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1. 发明申请

WO2008021436A3 INFRARED ENDOSCOPE FOR BRANCH SELECTION AND CANNULATION WITH GUIDEWIRE 审中-公开
标题翻译：红外线内窥镜用于分支选择和引导装置
公开(公告)号：WO2008021436A3
公开(公告)日：2008-11-20
申请号：PCT/US2007018144
申请日：2007-08-14
申请人： CARDIO OPTICS INC , AMUNDSON DAVID C
发明人： AMUNDSON DAVID C
IPC分类号： A61M31/00 , A61N1/30
CPC分类号： A61M25/0041 , A61B5/0086 , A61B5/6855
摘要： To accomplish coronary sinus sub-branch selection, an infrared imaging catheter has a distal end wherein a small curve is formed over the last centimeter of the distal end. The curve is at about a 60-120 degree angle. The curve permits the catheter to be torqued within the guiding sheath to image the CS sub-branch. When the catheter is completely in the sheath, the curve is absent since the spring constant of the curve is not great enough to curve inside the sheath. The curve only appears as the catheter is advanced out of the sheath. The further advancement out of the sheath results in a greater angle of the catheter. Moreover, the catheter may have a guidewire channel exiting the distal end of the catheter. This permits a guidewire to be inserted into the visualized sub-branch. Once inserted, the catheter is advanced over the guidewire into the observed branch.
摘要翻译：为了完成冠状窦下分支选择，红外成像导管具有远端，其中在远端的最后一厘米上形成小曲线。曲线约为60-120度角。该曲线允许导管在导引护套内扭转以对CS子支路成像。当导管完全处于护套中时，曲线不存在，因为曲线的弹簧常数不足以在护套内弯曲。曲线仅在导管超出鞘管时出现。鞘外的进一步前进导致导管角度更大。而且，导管可以具有离开导管远端的导丝通道。这允许将导丝插入可视化的分支中。一旦插入，将导管推进到导丝上进入观察分支。

2. 发明申请

WO2008024261A2 IMAGE-GUIDED THERAPY OF THE FOSSA OVALIS AND SEPTAL DEFECTS 审中-公开
标题翻译： FOSSA OVALIS和SEPTAL缺陷的图像指导治疗
公开(公告)号：WO2008024261A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/018143
申请日：2007-08-14
申请人： CARDIO-OPTICS, INC , AMUNDSON, David, C.
发明人： AMUNDSON, David, C.
IPC分类号： A61B10/04
CPC分类号： A61B17/0057 , A61B5/0086 , A61B18/24 , A61N7/00
摘要： The invention relates to direct imaging of the fossa ovalis and septal defects for the purpose of providing therapeutic approaches for either the opening or the closing of the fossa ovalis and for the closing of septal defects. In all cases, the therapeutic procedure is imaged under direct, real-time infrared imaging.
摘要翻译：本发明涉及卵圆形和间隔缺损的直接成像，目的是提供卵圆窝的开放或关闭以及闭合隔膜缺损的治疗方法。在所有情况下，治疗程序在直接的实时红外成像下成像。

3. 发明申请

WO2003039350A3 DIRECT, REAL-TIME IMAGING GUIDANCE OF CARDIAC CATHETERIZATION 审中-公开
公开(公告)号：WO2003039350A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/036441
申请日：2002-11-12
申请人： CARDIO-OPTICS, INC. , HANLIN, H., John , BLANKENSHIP, Larry , AMUNDSON, David
发明人： HANLIN, H., John , BLANKENSHIP, Larry , AMUNDSON, David
IPC分类号： A61B18/18
摘要： Devices (1) and methods for accomplishing tasks within a body using infrared imaging are disclosed which, in connection with other known components, are useful in ablation, stitching and other operations, identification of sizes and composition of objects, and the creation of maps by taking multiple images at different positions or times.

4. 发明申请

WO2006017517A3 TRANSPARENT ELECTRODE FOR THE RADIOFREQUENCY ABLATION OF TISSUE 审中-公开
公开(公告)号：WO2006017517A3
公开(公告)日：2006-02-16
申请号：PCT/US2005/027442
申请日：2005-08-03
申请人： CARDIO-OPTICS, INC. , KNIGHT, Bradley, P. , BLANKENSHIP, Larry , HANLIN, H., John , AMUNDSON, David
发明人： KNIGHT, Bradley, P. , BLANKENSHIP, Larry , HANLIN, H., John , AMUNDSON, David
IPC分类号： A61B18/18
摘要： A novel transparent electrode that uses a conductive coating to allow delivery of current to the heart as well as outward imaging through the electrode is described. The embodiments disclose a catheter incorporating an endoscope, whose imaging tip is coated with a conductive coating that is transparent in the endoscopic image. However, a transparent electrode may be fashioned for any imaging modality, such as intracardiac echocardiography (ICE), that finds the electrode to be transparent to the energy used. This electrode coating may be a thin, optically transparent or translucent coating of platinum or gold or may be a pattern with enough open spaces to see the underlying tissue, such as looking through a screen. A wire is connected to the conductive coating and routed to a radiofrequency generator.

5. 发明申请

WO2003053491A3 CORONARY SINUS ACCESS CATHETER WITH FORWARD-IMAGING 审中-公开
公开(公告)号：WO2003053491A3
公开(公告)日：2003-07-03
申请号：PCT/US2002/036191
申请日：2002-11-12
申请人： CARDIO-OPTICS, INC. , HANLIN, H., John , BLANKENSHIP, Larry , AMUNDSON, David
发明人： HANLIN, H., John , BLANKENSHIP, Larry , AMUNDSON, David
IPC分类号： A61B5/05
摘要： A coronary access catheter system simplifies the insertion of objects into distal branches of the coronary sinus (8). The system incorporates a real-time forward-imaging means to view the os (1) and the branches of the coronary sinus (8). Preferably, the catheter (11) uses near-infrared light as the forward-imaging means, but it could also include ultrasound or electromagnetic transducer. As the image is viewed, the catheter tip can be steered into the coronary sinus os (1) and deflected in a tight radius bend on the distal end to navigate the short radius, right angle turns found in the coronary sinus branches (8). At that point, a flexible sheath can be placed over the guide catheter (11) or objects such as guidewires can be inserted into channels of the guide catheter (11). The system consists of a catheter (11) and image acquisition unit, which displays the forward image.

6. 发明申请

WO2008021437A3 INFRARED SIDE IMAGING OF CARDIOVASCULAR STRUCTURES AND INDWELLING MEDICAL DEVICES 审中-公开
标题翻译：心脏血管结构红外成像和医疗器械
公开(公告)号：WO2008021437A3
公开(公告)日：2008-06-12
申请号：PCT/US2007018145
申请日：2007-08-14
申请人： CARDIO OPTICS INC , AMUNDSON DAVID C , BLANKENSHIP LARRY
发明人： AMUNDSON DAVID C , BLANKENSHIP LARRY
IPC分类号： A61B5/00
CPC分类号： A61B5/0086 , A61B5/0044
摘要： Disclosed is a infrared imager which views out of the side of the catheter at various angles depending on the application. This is accomplished by placing a prism or mirror near or at the distal end of the catheter to direct the light in an angular direction. The mirror/prism the catheter can be rotated to view the full 360 deg. angle of the cardiovascular structure. Alternatively, the prism/mirror itself could be rotated by manipulating a wire on the proximal end of the catheter which is connected to the prism or mirror internal in the catheter. In a similar manner, the prism/mirror angle could also be changed by manipulation of the proximal end of the wire.
摘要翻译：公开了一种根据应用以不同角度从导管侧观察的红外成像器。这是通过将棱镜或镜子放置在导管的远端附近或位于导管的远端来引导光线在角度方向上来实现的。镜子/棱镜导管可以旋转以观看360度全景。心血管结构的角度。或者，棱镜/反射镜本身可以通过操纵导管的近端上的导线旋转，该导线连接到导管内部的棱镜或镜子。以类似的方式，也可以通过操纵线的近端来改变棱镜/镜角。

7. 发明申请

WO2005081991A3 CORONARY SINUS LOCATOR SHEATH FOR BIVENTRICULAR PACING 审中-公开
标题翻译：用于双歧杆菌的冠状动脉定位器
公开(公告)号：WO2005081991A3
公开(公告)日：2006-04-20
申请号：PCT/US2005005813
申请日：2005-02-25
申请人： CARDIO OPTICS INC , AMUNDSON DAVID C , HANLIN JOHN H , BLANKENSHIP LARRY
发明人： AMUNDSON DAVID C , HANLIN JOHN H , BLANKENSHIP LARRY
IPC分类号： A61M25/06 , A61N1/05
CPC分类号： A61N1/056 , A61M25/0662 , A61M2025/018 , A61N2001/0578 , A61N2001/0585
摘要： A coronary sinus locater sheath is stabilized in the vicinity of the coronary sinus by a guidewire exiting the side of the sheath near the distal end and inserted into an identifiable anatomical feature. The procedure includes (1) inserting the guide sheath into a vein, (2) advancing the sheath until the right atrium is entered, (3) advancing the sheath into the IVC, (4) extending a guidewire through a port near the sheath's distal end , (5) retracting the sheath above the IVC into the right atrium, (6) articulating or rotating the sheath until the sheath is near the coronary sinus ostium, while the sheath is stabilized by the guidewire. Thus the sheath can be positioned near the coronary sinus ostium limiting the motion imparted to the sheath from the beating heart. An imaging catheter may be used in conjunction with the sheath. The sheath or catheter may include pacing electrodes.
摘要翻译：冠状静脉窦定位器护套通过离开护套侧面远端的导丝线在冠状窦附近稳定并插入到可识别的解剖特征中。该方法包括（1）将引导护套插入静脉中，（2）使护套前进，直到右心房进入，（3）使护套进入IVC，（4）将导丝穿过护套远端（5）将IVC上方的护套缩回到右心房，（6）关节或旋转护套，直到护套靠近冠状窦口，同时护套由导丝稳定。因此，护套可以定位在冠状窦口附近，限制从打浆心脏施加到鞘的运动。成像导管可以与护套一起使用。护套或导管可以包括起搏电极。

8. 发明申请

WO2003039350A2 DIRECT, REAL-TIME IMAGING GUIDANCE OF CARDIAC CATHETERIZATION 审中-公开
标题翻译：直接，实时成像心脏指导
公开(公告)号：WO2003039350A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/036441
申请日：2002-11-12
申请人： CARDIO-OPTICS, INC. , HANLIN, H., John , BLANKENSHIP, Larry , AMUNDSON, David
发明人： HANLIN, H., John , BLANKENSHIP, Larry , AMUNDSON, David
IPC分类号： A61B
CPC分类号： A61B1/018 , A61B8/12 , A61B18/1492 , A61B90/36 , A61B2018/00351 , A61B2090/373 , A61M25/0105
摘要： Devices and methods for accomplishing tasks within a body using infrared imaging are disclosed which, in connection with other known components, are useful in ablation, stitching and other operations, identification of sizes and composition of objects, and the creation of maps by taking multiple images at different positions or times.
摘要翻译：公开了使用红外成像在身体内完成任务的装置和方法，其结合其它已知组件可用于消融，拼接和其他操作，物体的大小和组成的识别以及通过拍摄多个图像来创建地图在不同的位置或时间。

9. 发明申请

WO2008021438A2 INFRARED IMAGING USING MULTIPLE WAVELENGTHS 审中-公开
标题翻译：利用多波长红外成像
公开(公告)号：WO2008021438A2
公开(公告)日：2008-02-21
申请号：PCT/US2007018146
申请日：2007-08-14
申请人： CARDIO OPTICS INC , AMUNDSON DAVID C , BLANKENSHIP LARRY
发明人： AMUNDSON DAVID C , BLANKENSHIP LARRY
IPC分类号： H01S3/30
CPC分类号： A61B5/0086 , A61B5/02007
摘要： For an infrared imaging catheter, means of achieving a spread of wavelengths or multiple wavelengths through a stacking arrangement of "monochromatic" laser diodes or LED's are disclosed. Since a stack of diodes or LED's have different temperatures, they produce a wavelength spread many times greater than a single laser diode or LED. The wavelength spread reduces speckle in the corresponding image. Adding wavelengths also improves the corresponding infrared image, since different wavelengths have different light penetration capabilities and can emphasize different biological entities.
摘要翻译：对于红外成像导管，公开了通过“单色”激光二极管或LED的堆叠布置实现波长或多个波长的扩散的手段。由于一堆二极管或LED具有不同的温度，它们产生的波长比单个激光二极管或LED大几倍。波长扩散减少了相应图像中的斑点。添加波长还改善了相应的红外图像，因为不同的波长具有不同的光穿透能力并且可以强调不同的生物实体。

10. 发明申请

WO2005081991A2 CORONARY SINUS LOCATOR SHEATH FOR BIVENTRICULAR PACING 审中-公开
标题翻译：用于双歧杆菌的冠状动脉定位器
公开(公告)号：WO2005081991A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/005813
申请日：2005-02-25
申请人： CARDIO-OPTICS, INC. , AMUNDSON, David, C. , HANLIN, John, H. , BLANKENSHIP, Larry
发明人： AMUNDSON, David, C. , HANLIN, John, H. , BLANKENSHIP, Larry
IPC分类号： A61M25/06 , A61N1/05
CPC分类号： A61N1/056 , A61M25/0662 , A61M2025/018 , A61N2001/0578 , A61N2001/0585
摘要： A coronary sinus locater sheath is stabilized in the vicinity of the coronary sinus by a guidewire exiting the side of the sheath near the distal end and inserted into an identifiable anatomical feature. The procedure includes (1) inserting the guide sheath into a vein, (2) advancing the sheath until the right atrium is entered, (3) advancing the sheath into the IVC, (4) extending a guidewire through a port near the sheath's distal end , (5) retracting the sheath above the IVC into the right atrium, (6) articulating or rotating the sheath until the sheath is near the coronary sinus ostium, while the sheath is stabilized by the guidewire. Thus the sheath can be positioned near the coronary sinus ostium limiting the motion imparted to the sheath from the beating heart. An imaging catheter may be used in conjunction with the sheath. The sheath or catheter may include pacing electrodes.
摘要翻译：冠状静脉窦定位器护套通过离开护套侧面远端的导丝线在冠状窦附近稳定并插入到可识别的解剖特征中。该方法包括（1）将引导护套插入静脉中，（2）使护套前进，直到右心房进入，（3）使护套进入IVC，（4）将导丝穿过护套远端（5）将IVC上方的护套缩回到右心房，（6）关节或旋转护套，直到护套靠近冠状窦口，同时护套由导丝稳定。因此，护套可以定位在冠状窦口附近，限制从打浆心脏施加到鞘的运动。成像导管可以与护套一起使用。护套或导管可以包括起搏电极。

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