 is selected from H and CH 3 , or R C1 and R C2 together with the carbon atom to which they are attached form the 1,1-cyclopropylene group (a), R N1 and R N2 are independently selected from H and R, where R is optionally substituted C 1-10 alkyl, C 3-20 heterocyclyl and C 5-20 aryl; or R N1 and R N2 , together with the nitrogen atom to which they are attached form an optionally substituted 5-7 membered, nitrogen containing, heterocyclic ring; Het is selected from: (i), where Y 1 and Y 3 are independently selected from CH and N, Y 2 is selected from CX and N and X is H, Cl or F; and (ii), where Q is O or S.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中：R 2，R 3，R 4和R 3 > 5 独立地选自H，C 1-7烷氧基，氨基，卤素或羟基; Y是-CR C 1 -C 2 - （CH 2）m - ，其中m是0或1， R 3选自CH 3 3

7. 发明申请

WO2007026157A1 ATM INHIBITOR 审中-公开
标题翻译： ATM抑制剂
公开(公告)号：WO2007026157A1
公开(公告)日：2007-03-08
申请号：PCT/GB2006/003230
申请日：2006-08-31
申请人： KUDOS PHARMACEUTICALS LIMITED , SMITH, Graeme, Cameron, Murray , MARTIN, Niall, Morrison, Barr , MENEAR, Keith, Allan , SLADE, Andrew, James , COCKCROFT, Xiao-Ling, Fan , GRIFFIN, Roger, John , MATTHEWS, Ian, Timothy, William , RIGOREAU, Laurent, Jean, Martin , NEWELL, David, Richard , CURTIN, Nicola, Jane , HUMMERSONE, Marc, Geoffrey
发明人： SMITH, Graeme, Cameron, Murray , MARTIN, Niall, Morrison, Barr , MENEAR, Keith, Allan , SLADE, Andrew, James , COCKCROFT, Xiao-Ling, Fan , GRIFFIN, Roger, John , MATTHEWS, Ian, Timothy, William , RIGOREAU, Laurent, Jean, Martin , NEWELL, David, Richard , CURTIN, Nicola, Jane , HUMMERSONE, Marc, Geoffrey
IPC分类号： C07D409/04 , A61K31/535 , A61P31/00 , A61P35/00
CPC分类号： C07D409/04
摘要： A compound of formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, and its use in treating diseases ameliorated by the inhibition of ATM.
摘要翻译：式（I）的化合物及其异构体，盐，溶剂合物，化学保护形式及其前药，以及其用于治疗通过抑制ATM而改善的疾病的用途。

8. 发明申请

WO2006090169A1 2,4-DIAMINO-PYRIDOPYRIMIDINE DERIVATIVES AND THEIR USE AS MTOR INHIBITORS 审中-公开
标题翻译： 2,4-二氨基 - 吡咯烷酮衍生物及其作为MTOR抑制剂的用途
公开(公告)号：WO2006090169A1
公开(公告)日：2006-08-31
申请号：PCT/GB2006/000671
申请日：2006-02-24
申请人： KUDOS PHARMACEUTICALS LIMITED , HUMMERSONE, Marc Geoffrey , GOMEZ, Sylvie , MENEAR, Keith Allan , COCKCROFT, Xiao-ling Fan , EDWARDS, Peter , LOH, Vincent Junior Ming Lai , SMITH, Graeme Cameron Murray
发明人： HUMMERSONE, Marc Geoffrey , GOMEZ, Sylvie , MENEAR, Keith Allan , COCKCROFT, Xiao-ling Fan , EDWARDS, Peter , LOH, Vincent Junior Ming Lai , SMITH, Graeme Cameron Murray
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof one of X 1 , X 2 and X 3 is N, and the others are CH; R N1 and R N2 together with the nitrogen atom to which they are attached form a nitrogen-containing heterocyclic ring having from 4 to 8 ring atoms; R N3 and R N4 together with the nitrogen atom to which they are attached form a nitrogen-containing heterocyclic ring having from 4 to 8 ring atoms and their use in treating diseases ameliorated by the inhibition of mTOR.
摘要翻译：式（I）化合物及其异构体，盐，溶剂化物，化学保护形式及其前药之一，X 1，X 2和X 3 >是N，其他是CH; R N1和R N2与它们所连接的氮原子一起形成具有4至8个环原子的含氮杂环; R 3 N 3和R 4 N 4与它们所连接的氮原子一起形成具有4至8个环原子的含氮杂环，并且其用于治疗改善的疾病通过抑制mTOR。

9. 发明申请

WO2003024949A1 DNA-PK INHIBITORS 审中-公开
标题翻译： DNA-PK抑制剂
公开(公告)号：WO2003024949A1
公开(公告)日：2003-03-27
申请号：PCT/GB2002/003781
申请日：2002-08-14
申请人： CANCER RESEARCH TECHNOLOGY LIMITED , GRIFFIN, Roger, John , GOLDING, Bernard, Thomas , NEWELL, David, Richard , CALVERT, Hilary, Alan , CURTIN, Nicola, Jane , HARDCASTLE, Ian, Robert , MARTIN, Niall, Morrison, Barr , SMITH, Graeme, Cameron, Murray , RIGOREAU, Laurent, Jean, Martin , COCKCROFT, Xiao-ling, Fan , LOH, Vincent, Junior, Ming-lai , WORKMAN, Paul , RAYNAUD, Florence, Irene , NUTLEY, Bernard, Paul
发明人： GRIFFIN, Roger, John , GOLDING, Bernard, Thomas , NEWELL, David, Richard , CALVERT, Hilary, Alan , CURTIN, Nicola, Jane , HARDCASTLE, Ian, Robert , MARTIN, Niall, Morrison, Barr , SMITH, Graeme, Cameron, Murray , RIGOREAU, Laurent, Jean, Martin , COCKCROFT, Xiao-ling, Fan , LOH, Vincent, Junior, Ming-lai , WORKMAN, Paul , RAYNAUD, Florence, Irene , NUTLEY, Bernard, Paul
IPC分类号： C07D309/38
CPC分类号： C07D417/04 , C07D309/38 , C07D311/22 , C07D311/92 , C07D471/04
摘要： The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R 1 and R 2 are independently hydrogen, an optionally substituted C 1-7 alkyl group, C 3-20 heterocyclyl group, or C 5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR 4 and O, O and CR' 4 and NR" 4 and N, where the unsaturation is in the appropriate place in the ring, and where one of R 3 and R 4 or R' 4 is an optionally substituted C 3-20 heteroaryl or C 5-20 aryl group, and the other of R 3 and R 4 or R' 4 is H, or R 3 and R 4 or R" 4 together are -A-B-, which collectively represent a fused optionally substituted aromatic ring. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.
摘要翻译：本发明涉及式（I）化合物及其异构体，盐，溶剂化物，化学保护形式及其前药在制备用于抑制DNA-PK活性的药物中的用途，其中R 1和R 2 独立地为氢，任选取代的C 1-7烷基，C 3-20杂环基或C 5-20芳基，或者可以与它们所连接的氮原子一起形成任选取代的杂环具有4至8个环原子; X和Y选自CR 4和O，O和CR'4和NR“4和N，其中不饱和键在环中适当的位置，并且其中R 3和 R 4或R'4是任选取代的C 3-20杂芳基或C 5-20芳基，R 3和R 4或R'4中的另一个是H或R' 3>和R 4或R“4一起是-AB-，它们共同表示稠合的任选取代的芳环。与PI3-激酶和/或ATM相比，化合物还选择性地抑制DNA-PK的活性。

10. 发明申请

WO2006090167A3 HYDRAZINOMETHYL, HYDR ZONOMETHYL AND 5-MEMBERED HETEROCYLIC COMPOUNDS WHICH ACT AS MTOR INHIBITORS AND THEIR USE AS ANTI CANCER AGENTS 审中-公开
标题翻译：氢化二甲基丙烯酸，氢化二甲基乙烯基醚和作为MT抑制剂的5组分的杂环化合物及其用作抗癌剂
公开(公告)号：WO2006090167A3
公开(公告)日：2007-05-10
申请号：PCT/GB2006000668
申请日：2006-02-24
申请人： KUDOS PHARM LTD , HUMMERSONE MARC GEOFFREY , GOMEZ SYLVIE , MENEAR KEITH ALLAN , COCKCROFT XIAO-LING FAN , SMITH GRAEME CAMERON MURRAY
发明人： HUMMERSONE MARC GEOFFREY , GOMEZ SYLVIE , MENEAR KEITH ALLAN , COCKCROFT XIAO-LING FAN , SMITH GRAEME CAMERON MURRAY
IPC分类号： C07D251/70 , A61K31/506 , A61K31/517 , A61K31/53 , C07D403/04
CPC分类号： C07D251/70 , C07D239/48 , C07D239/50 , C07D239/94 , C07D295/135 , C07D403/04 , C07D403/12 , C07D405/04 , C07D413/12 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I): A-B-C and isomers, salts, solvates, chemically protected forms, and prodrugs thereof wherein: B is selected from the group consisting of formula (i) where R N is H or Me; or B is a divalent C 5 heterocyclic residue containing one or two ring heteroatoms; A is formula (ii) R A3 and R A5 are independently selected from halo, OR O and R AC , where R O is H or Me, and R AC is H or C 1-4 alkyl; X A is selected from N and CR A4 , where R A4 is selected from H, OR O , CH 2 OH, CO 2 H, NHSO 2 Me and NHCOMe; R A2 and R A6 are independently selected from H, halo and OR O ; or R A3 and R A4 together with the carbon atoms to which they are attached, or RA2 and R A3 together with the carbon atoms to which they are attached, may form a C 5-6 heterocylic or heteroaromatic ring, containing at least one nitrogen ring atom; where if X is not N, 1 , 2, or 3 of R A2 to R A6 are not H; C is formula (iii) where X is selected from N and CH, Y is selected from N and CH, and Z is selected from N and CR C6 ; R C3 is selected from H, halo and an optionally substituted N-containing C 5-7 heterocyclic group; R C5 is a group selected from formula (iv) which group may be selected by one or two C 1-4 alkyl groups or a carboxy group; R C6 is H; or, when X and Y are N, R C5 and R C6 (when Z is CR C6 ) together with the carbon atoms to which they are attached may form a fused C 6 aromatic ring selected from the group consisting of formula (v).
摘要翻译：式（I）化合物：ABC及其异构体，盐，溶剂化物，化学保护形式及其前体药物，其中：B选自式（ⅰ），其中R N为H或Me ; 或B是含有一个或两个环杂原子的二价C 5 - 5杂环残基; A是式（ⅱ），R A3和R A5各自独立地选自卤素，O或O，其中R O是H或Me，且R AC是H或C 1-4烷基; 从其中R A4选自H，OR，O，CH，N， 2 OH，CO 2 H，NHSO 2 Me和NHCOMe; R A2和R A6各自独立地选自H，卤素和ORO; 或R A3与它们所连接的碳原子一起形成，或者与其连接的碳原子一起，或者R A2和R A3与其中的碳原子一起它们可以形成含有至少一个氮环原子的C 5〜6 - 杂环或杂芳环; 其中如果X不是N，则R A2与R A6之间的1,2或3不是H; C是式（ⅲ）其中X选自N和CH，Y选自N和CH，Z选自N和CR 6 C 6。 R 3选自H，卤素和任选取代的含N C的5-7杂环基; R 5是选自式（ⅳ）的基团，该基团可以被一个或两个C 1-4烷基或羧基选择; C 6 H 6是H; 或者当X和Y为N时，R 5和R 6 C（当Z为CR 6 C 6）时，与它们的碳原子一起可以形成选自由式（v）组成的组的稠合C 6芳香环。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式