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1. 发明申请

WO2006106291A1 INJECTION DEVICE 审中-公开
标题翻译：注射装置
公开(公告)号：WO2006106291A1
公开(公告)日：2006-10-12
申请号：PCT/GB2006/001018
申请日：2006-04-03
申请人： CILAG AG INTERNATIONAL , JENNINGS, Douglas, Ivan
发明人： JENNINGS, Douglas, Ivan
IPC分类号： A61M5/20 , A61M5/32
CPC分类号： A61M5/3243 , A61M5/2033 , A61M5/3202 , A61M5/3204 , A61M2005/208 , A61M2005/2086
摘要： An injection device (110) comprises a housing (112) having a syringe (114) with a discharge nozzle (118) . The syringe is movable between a retracted position in which the discharge nozzle is contained within the housing and an extended position in which the discharge nozzle extends from the housing. There is a syringe cap (180) for enclosing the discharge nozzle. The syringe cap is removable from the syringe by rotation relative to the syringe. A syringe carrier (150) in the housing is adapted to restrain rotation of the syringe relative to the housing as the cap is removed.
摘要翻译：注射装置（110）包括具有带有排放喷嘴（118）的注射器（114）的壳体（112）。注射器可以在其中排出喷嘴容纳在壳体中的缩回位置和排出喷嘴从壳体延伸的延伸位置之间移动。存在用于封闭排出喷嘴的注射器帽（180）。注射器帽可以通过相对于注射器旋转而从注射器移除。壳体中的注射器托架（150）适于在盖被移除时抑制注射器相对于壳体的旋转。

2. 发明申请

WO2005115514A1 INJECTION DEVICE 审中-公开
标题翻译：注射装置
公开(公告)号：WO2005115514A1
公开(公告)日：2005-12-08
申请号：PCT/GB2005/002135
申请日：2005-05-27
申请人： CILAG AG INTERNATIONAL , HARRISON, Nigel, David , HABESHAW, Rosemary, Louise
发明人： HARRISON, Nigel, David , HABESHAW, Rosemary, Louise
IPC分类号： A61M5/24
CPC分类号： A61M5/24 , A61M5/20 , A61M5/2033 , A61M5/31515 , A61M5/3204 , A61M5/326 , A61M2005/206
摘要： A syringe (114) is received with a housing, the syringe having a bore terminating at a forward end in a hypodermic needle (118) and at a rearward end in a flared opening (210) in which a bung (134a) having a bore (206) surrounded by a skirt (208) is inserted. A drive element (134) has a forward end consisting of a substantially flat annular region (200) that bears upon the skirt of the bung and surrounds a conical middle region (202) that is received in the bore (206) of the bung. An actuator advances the drive element (134) so as to advance the bung and discharge the contents of the syringe through the needle (118). The opening (210) in the rear of the glass syringe is flared by being provided with a radius. The combination of the radius at the opening and the projecting conical middle region of the drive element allows misalignments of the two to be managed during automated assembly.
摘要翻译：注射器（114）被容纳有壳体，注射器具有终止于皮下注射针（118）中的前端的孔，并且在扩张开口（210）中的后端处，其中具有孔的孔（134a）（206）被一个裙部（208）包围。驱动元件（134）具有一个前端，该前端由一个基本平坦的环形区域（200）构成，该环形区域（200）承载在该栓塞的裙部上，并且包围容纳在该膛孔内的锥形中间区域（202）。致动器使驱动元件（134）前进，从而使注射器的内容物通过针头（118）排出并排出。玻璃注射器后部的开口（210）通过设置半径而扩口。开口处的半径与驱动元件的突出的锥形中间区域的组合允许在自动组装期间管理两者的对准。

3. 发明申请

WO2005115510A1 INJECTION DEVICE 审中-公开
标题翻译：注射装置
公开(公告)号：WO2005115510A1
公开(公告)日：2005-12-08
申请号：PCT/GB2005/002126
申请日：2005-05-27
申请人： CILAG AG INTERNATIONAL , BARROW-WILLIAMS, Tim , HABESHAW, Rosie
发明人： BARROW-WILLIAMS, Tim , HABESHAW, Rosie
IPC分类号： A61M5/20
CPC分类号： A61M5/2033 , A61M5/3204 , A61M2005/206 , A61M2005/208 , A61M2005/3253
摘要： An injection device (110) is described having a housing (112) that receives a syringe (114). The syringe is biased by a return spring (126) from an extended position in which the needle (118) extends from the housing through an exit aperture (128) to a retracted position in which it does not. A drive spring (130) acts via a drive to advance the syringe from its retracted position to its extended position and discharge its contents through the needle and a return spring, brought into play when the drive has reached a nominal return position, restores the syringe to its retracted position. A releasable locking mechanism retains the syringe in its retracted position. A sleeve (119) projects from the exit aperture and can be depressed to release the locking mechanism. A trigger (300) has a rest position, in which it engages the drive, retaining it in a position corresponding to the retracted position of the syringe, and a depressed position, in which it no longer causes the drive to be so retained.
摘要翻译：描述了具有容纳注射器（114）的壳体（112）的注射装置（110）。注射器通过复位弹簧（126）从延伸位置偏置，在该位置中针（118）从壳体通过出口孔（128）延伸到缩回位置。驱动弹簧（130）通过驱动器作用，以将注射器从其缩回位置推进到其延伸位置，并且通过针头和复位弹簧将其内容物排出，当驱动器达到标称返回位置时，复原弹簧起作用，恢复注射器到其缩回位置。可释放的锁定机构将注射器保持在其缩回位置。套筒（119）从出口孔伸出并可被压下以释放锁定机构。触发器（300）具有静止位置，其中它与驱动器接合，将其保持在与注射器的缩回位置相对应的位置以及不再使驱动器保持的凹陷位置。

4. 发明申请

WO2005115508A1 INJECTION DEVICE 审中-公开
标题翻译：注射装置
公开(公告)号：WO2005115508A1
公开(公告)日：2005-12-08
申请号：PCT/GB2005/002116
申请日：2005-05-27
申请人： CILAG AG INTERNATIONAL , HABESHAW, Rosie , BARROW-WILLIAMS, Tim , BRADY, Matthew , HARRISON, Nigel
发明人： HABESHAW, Rosie , BARROW-WILLIAMS, Tim , BRADY, Matthew , HARRISON, Nigel
IPC分类号： A61M5/20
CPC分类号： A61M5/2033 , A61M5/3202 , A61M5/3204 , A61M5/3213 , A61M2005/206 , A61M2005/3109
摘要： An injection device (110) is described having a housing (112) and a housing closure means (130). The injection device (110) houses a syringe (114) having a needle (118) which is sealed by a boot (120). The housing closure means (130) is arranged so that the boot can be connected to the housing closure means simply, but cannot be removed from the housing closure means. The housing and housing closure means are arranged so that upon rotation of the housing closure means, the housing closure means is moved axially away from the housing and the boot and the boot is removed from the syringe. The injection device is simple to use and manufacture.
摘要翻译：描述了具有壳体（112）和壳体封闭装置（130）的注射装置（110）。注射装置（110）容纳具有由靴子（120）密封的针（118）的注射器（114）。壳体封闭装置（130）被布置成使得护罩可以简单地连接到壳体封闭装置，但是不能从壳体封闭装置移除。壳体和壳体封闭装置被布置成使得在壳体闭合装置旋转时，壳体闭合装置轴向地移动远离壳体并且护罩并且引导件从注射器移除。注射装置易于使用和制造。

5. 发明申请

WO2005063696A2 NOVEL CRYSTALLINE FORMS OF ENTACAPONE AND PRODUCTION THEREOF 审中-公开
标题翻译：恩他卡朋及其生产的新型结晶形态
公开(公告)号：WO2005063696A2
公开(公告)日：2005-07-14
申请号：PCT/CH2004000754
申请日：2004-12-27
申请人： CILAG AG , BADER THOMAS , FUREGATI MARKUS , JUNGMANN OLIVER
发明人： BADER THOMAS , FUREGATI MARKUS , JUNGMANN OLIVER
IPC分类号： C07C253/30 , C07C255/41 , A61K31/277 , A61P25/16
CPC分类号： C07C255/41 , C07B2200/13
摘要： The invention relates to three novel forms of entacapone. These are peripheral and selective COMT inhibitors which in combination with levodopa and decarboxylase inhibitors can be used to treating Parkinson's syndrome. Said novel forms arise by crystallization of entacapone in respectively determined conditions. In certain cases, entacapone can be used as a raw product, in a special case it can be used in situ as the product of Knoevenagel condensation of 3,4-dihydroxy-5-nitro-benzaldehyde and N,N-diethyl-2-cyano-acetamide. Also disclosed are improvements of said condensation in relation to the catalyst and the production of the two components thereof.
摘要翻译：描述恩他卡朋的三个新的结晶形式。这些是外周和选择性的COMT抑制剂，其 - 可用于帕金森氏病的治疗 - 结合左旋多巴和脱羧酶抑制剂。分别在特定条件下引起的恩他卡朋的结晶这些新的形式，。在某些情况下，恩他卡朋可以甚至在štítu产物3,4-二羟基-5-硝基 - 苯甲醛和N，N-二乙基-2-氰基乙酰胺的Knoevenagel缩合用作粗而，在特殊情况下。相对于该催化剂和生产它的两个部件的描述对这些缩合进一步的改进。

6. 发明申请

WO2004054645A2 INJECTION DEVICE 审中-公开
标题翻译：注射装置
公开(公告)号：WO2004054645A2
公开(公告)日：2004-07-01
申请号：PCT/GB2003/005494
申请日：2003-12-17
申请人： CILAG AG INTERNATIONAL , HARRISON, Nigel, David , BRADY, Matthew, James , BERMAN, Gregory , JOHNSTON, David, Maxwell , HABESHAW, Rosemary, Louise
发明人： HARRISON, Nigel, David , BRADY, Matthew, James , BERMAN, Gregory , JOHNSTON, David, Maxwell , HABESHAW, Rosemary, Louise
IPC分类号： A61M5/32
CPC分类号： A61M5/326 , A61M5/2033 , A61M2005/206 , A61M2005/3143 , A61M2005/31516
摘要： An injection device including a housing for containing a syringe having a bore extending from an end surface, a needle communicating with the bore through the end surface and a dispensing piston movable in said bore towards said end surface so as to expel the contents of the syringe through the needle, the housing having an opening at one end through which the needle may extend, a resilient member for biassing the syringe and the needle inwardly off the housing, a first coupling element moveable towards said one end so as to move the needle of the syringe out of the opening and to move the dispensing piston of the syringe towards the end surface, a mechanism operable to release the syringe such that the needle moves inwardly off the housing, a drive coupling for extending from said first coupling element to the dispensing piston of the syringe so as to transfer movement of said first coupling element to the dispensing piston wherein the mechanism is triggered to release the syringe and includes components to delay release of the syringe until a predetermined period after being triggered such that it can be ensured that the dispensing piston reaches the end surface before the syringe is released and/or the mechanism includes an inertial mass moveable with the first coupling element and drive coupling and a release member actuable by the inertial mass to release the syringe such that when the dispensing piston releases the end surface of the syringe and the first coupling element and drive coupling stop moving, the inertial mass continues to move so as to actuate the release member to release the syringe.
摘要翻译：一种注射装置，包括用于容纳具有从端表面延伸的孔的注射器的壳体，通过端表面与孔连通的针，以及可在所述孔中朝向所述端表面移动的分配活塞，以便排出注射器的内容物通过所述针，所述壳体在所述针可以延伸穿过的一端具有开口，用于将所述注射器和所述针向内偏离所述壳体的弹性构件，朝向所述一端可移动的第一联接元件，所述注射器离开所述开口并且使所述注射器的分配活塞朝向所述端表面移动，所述机构可操作以释放所述注射器，使得所述针向内移出所述壳体;驱动联接器，用于从所述第一联接元件延伸到所述分配以便将所述第一联接元件的运动传递到所述分配活塞，其中所述机构被触发以释放所述注射器包括用于延迟注射器释放直到在被触发之后的预定时间段的释放的部件，使得可以确保在注射器被释放之前分配活塞到达端面，和/或该机构包括可与第一联接元件一起移动的惯性块，以及驱动联接器和由惯性块致动的释放构件以释放注射器，使得当分配活塞释放注射器的端面并且第一联接元件和驱动联接件停止移动时，惯性质量块继续移动，以便致动释放构件释放注射器。

7. 发明申请

WO2011113476A2 METHOD FOR PRODUCING 2'-DEOXYADENOSINE COMPOUNDS 审中-公开
标题翻译：生产2'-脱氧腺苷化合物的方法
公开(公告)号：WO2011113476A2
公开(公告)日：2011-09-22
申请号：PCT/EP2010053352
申请日：2010-03-16
申请人： CILAG AG , JUNGMANN OLIVER , THALER ADRIAN , HAENSELER ROLF
发明人： JUNGMANN OLIVER , THALER ADRIAN , HAENSELER ROLF
CPC分类号： C07H19/173
摘要： (A) reacting the alkali metal salt of 2, 6-dichlorpurine with a 2-desoxy-3, 5 -di-O-p-toluoyl-alpha-D-erythro-pentofuranose or a derivative thereof, in a suitable organic solvent, said reaction optionally being carried out in the presence of a Lewis-acid, whereby a mixture comprising the intermediate N (9) -beta-compound, the N (7) -beta-regio- isomer, and the N (9) -alpha-stereoisomer is formed; (B) isolating from said reaction mixture formed the crude reaction product comprising the intermediate N (9) -beta- compound by a purification method, preferably by precipitation or crystallization, using a suitable organic solvent or a mixture of such organic solvents or a mixture of one or more of such organic solvents with water, without using a chromatographic purification method, and (C) subjecting the isolated intermediate N (9 ) -beta-compound to ammonolysis, where upon the 2 '-deoxyadenosine compound is formed, and (D) precipitating or crystallizing the 2 '-deoxyadenosine compound as formed in step (C) from a suitable organic solvent.
摘要翻译：（A）使2,6-二氯嘌呤的碱金属盐与2-脱氧-3,5-二-O-对甲苯酰-α-D-赤型呋喃糖或其衍生物在合适的有机溶剂中反应，所述反应任选地在路易斯酸存在下进行，由此得到包含中间体N（9） - β-化合物，N（7） - 对 - 位异构体和N（9）-α-立体异构体的混合物形成了; （B）通过纯化方法，优选通过沉淀或结晶，使用合适的有机溶剂或这种有机溶剂或混合物的混合物形成包含中间体N（9） - 乙酸酯化合物的粗制反应产物的一种或多种这样的有机溶剂与水反应，而不使用色谱纯化方法，和（C）使分离的中间体N（9） - β-化合物进行氨解，其中在形成2'-脱氧腺苷化合物时，和（ D）从合适的有机溶剂中使步骤（C）中形成的2'-脱氧腺苷化合物沉淀或结晶。

8. 发明申请

WO2011003455A1 VERFAHREN ZUR HERSTELLUNG VON 4-(ALKYL)-1-(2-METHYL-3-(2,6-DIMETHYLMORPHOLIN)PROPYL) BENZOLVERBINDUNGEN 审中-公开
标题翻译： PROCESS FOR 4-（烷基）-1-（2-甲基-3-（2,6-二甲基）丙基）苯化合物的制备
公开(公告)号：WO2011003455A1
公开(公告)日：2011-01-13
申请号：PCT/EP2009/058780
申请日：2009-07-09
申请人： CILAG AG , ALBRECHT, Uwe , ACKERMANN, Stefanie , SAWICKI, Marcin , WEIGL, Ulrich
发明人： ALBRECHT, Uwe , ACKERMANN, Stefanie , SAWICKI, Marcin , WEIGL, Ulrich
IPC分类号： C07D295/02
CPC分类号： C07D295/02
摘要： Verfahren zur Herstellung von 4-(Alkyl)-1-(2-methyl-3-(2,6- dimethylmorpholin)propyl)benzol, insbesondere zur Herstellung von 4-(1,1-Dimethylpropyl)-1-(2-methyl-3-(2,6-dimethylmorpholin)propyl)benzol (Amorolfin), mittels selektiver Reduktion der entsprechenden alpha-Benzylketoverbindung mit Wasserstoff, indem man die entsprechende 4-(Alkyl)-1-(2-methyl-1-oxo-3-(2,6- dimethylmorpholin)propyl)benzol-Verbindung als Salz einer starken Säure in einem geeigneten inerten Lösungsmittel vorlegt und dieses Salz in Gegenwart eines geeigneten Katalysators mit Wasserstoff hydriert.
摘要翻译：一种用于4-（烷基）-1-（2-甲基-3-（2,6-二甲基吗啉基）丙基）苯，特别是用于4-（1,1-二甲基丙基）的制备-1-（2-甲基的制备方法 -3-（2,6-二甲基吗啉基）丙基）苯（阿莫罗芬），通过与氢的相应的α-Benzylketoverbindung的选择性还原，由相应的4-（烷基反应）-1-（2-甲基-1-氧代-3- - （2,6-二甲基）丙基）苯化合物在合适的惰性溶剂表现为强酸的盐，并与氢的合适的催化剂的存在下氢化该盐。

9. 发明申请

WO2008131567A1 LÖSUNGSMITTELFREIE KRISTALLINE FORM VON NALTREXON 审中-公开
标题翻译：纳曲酮的无溶剂结晶形式
公开(公告)号：WO2008131567A1
公开(公告)日：2008-11-06
申请号：PCT/CH2007/000203
申请日：2007-04-27
申请人： CILAG AG , WEIGL, Ulrich , KÖTZ, Ulf
发明人： WEIGL, Ulrich , KÖTZ, Ulf
IPC分类号： C07D489/08 , A61K31/485 , A61P25/30
CPC分类号： C07D489/08
摘要： Lösungsmittelfreie kristalline polymorphe Form von Naltrexon, dadurch gekennzeichnet, dass diese die in Tabelle 1 aufgelisteten XRD-Daten aufweist und Verfahren zur Herstellung dieser polymorphen Form; und Verfahren zur Umwandlung dieser polymorphen Form von Naltrexon in eine an sich bekannte polymorphe Form von Naltrexon.
摘要翻译：纳曲酮的无溶剂的结晶多晶型物，其特征在于它已在表1中的XRD数据和用于制备这些多晶型物的过程中列出; 和纳曲酮的这些多晶型物的纳曲酮中的已知的多晶型转换过程。

10. 发明申请

WO2006106295A1 INJECTION DEVICE (ADAPTABLE DEVICE) 审中-公开
标题翻译：注射装置（适配装置）
公开(公告)号：WO2006106295A1
公开(公告)日：2006-10-12
申请号：PCT/GB2006/001031
申请日：2006-03-21
申请人： CILAG AG INTERNATIONAL , BARROW-WILLIAMS, Timothy, Donald , EDINGTON, David
发明人： BARROW-WILLIAMS, Timothy, Donald , EDINGTON, David
IPC分类号： A61M5/145
CPC分类号： A61M5/2033 , A61M5/24 , A61M5/326 , A61M2005/206 , A61M2005/208 , Y10T29/49904
摘要： An injection device (110) comprises a housing (112) adapted to receive a syringe (116) having a discharge nozzle (118) and a dispensing piston (114) movable in the syringe to expel the contents of the syringe through the discharge nozzle. There is also a drive (130) adapted to act on the syringe to advance it from a retracted position in which the discharge nozzle is contained within the housing to an extended position in which the discharge nozzle extends from the housing. A drive coupling (134) extends from the drive to the dispensing piston of the syringe so as to transfer movement of the drive to the piston. The drive coupling comprises a fixed-length drive coupling and an interchangeable drive coupling. There is also a method of manufacturing an injection device by assembling a first sub-assembly (210) and second sub-assembly (220) .
摘要翻译：注射装置（110）包括适于容纳具有排出喷嘴（118）的注射器（116）和可在注射器中移动的分配活塞（114）的壳体（112），以通过排出喷嘴排出注射器的内容物。还有一个适于作用在注射器上的驱动器（130），以将其从排出喷嘴容纳在壳体内的缩回位置推进到排出喷嘴从壳体延伸的延伸位置。驱动联轴器（134）从驱动器延伸到注射器的分配活塞，以便将驱动器的运动传递到活塞。驱动联轴器包括固定长度的驱动联轴器和可互换的驱动联轴器。还有一种通过组装第一子组件（210）和第二子组件（220）来制造注射装置的方法。

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