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1. 发明申请

WO2009133379A8 DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET AND QUINAZOLINONE-BASED INHIBITORS THEREOF 审中-公开
公开(公告)号：WO2009133379A8
公开(公告)日：2009-11-05
申请号：PCT/GB2009/001114
申请日：2009-05-01
申请人： F2G LIMITED , OLIVER, Jason, David , THAIN, John, Leslie , BROMLEY, Michael, John , SIBLEY, Graham, Edward, Morris , BIRCH, Michael
发明人： OLIVER, Jason, David , THAIN, John, Leslie , BROMLEY, Michael, John , SIBLEY, Graham, Edward, Morris , BIRCH, Michael
IPC分类号： C12Q1/32 , C12N9/02 , C07D239/72 , A61P31/10
摘要： A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.

2. 发明申请

WO2007091073A1 SYSTEME PROMOTEUR 审中-公开
标题翻译：系统推广
公开(公告)号：WO2007091073A1
公开(公告)日：2007-08-16
申请号：PCT/GB2007/000441
申请日：2007-02-07
申请人： F2G LTD , BROMLEY, Michael, John
发明人： BROMLEY, Michael, John
IPC分类号： C12N15/11 , C12N15/80
CPC分类号： C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2330/30
摘要： L'invention concerne une méthode d'expression d'une séquence polynucléotidique, qui consiste à exprimer cette séquence à partir d'une construction. Cette construction comprend ladite séquence liée de manière fonctionnelle à un promoteur présentant: i) une séquence d'ADN codant un promoteur fongique; ou ii) une séquence au moins à moitié identique à la séquence de i); ou iii) un fragment de i) ou de ii). Le système de l'invention met en oeuvre des méthodes améliorées de régulation contrôlée de gènes, qui permettent de rechercher un caractère essentiel, et donc de déterminer si un gène est une cible de médicament appropriée.
摘要翻译：发明协调组织多元化，包括éàer ette etteààà。。。。。。。。。。。。。。。。。 Cette建筑工程师laditeséquenceliéedemanièrefonctionnelleàun promoteurprésentant：i）uneséquenced'ADN codant un promoteur fongique; ou ii）uneséquenceau moinsàmoitiéidentiqueàlaséquencede i）; ou iii）un fragment de i）ou de ii）。 Lesystèmede l'invent met en oeuvre desméthodesamélioréesderégulationcontrôléedegènes，qui permettent de rechercher uncaractèreessentiel，et donc dedéterminersi ungèneest une cible demédicamentstipée。

3. 发明申请

WO2005083092A3 TRANSPOSON FROM ASPERGILLUS FUMATIGUS AND MUTAGENESIS THEREWITH 审中-公开
标题翻译：来自ASPERGILLUS FUMATIGUS和MUTAGENESIS的TRANSPOSON
公开(公告)号：WO2005083092A3
公开(公告)日：2005-12-15
申请号：PCT/GB2005000743
申请日：2005-02-28
申请人： F2G LTD , BROMLEY MICHAEL JOHN , HEY PETER
发明人： BROMLEY MICHAEL JOHN , HEY PETER
IPC分类号： C07K14/38 , C12N9/22 , C12N15/10 , C12N15/80
CPC分类号： C12N15/102 , C07K14/38
摘要： A nucleic acid or transposable element comprising one, two or more regions, wherein each region is selected from: (i) the sequence SEQ ID NO:l, 3, or 8, or (ii) a sequence which has at least 50 % identity with (i), or (iii) a sequence of at least 50 bases which is a fragment of (i) or (ii), wherein the nucleic acid or transposable element or sequence optionally has transposon activity.
摘要翻译：包含一个，两个或更多个区域的核酸或转座元件，其中每个区域选自：（i）序列SEQ ID NO：1,3或8，或（ii）具有至少50％同一性的序列（i）或（iii）至少50个碱基的序列，其是（i）或（ii）的片段，其中所述核酸或转座元件或序列任选具有转座子活性。

4. 发明申请

WO2005080588A2 2031 OXIDOREDUCTASE 审中-公开
标题翻译： 2031氧化剂
公开(公告)号：WO2005080588A2
公开(公告)日：2005-09-01
申请号：PCT/GB2005/000623
申请日：2005-02-18
申请人： F2G LTD , LAVENS, Sandra, Elizabeth , OLIVER, Jason, David , THAIN, John, Leslie , TUCKWELL, Daniel, Scott , BROMLEY, Michael, John
发明人： LAVENS, Sandra, Elizabeth , OLIVER, Jason, David , THAIN, John, Leslie , TUCKWELL, Daniel, Scott , BROMLEY, Michael, John
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , C12Q1/18 , G01N2333/37 , G01N2333/90209 , G01N2500/02
摘要： Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a NADH:flavin oxidoreductase protein which comprises the sequence shown by SEQ ID N0:3, (ii) a NADH:flavin oxidoreductase protein which is a homologue of (i) and which comprises the sequence shown by SEQ ID NO: 8, 12, 14, 19, 24, 42, 44, 83 or 85, (iii) a protein which has 50 % identity with (i) or (ii), (iv) a protein comprising a fragment of (i), (ii) or (iii) which fragment has a length of at least 50 amino acids, (v) a polynucleotide that comprises sequence which encodes (i), (ii), (iii) or (iv), (vi) a polynucleotide comprising sequence which has at least 70 % identity with the coding sequence of (v), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), (v) or (vi), wherein binding or modulation of (i), (ii), (iii), (iv), (v) or (vi) indicates that the candidate substance is an anti-fungal agent.
摘要翻译：鉴定靶向真菌的必需蛋白质或基因的抗真菌剂的方法，包括使候选物质与（i）包含SEQ ID NO：3所示序列的NADH：黄素氧化还原酶蛋白质接触，：（i）的同系物的黄素氧化还原酶蛋白，其包含SEQ ID NO：8,12,14,19,24,42,44,83或85所示的序列，（iii）具有50％与（i）或（ii）的同一性，（iv）包含（i），（ii）或（iii）的片段的蛋白质，该片段长度为至少50个氨基酸，（v）包含序列其编码（i），（ii），（iii）或（iv），（vi）包含与（v）的编码序列具有至少70％同一性的序列的多核苷酸，并确定候选物质是否结合或调节（i），（ii），（iii），（iv），（v）或（vi）中的（i），（ii），（iii） vi）表示候选物质是抗真菌剂。

5. 发明申请

WO2012042203A2 METHOD OF METAL DEPOSITION 审中-公开
标题翻译：金属沉积方法
公开(公告)号：WO2012042203A2
公开(公告)日：2012-04-05
申请号：PCT/GB2011001402
申请日：2011-09-28
申请人： UNIV LANCASTER , BOXALL COLIN , BROMLEY MICHAEL
发明人： BOXALL COLIN , BROMLEY MICHAEL
IPC分类号： C23C18/18
CPC分类号： H01L21/02697 , C23C18/14 , C23C18/1601 , C23C18/1603 , C23C18/1605 , C23C18/1642 , C23C18/1648 , C23C18/1667 , C23C18/1851 , C23C18/1879 , C23C18/31 , C23C18/44
摘要： A method of forming a metal layer on an electrically insulating substrate comprises depositing a photocatalyst layer onto the substrate and depositing a mask layer comprising voids on the substrate, such as a layer of latex microparticles with voids between them, to give an open pore structure to the mask. An electroless plating solution is then provided on the photocatalyst layer, and the photocatalyst layer and electroless plating solution are illuminated with actinic radiation whereby deposition of metal from the electroless plating solution to form a metal layer on the photocatalyst layer is initiated whereby the metal deposits in the voids of the mask layer. The mask layer is subsequently removed to leave a porous metal layer on the substrate. The method allows for deposition of porous metal films with controlled thickness and excellent adhesion onto electrically insulating substrates. The method is suitable for providing metal layers with controlled, regular porosity.
摘要翻译：在电绝缘衬底上形成金属层的方法包括将光催化剂层沉积到衬底上并将包含空隙的掩模层沉积在衬底上，例如在它们之间具有空隙的胶乳微粒层，以形成开孔结构面具。然后在光催化剂层上提供化学镀溶液，并且用光化辐射照射光催化剂层和化学镀溶液，由此开始从化学镀溶液中沉积金属以在光催化剂层上形成金属层，由此金属沉积在掩模层的空隙。随后去除掩模层以在基底上留下多孔金属层。该方法允许沉积具有受控厚度的多孔金属膜和在电绝缘基底上的优异粘附性。该方法适用于提供受控的，规则孔隙度的金属层。

6. 发明申请

WO2005095975A3 ANTI-FUNGAL TARGET GENES 审中-公开
标题翻译：抗真菌目标基因
公开(公告)号：WO2005095975A3
公开(公告)日：2006-03-23
申请号：PCT/GB2005001289
申请日：2005-04-04
申请人： F2G LTD , TUCKWELL DANIEL SCOTT , BROMLEY MICHAEL JOHN
发明人： TUCKWELL DANIEL SCOTT , BROMLEY MICHAEL JOHN
IPC分类号： G01N33/569 , A61K39/00 , C07K14/37 , C07K14/38 , C07K16/14 , C12N15/80 , C12Q1/68
CPC分类号： C07K14/38 , A61K39/00 , A61K2039/53 , G01N33/56961 , G01N2333/37 , G01N2333/38
摘要： Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a protein which comprises the sequence shown by SEQ ID NOS: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 74, 78, 82, 86 or 90 (ii) a protein which has 50% identity with (i), (iii) a protein comprising a fragment of (i) or (ii) which fragment has a length of at least 50 amino acids, (iv) a polynucleotide that comprises sequence which encodes (i), (ii) or (iii), (v) a polynucleotide comprising sequence which has at least 70% identity with the coding sequence of (iv), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), or (v), wherein binding or modulation of (i), (ii), (iii), (iv), or (v) indicates that the candidate substance is an anti-fungal agent.
摘要翻译：鉴定靶向真菌的必需蛋白质或基因的抗真菌剂的方法，包括使候选物质与（i）包含SEQ ID NO：3,7,11,15,19,23所示序列的蛋白质接触，27,31,35,39,43,47,51,55,59,67,67,74,78,82,86或90（ii）与（i），（iii）具有50％同一性的蛋白质，包含（i）或（ii）的片段的蛋白质，所述片段长度为至少50个氨基酸，（iv）多核苷酸，其包含编码（i），（ii）或（iii），（v）包含与（iv）的编码序列具有至少70％同一性并确定候选物质是否结合或调节（i），（ii），（iii），（iv）或（v）的序列的多核苷酸，（i），（ii），（iii），（iv）或（v）的结合或调节表明候选物质是抗真菌剂。

7. 发明申请

WO2005080588A3 2031 OXIDOREDUCTASE 审中-公开
公开(公告)号：WO2005080588A3
公开(公告)日：2005-12-15
申请号：PCT/GB2005000623
申请日：2005-02-18
申请人： F2G LTD , LAVENS SANDRA ELIZABETH , OLIVER JASON DAVID , THAIN JOHN LESLIE , TUCKWELL DANIEL SCOTT , BROMLEY MICHAEL JOHN
发明人： LAVENS SANDRA ELIZABETH , OLIVER JASON DAVID , THAIN JOHN LESLIE , TUCKWELL DANIEL SCOTT , BROMLEY MICHAEL JOHN
IPC分类号： C12Q1/18 , C12Q1/26
CPC分类号： C12Q1/26 , C12Q1/18 , G01N2333/37 , G01N2333/90209 , G01N2500/02
摘要： Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a NADH:flavin oxidoreductase protein which comprises the sequence shown by SEQ ID N0:3, (ii) a NADH:flavin oxidoreductase protein which is a homologue of (i) and which comprises the sequence shown by SEQ ID NO: 8, 12, 14, 19, 24, 42, 44, 83 or 85, (iii) a protein which has 50 % identity with (i) or (ii), (iv) a protein comprising a fragment of (i), (ii) or (iii) which fragment has a length of at least 50 amino acids, (v) a polynucleotide that comprises sequence which encodes (i), (ii), (iii) or (iv), (vi) a polynucleotide comprising sequence which has at least 70 % identity with the coding sequence of (v), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), (v) or (vi), wherein binding or modulation of (i), (ii), (iii), (iv), (v) or (vi) indicates that the candidate substance is an anti-fungal agent.
摘要翻译：鉴定靶向真菌必需蛋白质或基因的抗真菌剂的方法，包括使候选物质与（i）包含SEQ ID NO：3所示序列的NADH：黄素氧化还原酶蛋白质，（ii）NADH ：黄素氧化还原酶蛋白质，其是（i）的同源物并且包含SEQ ID NO：8,12,14,19,24,42,44,83或85所示的序列，（iii）具有50％（i）或（ii）的同一性，（iv）包含（i），（ii）或（iii）的片段的蛋白质，该片段具有至少50个氨基酸的长度，（v）包含序列（）），（ⅱ），（ⅲ）或（））的多核苷酸，（））包含与（））的编码序列具有至少70％同一性的序列的多核苷酸，并确定候选物质是否结合或调节（i），（ii），（iii），（iv），（v）或（vi） vi）表示候选物质是抗真菌剂。

8. 发明申请

WO2010139952A1 ANTIFUNGAL TARGET 审中-公开
标题翻译：反制目标
公开(公告)号：WO2010139952A1
公开(公告)日：2010-12-09
申请号：PCT/GB2010/001091
申请日：2010-06-04
申请人： F2G LTD , OLIVER, Jason David , DOBB, Katharine Sarah , KAYE, Sarah Jane , THAIN, John Leslie , TUCKWELL, Daniel Scott , BROMLEY, Michael John
发明人： OLIVER, Jason David , DOBB, Katharine Sarah , KAYE, Sarah Jane , THAIN, John Leslie , TUCKWELL, Daniel Scott , BROMLEY, Michael John
IPC分类号： C12N9/10 , C12N9/12 , C12Q1/48
CPC分类号： C12Q1/18 , C12N9/1288
摘要： A method of identifying an antifungal agent which targets a PPTB protein of a fungus comprising determining whether a candidate compound binds to or inhibits a PPTB protein, wherein binding or inhibition indicates that the candidate substance is an antifungal agent.
摘要翻译：鉴定靶向真菌的PPTB蛋白的抗真菌剂的方法，包括确定候选化合物是否结合或抑制PPTB蛋白，其中结合或抑制表明候选物质是抗真菌剂。

9. 发明申请

WO2009133379A2 ANTIFUNGAL TARGET 审中-公开
标题翻译：反制目标
公开(公告)号：WO2009133379A2
公开(公告)日：2009-11-05
申请号：PCT/GB2009001114
申请日：2009-05-01
申请人： F2G LTD , OLIVER JASON DAVID , THAIN JOHN LESLIE , BROMLEY MICHAEL JOHN , SIBLEY GRAHAM EDWARD MORRI , BIRCH MICHAEL
发明人： OLIVER JASON DAVID , THAIN JOHN LESLIE , BROMLEY MICHAEL JOHN , SIBLEY GRAHAM EDWARD MORRI , BIRCH MICHAEL
IPC分类号： C12Q1/32 , A61P31/10 , C07D239/72 , C12N9/02
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
摘要： A method of identifying an antifungal agent which targets a DHODH protein of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent.
摘要翻译：鉴定靶向真菌的DHODH蛋白质的抗真菌剂的方法，包括使候选物质与真菌DHODH蛋白质接触并确定候选物质是否结合或调节DHODH蛋白质，其中结合或调节表明候选物质是抗真菌剂剂。

10. 发明申请

WO2006059111A2 FUNGAL SIGNALLING AND METABOLIC ENZYMES 审中-公开
标题翻译：真菌信号和代谢酶
公开(公告)号：WO2006059111A2
公开(公告)日：2006-06-08
申请号：PCT/GB2005/004604
申请日：2005-12-01
申请人： F2G LTD , BROGDEN, Nina , BROMLEY, Michael, John , CARR, Paul, David , KAYE, Sarah, Jane , OLIVER, Jason, David , TUCKWELL, Daniel, Scott
发明人： BROGDEN, Nina , BROMLEY, Michael, John , CARR, Paul, David , KAYE, Sarah, Jane , OLIVER, Jason, David , TUCKWELL, Daniel, Scott
IPC分类号： G01N33/569 , G01N33/50 , C12Q1/20 , C12Q1/68 , C12Q1/527
CPC分类号： C12N9/88 , C07K14/38 , C12Q1/18
摘要： Method of identifying an anti-fungal agent which targets an essential protein or gene of a fungus comprising contacting a candidate substance with (i) a protein which comprises the sequence shown by SEQ ID NOS: 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36, 39, 42, 45, 48, 50, 53, 56, 59, 61 or 63, or (ii) a protein which has 60% identity with (i), or (iii) a protein comprising a fragment of (i) or (ii) which fragment has a length of at least 50 amino acids, or (iv) a polynucleotide that comprises a sequence which encodes (i), (ii) or (iii), or (v) a polynucleotide comprising a sequence which has at least 70% identity with the coding sequence of (iv), and determining whether the candidate substance binds or modulates (i), (ii), (iii), (iv), or (v), wherein binding or modulation of (i), (ii), (iii), (iv), or (v) indicates that the candidate substance is an anti-fungal agent.
摘要翻译：鉴定靶向真菌的必需蛋白质或基因的抗真菌剂的方法，包括使候选物质与（i）包含SEQ ID NO：3,6,9,12,15,18的序列的蛋白质接触，21,24,27,30,33,36,39,42,45,48,50,53,56,59,61或63，或（ii）与（i）具有60％同一性的蛋白质，或（iii）包含（i）或（ii）的片段的蛋白质，所述片段具有至少50个氨基酸的长度，或（iv）包含编码（i），（ii）或（iii）的序列的多核苷酸），或（v）多核苷酸，其包含与（iv）的编码序列具有至少70％同一性的序列，并确定候选物质是否结合或调节（i），（ii），（iii），（iv ）或（v），其中（i），（ii），（iii），（iv）或（v）的结合或调节表明候选物质是抗真菌剂。

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