专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013033609A2 METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF CANCER 审中-公开
标题翻译：癌症治疗和诊断的方法和组成
公开(公告)号：WO2013033609A2
公开(公告)日：2013-03-07
申请号：PCT/US2012/053472
申请日：2012-08-31
申请人： ONCOCYTE CORPORATION , CHAPMAN, Karen , WAGNER, Joseph , WEST, Michael , KIDD, Jennifer, Lorrie , PRENDES, Maria , LACHER, Marcus
发明人： CHAPMAN, Karen , WAGNER, Joseph , WEST, Michael , KIDD, Jennifer, Lorrie , PRENDES, Maria , LACHER, Marcus
IPC分类号： G01N33/574
CPC分类号： G01N33/57488 , C12Q1/6886 , G01N33/57484 , G01N33/6893
摘要： The invention relates to methods of detecting cancer in a sample obtained from subject. The invention also provides kits and reagents for detecting cancer as well therapeutics and methods of treating cancer.
摘要翻译：本发明涉及从受试者获得的样品中检测癌症的方法。本发明还提供用于检测癌症的试剂盒和试剂以及治疗和治疗癌症的方法。

2. 发明申请

WO2012178128A1 METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF CANCER 审中-公开
标题翻译：癌症治疗和诊断的方法和组成
公开(公告)号：WO2012178128A1
公开(公告)日：2012-12-27
申请号：PCT/US2012/043903
申请日：2012-06-23
申请人： ONCOCYTE CORPORATION , WEST, Michael , CHAPMAN, Karen , WAGNER, Joseph , KIDD, Jennifer, Lorie , PRENDES, Maria, J. , LACHER, Markus
发明人： WEST, Michael , CHAPMAN, Karen , WAGNER, Joseph , KIDD, Jennifer, Lorie , PRENDES, Maria, J. , LACHER, Markus
IPC分类号： C40B30/04
CPC分类号： C12Q1/6886 , G01N33/57407 , G01N33/57415 , G01N33/57484
摘要： Embodiments of the disclosure are directed to methods of diagnosis, prognosis and treatment of cancer. In some embodiments, the methods include targeting a marker that is expressed at abnormal levels in bladder cancer tissue in comparison to normal somatic tissue. Some embodiments are directed to methods of treating cancer comprising administering a composition including a therapeutic that affects the expression or function of a target marker. Some embodiments are directed to methods of detecting cancer comprising detecting a level of a target marker associated with the cancer,
摘要翻译：本公开的实施方案涉及癌症的诊断，预后和治疗方法。在一些实施方案中，所述方法包括靶向与正常体细胞组织相比在膀胱癌组织中以异常水平表达的标记。一些实施方案涉及治疗癌症的方法，包括施用包含影响靶标志的表达或功能的治疗剂的组合物。一些实施方案涉及检测癌症的方法，包括检测与癌症相关的靶标志的水平，

3. 发明申请

WO2011023962A3 EATING AID 审中-公开
公开(公告)号：WO2011023962A3
公开(公告)日：2011-03-03
申请号：PCT/GB2010/001625
申请日：2010-08-27
申请人： CHAPMAN, Karen Margaret , COLLINGS, Simon James , BATT, Michael Steven , SADOWSKI, Michal
发明人： CHAPMAN, Karen Margaret , COLLINGS, Simon James , BATT, Michael Steven , SADOWSKI, Michal
IPC分类号： A63H18/00 , A63H19/00 , A47G23/06 , A47G19/08 , A47G19/02
摘要： A Child's eating aid is described. The aid includes a track that defines a path to be followed by a number of carriages. The carriages each include an upper part shaped to receive a different foodstuff and a lower part for following the path defined by the track. In one embodiment, the upper part of the carriages is attached to the lower part in a detachable manner so that it can be separated from the carriage to be washed after the meal. The track can be defined by mat that can be rolled-up when not in use or that is formed from a plurality of segments that can be connected together to define the track.

4. 发明申请

WO2007062198A1 METHODS TO ACCELERATE THE ISOLATION OF NOVEL CELL STRAINS FROM PLURIPOTENT STEM CELLS AND CELLS OBTAINED THEREBY 审中-公开
标题翻译：用于加速从其中获得的细胞干细胞和细胞分离新细胞株的方法
公开(公告)号：WO2007062198A1
公开(公告)日：2007-05-31
申请号：PCT/US2006/045352
申请日：2006-11-21
申请人： ADVANCED CELL TECHNOLOGY, INC. , WEST, Michael D. , SARGENT, Geoffrey , MURAI, James Teruo , KESSLER, Steve , CHAPMAN, Karen
发明人： WEST, Michael D. , SARGENT, Geoffrey , MURAI, James Teruo , KESSLER, Steve , CHAPMAN, Karen
IPC分类号： C12N5/06 , A61K45/00
CPC分类号： C12N5/0606
摘要： This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.
摘要翻译：本发明一般涉及区分多能干细胞（例如胚胎干，胚胎胚芽或胚源性细胞）的方法，以从细胞的异质混合物获得细胞亚群，其中与原始多能性相比，细胞亚群具有降低的分化潜能干细胞和亚群能够繁殖的地方。

5. 发明申请

WO9814592A3 TELOMERASE REVERSE TRANSCRIPTASE 审中-公开
标题翻译： TELOMERASE逆向转录
公开(公告)号：WO9814592A3
公开(公告)日：1999-04-01
申请号：PCT/US9717618
申请日：1997-10-01
申请人： GERON CORP , UNIV TECHNOLOGY CORP , CECH THOMAS R , LINGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B , HARLEY CALVIN B , ANDREWS WILLIAM H
发明人： CECH THOMAS R , LINGNER JOACHIM , NAKAMURA TORU , CHAPMAN KAREN B , MORIN GREGG B , HARLEY CALVIN B , ANDREWS WILLIAM H
IPC分类号： A01K67/027 , A61K31/70 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61P35/00 , A61P43/00 , C07K5/10 , C07K5/107 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/54 , C12N15/85 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12Q1/68 , C12R1/19 , C12R1/84 , C12R1/91 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/573 , C12N15/11
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N9/1241 , C12N9/1276 , C12N15/1137 , C12N2310/15 , C12N2310/315 , C12Y207/07049 , Y10S530/827 , Y10S530/828
摘要： The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus, and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.
摘要翻译：本发明涉及新型端粒酶核酸和氨基酸。特别地，本发明涉及编码各种端粒酶蛋白亚基和基序的核酸和氨基酸序列，包括Euplotes aediculatus的123kDa和43kDa端粒酶蛋白亚基，以及来自粟酒裂殖酵母，酵母属序列和人端粒酶的相关序列。本发明还涉及包含这些端粒酶蛋白亚基的多肽，以及含有这些亚单位的功能性多肽和核糖核蛋白。

6. 发明申请

WO2013033629A3 METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF COLORECTAL CANCER 审中-公开
标题翻译：用于治疗和诊断彩色癌的方法和组合
公开(公告)号：WO2013033629A3
公开(公告)日：2013-04-25
申请号：PCT/US2012053518
申请日：2012-08-31
申请人： ONCOCYTE CORP , CHAPMAN KAREN , WAGNER JOSEPH , WEST MICHAEL , KIDD JENNIFER LORRIE , PRENDES MARIA , LACHER MARCUS
发明人： CHAPMAN KAREN , WAGNER JOSEPH , WEST MICHAEL , KIDD JENNIFER LORRIE , PRENDES MARIA , LACHER MARCUS
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , G01N33/57419
摘要： Methods, compositions and kits relating to the detection, diagnosis and treatment of colorectal cancer are provided. Protein agents, including antibodies, or nucleic acid agents, including DNA, are used to detect expression levels of one or more specific biomarkers in a panel, including SPINK4, L1TDI, LY6G6D, APOBEC1, LOC729669, COL10A, SLC35D_1024, MMP7, MMP12, NMU and WNT10A. The expression level of one or more biomarkers in a subject sample is compared to the expression level(s) relative in a reference sample comprising non-cancerous cells. A higher level of expression in the subject sample relative to the non-cancerous cells indicates that the sample has colorectal cancer cells.
摘要翻译：提供了与结肠直肠癌的检测，诊断和治疗相关的方法，组合物和试剂盒。蛋白质试剂（包括抗体）或核酸试剂（包括DNA）用于检测面板中一种或多种特异性生物标志物的表达水平，包括SPINK4，L1TDI，LY6G6D，APOBEC1，LOC729669，COL10A，SLC35D_1024，MMP7，MMP12，NMU 和WNT10A。将受试者样品中一种或多种生物标志物的表达水平与包含非癌细胞的参照样品中的表达水平进行比较。相对于非癌细胞，受试者样品中较高水平的表达表明样品具有结肠直肠癌细胞。

7. 发明申请

WO2011150105A2 IMPROVED METHODS OF SCREENING EMBRYONIC PROGENITOR CELL LINES 审中-公开
标题翻译：筛选胚胎细胞细胞系的改进方法
公开(公告)号：WO2011150105A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/037969
申请日：2011-05-25
申请人： BIOTIME INC. , WEST, Michael D. , STERNBERG, Hal , CHAPMAN, Karen B.
发明人： WEST, Michael D. , STERNBERG, Hal , CHAPMAN, Karen B.
IPC分类号： C12P21/06
CPC分类号： C07K14/51
摘要： Aspects of the present invention include methods and compositions related to the production and use of numerous clonal lineages of embryonic progenitor cell lines derived from differentiating cultures of primordial stem cells with diverse molecular markers and having been cultured for > 21 doublings of clonal expansion. The robustness of these clonally-purified lines, their ability to expand for >40 passages while maintaining their pattern of gene expression, lack of tumorigenicity, and their embryonic pattern of gene expression offers novel compositions and methods for modeling numerous differentiation pathways for the first time in vitro, and for the manufacture of purified product not existing in such a purified state in nature or using other manufacturing modalities. Representative progenitor cell lines described herein are capable of development into cutaneous adipocytes, blood-brain barrier cells, neuronal cells, or smooth muscle cells each with therapeutic potential.
摘要翻译：本发明的方面包括与衍生自具有不同分子标记的原始干细胞的分化培养物的胚胎祖细胞系的许多克隆谱系的生产和使用相关的方法和组合物，并且已经培养了> 21倍的克隆扩增。这些克隆纯化品系的稳健性，其扩展40代的能力，同时保持其基因表达模式，缺乏致瘤性，并且其胚胎基因表达模式提供了新的组合物和方法，用于首次建模多种分化途径并且用于制造在本质上不存在于纯化状态的纯化产物或使用其它制造方式。本文描述的代表性祖细胞系能够发展成具有治疗潜力的皮肤脂肪细胞，血脑屏障细胞，神经元细胞或平滑肌细胞。

8. 发明申请

WO2011103343A2 METHODS FOR TELOMERE LENGTH AND GENOMIC DNA QUALITY CONTROL ANALYSIS IN PLURIPOTENT STEM CELLS 审中-公开
标题翻译：多发性干细胞中TELOMERE LENGTH和GENOMIC DNA质量控制分析方法
公开(公告)号：WO2011103343A2
公开(公告)日：2011-08-25
申请号：PCT/US2011/025316
申请日：2011-02-17
申请人： BIOTIME INC. , WEST, Michael D. , CHAPMAN, Karen B. , FUNK, Walter David
发明人： WEST, Michael D. , CHAPMAN, Karen B. , FUNK, Walter David
IPC分类号： C12Q1/68 , C12N15/12 , C12N5/0735 , C12N5/074
CPC分类号： C12Q1/6881 , C12Q2600/158
摘要： The generation of clinical-grade cell-based therapies from human embryonic stem cells or cells reprogrammed to pluripotency from somatic cells, requires stringent quality controls to insure that the cells have long enough telomeres and resulting cellular lifespan to be clinically useful, and normal gene expression and genomic integrity so as to insure cells with a desired and reproducible phenotype and to reduce the risk of the malignant transformation of cells. Assays useful in identifying human embryonic stem cell lines and pluripotent cells resulting from the transcriptional reprogramming of somatic cells that have embryonic telomere length are described as well as quality control assays for screening genomic integrity in cells expanded and banked for therapeutic use, as well as assays to identify cells capable of abnormal immortalization.
摘要翻译：从人类胚胎干细胞或从体细胞重编程为多能性的细胞产生临床级细胞治疗需要严格的质量控制，以确保细胞具有足够长的端粒，并导致细胞寿命在临床上有用，并且正常的基因表达和基因组完整性，以确保细胞具有所需和可重现的表型，并降低细胞恶性转化的风险。描述了用于鉴定人胚胎干细胞系和由具有胚胎端粒长度的体细胞的转录重编程产生的多能细胞的测定以及用于筛选扩增和储存用于治疗用途的细胞中的基因组完整性的质量控制测定，以及测定以识别能够异常永生化的细胞。

9. 发明申请

WO2007058671A1 NOVEL USES OF CELLS WITH PRENATAL PATTERNS OF GENE EXPRESSION 审中-公开
标题翻译：使用基因表达的初步模式的细胞的新用途
公开(公告)号：WO2007058671A1
公开(公告)日：2007-05-24
申请号：PCT/US2006/013519
申请日：2006-04-11
申请人： WEST, Michael, D. , CHAPMAN, Karen
发明人： WEST, Michael, D. , CHAPMAN, Karen
IPC分类号： C12N5/06 , A61K45/00
CPC分类号： C12N5/0656 , A61K35/12 , C12N2506/02
摘要： This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
摘要翻译：本发明一般涉及获得具有与发育中的哺乳动物胚胎或胎儿相似的基因表达模式的哺乳动物细胞和组织的方法，以及这些细胞和组织在治疗人类疾病和年龄相关病症中的用途。更具体地，本发明涉及用于鉴定，扩增培养和配制哺乳动物多能干细胞和分化细胞，其在成年人的细胞基因表达模式上不同，因此提供了独特的特征，其提供了新的治疗策略退行性疾病的治疗。

10. 发明申请

WO2007019398A1 IMPROVED METHODS OF REPROGRAMMING ANIMAL SOMATIC CELLS 审中-公开
标题翻译：改进动物皮肤细胞的方法
公开(公告)号：WO2007019398A1
公开(公告)日：2007-02-15
申请号：PCT/US2006/030632
申请日：2006-08-03
申请人： ADVANCED CELL TECHNOLOGY, INC. , WEST, Michael, D. , CHAPMAN, Karen, B. , SARGENT, Roy, Geoffrey
发明人： WEST, Michael, D. , CHAPMAN, Karen, B. , SARGENT, Roy, Geoffrey
IPC分类号： C12N5/00
CPC分类号： C12N5/0606 , A01K67/0271 , C12N5/0676 , C12N5/16 , C12N15/873 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2501/606 , C12N2501/72 , C12N2506/00 , C12N2506/11 , C12Q1/6881 , C12Q2600/158
摘要： This invention generally relates to methods to obtain mammalian cells and tissues with patterns of gene expression similar to that of a developing mammalian embryo or fetus, and the use of such cells and tissues in the treatment of human disease and age-related conditions. More particularly, the invention relates to methods for identifying, expanding in culture, and formulating mammalian pluripotent stem cells and differentiated cells that differ from cells in the adult human in their pattern of gene expression, and therefore offer unique characteristics that provide novel therapeutic strategies in the treatment of degenerative disease.
摘要翻译：本发明一般涉及获得具有与发育中的哺乳动物胚胎或胎儿相似的基因表达模式的哺乳动物细胞和组织的方法，以及这些细胞和组织在治疗人类疾病和年龄相关病症中的用途。更具体地，本发明涉及用于鉴定，扩增培养和配制哺乳动物多能干细胞和分化细胞，其在成年人的细胞基因表达模式上不同，因此提供了独特的特征，其提供了新的治疗策略退行性疾病的治疗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式