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1. 发明申请

WO2007120248A3 NANOPOROUS SUBSTRATES FOR ANALYTICAL METHODS 审中-公开
公开(公告)号：WO2007120248A3
公开(公告)日：2007-10-25
申请号：PCT/US2006/048460
申请日：2006-12-20
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , FERRARI, Mauro , CHENG, Mark, Ming-cheng , CUDA, Giovanni , GASPARI, Marco , GEHO, David , LIOTTA, Lance , PETRICOIN, Emmanuel , ROBERTSON, Fredika , TERRACCIANO, Rosa
发明人： FERRARI, Mauro , CHENG, Mark, Ming-cheng , CUDA, Giovanni , GASPARI, Marco , GEHO, David , LIOTTA, Lance , PETRICOIN, Emmanuel , ROBERTSON, Fredika , TERRACCIANO, Rosa
IPC分类号： G01N33/68 , B01D15/38 , C07K1/22 , G01N30/90 , B01D15/10
摘要： Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.

2. 发明申请

WO2012112746A1 BIOCOMPATIBLE GRAPHENE SENSOR 审中-公开
标题翻译：生物成像传感器
公开(公告)号：WO2012112746A1
公开(公告)日：2012-08-23
申请号：PCT/US2012/025377
申请日：2012-02-16
申请人： WAYNE STATE UNIVERSITY , CHENG, Mark, Ming-Cheng , ZHOU, Zhixian
发明人： CHENG, Mark, Ming-Cheng , ZHOU, Zhixian
IPC分类号： G01N21/00 , H01L21/336
CPC分类号： G01N27/4145 , A61B5/14503 , A61B5/6852 , G01N33/5438 , G01N33/54386
摘要： A graphene biosensor is formed on an electrically insulating substrate with a single- layer graphene sheet arranged between two metallic electrodes. The graphene sheet is in electrical contact with the metallic electrodes. The graphene sheet has perforations creating edges in the graphene sheet. The perforations may be holes on a micrometer scale or in a nanometer scale. The biosensor can be configured as an ISFET. The graphene sheet may comprise affinity probes immobilized on the edges for attaching specific molecules to the graphene sheet. Several graphene sheets may be arranged in a microarray with different affinity probes on different graphene sheets. The sensor may also be arranged on the distal end of a catheter for in situ measurements in a body vessel.
摘要翻译：石墨烯生物传感器形成在电绝缘基板上，其中单层石墨烯片布置在两个金属电极之间。石墨烯片与金属电极电接触。石墨烯片具有在石墨烯片中产生边缘的穿孔。穿孔可以是微米级或纳米级的孔。生物传感器可以配置为ISFET。石墨烯片可以包含固定在边缘上的亲和探针，用于将特定分子附着到石墨烯片上。可以在具有不同的石墨烯片上的不同亲和探针的微阵列中排列几个石墨烯片。传感器还可以布置在导管的远端，用于在体内容器中进行原位测量。

3. 发明申请

WO2007120248A2 NANOPOROUS SUBSTRATES FOR ANALYTICAL METHODS 审中-公开
标题翻译：用于分析方法的纳米基材
公开(公告)号：WO2007120248A2
公开(公告)日：2007-10-25
申请号：PCT/US2006048460
申请日：2006-12-20
申请人： UNIV OHIO STATE RES FOUND , UNIV TEXAS , FERRARI MAURO , CHENG MARK MING-CHENG , CUDA GIOVANNI , GASPARI MARCO , GEHO DAVID , LIOTTA LANCE , PETRICOIN EMMANUEL , ROBERTSON FREDIKA , TERRACCIANO ROSA
发明人： FERRARI MAURO , CHENG MARK MING-CHENG , CUDA GIOVANNI , GASPARI MARCO , GEHO DAVID , LIOTTA LANCE , PETRICOIN EMMANUEL , ROBERTSON FREDIKA , TERRACCIANO ROSA
CPC分类号： G01N1/405 , B01D15/00 , B01D15/08 , B01J20/103 , B01J20/2808 , B01J2220/54 , B01L3/5023 , B82Y5/00 , C07K1/30 , C07K1/34 , G01N33/6803 , Y10T436/2525 , Y10T436/255
摘要： Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.
摘要翻译：可以使用纳米多孔材料来富集样品，以便随后分析样品中所含的物质。该方法显示为丰富低分子量蛋白质组中物种的产量，允许检测低纳摩尔范围内的小肽。

4. 发明申请

WO2013116675A1 ELECTROWETTING ON DIELECTRIC USING GRAPHENE 审中-公开
标题翻译：使用石墨电介质电镀
公开(公告)号：WO2013116675A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024377
申请日：2013-02-01
申请人： WAYNE STATE UNIVERSITY , CHENG, Mark, Ming-Cheng , TAN, Xuebin , ZHOU, Zhixian
发明人： CHENG, Mark, Ming-Cheng , TAN, Xuebin , ZHOU, Zhixian
IPC分类号： B03C5/02
CPC分类号： B01L99/00 , B01L3/502784 , B01L2400/0427 , B03C5/02 , G02B26/005 , H01G11/32 , Y02E60/13
摘要： An electrowetting device and a method of electrowetting may be provided. An electrode may be provided. The electrode has a graphene layer having a first side and a second side that opposes the first side. The electrode also has a dielectric layer disposed on the first side of the graphene layer. A liquid droplet is disposed on the dielectric layer. A voltage is applied through the droplet and the electrode. A contact angle between the dielectric layer and an edge of the liquid droplet contacting the dielectric layer changes in response to the applied voltage.
摘要翻译：可以提供电润湿装置和电润湿方法。可以提供电极。电极具有石墨烯层，其具有与第一侧相对的第一侧和第二侧。电极还具有设置在石墨烯层的第一侧上的电介质层。液滴设置在电介质层上。通过液滴和电极施加电压。电介质层与接触电介质层的液滴的边缘之间的接触角随施加的电压而变化。

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