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1. 发明申请

WO2008054466A2 DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS USING CORE-SHELL TECTO (DENDRITIC POLYMERS) 审中-公开
标题翻译：使用核壳TECTO（树枝状聚合物）交付生物活性材料
公开(公告)号：WO2008054466A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/005681
申请日：2007-03-03
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , DEMATTEI, Cordell, R. , HUANG, Baohua , REYNA, Lori, A. , SVENSON, Sonke , SWANSON, Douglas, R. , TOMALIA, Donald, A. , ZHURAVEL, Michael, A. , PULGAM, Veera, Reddy
发明人： DEMATTEI, Cordell, R. , HUANG, Baohua , REYNA, Lori, A. , SVENSON, Sonke , SWANSON, Douglas, R. , TOMALIA, Donald, A. , ZHURAVEL, Michael, A. , PULGAM, Veera, Reddy
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , A61K9/5146 , A61K47/59 , A61K47/595 , A61K47/60 , C08G83/003 , Y02A50/463
摘要： The present invention concerns core-shell tecto (dendritic polymers) that are associated with biologically active materials (such as nucleic acids for use for RNAi and in transfection). Also included are formulations for their use. The constructs are useful for the delivery of drugs to an animal or plant and may be in vivo , in vitro or ex vivo .
摘要翻译：本发明涉及与生物活性物质（例如用于RNAi和转染的核酸）相关的核 - 壳结构（树状聚合物）。还包括它们的使用配方。该构建体可用于将药物递送至动物或植物，并且可以在体内，体外或离体。 >

2. 发明申请

WO2005019290A3 ULTRA HIGH MOLECULAR WEIGHT HYBRID DENDRIGRAFT ARCHITECTURES 审中-公开
标题翻译：超高分子量混合动力架构
公开(公告)号：WO2005019290A3
公开(公告)日：2006-07-20
申请号：PCT/US2004025045
申请日：2004-08-03
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R
IPC分类号： C08G81/00 , C08F271/02 , C08G20060101 , C08G83/00
CPC分类号： C08G83/002 , C08G83/005
摘要： Mono-reactive dendrigrafts prepared by convergent self-branching polymerization and their subsequent grafting to linear, dendritic, and dendrigraft, branched, and hyper-branched substrates to prepare ultra-high molecular weight dendrigraft architectures using alkyl halides and aryl halides as initiators.
摘要翻译：通过收敛的自支化聚合制备的单反应性树枝状物，并将它们随后接枝到线型，树枝状和树枝状结构，支化和超支化底物上，以制备超高分子量树枝状结构，使用烷基卤和芳基卤化物引发剂。

3. 发明申请

WO2006065266A2 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的聚合物聚合物
公开(公告)号：WO2006065266A2
公开(公告)日：2006-06-22
申请号：PCT/US2005013864
申请日：2005-04-20
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY
IPC分类号： C08F20/02
CPC分类号： C08G83/003 , C08G59/1477 , C08G59/32 , C08G59/3227 , C08G59/5026
摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymer are made by use of fast, reactive ring opening chemistry (or other fast reactions) combined with the use of branch cell reagants in a controlled way to rapidly and precisely build dendrimer structures, generation by generation, with precise structures with cleaner chemistry, typically single products, lower excesses of reagants, lower levels of dilution, higher capacity method, more easily scale to commercial dimensions, new ranges of materials, and lower cost. The dendrimer composition prepared have novel internal functionality, greater stability, e.g., thermal stability and less or no reverse Michaels reaction, and which reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of poly-functional branch cell reagents with polyfunctional surfaces do not create gelled materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic have additional properties due to the unique characteristics of the dendritic polymer.
摘要翻译：公开了具有增强的扩增和内部功能的树枝状聚合物。这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞反应物以受控的方式制备，以快速和精确地构建树枝状聚合物结构，一代代，具有更清洁化学物质的精确结构，通常是单一产品，较低的反应物过剩，较低的稀释水平，更高的容量方法，更容易扩展到商业尺寸，新的材料范围和较低的成本。所制备的树枝状聚合物组合物具有新的内部官能团，更高的稳定性，例如热稳定性和更少或没有反向迈克尔斯反应，并且在较低代次下达到包封表面密度。出乎意料的是，具有多官能表面的多功能分支细胞试剂的这些反应不产生胶凝材料。这种树枝状聚合物可用作油/水乳液的破乳剂，制造纸中的湿强剂，质子清除剂，电子显微镜校准标准品，制备尺寸选择性膜，以及用于改进水性配方如油漆中的粘度的试剂。当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，这些树枝状结构具有额外的性质。

4. 发明申请

WO2006115547A3 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的聚合物聚合物
公开(公告)号：WO2006115547A3
公开(公告)日：2009-06-04
申请号：PCT/US2005047635
申请日：2005-12-21
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
IPC分类号： C08J3/00 , C08J9/32 , C08K9/00 , C12N15/87
CPC分类号： C12N15/87 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/00 , A61K49/0002 , B82Y5/00 , B82Y10/00 , C08G83/003 , C08L101/005 , C09B67/0013
摘要： Dendritic polymers of the macromolecular structure of Figure 1 are disclosed. The dendritic polymers have enhanced amplification and interior functionality. The dendritic polymers are made by use of fact, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled manner to rapidly and precisely build dendritic structures with cleaner chemistry and often with single products. Additional benefits include lower excesses of regents, lower levels of dilution, higher capacity, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The compositions prepared have novel internal functionality, including increased thermal stability and no reverse Michael's reaction, and reach encapsulation surface densities at lower generations.
摘要翻译：公开了图1的大分子结构的树枝状聚合物。树枝状聚合物具有增强的扩增和内部功能。树枝状聚合物通过使用事实，反应性开环化学（或其它快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建具有更清洁化学物质的树突状结构并且经常与单一产物一起制备。额外的好处包括摄入量过低，稀释水平降低，容量更大，容易扩展到商业尺寸，新的材料范围以及更低的成本。制备的组合物具有新颖的内部功能，包括增加的热稳定性和没有相反的迈克尔反应，并在较低的代下达到包封表面密度。

5. 发明申请

WO2008013618A1 PROCESS FOR PREPARING ALKYNE INTERMEDIATES FOR DENDRITIC POLYMERS 审中-公开
标题翻译：制备聚合物烯烃中间体的方法
公开(公告)号：WO2008013618A1
公开(公告)日：2008-01-31
申请号：PCT/US2007/014404
申请日：2007-06-20
申请人： DENDRITIC NANOTECHNOLOGIES, INC. , TOMALIA, Donald, A. , SWANSON, Douglas, R.
发明人： TOMALIA, Donald, A. , SWANSON, Douglas, R.
IPC分类号： A01N57/00 , A61K31/66
CPC分类号： C07D295/205 , C07D249/04
摘要： This invention provides a process for preparing alkyne intermediates used for making dendritic polymers. This process concerns alkyne compounds, useful as "clickable intermediates" to produce novel core reagents, branch cell reagents, surface group reagents, dendron reagents, oligomeric extender reagents, dendrimer core reagents, or dendrimer shell reagents suitable for preparing dendritic polymers, which comprises: 1) reacting acetylenic halides ( i.e. chlorides, bromides or iodides) or acetylenic mesylates/tosylates with 2-alkyl/aryl-2-oxazolines or oxazines to produce N-acetylenic-2-oxazolinium or 2-oxazinium cation salts; and 2) reacting N-acetylenic-2-oxazolinium or 2-oxazinium cation salts as catalytic reagents for the polymerization of 2-alkyl/aryl-2-oxazolines or 2-alkyl/aryl-2-oxazines; or 3) reacting propargyl tosylate or propargyl halides with 2-ethyl-2-oxazoline and then polymerizing to alkyne substituted poly(2-ethyl-2-oxazolines) with a degree of polymerization ( i.e. , dp=1-100); or 4) reacting propargyl tosylate with 2-ethyl-2-oxazoline (1:1) in the presence of sodium bromide or sodium iodide in acetonitrile to form N-propargyl-2-oxazolinium bromides/iodides, respectively; or 5) reacting 3-butyne-1,4-ditosylate in the presence of sodium iodide or sodium bromide in acetonitrile to form 3-butyne-1,4-dioxazolinium iodide or bromide, respectively.
摘要翻译：本发明提供了制备用于制备树枝状聚合物的炔烃中间体的方法。该方法涉及可用作“可点击中间体”的炔基化合物，用于制备适用于制备树枝状聚合物的新型核心试剂，支链细胞试剂，表面试剂，树枝状试剂，低聚延伸剂试剂，树枝状聚合物核试剂或树枝状大分子壳试剂，其包括： 1）使炔基卤化物（即氯化物，溴化物或碘化物）或炔丙基甲磺酸酯/甲苯磺酸酯与2-烷基/芳基-2-恶唑啉或恶嗪反应，生成N-炔属-2-恶唑啉鎓或2-恶嗪鎓阳离子盐; 和2）N-炔属-2-恶唑啉鎓或2-恶嗪鎓阳离子盐作为用于2-烷基/芳基-2-恶唑啉或2-烷基/芳基-2-恶嗪的聚合的催化剂; 或3）使炔丙基甲苯磺酸酯或炔丙基卤化物与2-乙基-2-恶唑啉反应，然后聚合成具有聚合度（即dp = 1-100）的炔取代的聚（2-乙基-2-恶唑啉）; 或4）在溴化钠或碘化钠存在下，在乙腈存在下，使甲磺酸炔丙酯与2-乙基-2-恶唑啉（1:1）反应，分别形成N-炔丙基-2-恶唑啉溴化物/碘化物; 或5）在碘化钠或溴化钠存在下在乙腈中的3-丁炔-1,4-二硫酸酯反应，分别形成3-丁炔-1,4-二氧杂环丁烷碘化物或溴化物。

6. 发明申请

WO2006115547A8 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的聚合物聚合物
公开(公告)号：WO2006115547A8
公开(公告)日：2007-02-15
申请号：PCT/US2005047635
申请日：2005-12-21
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
IPC分类号： A61K48/00 , A61K31/785 , C12N15/87
CPC分类号： C12N15/87 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/00 , A61K49/0002 , B82Y5/00 , B82Y10/00 , C08G83/003 , C08L101/005 , C09B67/0013
摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
摘要翻译：公开了具有增强的扩增和内部功能的树枝状聚合物。这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建树突状结构，一代代，具有更清洁的化学，通常单一产品，较低的试剂过量，较低的稀释水平，更高的容量方法，更容易扩展到商业尺寸，新的材料范围和更低的成本。制备的树枝状组合物具有新颖的内部功能，更高的稳定性（例如，热稳定性和更少或没有反向迈克尔反应），并在较低代次达到包封表面密度。出乎意料的是，多功能分支细胞试剂与多官能核心的这些反应不产生交联材料。这种树枝状聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强剂，质子清除剂，聚合物，纳米尺寸单体，用于电子显微镜的校准标准品，制备尺寸选择性膜，以及用于在水性制剂中改性粘度的试剂作为油漆。当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，例如药物递送，转染和诊断，这些树枝状聚合物具有用于承载材料的附加性能。

7. 发明申请

WO1997006833A1 HYPER COMB-BRANCHED POLYMER CONJUGATES 审中-公开
标题翻译：超高分子量分散聚合物
公开(公告)号：WO1997006833A1
公开(公告)日：1997-02-27
申请号：PCT/US1996013080
申请日：1996-08-09
申请人： DENTRITECH, INC. , YIN, Rui , TOMALIA, Donald, A. , HEDSTRAND, David, M. , SWANSON, Douglas, R. , BAKER, James, R., Jr. , KUKOWSKA-LATALLO, Jolanta, F.
发明人： DENTRITECH, INC.
IPC分类号： A61K51/02
CPC分类号： A61Q13/00 , A61K8/90 , A61K47/56 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/595 , A61K47/61 , A61K47/641 , A61K47/6885 , A61K47/6949 , A61K48/00 , A61K49/0043 , A61K49/0054 , A61K2800/54 , A61K2800/57 , B82Y5/00 , C08G83/005 , C12N15/87 , Y10S424/16 , Y10S525/902
摘要： A novel class of hyper comb-branched polymers conjugated with carried materials are disclosed.
摘要翻译：公开了一种与携带材料共轭的新型超梳状支化聚合物。

8. 发明申请

WO2008054466A3 DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS USING CORE-SHELL TECTO (DENDRITIC POLYMERS) 审中-公开
标题翻译：使用核壳TECTO（DENDRITIC POLYMERS）生物活性材料的交付
公开(公告)号：WO2008054466A3
公开(公告)日：2008-10-16
申请号：PCT/US2007005681
申请日：2007-03-03
申请人： DENDRITIC NANOTECHNOLOGIES INC , DEMATTEI CORDELL R , HUANG BAOHUA , REYNA LORI A , SVENSON SONKE , SWANSON DOUGLAS R , TOMALIA DONALD A , ZHURAVEL MICHAEL A , PULGAM VEERA REDDY
发明人： DEMATTEI CORDELL R , HUANG BAOHUA , REYNA LORI A , SVENSON SONKE , SWANSON DOUGLAS R , TOMALIA DONALD A , ZHURAVEL MICHAEL A , PULGAM VEERA REDDY
IPC分类号： A01N47/00
CPC分类号： A61K48/00 , A61K9/5146 , A61K47/59 , A61K47/595 , A61K47/60 , C08G83/003
摘要： The present invention concerns core-shell tecto (dendritic polymers) that are associated with biologically active materials (such as nucleic acids for use for RNAi and in transfection). Also included are formulations for their use. The constructs are useful for the delivery of drugs to an animal or plant and may be in vivo, in vitro or ex vivo.
摘要翻译：本发明涉及与生物活性材料（例如用于RNAi和转染的核酸）相关的核 - 壳结构（树枝状聚合物）。还包括其使用的配方。所述构建体可用于将药物递送至动物或植物，并且可以在体内或体外进行。

9. 发明申请

WO2007149501A3 PROCESS FOR PREPARING DENDRITIC POLYMERS USING MICROWAVE ASSISTED SYNTHESIS 审中-公开
标题翻译：使用微波辅助合成法制备聚合物的方法
公开(公告)号：WO2007149501A3
公开(公告)日：2008-09-12
申请号：PCT/US2007014403
申请日：2007-06-20
申请人： DENDRITIC NANO TECHNOLOGIES IN , HUANG BAOHUA , SWANSON DOUGLAS R , PULGAM VEERA REDDY , TOMALIA DONALD A
发明人： HUANG BAOHUA , SWANSON DOUGLAS R , PULGAM VEERA REDDY , TOMALIA DONALD A
IPC分类号： C08G59/50 , C08G59/54 , C08G73/00 , C08G73/02 , C08G73/04 , C08G73/08
CPC分类号： C08G73/028 , C08G73/024 , C08G73/1046 , C08G83/003
摘要： The present invention provides an improved process for preparing dendritic polymers where a core is reacted with a branch cell reagent (BR) and/or an extender using microwave radiation wherein, compared with prior processes, the amount of (BR) required is not in large excessive amounts, the time of the reaction is greatly reduced, and the purity of the final dendritic polymer is increased.
摘要翻译：本发明提供了一种制备树突状聚合物的改进方法，其中芯与分支细胞试剂（BR）和/或使用微波辐射的增量剂反应，其中与现有方法相比，所需量（BR）不大过量，反应时间大大降低，最终树枝状聚合物的纯度提高。

10. 发明申请

WO2008054466A9 DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS USING CORE-SHELL TECTO (DENDRITIC POLYMERS) 审中-公开
标题翻译：使用核壳TECTO（树枝状聚合物）交付生物活性材料
公开(公告)号：WO2008054466A9
公开(公告)日：2008-06-26
申请号：PCT/US2007005681
申请日：2007-03-03
申请人： DENDRITIC NANOTECHNOLOGIES INC , DEMATTEI CORDELL R , HUANG BAOHUA , REYNA LORI A , SVENSON SONKE , SWANSON DOUGLAS R , TOMALIA DONALD A , ZHURAVEL MICHAEL A , PULGAM VEERA REDDY
发明人： DEMATTEI CORDELL R , HUANG BAOHUA , REYNA LORI A , SVENSON SONKE , SWANSON DOUGLAS R , TOMALIA DONALD A , ZHURAVEL MICHAEL A , PULGAM VEERA REDDY
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , A61K9/5146 , A61K47/59 , A61K47/595 , A61K47/60 , C08G83/003
摘要： The present invention concerns core-shell tecto (dendritic polymers) that are associated with biologically active materials (such as nucleic acids for use for RNAi and in transfection). Also included are formulations for their use. The constructs are useful for the delivery of drugs to an animal or plant and may be in vivo, in vitro or ex vivo.
摘要翻译：本发明涉及与生物活性物质（例如用于RNAi和转染的核酸）相关的核 - 壳结构（树状聚合物）。还包括它们的使用配方。该构建体可用于将药物递送至动物或植物，并且可以在体内，体外或离体。

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