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1. 发明申请

WO2011044157A1 HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS 审中-公开
标题翻译：杂环化合物可用作PDK1抑制剂
公开(公告)号：WO2011044157A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/051517
申请日：2010-10-05
申请人： BIOGEN IDEC MA INC. , SUNESIS PHARMACEUTICALS, INC. , ARNDT, Joseph , CHAN, Timothy , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , LEE, Wen-Cherng , LIN, Edward, Yin-shiang , SCOTT, Daniel , SUN, Lihong , THOMAS, Jermaine , VAN VLOTEN, Kurt , WANG, Deping , ZHANG, Lei , ERLANSON, Daniel
发明人： ARNDT, Joseph , CHAN, Timothy , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , LEE, Wen-Cherng , LIN, Edward, Yin-shiang , SCOTT, Daniel , SUN, Lihong , THOMAS, Jermaine , VAN VLOTEN, Kurt , WANG, Deping , ZHANG, Lei , ERLANSON, Daniel
IPC分类号： A61K31/50
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
摘要翻译：本发明提供可用作PDK1抑制剂的化合物。本发明还提供了其组合物，以及治疗PDK1介导的疾病的方法。

2. 发明申请

WO2011029043A1 HETEROARYL BTK INHIBITORS 审中-公开
标题翻译： HETEROARYL BTK抑制剂
公开(公告)号：WO2011029043A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047879
申请日：2010-09-03
申请人： BIOGEN IDEC MA INC. , SUNESIS PHARMACEUTICALS, INC. , BUI, Minna , CONLON, Patrick , ERLANSON, Daniel, A. , FAN, Junfa , GUAN, Bing , HOPKINS, Brian, T. , ISHCHENKO, Alexey , JENKINS, Tracy, J. , KUMARAVEL, Gnanasambandam , MARCOTTE, Doug , POWELL, Noel , SCOTT, Daniel , TAVERAS, Art , WANG, Deping , ZHONG, Min
发明人： BUI, Minna , CONLON, Patrick , ERLANSON, Daniel, A. , FAN, Junfa , GUAN, Bing , HOPKINS, Brian, T. , ISHCHENKO, Alexey , JENKINS, Tracy, J. , KUMARAVEL, Gnanasambandam , MARCOTTE, Doug , POWELL, Noel , SCOTT, Daniel , TAVERAS, Art , WANG, Deping , ZHONG, Min
IPC分类号： A01N43/42
CPC分类号： C07D473/34 , C07D239/70 , C07D401/04 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译：本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。

3. 发明申请

WO2011029046A1 BRUTON'S TYROSINE KINASE INHIBITORS 审中-公开
标题翻译： BRUTON的酪氨酸激酶抑制剂
公开(公告)号：WO2011029046A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047883
申请日：2010-09-03
申请人： BIOGEN IDEC MA INC. , ERLANSON, Daniel, A. , MARCOTTE, Doug , KUMARAVEL, Gnanasambandam , FAN, Junfa , WANG, Deping , CUERVO, Julio, H. , SILVIAN, Laura , POWELL, Noel , BUI, Minna , HOPKINS, Brian, T. , TAVERAS, Art , GUAN, Bing , CONLON, Patrick , ZHONG, Min , JENKINS, Tracy, J. , SCOTT, Daniel , SUNESIS PHARMACEUTICALS, INC. , LUGOVSKOY, Alexey, A.
发明人： ERLANSON, Daniel, A. , MARCOTTE, Doug , KUMARAVEL, Gnanasambandam , FAN, Junfa , WANG, Deping , CUERVO, Julio, H. , SILVIAN, Laura , POWELL, Noel , BUI, Minna , HOPKINS, Brian, T. , TAVERAS, Art , GUAN, Bing , CONLON, Patrick , ZHONG, Min , JENKINS, Tracy, J. , SCOTT, Daniel , LUGOVSKOY, Alexey, A.
IPC分类号： A01N43/54 , C07D471/04 , C07D471/22
CPC分类号： C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
摘要： The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
摘要翻译：本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。

4. 发明申请

WO2012058645A1 HETEROCYCLIC TYROSINE KINASE INHIBITORS 审中-公开
标题翻译：杂环酪氨酸激酶抑制剂
公开(公告)号：WO2012058645A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/058472
申请日：2011-10-28
申请人： BIOGEN IDEC MA INC. , SUNESIS PHARMACEUTICALS, INC. , HOPKINS, Brian, T. , SCOTT, Daniel , CONLON, Patrick , JENKINS, Tracy, J. , POWELL, Noel , GUAN, Bing , CURERVO, Julio, H. , WANG, Deping , TAVERAS, Art
发明人： HOPKINS, Brian, T. , SCOTT, Daniel , CONLON, Patrick , JENKINS, Tracy, J. , POWELL, Noel , GUAN, Bing , CURERVO, Julio, H. , WANG, Deping , TAVERAS, Art
IPC分类号： C07D211/60
CPC分类号： A61K31/553 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , C07D401/12 , C07D403/04 , C07D413/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same. In certain embodiments, the present invention provides pharmaceutical formulations comprising provided compounds. In certain embodiments, the present invention provides a method of decreasing enzymatic activity of a Tec kinase family member. In some embodiments, such methods include contacting a Tec kinase family member with an effective amount of a Tec kinase family member inhibitor. In certain embodiments, the present invention provides a method of treating a disorder responsive to Tec kinase family inhibition in a subject in need thereof.
摘要翻译：本发明提供了可用作Tec家族激酶抑制剂的化合物，其组合物及其使用方法。在某些实施方案中，本发明提供包含提供的化合物的药物制剂。在某些实施方案中，本发明提供了降低Tec激酶家族成员的酶活性的方法。在一些实施方案中，此类方法包括使Tec激酶家族成员与有效量的Tec激酶家族成员抑制剂接触。在某些实施方案中，本发明提供了在有需要的受试者中治疗对Tec激酶家族抑制有响应的病症的方法。

5. 发明申请

WO2006019632A3 CELL ADHESION INHIBITORS 审中-公开
公开(公告)号：WO2006019632A3
公开(公告)日：2006-02-23
申请号：PCT/US2005/024351
申请日：2005-07-08
申请人： BIOGEN IDEC MA INC. , LEE, Wen-Cherng , PEPINSKY, Blake, R. , CORNEBISE, Mark , SCOTT, Daniel , PETER, Russell, C.
发明人： LEE, Wen-Cherng , PEPINSKY, Blake, R. , CORNEBISE, Mark , SCOTT, Daniel , PETER, Russell, C.
IPC分类号： C07K5/06 , C07D403/02
摘要： Cell adhesion inhibitors can interact with VLA-4 molecules and inhibits VLA-4 dependent cell adhesion. An inhibitor including a polyethylene glycol moiety can have advantageous pharmaceutical properties.

6. 发明申请

WO2005105766A3 ARYLPHENYLAMINO-AND ARYLPHENYLETHER-SULFIDE DERIVATIVES, USEFUL FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
公开(公告)号：WO2005105766A3
公开(公告)日：2005-11-10
申请号：PCT/US2005/014802
申请日：2005-04-28
申请人： ICOS CORPORATION , BIOGEN IDEC MA INC. , GUCKIAN, Kevin , JACOBSON, Irina , SCOTT, Daniel , SOWELL, C., Gregory
发明人： GUCKIAN, Kevin , JACOBSON, Irina , SCOTT, Daniel , SOWELL, C., Gregory
IPC分类号： C07D295/18
摘要： The present invention relates in part to compounds of formulas (I) and (III): and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.

7. 发明申请

WO2005105770A2 ARYLPHENYLAMINO-, ARYLPHENYLAMIDE-, AND ARYLPHENYLETHER-SULFIDE DERIVATIVES 审中-公开
标题翻译：芳基苯胺，芳基酰胺和芳基苯磺酰胺衍生物
公开(公告)号：WO2005105770A2
公开(公告)日：2005-11-10
申请号：PCT/US2005/014778
申请日：2005-04-28
申请人： ICOS CORPORATION , BIOGEN IDEC MA INC. , CHIN, Donovan , DURAND-REVILLE, Thomas , FAROUZ, Francine, S. , FOWLER, Kerry, W. , GUCKIAN, Kevin , JACOBSON, Irina , KASAR, Ramesh , PETTER, Russell, C. , SCOTT, Daniel , SOWELL, Gregory, C. , THORSETT, Eugene , YIN-SHIANG LIN, Edward
发明人： CHIN, Donovan , DURAND-REVILLE, Thomas , FAROUZ, Francine, S. , FOWLER, Kerry, W. , GUCKIAN, Kevin , JACOBSON, Irina , KASAR, Ramesh , PETTER, Russell, C. , SCOTT, Daniel , SOWELL, Gregory, C. , THORSETT, Eugene , YIN-SHIANG LIN, Edward
IPC分类号： C07D307/54
CPC分类号： C07D233/64 , C07C323/62 , C07C2601/14 , C07C2602/44 , C07D207/14 , C07D207/26 , C07D211/56 , C07D211/58 , C07D213/34 , C07D213/56 , C07D231/40 , C07D257/04 , C07D261/08 , C07D261/10 , C07D295/185 , C07D307/54 , C07D309/14 , C07D333/34 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12 , C07D451/02 , C07D451/04
摘要： The present invention relates in part to compounds of formulas I and III: and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.
摘要翻译：本发明部分地涉及式I和III的化合物及其药学上可接受的盐和前药。这些化合物可用于治疗疾病如炎症和免疫疾病。本发明还涉及包含这些化合物的药物组合物，以及抑制受试者的炎症或抑制免疫应答的方法。

8. 发明申请

WO2007017850A1 CLOSING MECHANISM FOR BREWING DEVICE 审中-公开
标题翻译：关闭设备的关闭机制
公开(公告)号：WO2007017850A1
公开(公告)日：2007-02-15
申请号：PCT/IB2006/052794
申请日：2006-08-11
申请人： THE PROCTER & GAMBLE COMPANY , COLMAN, Arne, Benjamin , CURTIS, Terence, Graham , DALTON, David, Andrew , SCOTT, Daniel
发明人： COLMAN, Arne, Benjamin , CURTIS, Terence, Graham , DALTON, David, Andrew , SCOTT, Daniel
IPC分类号： A47J31/44
CPC分类号： A47J31/24 , A47J31/4407
摘要： A closure mechanism (18) particularly useful in a brewing device (10) includes a cover member (38) rotatably disposed above the brewing device (10). A slider member (36) is slidably disposed within an interior cavity (56) of the cover member (38) and has one or more tabs (74,76,78) which may extend outside of the interior cavity (56). The brewing device (10) has one or more receptacles (80,82,84) for receiving the tabs (74,76,78) when the cover member (38) is closed. A lid member (32) on top of the cover member (38) may push the tabs (74,76,78) into the receptacles (80,82,84) through a link member (34). A release arm (86) is disposed within the brewing device (10) and has at least one blocker (92,94) which releasably holds a tab (76,78) of the slider member (36) within a receptacle (80,82) when the cover member (38) is closed.
摘要翻译：特别可用于冲泡装置（10）的封闭机构（18）包括可旋转地设置在冲泡装置（10）上方的盖构件（38）。滑动构件（36）可滑动地设置在所述盖构件（38）的内部空腔（56）内，并且具有可延伸到所述内部空腔（56）外部的一个或多个突出部（74,76,78）。当所述盖构件（38）关闭时，所述冲煮装置（10）具有一个或多个用于容纳所述突片（74,76,78）的插座（80,82,84）。在盖构件（38）的顶部上的盖构件（32）可以通过连接构件（34）将突出部（74,76,78）推入插座（80,82,84）。释放臂（86）设置在冲泡装置（10）内并且具有至少一个阻挡件（92,94），其可释放地将滑动构件（36）的突片（76,78）保持在容器（80,82）内）当盖构件（38）关闭时。

9. 发明申请

WO2020193783A1 A GROUND MOVEMENT MONITORING SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2020193783A1
公开(公告)日：2020-10-01
申请号：PCT/EP2020/058835
申请日：2020-03-27
申请人： SCOTT, Daniel , SCOTT, Peter
发明人： SCOTT, Daniel , SCOTT, Peter
IPC分类号： G01B7/24 , E02D1/02 , E21B49/00
摘要： A ground movement monitoring system comprising a rigid support (304), a magnetically sensitive probe (200) and a magnet (100), wherein the probe (200) is capable of detecting a displacement of the magnet (100), wherein in use the magnet (100) is configured to be fixed in the ground (320, 330, 340), the support (304) is configured to be located in the ground (320, 330, 340), an end of the support (304) being fixed in position relative to the ground (320, 330, 340), and the probe (200) is configured to be attached to the support (304) proximally to the magnet (100), wherein the displacement of the magnet (100) as detected by the probe (200) is communicated to a surface system (308), the surface system (308) being configured to record any displacement of the magnet (100).

10. 发明申请

WO2022074390A1 SINGLE-USE SANITARY TRI-CLAMP 审中-公开
公开(公告)号：WO2022074390A1
公开(公告)日：2022-04-14
申请号：PCT/GB2021/052586
申请日：2021-10-07
申请人： SCOTT, Daniel
发明人： SCOTT, Daniel
IPC分类号： F16L23/06 , A61M39/10
摘要： A clamp (10) having a first arcuate clamp member (12) pivotally connected to a second arcuate clamp member (14) via a first pivot member (16) located at one end of the clamp members, the clamp members being pivotable between an open configuration in which the free ends (18, 20) of the clamp members are displaced from one another facilitating the insertion of the mating pipe flanges to be clamped, and a closed configuration wherein the free ends (18, 20) of the clamp members contact one another and encircle the mating flanged end connections. Associated with the first arcuate clamp member is an arcuate articulated lever (30) which itself is (5) pivotally attached by a third pivot member (32) linking to member (34), which is itself pivotally attached by second pivot member (36) to the free end of the first clamp member (12).

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