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1. 发明申请

WO2008030591A2 PEHAM DENDRIMERS AS EXCIPIENTS 审中-公开
标题翻译： PEHAM DENDRIMERS作为例外
公开(公告)号：WO2008030591A2
公开(公告)日：2008-03-13
申请号：PCT/US2007019601
申请日：2007-09-07
申请人： DENDRITIC NANOTECHNOLOGIES INC , SVENSON SONKE , CHAUHAN ABHAY SINGH
发明人： SVENSON SONKE , CHAUHAN ABHAY SINGH
IPC分类号： A61K9/18
CPC分类号： A61K47/34 , A61K47/6949 , B82Y5/00
摘要： The present invention concerns poly(etherhydroxylamine) PEHAM dendritic polymers wherein they function as excipients for the enhancement of water solubility of poorly water soluble (hydrophobic) Active Materials or enhancement of oil solubility of poorly oil soluble (hydrophilic) Active Materials. These dendritic polymers can have Active Materials associated with them by one or more of the following: (a) by adsorption onto the surface or (b) encapsulation into the interior of the dendritic polymers or (c) a mixture of both where these interactions are driven by one or more of the following (i) electrostatic attraction, (ii) hydrogen bonding between dendritic polymers and Active Material and (iii) hydrophobic or hydrophilic interactions or mixtures of these interactions. Additionally, these associated Active Materials can be associated with dendritic polymers through chemical bonding to the surface or to internal functionalities (IF) of PEHAM dendritic polymers or both. Such bonding is done either directly between PEHAM dendritic polymers and Active Material molecules or via a linker that can have a hydrolysable bond to the Active Material. In addition, a chemical entity with strong interaction to the Active Material and dendritic polymers can be associated with the dendritic polymer prior to adsorption or encapsulation of the Active Material or together with the Active Material.
摘要翻译：本发明涉及聚（醚羟胺）PEHAM树枝状聚合物，其中它们用作增强水溶性（疏水性）活性材料的水溶性的赋形剂，或者提高油溶性（亲水性）活性物质的油溶性。这些树枝状聚合物可以通过一种或多种以下物质与其相关的活性材料：（a）通过吸附到表面上或（b）包封到树枝状聚合物的内部，或（c）两者的混合物，其中这些相互作用是由以下一个或多个（i）静电吸引，（ii）树枝状聚合物和活性材料之间的氢键和（iii）疏水或亲水相互作用或这些相互作用的混合物驱动。另外，这些相关的活性材料可以通过与表面的化学键合或PEHAM树枝状聚合物的内部功能（IF）或两者结合而与树枝状聚合物缔合。这种键合可以直接在PEHAM树枝状聚合物和活性材料分子之间进行，或者通过可以与活性材料具有可水解键的接头进行。此外，与活性物质和树枝状聚合物具有强相互作用的化学物质在活性物质的吸附或包封之前或与活性物质一起可与树枝状聚合物缔合。

2. 发明申请

WO2011053605A1 PEHAM DENDRIMERS FOR USE IN AGRICULTURE 审中-公开
标题翻译： PEHAM DENDRIMERS用于农业
公开(公告)号：WO2011053605A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/054164
申请日：2010-10-26
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , STARPHARMA PTY LTD , HAYES, Rayan, Terrell , OWEN, James, David , CHAUHAN, Abhay, Singh , PULGAM, Veera, Reddy
发明人： HAYES, Rayan, Terrell , OWEN, James, David , CHAUHAN, Abhay, Singh , PULGAM, Veera, Reddy
IPC分类号： A01N25/12
CPC分类号： A01N25/22 , A01N25/24 , A01N25/30 , C08L101/005 , A01N33/18 , A01N43/54 , A01N43/653 , A01N47/02 , A01N47/20 , A01N59/20
摘要： Specific PEHAM dendrimers are used in a formulation with an active agent for agricultural purposes, particularly for increasing the efficacy of the active agent in various ways, such as by improving solubility of the active agent in the formulation, by improving adhesion and penetration of the active agent to plant surfaces, by improving the water- fastness of the active agent to the plant or seed, by providing protection of the active agent from UV damage, by increasing soil penetration of the active agent to reach the plant roots or under soil parts, or by reducing soil adhesion of the active agent to reach the plant roots or under soil parts, or reducing enzymatic degradation of the active agent by the plant or seed or microorganisms in the soil.
摘要翻译：具体的PEHAM树枝状大分子用于具有用于农业目的的活性剂的制剂中，特别是用于以各种方式增加活性剂的功效，例如通过改善活性剂在制剂中的溶解度，通过改善活性物质的粘附性和渗透性通过提高活性剂对UV损伤的保护，通过增加活性剂到达植物根部或土壤部分的土壤渗透，提高活性剂对植物或种子的耐水性，或通过减少活性剂到达植物根部或土壤部分的土壤粘附，或减少土壤中植物或种子或微生物对活性剂的酶降解。

3. 发明申请

WO2007149500A3 FORMULATIONS CONTAINING HYBRID DENDRIMERS 审中-公开
公开(公告)号：WO2007149500A3
公开(公告)日：2007-12-27
申请号：PCT/US2007/014402
申请日：2007-06-20
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , CHAUHAN, Abhay, Singh , SVENSON, Sonke
发明人： CHAUHAN, Abhay, Singh , SVENSON, Sonke
IPC分类号： A61K31/74 , A61K47/48
摘要： The present invention concerns hybrid dendrimers comprising a mixture, at the same or different ratios, of at least two dendritic polymers or dendronized polymers that have at least one difference between them. The surfaces of the dendritic polymer or dendronized polymer may be further modified by known methods. Also included are formulations of hybrid dendrimers wherein the dendritic polymers have the same drug present at either identical or different loading concentrations but have different release profiles. Such formulations of hybrid dendrimers may have different guest molecules present at either identical or different loading concentrations but have different release profiles. Additionally a method of using a hybrid dendrimer for delivery of a drug or guest moiety in order to provide increased solubility to poorly soluble drugs or guest moieties is provided.

4. 发明申请

WO2003080121A1 MACROMOLECULAR COMPOUNDS AS POTENTIAL ANTI-INFLAMMATORY AGENTS 审中-公开
标题翻译：大分子化合物作为潜在的抗炎药物
公开(公告)号：WO2003080121A1
公开(公告)日：2003-10-02
申请号：PCT/IB2002/000689
申请日：2002-03-26
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , CHAUHAN, Abhay, Singh , DIWAN, Prakash, Vamanrao , JAIN, Narendra, Kumar , RAGHAVAN, Kondapuram, Vijaya
发明人： CHAUHAN, Abhay, Singh , DIWAN, Prakash, Vamanrao , JAIN, Narendra, Kumar , RAGHAVAN, Kondapuram, Vijaya
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/6949
摘要： The present invention relates to a composition and use of the composition exhibiting anti-inflammatory activity comprising of a momodisperse macromolecular polymers such as dendrimer having a plurality of terminalgroups or such molecules bound/complexed to drug moieties having anti-inflammatory activity or which assistin anti-inflammatory activity and its use in the pharmaceutical formulation for treating disease or pathological conditions associated with inflammation.
摘要翻译：本发明涉及具有抗炎活性的组合物的组合物和用途，其包含分子量大的分子聚合物，例如具有多个端基的树枝状大分子或与具有抗炎活性的药物部分结合/络合的分子，炎症活性及其在药物制剂中的用途，用于治疗与炎症相关的疾病或病理状况。

5. 发明申请

WO2007149500A9 FORMULATIONS CONTAINING HYBRID DENDRIMERS 审中-公开
标题翻译：含有混合树枝的配方
公开(公告)号：WO2007149500A9
公开(公告)日：2008-03-20
申请号：PCT/US2007014402
申请日：2007-06-20
申请人： DENDRITIC NANOTECHNOLOGIES INC , CHAUHAN ABHAY SINGH , SVENSON SONKE
发明人： CHAUHAN ABHAY SINGH , SVENSON SONKE
IPC分类号： A61K31/785
CPC分类号： A61K31/785
摘要： The present invention concerns hybrid dendrimers comprising a mixture, at the same or different ratios, of at least two dendritic polymers or dendronized polymers that have at least one difference between them. The surfaces of the dendritic polymer or dendronized polymer may be further modified by known methods. Also included are formulations of hybrid dendrimers wherein the dendritic polymers have the same drug present at either identical or different loading concentrations but have different release profiles. Such formulations of hybrid dendrimers may have different guest molecules present at either identical or different loading concentrations but have different release profiles. Additionally a method of using a hybrid dendrimer for delivery of a drug or guest moiety in order to provide increased solubility to poorly soluble drugs or guest moieties is provided.
摘要翻译：本发明涉及包含以相同或不同比例的至少两种树枝状聚合物或树枝状聚合物的混合树枝状聚合物，所述树枝状聚合物或树枝化聚合物在它们之间具有至少一个差异。树枝状聚合物或树枝状聚合物的表面可以通过已知方法进一步改性。还包括其中树枝状聚合物具有相同或不同负载浓度但具有不同释放曲线的相同药物的混合树枝状聚合物的制剂。混合树枝状聚合物的这种制剂可以具有不同的客体分子，以相同或不同的负载浓度存在，但具有不同的释放曲线。另外提供了使用混合树枝状聚合物递送药物或客体部分以便提供溶解性差的药物或客体部分的方法。

6. 发明申请

WO2008030591A3 PEHAM DENDRIMERS AS EXCIPIENTS 审中-公开
公开(公告)号：WO2008030591A3
公开(公告)日：2008-03-13
申请号：PCT/US2007/019601
申请日：2007-09-07
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , SVENSON, Sonke , CHAUHAN, Abhay, Singh
发明人： SVENSON, Sonke , CHAUHAN, Abhay, Singh
IPC分类号： A61K31/74 , C08G73/06 , C08G65/34
摘要： The present invention concerns poly(etherhydroxylamine) PEHAM dendritic polymers wherein they function as excipients for the enhancement of water solubility of poorly water soluble (hydrophobic) Active Materials or enhancement of oil solubility of poorly oil soluble (hydrophilic) Active Materials. These dendritic polymers can have Active Materials associated with them by one or more of the following: (a) by adsorption onto the surface or (b) encapsulation into the interior of the dendritic polymers or (c) a mixture of both where these interactions are driven by one or more of the following (i) electrostatic attraction, (ii) hydrogen bonding between dendritic polymers and Active Material and (iii) hydrophobic or hydrophilic interactions or mixtures of these interactions. Additionally, these associated Active Materials can be associated with dendritic polymers through chemical bonding to the surface or to internal functionalities (IF) of PEHAM dendritic polymers or both. Such bonding is done either directly between PEHAM dendritic polymers and Active Material molecules or via a linker that can have a hydrolysable bond to the Active Material. In addition, a chemical entity with strong interaction to the Active Material and dendritic polymers can be associated with the dendritic polymer prior to adsorption or encapsulation of the Active Material or together with the Active Material.

7. 发明申请

WO2006115547A2 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的聚合物聚合物
公开(公告)号：WO2006115547A2
公开(公告)日：2006-11-02
申请号：PCT/US2005/047635
申请日：2005-12-21
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , TOMALIA, Donald, A. , SWANSON, Douglas, R. , HUANG, Baohua , PULGAM, Verra, Reddy , HEINZELMANN, Joseph, R. , SVENSON, Sonke , REYNA, Lori, A. , ZHURAVEL, Michael, A. , CHAUHAN, Abhay, Singh , DeMATTEI, Cordell, R.
发明人： TOMALIA, Donald, A. , SWANSON, Douglas, R. , HUANG, Baohua , PULGAM, Verra, Reddy , HEINZELMANN, Joseph, R. , SVENSON, Sonke , REYNA, Lori, A. , ZHURAVEL, Michael, A. , CHAUHAN, Abhay, Singh , DeMATTEI, Cordell, R.
IPC分类号： A61K48/00 , A61K31/785
CPC分类号： C12N15/87 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/00 , A61K49/0002 , B82Y5/00 , B82Y10/00 , C08G83/003 , C08L101/005 , C09B67/0013
摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
摘要翻译：公开了具有增强的扩增和内部功能的树枝状聚合物。这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建树突状结构，一代代，具有更清洁的化学，通常单一产品，较低的试剂过量，较低的稀释水平，更高的容量方法，更容易缩放到商业尺寸，新的材料范围以及更低的成本。制备的树枝状组合物具有新颖的内部功能，更高的稳定性（例如，热稳定性和较少或没有反向迈克尔反应），并且在较低代次下达到包封表面密度。出乎意料的是，多官能分支细胞试剂与多官能核心的这些反应不产生交联材料。这种树枝状聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强剂，质子清除剂，聚合物，纳米尺寸单体，用于电子显微镜的校准标准品，制备尺寸选择性膜，以及用于在水性制剂中改性粘度的试剂作为油漆。当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，例如用于药物递送，转染和诊断，这些树枝状聚合物具有携带材料的附加性质。

8. 发明申请

WO2003080088A1 THERAPEUTIC EDIBLE COMPOSITION FOR TREATING HYPERGLYCEMIA 审中-公开
标题翻译：用于治疗高血压的治疗食用组合物
公开(公告)号：WO2003080088A1
公开(公告)日：2003-10-02
申请号：PCT/IB2002/001151
申请日：2002-03-26
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , CHAUHAN, Abhay, Singh , CHALASANI, Kishore, Babu , SURAPANINI, Sridevi , YANDRAPU, Sharath, Kumar , KATARAM, Rajasekhar , CHARY, Govardhana, Maroju , DIWAN, Prakash, Vamanrao , RAGHAVAN, Kondapura, Vijaya
发明人： CHAUHAN, Abhay, Singh , CHALASANI, Kishore, Babu , SURAPANINI, Sridevi , YANDRAPU, Sharath, Kumar , KATARAM, Rajasekhar , CHARY, Govardhana, Maroju , DIWAN, Prakash, Vamanrao , RAGHAVAN, Kondapura, Vijaya
IPC分类号： A61K35/78
CPC分类号： A61K36/53 , A61K36/58 , A61K36/736 , A61K36/75 , A61K36/87 , A61K2300/00
摘要： A therapeutic or an edible composition comprising at least three of the five herbs selected from Prunus amygdales , Ocimum sanctum , Azadirachta indica , Aegle marelose and Vitus vinefera , is provided for the treatment of hyperglycemia, especially for non-insulin dependent diabetic subjects, and the herbal compositionhas significantly reduced the blood glucose levels in both diabetic and non-diabetic experimental subjectshaving elevated blood glucose levels.
摘要翻译：提供了包含选自杏仁（Amygdales），圣蛾（Ocimum sanctum），楝树（Azadirachta indica），A麦草（Aegle marelose）和维生素（Vitus vinefera））的五种草药中的至少三种的治疗或可食用组合物，用于治疗高血糖症，特别是对于非胰岛素依赖性糖尿病受试者，草药组合物显着降低糖尿病和非糖尿病实验受试者血糖水平升高的血糖水平。

9. 发明申请

WO2006115547A3 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的聚合物聚合物
公开(公告)号：WO2006115547A3
公开(公告)日：2009-06-04
申请号：PCT/US2005047635
申请日：2005-12-21
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
IPC分类号： C08J3/00 , C08J9/32 , C08K9/00 , C12N15/87
CPC分类号： C12N15/87 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/00 , A61K49/0002 , B82Y5/00 , B82Y10/00 , C08G83/003 , C08L101/005 , C09B67/0013
摘要： Dendritic polymers of the macromolecular structure of Figure 1 are disclosed. The dendritic polymers have enhanced amplification and interior functionality. The dendritic polymers are made by use of fact, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled manner to rapidly and precisely build dendritic structures with cleaner chemistry and often with single products. Additional benefits include lower excesses of regents, lower levels of dilution, higher capacity, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The compositions prepared have novel internal functionality, including increased thermal stability and no reverse Michael's reaction, and reach encapsulation surface densities at lower generations.
摘要翻译：公开了图1的大分子结构的树枝状聚合物。树枝状聚合物具有增强的扩增和内部功能。树枝状聚合物通过使用事实，反应性开环化学（或其它快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建具有更清洁化学物质的树突状结构并且经常与单一产物一起制备。额外的好处包括摄入量过低，稀释水平降低，容量更大，容易扩展到商业尺寸，新的材料范围以及更低的成本。制备的组合物具有新颖的内部功能，包括增加的热稳定性和没有相反的迈克尔反应，并在较低的代下达到包封表面密度。

10. 发明申请

WO2007149500A2 FORMULATIONS CONTAINING HYBRID DENDRIMERS 审中-公开
标题翻译：含有混合染料的配方
公开(公告)号：WO2007149500A2
公开(公告)日：2007-12-27
申请号：PCT/US2007014402
申请日：2007-06-20
申请人： DENDRITIC NANOTECHNOLOGIES INC , CHAUHAN ABHAY SINGH , SVENSON SONKE
发明人： CHAUHAN ABHAY SINGH , SVENSON SONKE
IPC分类号： A61K31/785
CPC分类号： A61K31/785
摘要： The present invention concerns hybrid dendrimers comprising a mixture, at the same or different ratios, of at least two dendritic polymers or dendronized polymers that have at least one difference between them. The surfaces of the dendritic polymer or dendronized polymer may be further modified by known methods. Also included are formulations of hybrid dendrimers wherein the dendritic polymers have the same drug present at either identical or different loading concentrations but have different release profiles. Such formulations of hybrid dendrimers may have different guest molecules present at either identical or different loading concentrations but have different release profiles. Additionally a method of using a hybrid dendrimer for delivery of a drug or guest moiety in order to provide increased solubility to poorly soluble drugs or guest moieties is provided.
摘要翻译：本发明涉及混合树枝状大分子，其包含相同或不同比例的至少两种在其间具有至少一个差异的树枝状聚合物或树枝状聚合物的混合物。树枝状聚合物或树枝状聚合物的表面可以通过已知方法进一步修饰。还包括混合树枝状大分子的制剂，其中树状聚合物具有相同的药物，以相同或不同的负载浓度存在但具有不同的释放曲线。混合树枝状大分子的这种配方可以具有以相同或不同负载浓度存在但具有不同释放曲线的不同客体分子。另外，提供了使用混合树枝状大分子递送药物或客体部分以提供对难溶性药物或客体部分的增加的溶解度的方法。

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