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1. 发明申请

WO2018102727A1 CAPSULE, IN-LINE MAGNETIC VALVE SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2018102727A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/064285
申请日：2017-12-01
申请人： ALFADHEL, Ahmed , HSU, Meng-Chun , BORKHOLDER, David, A.
发明人： ALFADHEL, Ahmed , HSU, Meng-Chun , BORKHOLDER, David, A.
IPC分类号： B05D7/00 , A61K9/16 , A61K9/14 , A61K9/28
CPC分类号： F16K99/0053 , B01L3/5023 , B01L3/5027 , B01L3/502738 , B01L2200/026 , B01L2200/147 , B01L2400/043 , B01L2400/0672 , B01L2400/0677 , C01G49/08 , F16K99/0019 , F16K99/0021 , H01F1/0018 , H01F1/44
摘要： A capsule is disclosed which includes a flexible outer shell capable of transforming into an asymmetric shape; an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles, wherein the magnetic particles can move in response to an applied magnetic field. A valve system includes an in-line valve sized to fit within a flow channel including a capsule having a flexible outer shell containing an internal medium encapsulated by the outer shell, the medium including a plurality of magnetic particles; and a magnetic field source disposed about the exterior wall of the channel.

2. 发明申请

WO2014055584A1 SYSTEMS AND METHODS FOR MAPPING AN EXPLOSIVE EVENT 审中-公开
标题翻译：用于映射爆炸事件的系统和方法
公开(公告)号：WO2014055584A1
公开(公告)日：2014-04-10
申请号：PCT/US2013/062957
申请日：2013-10-02
申请人： BORKHOLDER, David A. , ROGERS, Jeffrey L.
发明人： BORKHOLDER, David A. , ROGERS, Jeffrey L.
IPC分类号： F42D3/06 , F42D99/00 , G06F17/00 , G09B9/00
CPC分类号： G01N33/227 , F42D3/06 , F42D99/00 , G09B9/003 , G09B19/00
摘要： Systems and methods for mapping an explosive event are discussed. In an example, a system (400) for mapping an explosive event can include a plurality of sensor devices (10(A) - 10(N)) and a data analysis system. Each of the plurality of sensor devices (10(A) -10(N)) can include an environmental sensor to measure at least one parameter of an explosive event caused by an explosive device (410). Each sensor device can also include a time synchronization circuit to synchronize time stamping of the parameter measured by the environmental sensor, and a wireless communication interface. The data analysis system can access measurement data generated by the plurality of sensor devices (10(A) - 10(N)) and analyze the measurement data to produce a visualization mapping the measurements onto a virtual representation of the test environment (420).
摘要翻译：讨论了用于映射爆炸事件的系统和方法。在一个示例中，用于映射爆炸事件的系统（400）可以包括多个传感器设备（10（A）-10（N））和数据分析系统。多个传感器装置（10（A）-10（N））中的每一个可以包括用于测量由爆炸装置（410）引起的爆炸事件的至少一个参数的环境传感器。每个传感器装置还可以包括时间同步电路，以同步由环境传感器测量的参数的时间戳和无线通信接口。数据分析系统可以访问由多个传感器设备（10（A）-10（N））产生的测量数据，并且分析测量数据以产生将测量映射到测试环境的虚拟表示（420）上的可视化。

3. 发明申请

WO2012116333A2 EVENT DOSIMETER DEVICE AND METHODS THEREOF 审中-公开
标题翻译：事件剂量器件及其方法
公开(公告)号：WO2012116333A2
公开(公告)日：2012-08-30
申请号：PCT/US2012/026627
申请日：2012-02-24
申请人： ROCHESTER INSTITUTE OF TECHNOLOGY , BORKHOLDER, David, A. , KOVACS, Gregory, T.a. , ROGERS, Jeffrey
发明人： BORKHOLDER, David, A. , KOVACS, Gregory, T.a. , ROGERS, Jeffrey
CPC分类号： A61B5/4064 , A61B5/1112 , A61B5/165 , A61B5/6803 , A61B5/7275 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , F41H1/02 , F41H1/04 , F42D5/00 , G06F19/00 , Y10T29/49002
摘要： A dosimetry device includes at least one sensor in a housing and a dosimetry processing device with a memory. The dosimetry processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the sensor; storing the readings; conducting an analysis of the stored readings to determine an injury risk assessment; and outputting at least one of the conducted analysis of the determined injury risk assessment or the stored readings.
摘要翻译：剂量测定装置包括壳体中的至少一个传感器和具有存储器的剂量测定处理装置。剂量测定处理装置耦合到壳体中的至少一个传感器。剂量测定处理装置被配置为执行存储在存储器中的编程指令，包括：从传感器获得读数; 存储读数; 对存储的读数进行分析以确定伤害风险评估; 并且输出所确定的伤害风险评估或存储的读数的进行分析中的至少一个。

4. 发明申请

WO2012116332A3 METHODS FOR MONITORING EXPOSURE TO AN EVENT AND DEVICES THEREOF 审中-公开
公开(公告)号：WO2012116332A3
公开(公告)日：2012-08-30
申请号：PCT/US2012/026625
申请日：2012-02-24
申请人： ROCHESTER INSTITUTE OF TECHNOLOGY , BORKHOLDER, David, A. , DEBUSSCHERE, Derek
发明人： BORKHOLDER, David, A. , DEBUSSCHERE, Derek
IPC分类号： A61B6/00 , G01T7/00
摘要： A method, non-transitory computer readable medium, and apparatus that includes obtaining, by a dosimetry computing device, sensor readings from at least one sensor. An event is identified, by the dosimetry computing device, based on at least one of one or more of the obtained sensor readings or one or more determinations based on the obtained sensor readings meeting one or more selection. At least one of the one or more determinations or the sensor readings which meet one or more of the selection criteria when the event is identified is stored by the dosimetry computing device.

5. 发明申请

WO2012116332A2 METHODS FOR MONITORING EXPOSURE TO AN EVENT AND DEVICES THEREOF 审中-公开
标题翻译：监视暴露于事件的方法及其装置
公开(公告)号：WO2012116332A2
公开(公告)日：2012-08-30
申请号：PCT/US2012026625
申请日：2012-02-24
申请人： ROCHESTER INST TECH , BORKHOLDER DAVID A , DEBUSSCHERE DEREK
发明人： BORKHOLDER DAVID A , DEBUSSCHERE DEREK
IPC分类号： A61B6/00 , G01T7/00
CPC分类号： A61B5/11 , A61B5/4064 , A61B5/7275 , A61B5/7282 , A61B2560/0209 , A61B2560/0242 , G06Q50/22
摘要： A method, non-transitory computer readable medium, and apparatus that includes obtaining, by a dosimetry computing device, sensor readings from at least one sensor. An event is identified, by the dosimetry computing device, based on at least one of one or more of the obtained sensor readings or one or more determinations based on the obtained sensor readings meeting one or more selection. At least one of the one or more determinations or the sensor readings which meet one or more of the selection criteria when the event is identified is stored by the dosimetry computing device.
摘要翻译：一种方法，非临时性计算机可读介质和装置，其包括通过剂量计算装置从至少一个传感器获取传感器读数。由剂量计算装置基于获得的传感器读数中的一个或多个传感器读数中的至少一个或基于获得的传感器读数满足一个或多个选择的一个或多个确定来识别事件。剂量计算装置存储当识别事件时满足一个或多个选择标准的一个或多个确定或传感器读数中的至少一个。

6. 发明申请

WO2012116330A3 EVENT MONITORING DOSIMETRY APPARATUSES AND METHODS THEREOF 审中-公开
公开(公告)号：WO2012116330A3
公开(公告)日：2012-08-30
申请号：PCT/US2012/026622
申请日：2012-02-24
申请人： ROCHESTER INSTITUTE OF TECHNOLOGY , BORKHOLDER, David, A. , FASSLER, Werner , BLAIR, Andrew , SHERMAN, Kim , DEBUSSCHERE, Derek
发明人： BORKHOLDER, David, A. , FASSLER, Werner , BLAIR, Andrew , SHERMAN, Kim , DEBUSSCHERE, Derek
IPC分类号： G01T1/02 , G01T7/00
摘要： A dosimetry apparatus includes at least one sensor in a housing, a cover configured to permit compression waves to pass through, the cover is seated over the at least one sensor, and a dosimetry processing device with a memory. The dosimetry processing device is coupled to the at least one sensor in the housing. The dosimetry processing device is configured to execute programmed instructions stored in the memory comprising: obtaining readings from the at least one sensor; storing the readings with a time and date stamp when obtained; conducting an analysis based on the obtained readings; and outputting at least one of the stored readings or the conducted analysis.

7. 发明申请

WO2021146618A1 NONINVASIVE DIAGNOSTICS OF PROXIMAL HEART HEALTH BIOMARKERS 审中-公开
公开(公告)号：WO2021146618A1
公开(公告)日：2021-07-22
申请号：PCT/US2021/013725
申请日：2021-01-15
申请人： LIBERSON, Alexander S. , VAHEDEIN, Yashar Seyed , BORKHOLDER, David A.
发明人： LIBERSON, Alexander S. , VAHEDEIN, Yashar Seyed , BORKHOLDER, David A.
IPC分类号： A61B5/00 , A61B5/02 , A61B5/021 , A61B5/026 , G16H50/50 , A61B2560/0223 , A61B5/02007 , A61B5/0205 , A61B5/02125 , A61B5/022 , A61B5/02416 , A61B5/029 , A61B5/318 , A61B5/7278 , A61B8/0891 , G16H50/30
摘要： An integrated bioinstrumentation system, combining an accurate and robust quasi 1D computational model with experimental peripheral measurements, is designed to extract information on other quantities of interest, for which the direct measurements are not feasible. The system is able to quantify and visualize the distributions of a cardiac output (CO), aortic blood pressure (BP), flow, velocity, and aortic arterial compliance, based on a peripheral analysis of a pulse transit time (PTT) measured at the available peripheral sites. A preliminary calibration stage extracts the arterial properties from simultaneous measurements of a pulse transit time, and an upper arm blood pressure. Obtained transfer functions, linking noninvasive peripheral measurements to the aortic pressure, cardiac output, aortic compliance and others serve to quantify the indicators of cardiac morbidity and mortality.

8. 发明申请

WO2017083703A1 ULTRA-THIN NANOMETER-SCALE POLYMERIC MEMBRANES 审中-公开
标题翻译：超薄纳米级聚合物膜
公开(公告)号：WO2017083703A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061608
申请日：2016-11-11
申请人： GETPREECHARSAWAS, Jirachai , BORKHOLDER, David, A.
发明人： GETPREECHARSAWAS, Jirachai , BORKHOLDER, David, A.
IPC分类号： B01D61/02 , B01D69/12
CPC分类号： B01D67/0023 , B01D61/025 , B01D61/027 , B01D61/422 , B01D63/088 , B01D67/0009 , B01D67/0088 , B01D69/02 , B01D69/10 , B01D69/12 , B01D69/122 , B01D2323/16 , B01D2323/30 , F04B43/043
摘要： Ultra-thin nanometer-scale freestanding polymeric membranes and methods for producing ultra-thin nanometer- scale freestanding recast membranes and ultra-thin a nanometer- scale freestanding cross-linked membranes with solid internal backbone are disclosed.
摘要翻译：公开了超薄纳米级独立式聚合物膜和用于制造超薄纳米级独立式重铸膜和具有固体内部骨架的超薄纳米级独立交联膜的方法。

9. 发明申请

WO2016081517A3 PULSE WAVE VELOCITY, ARTERIAL COMPLIANCE, AND BLOOD PRESSURE 审中-公开
标题翻译：脉搏波速度，手术合格率和血压
公开(公告)号：WO2016081517A3
公开(公告)日：2016-08-04
申请号：PCT/US2015061188
申请日：2015-11-17
申请人： BORKHOLDER DAVID A , LIBERSON ALEXANDER S , LILLIE JEFFREY S , DAY STEVEN W
发明人： BORKHOLDER DAVID A , LIBERSON ALEXANDER S , LILLIE JEFFREY S , DAY STEVEN W
IPC分类号： A61B5/021
CPC分类号： A61B5/021 , A61B5/02007 , A61B5/02108 , A61B5/0285 , A61B5/0295 , A61B5/0456 , A61B5/055 , G09B23/28 , G09B23/288 , G09B23/30
摘要： Disclosed are methods for determining physiological parameters of an individual including blood pressure, arterial compliance, flow velocity, and pressure wave velocity. A noninvasive method for determining the blood pressure of a patient is based on measurements of flow velocity, pulse wave velocity and arterial compliance. A noninvasive method for determining the arterial compliance of a patient is based on measurements of blood pressure, flow velocity, and pulse wave velocity.
摘要翻译：公开了用于确定个体的生理参数的方法，包括血压，动脉顺应性，流速和压力波速度。用于确定患者血压的非侵入性方法是基于流速，脉搏波速度和动脉顺应性的测量。用于确定患者的动脉顺应性的非侵入性方法是基于血压，流速和脉搏波速度的测量。

10. 发明申请

WO2016081519A1 BLOOD PRESSURE AND ARTERIAL COMPLIANCE ESTIMATION FROM ARTERIAL SEGMENTS 审中-公开
标题翻译：血浆压力和尸体合并评估
公开(公告)号：WO2016081519A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/061190
申请日：2015-11-17
申请人： BORKHOLDER, David A. , LIBERSON, Alexander S. , LILLIE, Jeffrey S.
发明人： BORKHOLDER, David A. , LIBERSON, Alexander S. , LILLIE, Jeffrey S.
IPC分类号： A61B5/021 , A61B5/0285 , G09B23/28
CPC分类号： A61B5/021 , A61B5/02007 , A61B5/02125 , A61B5/0285 , A61B5/0295 , A61B5/0456 , G09B23/28 , G09B23/288 , G09B23/30
摘要： A noninvasive method for monitoring the blood pressure and arterial compliance of a patient based on measurements of a flow velocity and a pulse wave velocity is described. An embodiment uses a photoplethysmograph and includes a method to monitor the dynamic behavior of the arterial blood flow, coupled with a hemodynamic mathematical model of the arterial blood flow motion in a fully nonlinear vessel. A derived mathematical model creates the patient specific dependence of a blood pressure versus PWV and blood velocity, which allows continuous monitoring of arterial blood pressure.
摘要翻译：描述了基于流速和脉搏波速度的测量来监测患者的血压和动脉顺应性的非侵入性方法。一个实施例使用光电容积法，并且包括监测动脉血流的动态行为的方法，以及完全非线性血管中的动脉血流运动的血液动力学数学模型。派生的数学模型创建了血压对PWV和血液速度的患者特异性依赖性，其允许连续监测动脉血压。

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