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1. 发明申请

WO2009073625A1 SENSORS EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS 审中-公开
标题翻译：使用组合人工受体的传感器
公开(公告)号：WO2009073625A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085181
申请日：2008-12-01
申请人： RECEPTORS LLC , CARLSON, Robert, E. , WELLER ROSKA, Rachel, L. , BROSE, Stephen, A.
发明人： CARLSON, Robert, E. , WELLER ROSKA, Rachel, L. , BROSE, Stephen, A.
IPC分类号： G01N33/543 , A61B5/00
CPC分类号： G01N33/543 , A61B5/0031 , A61B5/14532 , A61B5/14865
摘要： The present invention relates to sensors including artificial receptors and methods of using them. In an embodiment, the present invention includes an artificial receptor as a component of a receptor system including a ligand permeable interface that isolates the artificial receptor from certain components of the surrounding environment. In an embodiment, the present invention includes an artificial receptor and a competitor against a ligand of interest. hi an embodiment, the present invention includes a competitive artificial receptor as a component of a detector system including a semipermeable membrane that isolates the competitive artificial receptor from certain components of the surrounding environment. This embodiment also includes the competitor and a detector operatively coupled to the competitive artificial receptor. The detector produces a signal indicating binding of the competitor and/or the ligand of interest to the artificial receptor. The detector system is configured so that the competitor is retained in the environs of the artificial receptor at least in part by the ligand permeable interface.
摘要翻译：本发明涉及包括人造受体的传感器及其使用方法。在一个实施方案中，本发明包括作为受体系统的组分的人造受体，其包括将人造受体与周围环境的某些组分隔离的配体可渗透界面。在一个实施方案中，本发明包括人造受体和针对目的配体的竞争物。在一个实施方案中，本发明包括作为检测器系统的组分的竞争性人造受体，其包括将竞争性人造受体与周围环境的某些组分隔离的半透膜。该实施例还包括竞争者和可操作地耦合到竞争性人造受体的检测器。检测器产生指示竞争剂和/或目标配体与人造受体结合的信号。检测器系统被配置为使得竞争者至少部分地通过配体可渗透界面保留在人造受体的环境中。

2. 发明申请

WO2005003326A3 ARTIFICIAL RECEPTORS INCLUDING REVERSIBLY IMMOBILIZED BUILDING BLOCKS AND METHODS 审中-公开
标题翻译：人工受体包括可逆的建筑块和方法
公开(公告)号：WO2005003326A3
公开(公告)日：2006-07-06
申请号：PCT/US2004009649
申请日：2004-03-29
申请人： RECEPTORS LLC , CARLSON ROBERT E
发明人： CARLSON ROBERT E
IPC分类号： A61L2/00 , B01J19/00 , B05D3/00 , C07H21/04 , C07K14/705 , C12N20060101 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/00
CPC分类号： G01N33/54366 , B01J19/0046 , B01J2219/00387 , B01J2219/00511 , B01J2219/00533 , B01J2219/00583 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/0072 , C07B2200/11 , C40B30/04 , C40B40/04 , C40B50/14 , G01N33/5436
摘要： The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds, which can be mobile or reversibly immobilized on a surface.
摘要翻译：本发明涉及人造受体，人造受体或候选人受体的阵列或微阵列，其制备方法和组合物，以及使用它们的方法。每个人造受体包括多个结构单元化合物，其可移动或可逆地固定在表面上。

3. 发明申请

WO2006029383A2 COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING PEPTIDE BUILDING BLOCKS 审中-公开
公开(公告)号：WO2006029383A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/032345
申请日：2005-09-09
申请人： RECEPTORS LLC , CARLSON, Robert, E.
发明人： CARLSON, Robert, E.
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , C07K7/06 , C07K14/705 , Y02P20/55
摘要： The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds. In an embodiment, at least one of the building blocks includes or is a peptide moiety. In an embodiment, the building block can be a peptide or peptidomimetic of Formula A: R I R 2 N-R 3 -(R 4 ) n -X-(R 5 ) m -Y-C(O)-R 6 in which R 1 and R 2 can independently be hydrogen or any suitable blocking or protecting group for an amino-terminal nitrogen of a peptide. Suitable blocking or protecting groups include those described in Green, TW; Wuts, PGM (1999), Protective Groups in Organic Synthesis Third Edition, Wiley-Interscience, New York, 779 pp. In an embodiment, R 1 or R 2 is hydrogen. In an embodiment, R 1 is hydrogen and R 2 is R 7 (O)C-, in which R 7 can be lower (e.g., Cl to C6) alkyl, substituted lower (e.g., C1 to C6) alkyl, aryl, substituted aryl, or the like. In an embodiment, R 1 is hydrogen and R 2 is CH 3 (O)C-. In an embodiment, R 1 and R 2 are hydrogen. R 3 can be absent or can be an amino acid, for example, an amino acid with a heteroatom on its side chain. Such amino acids include arginine, lysine, aspartic acid, glutamic acid, cysteine, glutamine, histidine, leucine, valine, methionine, phenylalanine, tyrosine, serine, threonine, and tryptophan. In an embodiment, R 3 is arginine, lysine, aspartic acid, glutamic acid, cysteine, tyrosine, serine, or threonine. In an embodiment, R 3 is arginine, lysine, aspartic acid, or glutamic acid. In an embodiment, R 3 is arginine or lysine. In an embodiment, R 3 is lysine. n can be 0, or n can be, for example, 1-25. In an embodiment, n=4-16. In an embodiment, n=3-6. In an embodiment, n=4. Each of the n R 4 can independently be an amino acid. Suitable amino acids include any of the 20 naturally occurring amino acids. Each of the n R 4 can independently be an amino acid with a small or unreactive side chain. In an embodiment, each of the n R 4 is independently alanine, valine, proline, or glycine. In an embodiment, each of the n R 4 is independently alanine or glycine. In an embodiment, each of the R 4 is independently alanine or glycine and n=4. In an embodiment, each of the (R 4 ) n is -Ala-Gly-Ala-Gly-. m can be 0, or m can be, for example, 1-6. In an embodiment, m=l-3. In an embodiment, m=1. In an embodiment, m=2. Each of the m R 5 can independently be an amino acid. Suitable amino acids include any of the 20 naturally occurring amino acids. Each of the m R 5 can independently be an amino acid with a small or unreactive side chain. In an embodiment, each of the m R 5 is independently alanine, valine, proline, or glycine. In an embodiment, each of the m R 5 is independently alanine or glycine. In an embodiment, R 5 is alanine or glycine and m=1. In an embodiment, R 5 is glycine and m=l. In an embodiment, R 5 is alanine and m=l. In an embodiment, (R 5 ) m has the formula -NR 8 -R 9 -CO- in which R 8 can be H or an organic moiety and R 9 can be an organic moiety. In certain embodiments, R 8 is H, lower (e.g., C1 to C6) alkyl, substituted lower (e.g., Cl to C6) alkyl, aryl, substituted aryl, or the like; and R 9 is lower (e.g., C1 to C6) alkyl, substituted lower (e.g., C1 to C6) alkyl, aryl, substituted aryl, or the like. In certain embodiments, R 8 is H; and R 9 is lower (e.g., C1 to C6) alkyl (e.g., branched lower alkyl). X and Y can independently be an amino acid, a dipeptide moiety (e.g., two amino acids linked by a peptide bond) or a tripeptide moiety (e.g., three amino acids linked by peptide bonds). Suitable amino acids include any of the 20 naturally occurring amino acids. Suitable dipeptide moieties include any two of the 20 naturally occurring amino acids. Suitable tripeptide moieties include any three of the 20 naturally occurring amino acids. In an embodiment, the amino acid or amino acids include or are arginine, glutamine, histidine, leucine, valine, methionine, phenylalanine, tyrosine, serine, threonine, or tryptophan. In an embodiment, the amino acid or amino acids include or are arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, phenylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine. In an embodiment, X and Y are independently arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, phenylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine. In an embodiment, X is arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, henylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine. In an embodiment, Y is arginine, glutamine, histidine, methionine, threonine, tryptophan, aspartic acid, glutamic acid, leucine, phenylalanine, asparagine, isoleucine, serine, valine, tyrosine, or alanine. In an embodiment, X and Y are independently arginine, glutamine, histidine, methionine, tyrosine, threonine, or tryptophan. In an embodiment, X is arginine, glutamine, histidine, methionine, tyrosine, threonine, or tryptophan. In an embodiment, Y is arginine, glutamine, histidine, methionine, tyrosine, threonine, or tryptophan. R 6 can be hydrogen or any suitable blocking or protecting group for an carboxyl-tenninal carboxyl

4. 发明申请

WO2006028930A2 COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING TETHER BUILDING BLOCKS ON SCAFFOLDS 审中-公开
标题翻译：组合式人工受体，包括牙槽骨上的积木块
公开(公告)号：WO2006028930A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/031213
申请日：2005-09-01
申请人： RECEPTORS LLC , CARLSON, Robert, E.
发明人： CARLSON, Robert, E.
IPC分类号： G01N33/543
CPC分类号： G01N33/566 , G01N33/531 , G01N33/543 , G01N33/54353 , G01N33/6845 , G01N2500/00 , G01N2600/00
摘要： The present invention relates to artificial receptors on scaffolds, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds coupled to a scaffold. In an embodiment, at least one of the building blocks includes a tether moiety. The tether can provide spacing or distance between the recognition element and the scaffold to which the building block is immobilized. A tether moiety can have any of a variety of characteristics or properties including flexibility, rigidity or stiffness, ability to bond to another tether moiety, and the like.
摘要翻译：本发明涉及支架上的人造受体，制备它们的方法和组合物，以及使用它们的方法。每个人造受体包括与支架偶联的多种结构单元化合物。在一个实施方案中，至少一个构件包括系链部分。系绳可以在识别元件和构件被固定到的支架之间提供间隔或距离。系链部分可具有多种特性或性质中的任何一种，包括柔韧性，刚性或刚性，与另一系链部分结合的能力等。

5. 发明申请

WO2005024382A9 NANODEVICES EMPLOYING COMBINATORIAL ARTIFICIAL RECEPTORS 审中-公开
标题翻译：纳米组合使用组合人工受体
公开(公告)号：WO2005024382A9
公开(公告)日：2005-06-09
申请号：PCT/US2004029046
申请日：2004-09-03
申请人： RECEPTORS LLC , CARLSON ROBERT E
发明人： CARLSON ROBERT E
IPC分类号： B01J19/00 , G01N33/543 , G01N33/566 , G01N33/68
CPC分类号： G01N33/588 , B01J19/0046 , B01J2219/00524 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00738 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C07K14/705 , C12N2810/00 , C12N2810/50 , C40B80/00 , G01N33/54326 , G01N33/54346 , G01N33/552
摘要： The present invention includes nanodevices employing combinatorial artificial receptors and methods for making and using the same. In an embodiment the invention includes a method of adhering components together. In an embodiment, the invention includes a device including a first component adhered to a second component via a binding pair of artificial receptors. In an embodiment, the invention includes an agent delivery device having a capsule, and an active agent. In an embodiment, the invention can include a detection device having a magnetic particle and an artificial receptor disposed thereon. In an embodiment, the invention can include a detection device having a quantum dot and an artificial receptor disposed on the quantum dot. In an embodiment, the invention includes a detection device having first particles and second particles that aggregate in the present of a target ligand. In an embodiment, the invention includes a detection device having a cantilever and an artificial receptor disposed thereon. In an embodiment, the invention can include a detection device having a substrate and an artificial receptor disposed thereon. In an embodiment, the invention can include a device for selective removal of a target component including a substrate and an artificial receptor disposed thereon.
摘要翻译：本发明包括采用组合人工受体的纳米器件及其制备和使用方法。在一个实施例中，本发明包括将组件粘合在一起的方法。在一个实施方案中，本发明包括一种装置，该装置包括经由人造受体的结合对粘附到第二组分的第一组分。在一个实施方案中，本发明包括具有胶囊和活性剂的药剂递送装置。在一个实施例中，本发明可以包括具有设置在其上的磁性颗粒和人造受体的检测装置。在一个实施例中，本发明可以包括具有设置在量子点上的量子点和人造受体的检测装置。在一个实施方案中，本发明包括具有第一颗粒和第二颗粒的检测装置，所述第一颗粒和第二颗粒在靶配体存在时聚集。在一个实施例中，本发明包括具有悬臂和位于其上的人造接收器的检测装置。在一个实施例中，本发明可以包括具有衬底和设置在其上的人造受体的检测装置。在一个实施例中，本发明可以包括用于选择性去除包括衬底和位于其上的人造受体的目标组件的装置。

6. 发明申请

WO2012135034A9 FIBER WITH MICROBIAL REMOVAL, MICRO-BIOCIDAL, OR STATIC GROWTH CAPABILITY 审中-公开
标题翻译：具有微生物去除，微生物或静态生长能力的纤维
公开(公告)号：WO2012135034A9
公开(公告)日：2012-12-27
申请号：PCT/US2012030363
申请日：2012-03-23
申请人： RECEPTORS LLC , CARLSON ROBERT E , HEIKKILA KURT E , SCHMIDT KAREN SCHLICHTMANN , CARLSON ROBERT M
发明人： CARLSON ROBERT E , HEIKKILA KURT E , SCHMIDT KAREN SCHLICHTMANN , CARLSON ROBERT M
IPC分类号： A01N25/10 , A01N25/34 , A01N33/02 , A01N33/12 , A61L2/16 , A61L2/26 , D06M13/332
CPC分类号： D06M13/332 , A01N25/10 , A01N25/34 , A61L2/232 , B01D2239/0442 , B01D2239/0622 , D06M13/21 , D06M13/342 , D06M13/415 , D06M16/00 , A01N37/38 , A01N43/40
摘要： The fiber structures in the form of a fiber (or fiber mass), woven or nonwoven fabric, fiber absorbent layers, mats or bats or other collection of fiber can be modified to be microbiocidal, bacteriostatic, obtain immobilized microbes, etc. The disclosed fiber has the unique ability to capture and hold microbes or microbial generating units within the fiber mass.
摘要翻译：纤维（或纤维物质），织造或非织造织物，纤维吸收层，垫子或蝙蝠或其他纤维集合形式的纤维结构可以被修饰为杀微生物，抑菌，获得固定的微生物等。所公开的纤维具有独特的捕获和保持纤维质量内的微生物或微生物生成单元的能力。

7. 发明申请

WO2012135034A1 FIBER WITH MICROBIAL REMOVAL, MICRO-BIOCIDAL, OR STATIC GROWTH CAPABILITY 审中-公开
标题翻译：纤维与微生物去除，微生物或静态生长能力
公开(公告)号：WO2012135034A1
公开(公告)日：2012-10-04
申请号：PCT/US2012/030363
申请日：2012-03-23
申请人： RECEPTORS LLC , CARLSON, Robert E. , HEIKKILA, Kurt E. , SCHMIDT, Karen Schlichtmann , CARLSON, Robert M.
发明人： CARLSON, Robert E. , HEIKKILA, Kurt E. , SCHMIDT, Karen Schlichtmann , CARLSON, Robert M.
IPC分类号： A01N25/10 , A01N25/34 , A01N33/02 , A01N33/12 , A61L2/16 , A61L2/26 , D06M13/332
CPC分类号： D06M13/332 , A01N25/10 , A01N25/34 , A61L2/232 , B01D2239/0442 , B01D2239/0622 , D06M13/21 , D06M13/342 , D06M13/415 , D06M16/00 , A01N37/38 , A01N43/40
摘要： The fiber structures in the form of a fiber (or fiber mass), woven or nonwoven fabric, fiber absorbent layers, mats or bats or other collection of fiber can be modified to be microbiocidal, bacteriostatic, obtain immobilized microbes, etc. The disclosed fiber has the unique ability to capture and hold microbes or microbial generating units within the fiber mass.
摘要翻译：纤维（或纤维团），纺织或非织造织物，纤维吸收层，垫或蝙蝠或其他纤维集合形式的纤维结构可以被修饰为具有杀微生物，抑菌，获得固定化的微生物等。所公开的纤维具有捕获和保持纤维块内的微生物或微生物发生单元的独特能力。

8. 发明申请

WO2006029234A1 COMBINATORIAL ARTIFICIAL RECEPTORS INCLUDING TETHER BUILDING BLOCKS 审中-公开
标题翻译：组合人体受体，包括四面体块
公开(公告)号：WO2006029234A1
公开(公告)日：2006-03-16
申请号：PCT/US2005/031922
申请日：2005-09-02
申请人： RECEPTORS LLC , CARLSON, Robert, E.
发明人： CARLSON, Robert, E.
IPC分类号： G01N33/543
CPC分类号： G01N33/566 , G01N33/531 , G01N33/543 , G01N33/54353 , G01N33/6845 , G01N2500/00 , G01N2600/00
摘要： The present invention relates to artificial receptors, arrays or microarrays of artificial receptors or candidate artificial receptors, methods of and compositions for making them, and methods of using them. Each artificial receptor includes a plurality of building block compounds. In an embodiment, at least one of the building blocks includes a tether moiety. The tether can provide spacing or distance between the recognition element and the support or scaffold to which the building block is immobilized. A tether moiety can have any of a variety of characteristics or properties including flexibility, rigidity or stiffness, ability to bond to another tether moiety, and the like.
摘要翻译：本发明涉及人造受体，人造受体或候选人受体的阵列或微阵列，其制备方法和组合物，以及使用它们的方法。每个人造受体包括多个构建块化合物。在一个实施方案中，至少一个构建块包括系链部分。系链可以在识别元件和构建块固定到其上的支撑物或支架之间提供间隔或距离。系链部分可以具有包括柔性，刚性或刚度，结合到另一系链部分的能力等各种特性或性质中的任何一种。

9. 发明申请

WO2005024433A3 BUILDING BLOCKS FOR ARTIFICIAL RECEPTORS 审中-公开
标题翻译：人工受体的构建块
公开(公告)号：WO2005024433A3
公开(公告)日：2005-04-14
申请号：PCT/US2004029121
申请日：2004-09-03
申请人： RECEPTORS LLC , CARLSON ROBERT E
发明人： CARLSON ROBERT E
IPC分类号： B01J19/00 , G01N33/543 , G01N33/566 , G01N33/68
CPC分类号： C07K14/705 , B01J19/0046 , B01J2219/00524 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00738 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C40B80/00 , G01N33/6845
摘要： The present invention relates to building blocks for making or forming candidate artificial receptors. A building block can provide one or more structural characteristics such as positive charge, negative charge, acid, base, electron acceptor, electron donor, hydrogen bond donor, hydrogen bond acceptor, free electron pair, Ir electrons, charge polarization, hydrophilicity, hydrophobicity, and the like. A building block can be bulky or it can be small.
摘要翻译：本发明涉及用于制造或形成候选人造受体的构件。积木可提供一个或多个结构特征，例如正电荷，负电荷，酸，碱，电子受体，电子供体，氢键供体，氢键受体，自由电子对，Ir电子，电荷极化，亲水性，疏水性，等等。积木可能笨重或可能很小。

10. 发明申请

WO2005024433A2 BUILDING BLOCKS FOR ARTIFICIAL RECEPTORS 审中-公开
标题翻译：人工受体建筑块
公开(公告)号：WO2005024433A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/029121
申请日：2004-09-03
申请人： RECEPTORS LLC , CARLSON, Robert, E.
发明人： CARLSON, Robert, E.
IPC分类号： G01N33/68
CPC分类号： C07K14/705 , B01J19/0046 , B01J2219/00524 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00738 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C40B80/00 , G01N33/6845
摘要： The present invention relates to building blocks for making or forming candidate artificial receptors. A building block can provide one or more structural characteristics such as positive charge, negative charge, acid, base, electron acceptor, electron donor, hydrogen bond donor, hydrogen bond acceptor, free electron pair, Ir electrons, charge polarization, hydrophilicity, hydrophobicity, and the like. A building block can be bulky or it can be small.
摘要翻译：本发明涉及用于制造或形成候选人造受体的结构单元。结构单元可以提供一个或多个结构特征，例如正电荷，负电荷，酸，碱，电子受体，电子给体，氢键供体，氢键受体，自由电子对，Ir电子，电荷极化，亲水性，疏水性，等等。建筑块体积大或者可以小。

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