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1. 发明申请

WO2011085988A1 METHODS FOR THE PREPARATION OF BIOCOMPATIBLE POLYMERS, THE POLYMERS AND THEIR USES 审中-公开
标题翻译：生物聚合物聚合物的制备方法，聚合物及其用途
公开(公告)号：WO2011085988A1
公开(公告)日：2011-07-21
申请号：PCT/EP2011/000129
申请日：2011-01-11
申请人： CHEMISCHES INSTITUT SCHAEFER AG , SCHAEFER, Rolf , HITZ, Hans
发明人： SCHAEFER, Rolf , HITZ, Hans
IPC分类号： C08F8/30 , G02B1/04
CPC分类号： G02B1/043 , C08F8/30 , Y10S514/912 , C08F222/06
摘要： The subject invention relates to a method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions. The invention further encompasses the resulting biocompatible polymer and articles made from the polymer, in particular contact and intraocular lenses.
摘要翻译：本发明涉及制备生物相容性聚合物的方法，其包含具有游离α-氨基和羧基官能团的ε连接的L-赖氨酸。本发明还包括所得的生物相容性聚合物和由聚合物制成的制品，特别是接触和眼内透镜。

2. 发明申请

WO2009007827A9 NOVEL DICLOFENAC ESTERS AND USES THEREOF 审中-公开
公开(公告)号：WO2009007827A9
公开(公告)日：2009-01-15
申请号：PCT/IB2008/001781
申请日：2008-07-03
申请人： CHEMISCHES INSTITUT SCHAEFER AG , HITZ, Hans , SCHAEFER, Rolf
发明人： HITZ, Hans , SCHAEFER, Rolf
IPC分类号： C07C229/60 , A61K31/245 , A61P29/00
摘要： The present invention relates to novel cycloalkyl alkyl and fluoroalkyl esters of diclofenac that more readily penetrate membrane systems than diclofenac (acid) or prior art esters of diclofenac. Pharmaceutical compositions comprising these esters as well as methods for treating inflammatory conditions using the latter compositions are also disclosed.

3. 发明申请

WO2006126095A3 BIOCOMPATIBLE POLYMERS AND CO-POLYMERS COMPRISING AMINO ACIDS IN THE SIDE CHAIN 审中-公开
公开(公告)号：WO2006126095A3
公开(公告)日：2006-11-30
申请号：PCT/IB2006/001722
申请日：2006-05-22
申请人： CHEMISCHES INSTITUT SCHAEFER AG , HITZ, Hans , SCHAEFER, Rolf , SCHAEFER, Christoph
发明人： HITZ, Hans , SCHAEFER, Rolf , SCHAEFER, Christoph
IPC分类号： C08F220/36
摘要： The invention relates to highly biocompatible or biophilic un-cross-linked or cross-linked polymers comprising one or more side-chain active acrylic amino acids of formula (I). The invention further concerns various highly biocompatible, cross-linked co-polymers comprising one or more monomers of formula (I), and one or more other polymerizable monomers. Uses of such polymers and co-polymers for the production of contact lenses, intraocular lenses, implants, wound healing slabs, additives for food and cosmetics, conductive plastics, spinnable fibers, and the like are disclosed.

4. 发明申请

WO2012123275A1 THERMO-RESPONSIVE HYDROGEL COMPOSITIONS 审中-公开
标题翻译：热应答水凝胶组合物
公开(公告)号：WO2012123275A1
公开(公告)日：2012-09-20
申请号：PCT/EP2012/053765
申请日：2012-03-05
申请人： CHEMISCHES INSTITUT SCHAEFER , ILLINOIS INSTITUTE OF TECHNOLOGY , BREY, Eric , DRAPALA, Pawel , HITZ, Hans , JIANG, Bin , KANG-MIELER, Jennifer , PEREZ-LUNA, Victor , SCHAEFER, Rolf
发明人： BREY, Eric , DRAPALA, Pawel , HITZ, Hans , JIANG, Bin , KANG-MIELER, Jennifer , PEREZ-LUNA, Victor , SCHAEFER, Rolf
IPC分类号： A61K47/32 , A61K47/48
CPC分类号： A61K47/32 , A61K9/0014 , A61K9/0048 , A61K9/06 , A61K9/5153 , A61K31/573 , A61K47/34
摘要： A thermo-responsive hydrogel, including a biocompatible monomer and/or polymer having a side chain-linked amino acid. The hydrogel is thermo-responsive at a physiological temperature, and can include, incorporate, or encapsulate a treatment agent, such as a drug composition, a biomolecule, and/or a nanoparticle. The hydrogel is useful in delivering the treatment agent. The hydrogel is in a first physicochemical state for administration to a mammal. The hydrogel is thermo-responsive at a physiological temperature of the mammal, and changes to a second physicochemical state that is more solid than the first physicochemical state. In the second physicochemical state the thermo-responsive hydrogel releases the treatment agent.
摘要翻译：一种热响应性水凝胶，包括具有侧链连接的氨基酸的生物相容性单体和/或聚合物。水凝胶在生理温度下是热响应的，并且可以包括，掺入或包封处理剂，例如药物组合物，生物分子和/或纳米颗粒。水凝胶可用于递送处理剂。水凝胶处于哺乳动物的第一物理化学状态。水凝胶在哺乳动物的生理温度下是热应答的，并且变成比第一物理化学状态更固体的第二物理化学状态。在第二个物理化学状态下，热响应性水凝胶释放处理剂。

5. 发明申请

WO2010038129A1 MUCOMIMETIC COMPOSITIONS AND USES THEREFORE 审中-公开
标题翻译： MUCOMIMETIC COMPOSITIONS及其用途
公开(公告)号：WO2010038129A1
公开(公告)日：2010-04-08
申请号：PCT/IB2009/006972
申请日：2009-09-28
申请人： CHEMISCHES INSTITUT SCHAEFER AG , SCHAEFER, Rolf
发明人： SCHAEFER, Rolf
IPC分类号： A61K9/00 , A61K9/06 , A61K31/728 , A61K47/02 , A61K47/34 , A61K47/36 , A61K47/38 , A61L12/14 , A61K31/785
CPC分类号： A61K9/0048
摘要： The present invention relates to mucomimetic and ophthalmic solutions comprising a cationic polymeric antimicrobial agent such as polyaminopropyl biguanide and a magnesium, calcium or magnesium/calcium complex of an anionic polymer such as hyaluronate, alginate, carboxymethyl cellulose, chondroitin sulfate or mixtures thereof. In specific embodiments, the solutions include additional components such as a surfactant, preferably polysorbate 20, a viscosity-modifying agent, preferably hydroxypropylmethyl cellulose, carboxymethyl cellulose or hydroxyethyl cellulose, a tonicity agent and a buffer. The solutions are biocompatible with and are highly comfortable when administered to mucous membranes, including those of the eye, as well as are effective disinfectants.
摘要翻译：本发明涉及包含阳离子聚合抗微生物剂如聚氨基丙基双胍的阴模溶液和眼用溶液以及阴离子聚合物如透明质酸盐，藻酸盐，羧甲基纤维素，硫酸软骨素或其混合物的镁，钙或镁/钙络合物。在具体实施方案中，溶液包括另外的组分，例如表面活性剂，优选聚山梨酯20，粘度调节剂，优选羟丙基甲基纤维素，羧甲基纤维素或羟乙基纤维素，张度剂和缓冲剂。当给予粘膜（包括眼睛的那些）以及有效的消毒剂时，溶液是生物相容的并且是高度舒适的。

6. 发明申请

WO2012110471A1 CEFUROXIME SAFETY DELIVERY SYSTEM 审中-公开
标题翻译： CEFUROXIME安全递送系统
公开(公告)号：WO2012110471A1
公开(公告)日：2012-08-23
申请号：PCT/EP2012/052442
申请日：2012-02-14
申请人： CHEMISCHES INSTITUT SCHAEFER AG , SCHAEFER, Rolf
发明人： SCHAEFER, Rolf
IPC分类号： A61K9/00 , A61M5/178 , A61M5/315 , A61J1/20 , A61M5/19 , A61M5/24
CPC分类号： A61J1/2096 , A61J1/00 , A61J1/20 , A61J1/2089 , A61K9/0048 , A61K31/546 , A61M5/00 , A61M5/178 , A61M5/19 , A61M5/2448 , A61M5/31596 , F16D43/18
摘要： The present invention relates to safety delivery systems for intracameral administration of an appropriate dose of cefuroxime subsequent to cataract and other eye surgery. A preferred embodiment of an cefuroxime safety delivery system according to the invention comprises (a) a perforable sterile vial sterile-filled with a measured amount of cefuroxime, (b) a reconstitution syringe with a male luer fitting sterile-filled with 0.1 ml of isotonic salt solution per mg cefuroxime in the perforable vial and a vial adapter with a female luer fitting or one or more needles with female luer fitting, and (c) one or more sterilized delivery syringes with male luer fitting, each delivery syringe being capable of holding at least 0.1 ml of ejectable liquid and containing a marking indicating a fill volume of 0.1 ml of ejectable liquid.
摘要翻译：本发明涉及用于在白内障和其它眼睛手术之后的适当剂量的头孢呋辛的腔内施用的安全递送系统。根据本发明的头孢呋辛安全递送系统的优选实施方案包括（a）无菌填充有测量量的头孢呋辛的穿孔无菌小瓶，（b）具有无菌填充有0.1ml等渗剂的雄性鲁尔配方的重构注射器在可穿孔小瓶中的每mg头孢呋辛盐溶液和具有阴性鲁尔接头或具有阴性鲁尔接头的一个或多个针的小瓶适配器，以及（c）一个或多个带有雄性鲁尔接头的灭菌递送注射器，每个输送注射器能够保持至少0.1ml的可喷射液体，并含有一个标记，指示填充体积为0.1ml的可喷射液体。

7. 发明申请

WO2012110057A1 CEFUROXIME SAFETY KIT 审中-公开
标题翻译： CEFUROXIME安全包
公开(公告)号：WO2012110057A1
公开(公告)日：2012-08-23
申请号：PCT/EP2011/000848
申请日：2011-02-15
申请人： CHEMISCHES INSTITUT SCHAEFER AG , SCHAEFER, Rolf
发明人： SCHAEFER, Rolf
IPC分类号： A61K9/00 , A61M5/178 , A61M5/315 , A61J1/20
CPC分类号： A61J1/2096 , A61J1/00 , A61J1/20 , A61J1/2089 , A61K9/0048 , A61K31/546 , A61M5/00 , A61M5/178 , A61M5/19 , A61M5/2448 , A61M5/31596 , F16D43/18
摘要： The present invention relates to safety kits for intracameral administration of an appropriate dose of cefuroxime subsequent to cataract and other eye surgery. A preferred embodiment of an cefuroxime safety kit according to the invention comprises (a) a perforable sterile vial sterile-filled with a measured amount of cefuroxime, (b) a sterilized reconstitution syringe, and (c) one or more sterilized delivery syringes.
摘要翻译：本发明涉及用于在白内障和其它眼睛手术之后的适当剂量的头孢呋辛的腔内施用的安全套件。根据本发明的头孢呋辛安全套件的优选实施方案包括（a）无菌填充有测量量的头孢呋辛的穿孔无菌瓶，（b）灭菌的重组注射器，和（c）一个或多个灭菌的输送注射器。

8. 发明申请

WO2009037562A2 NUTRITIONAL SUPPLEMENT FORMULATIONS FOR INCLUSION IN FOODS AND FORTIFIED FOODS COMPRISING SUCH SUPPLEMENTS 审中-公开
标题翻译：用于包装在食品中的营养补充配方和包含此类补充品的特殊食品
公开(公告)号：WO2009037562A2
公开(公告)日：2009-03-26
申请号：PCT/IB2008/002460
申请日：2008-09-15
申请人： CHEMISCHES INSTITUT SCHAEFER AG , HITZ, Hans , SCHAEFER, Rolf , SCHAEFER, Christoph
发明人： HITZ, Hans , SCHAEFER, Rolf , SCHAEFER, Christoph
CPC分类号： A23G1/426 , A23L33/105 , A23L33/15 , A23L33/155 , A23L33/16 , A23L33/17 , A23V2002/00 , A61K31/355 , A61K31/375 , A61K33/30 , A61K33/34 , A61K45/06 , A61K2300/00 , A23V2250/1642 , A23V2250/1584 , A23V2250/712 , A23V2250/708 , A23V2250/211 , A23V2250/7052 , A23V2250/706 , A23V2250/702 , A23V2250/0612 , A23V2250/0644 , A23V2250/213 , A23V2250/1626 , A23V2250/1572 , A23V2250/1588 , A23V2250/7046 , A23V2250/705 , A23V2250/7056 , A23V2250/1882 , A23V2200/302
摘要： The present invention relates to formulations adapted from the original AREDS formula that are suitable for introduction into a measured amount or volume of a food as well as to foods containing these formulations. These fortified foods are expected to provide patients afflicted with or at risk for developing macular degeneration or other age-related deficiencies with alternative and more palatable sources of the ingredients of the original AREDS formula than those currently available in the market.
摘要翻译：本发明涉及适于引入测量量或体积的食物以及含有这些制剂的食品的原始AREDS配方的制剂。这些强化食物预计会为那些患有原发性黄斑变性或其他与年龄相关的黄斑变性或其他与年龄有关的缺陷的患者提供患有原始AREDS配方的成分来源的患者，而不是目前市场上可获得的食物。

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