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1. 发明申请

WO2010123205A2 CONSTANT TEMPERATURE AGITATING DEVICE AND AGITATING METHOD USING THE SAME 审中-公开
标题翻译：恒温恒温装置及其使用方法
公开(公告)号：WO2010123205A2
公开(公告)日：2010-10-28
申请号：PCT/KR2010001792
申请日：2010-03-24
申请人： COLLEGE MEDICINE POCHON CHA UNIV IND ACAD COOP FOUND , CHUNG KWANG HOE , LEE KWANG-HYOUNG , CHOI HAENG-SUK , KO JUNG-JAE
发明人： CHUNG KWANG HOE , LEE KWANG-HYOUNG , CHOI HAENG-SUK , KO JUNG-JAE
IPC分类号： B01F11/00 , B01F15/06
CPC分类号： B01F11/0008 , B01F11/0014 , B01F15/065 , B01F2015/062 , B01L7/00 , B01L9/06 , B01L9/52 , B01L2300/1827
摘要： A constant temperature agitating device for agitating substances received in a container comprises a base, a container receiving body part and a shaking motion part. The container receiving body part is positioned at an upper part of the base, and includes upper and lower body parts for covering the upper and lower parts of the container so as to receive the container, wherein the inner surfaces of the upper and lower body parts which contact with the container form a container receiving part corresponding to the outer surface of the container. The shaking motion part shakes the container receiving body part against the base. The container receives heat via the inner surface contacting with the container receiving part.
摘要翻译：用于搅拌容纳在容器中的物质的恒温搅拌装置包括基座，容器容纳体部和摇动部分。容器容纳体部分位于基部的上部，并且包括用于覆盖容器的上部和下部以容纳容器的上部和下部主体部分，其中上部和下部主体部分的内表面其与容器接触形成与容器的外表面相对应的容器接收部分。摇动运动部件将容器接收体部分摇动到底座上。容器通过与容器接收部分接触的内表面接收热量。

2. 发明申请

WO2009157646A9 PRODUCTION METHOD FOR A NANOPATTERNED EPOXY SUBSTRATE 审中-公开
标题翻译：纳米级环氧树脂基材的生产方法
公开(公告)号：WO2009157646A9
公开(公告)日：2010-03-04
申请号：PCT/KR2009001916
申请日：2009-04-14
申请人： BIOBUD CO LTD , CHUNG KWANG HOE , HONG SUNG YU , DOH HYUN JU , CHOI JIN SUB , LIM JAE HOON , KIM SUNG JOONG
发明人： CHUNG KWANG HOE , HONG SUNG YU , DOH HYUN JU , CHOI JIN SUB , LIM JAE HOON , KIM SUNG JOONG
IPC分类号： B82B3/00
CPC分类号： G01N33/4905
摘要： The present invention relates to a production method for an epoxy substrate exhibiting a nanopattern, comprising the stages of: (a) forming a titanium oxide film by anodization of a titanium substrate; (b) obtaining a titanium substrate having a concave shape formed on its surface by removing the titanium oxide film from the titanium substrate on which the titanium oxide film has been formed; (c) coating an epoxy resin onto the titanium substrate on which the concave shape has been formed; and (d) obtaining an epoxy substrate formed with a nanopattern of convex surfaces by removing the titanium substrate. In the production method of the present invention, an epoxy substrate formed with a nanopattern of convex surfaces is produced after anodizing titanium, coating an epoxy resin onto a nanopattern formed with a concave shape on the titanium surface, and removing the titanium substrate. This straightforward process makes it possible to efficiently produce an epoxy resin exhibiting a nanopattern for the measurement of blood coagulation formed with a fine pattern which is uniform and on the nano scale. Further, the epoxy substrate produced by means of the present invention makes it possible to efficiently use an electrochemical technique to ascertain whether or not blood coagulation is present in a blood sample.
摘要翻译：本发明涉及一种表现出纳米图案的环氧树脂基板的制造方法，其特征在于，包括：（a）通过钛基板的阳极氧化而形成氧化钛膜; （b）从形成有氧化钛膜的钛基板上除去氧化钛膜，得到表面形成有凹形状的钛基板; （c）将环氧树脂涂布到已经形成凹形的钛基板上; 和（d）通过除去钛基材得到形成有凸面的纳米图案的环氧树脂基材。在本发明的制造方法中，在阳极氧化钛之后，在钛表面上涂布环氧树脂到形成为凹形的纳米图案上，并除去钛基板，制作形成有凸面的纳米图案的环氧树脂基板。这种直接的方法使得可以有效地制备出显示用于测量均匀且纳米尺度的精细图案形成的凝血的纳米图案的环氧树脂。此外，通过本发明制造的环氧树脂基板使得可以有效地使用电化学技术来确定血液样品中是否存在凝血。

3. 发明申请

WO2009084841A3 MUTATED NUCLEOTIDE SEQUENCES OF BATROXOBIN, MUTATED ALPHA FACTOR SECRETION SIGNAL SEQUENCE AND PROCESSES FOR PREPARING BATROXOBIN USING THE SAME 审中-公开
标题翻译：巴克洛新突变的核苷酸序列，突变的α因子分泌信号序列以及使用相同的方法制备巴比妥脂的方法
公开(公告)号：WO2009084841A3
公开(公告)日：2009-09-17
申请号：PCT/KR2008007605
申请日：2008-12-23
申请人： BIOBUD CO LTD , SOHN YOUNG-DOUG , KIM BUM JOON , KIM OK HWAN , KIM KYOUNG JUN , SHIN JI HUN , HONG SUNG YU , HWANG JAE HOON , CHUNG KWANG HOE
发明人： SOHN YOUNG-DOUG , KIM BUM JOON , KIM OK HWAN , KIM KYOUNG JUN , SHIN JI HUN , HONG SUNG YU , HWANG JAE HOON , CHUNG KWANG HOE
IPC分类号： C12N9/64
CPC分类号： C12N9/6418 , C07K2319/02
摘要： The present invention relates to a batroxobin-encoding nucleotide sequence and/or a mutated a-factor secretion signal sequence, and a vector and a transformant using the same. The batroxobin-encoding nucleotide sequence of this invention exhibits an excellent expression efficiency in yeast, particular Pichia pastoris and the recombinant batroxobin is obtained at 4-13 fold higher yield than natural-occurring batroxobin-encoding sequences. The protein expression system which uses the batroxobin-encoding nucleotide sequence as well as mutated a-factor secretion signal peptide sequence of this invention obtains the recombinant batroxobin at about 20-fold higher yield than natural-occurring batroxobin-encoding sequences. In addition, the recombinant batroxobin prepared using the sequence of this invention has a significantly plausible activity and stability compared with natural-occuring batroxobin.
摘要翻译：本发明涉及编码巴曲酶的核苷酸序列和/或突变的α-因子分泌信号序列，以及使用其的载体和转化体。本发明的巴曲酶编码核苷酸序列在酵母，特别是巴斯德毕赤酵母中表现出优异的表达效率，并且以比天然存在的巴曲酶编码序列高4-13倍的产率获得重组巴曲酶。使用本发明的巴曲酶编码核苷酸序列以及突变的α-因子分泌信号肽序列的蛋白质表达系统以比天然存在的巴曲酶编码序列高约20倍的产量获得重组巴曲酶。此外，与天然存在的巴曲酶相比，使用本发明的序列制备的重组巴曲酶具有显着合理的活性和稳定性。

4. 发明申请

WO2004081023A1 SOLUBILIZATION METHOD OF WATER-INSOLUBLE CURCUMIN 审中-公开
标题翻译：水不溶性凝灰质的溶解方法
公开(公告)号：WO2004081023A1
公开(公告)日：2004-09-23
申请号：PCT/KR2004/000529
申请日：2004-03-12
申请人： BIOBUD CO. LTD. , HYUNDAI PHARM. IND. CO., LTD. , JUNG, In-Hak , KANG, Seung-Woo , HONG, Sung-Yu , KANG, Soo-Jung , KOH, You-Seok , CHUNG, Kwang-Hoe
发明人： JUNG, In-Hak , KANG, Seung-Woo , HONG, Sung-Yu , KANG, Soo-Jung , KOH, You-Seok , CHUNG, Kwang-Hoe
IPC分类号： C07H15/203
CPC分类号： C07C49/255
摘要： A method for solubilization of curcumin and a water-soluble curcumin prepared by this method are disclosed. The method prepares a water-soluble curcumin by covalent-bonding sugar to the curcumin, thereby making the curcumin, which was insoluble to water, into a water-soluble curcumin. This water-soluble curcumin may be applied to more fields such as food, soluble drugs and dyes.
摘要翻译：公开了通过该方法制备的姜黄素和水溶性姜黄素的增溶方法。该方法通过将糖共价键合到姜黄素中制备水溶性姜黄素，由此将不溶于水的姜黄素制成水溶性姜黄素。这种水溶性姜黄素可用于更多领域，如食品，可溶性药物和染料。

5. 发明申请

WO2003018065A1 ANTI-CANCER AGENTS COMPRISING DISINTEGRIN GENES AND THE TREATING METHODS 审中-公开
标题翻译：包含灭菌基因和治疗方法的抗癌药物
公开(公告)号：WO2003018065A1
公开(公告)日：2003-03-06
申请号：PCT/KR2001/001461
申请日：2001-08-29
申请人： CHUNG, Kwang-Hoe , PARK, Yong-Serk , KIM, Soo-In , HONG, Sung-Yu , SOHN, Young-Doug , JANG, Yang-Soo , HUN, Chin-Kyu , KIM, Doo-Sik
发明人： CHUNG, Kwang-Hoe , PARK, Yong-Serk , KIM, Soo-In , HONG, Sung-Yu , SOHN, Young-Doug , JANG, Yang-Soo , HUN, Chin-Kyu , KIM, Doo-Sik
IPC分类号： A61K48/00
CPC分类号： C12N15/88 , A61K9/127 , A61K48/00 , A61K48/0025 , C07K14/46 , C12N15/86 , C12N2750/14143
摘要： The present invention relates to liposome complex comprising a novel disintegrin, saxatilin, gene derived from Agkistrodon saxatilis and methods for curing and preventing tumors by transferring the complexes to a living body.
摘要翻译：本发明涉及脂质体复合物，其包含新颖的解联蛋白，萨克西汀，源自Ag蛇毒素的基因，以及通过将复合物转移到活体来固化和预防肿瘤的方法。

6. 发明申请

WO2011136500A3 MULTI-CORE-SHELL NANOPARTICLES 审中-公开
标题翻译：多核壳纳米粒子
公开(公告)号：WO2011136500A3
公开(公告)日：2012-04-05
申请号：PCT/KR2011002870
申请日：2011-04-21
申请人： CHABIOMED CO LTD , YOON TAE JONG , CHUNG KWANG-HOE , KO JUNG-JAE
发明人： YOON TAE JONG , CHUNG KWANG-HOE , KO JUNG-JAE
IPC分类号： B82B3/00 , A61K49/06 , B82B1/00
CPC分类号： A61K49/1848
摘要： The present invention relates to core-shell nanoparticles comprising: a manganese-containing magnetic nanoparticle (Mn-MNP) multi-core; and a silica shell coating the multi-core. Since the core-shell nanoparticles used in the present invention have high saturation magnetization (Ms) value and transverse relaxivity (R2), a sensor of the present invention using the same can detect analytes with remarkably improved sensitivity. It is possible to detect a trace amount of analytes, for example, a protein or a nucleic acid molecule as an anti-cancer marker in the blood, a chemical material, and the like with the improved sensitivity. Therefore, the core-shell nanoparticles of the present invention can be useful in an effective and practical magnetic nanoparticle system and a magnetic sensing method or a contrast medium using the same due to excellent magnetic characteristics, in vivo non-toxicity, high solubility and easy surface modification.
摘要翻译：本发明涉及核 - 壳纳米颗粒，其包含：含锰磁性纳米颗粒（Mn-MNP）多核; 和涂覆多芯的二氧化硅壳。由于本发明中使用的核 - 壳纳米粒子具有高的饱和磁化强度（Ms）值和横向弛豫度（R2），所以使用该传感器的本发明的传感器可以以显着提高的灵敏度检测分析物。可以检测痕量的分析物，例如蛋白质或核酸分子，作为血液中的抗癌标志物，具有改善的敏感性的化学物质等。因此，本发明的核 - 壳纳米颗粒可用于有效和实用的磁性纳米颗粒系统和磁感应方法或使用其的造影剂，由于其优异的磁特性，体内无毒性，高溶解性和易于使用表面改性。

7. 发明申请

WO2009084841A2 MUTATED NUCLEOTIDE SEQUENCES OF BATROXOBIN, MUTATED ALPHA FACTOR SECRETION SIGNAL SEQUENCE AND PROCESSES FOR PREPARING BATROXOBIN USING THE SAME 审中-公开
标题翻译：巴豆红素的突变核苷酸序列，突变的ALPHA因子分泌信号序列和使用其制备巴豆红素的方法
公开(公告)号：WO2009084841A2
公开(公告)日：2009-07-09
申请号：PCT/KR2008/007605
申请日：2008-12-23
申请人： BIOBUD CO., LTD. , SOHN, Young-Doug , KIM, Bum Joon , KIM, Ok Hwan , KIM, Kyoung Jun , SHIN, Ji Hun , HONG, Sung Yu , HWANG, Jae Hoon , CHUNG, Kwang Hoe
发明人： SOHN, Young-Doug , KIM, Bum Joon , KIM, Ok Hwan , KIM, Kyoung Jun , SHIN, Ji Hun , HONG, Sung Yu , HWANG, Jae Hoon , CHUNG, Kwang Hoe
IPC分类号： C12N9/64
CPC分类号： C12N9/6418 , C07K2319/02
摘要： The present invention relates to a batroxobin-encoding nucleotide sequence and/or a mutated α-factor secretion signal sequence, and a vector and a transformant using the same. The batroxobin-encoding nucleotide sequence of this invention exhibits an excellent expression efficiency in yeast, particular Pichia pastoris and the recombinant batroxobin is obtained at 4-13 fold higher yield than natural-occurring batroxobin-encoding sequences. The protein expression system which uses the batroxobin-encoding nucleotide sequence as well as mutated α-factor secretion signal peptide sequence of this invention obtains the recombinant batroxobin at about 20-fold higher yield than natural-occurring batroxobin-encoding sequences. In addition, the recombinant batroxobin prepared using the sequence of this invention has a significantly plausible activity and stability compared with natural-occuring batroxobin.
摘要翻译：本发明涉及一种编码巴曲酶的核苷酸序列和/或突变的a因子分泌信号序列，以及使用该序列的载体和转化体。本发明的巴曲酶编码核苷酸序列在酵母，特别是巴斯德毕赤酵母中表现出优异的表达效率，并且以比天然存在的巴曲酶编码序列高出4-13倍的产量获得重组巴曲酶。使用巴曲酶编码核苷酸序列以及本发明的突变型a因子分泌信号肽序列的蛋白质表达系统获得比天然存在的巴曲酶编码序列高约20倍的重组巴曲酶。此外，使用本发明的顺序制备的重组巴曲酶与天然发生的巴曲酶相比具有显着似乎合理的活性和稳定性。

8. 发明申请

WO2008102932A1 COMPOSITIONS FOR TREATING HYPERPROLIFERATIVE VASCULAR DISORDERS AND CANCERS 审中-公开
标题翻译：用于治疗高血压性血管疾病和癌症的组合物
公开(公告)号：WO2008102932A1
公开(公告)日：2008-08-28
申请号：PCT/KR2007/002512
申请日：2007-05-23
申请人： BIOBUD CO., LTD. , CHUNG, Kwang Hoe , PAK, Chwang Siek , HONG, Sung Yu , KANG, Soo Jung , SOHN, Young Doug , HWANG, Jae Hoon , CHOI, Eun Bok , YON, Gyu Hwan , LEE, Hyeon-Kyu , YANG, Heui Cheol
发明人： CHUNG, Kwang Hoe , PAK, Chwang Siek , HONG, Sung Yu , KANG, Soo Jung , SOHN, Young Doug , HWANG, Jae Hoon , CHOI, Eun Bok , YON, Gyu Hwan , LEE, Hyeon-Kyu , YANG, Heui Cheol
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： The present invention relates to a pharmaceutical composition for preventing or treating hyperproliferative vascular disorders, and a pharmaceutical anticancer composition comprising the compound represented by the Formula 1. The present compounds exhibit IC 50 values of less than 0.16 μM for vascular smooth muscle cells and cancer cells to effectively prevent proliferation of vascular smooth muscle cells and cancer cells, thereby ensuring prevention or treatment of hyperproliferative vascular disorders such as arteriosclerosis and restenosis, and cancers.
摘要翻译：本发明涉及用于预防或治疗过度增殖性血管疾病的药物组合物，以及含有式1表示的化合物的药物抗癌组合物。本发明化合物的IC 50值小于0.16μM，血管平滑肌细胞和癌细胞，以有效地防止血管平滑肌细胞和癌细胞的增殖，从而确保预防或治疗过度增生性血管疾病如动脉硬化和再狭窄以及癌症。

9. 发明申请

WO2005045022A1 THROMBIN-LIKE RECOMBINANT BATROXOBIN EXPRESSED BY PICHIA SP.AND PRODUCTION METHOD THEREOF 审中-公开
标题翻译：通过PICHIA SP表示的类似THROMBIN的重组巴豆红素及其生产方法
公开(公告)号：WO2005045022A1
公开(公告)日：2005-05-19
申请号：PCT/KR2003/002318
申请日：2003-10-31
申请人： BIOBUD CO., LTD. , YOU, Weon-Kyoo , CHOI, Won-Seok , KOH, You-Seok , KANG, Seung-Woo , CHUNG, Kwang-Hoe
发明人： YOU, Weon-Kyoo , CHOI, Won-Seok , KOH, You-Seok , KANG, Seung-Woo , CHUNG, Kwang-Hoe
IPC分类号： C12N9/74
CPC分类号： C12N9/6429 , C12Y304/21005
摘要： A recombinant thrombin-like enzyme batroxobin expressed by yeast, a production method thereof, and use of the batroxobin as a hemostatic agent or antithrombotic agent is disclosed. In order to express recombinant thrombin-like enzyme, an expression vector is prepared by inserting cDNA encoding the enzyme, the transformed cell is prepared by introducing the expression vector into the cell, the transformed cell then is incubated and the recombinant thrombin-like enzyme is obtained from the cell. The recombinant thrombin-like enzyme may be usefully used as a hemostatic agent because the enzyme effectively decrease bleeding time and blood coagulation time and does not affect various blood coagulation factors. The recombinant thrombin-like enzyme is also useful for a hemostatic agent or antithrombotic agent comprising the recombinant thrombin-like enzyme as an active component.
摘要翻译：公开了由酵母表达的重组凝血酶样酶巴曲酶，其制备方法，以及巴曲酶作为止血剂或抗血栓剂的用途。为了表达重组凝血酶样酶，通过插入编码该酶的cDNA来制备表达载体，通过将表达载体导入细胞来制备转化细胞，然后将转化的细胞孵育，重组凝血酶样酶为从细胞获得。重组凝血酶样酶可有效地用作止血剂，因为该酶有效地减少了出血时间和凝血时间，并且不影响各种凝血因子。重组凝血酶样酶也可用于包含重组凝血酶样酶作为活性成分的止血剂或抗血栓形成剂。

10. 发明申请

WO1997002286A1 NOVEL ANTIBIOTIC PEPTIDES 审中-公开
标题翻译：新型抗生素PEPTIDES
公开(公告)号：WO1997002286A1
公开(公告)日：1997-01-23
申请号：PCT/KR1996000034
申请日：1996-03-11
申请人： MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE , LEE, Keun-Hyeung , HONG, Sung-Yu , CHO, Hyun-Sook , LEE, Bok-Leul , CHUNG, Kwang-Hoe , YOON, Jeong-Hyeok , OH, Jong-Eun , MOON, Hong-Mo
发明人： MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE
IPC分类号： C07K07/04
CPC分类号： C07K14/43563 , A61K38/00
摘要： The present invention relates to novel antibiotic peptides which possess antibacterial and/or antifungal activities causing no cytotoxicity, and to antibacterial and/or antifungal agents containing said peptides as active ingredients. In accordance with the present invention, it has been discovered that: a number of chemically-synthesized peptides which are derived from Tenecin, show superior antibacterial and/or antifungal activities, while causing no untoward effects, and they can be applied for the development of antibacterial and/or antifungal agents.
摘要翻译：本发明涉及具有不引起细胞毒性的抗细菌和/或抗真菌活性的新型抗生素肽以及含有所述肽作为活性成分的抗菌剂和/或抗真菌剂。根据本发明，已经发现：从Tenecin衍生的许多化学合成的肽显示出优异的抗菌和/或抗真菌活性，同时不会产生不利影响，并且它们可用于开发抗菌和/或抗真菌剂。

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