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1. 发明申请

WO2010141806A2 COMPOSITIONS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的组合物和方法
公开(公告)号：WO2010141806A2
公开(公告)日：2010-12-09
申请号：PCT/US2010/037382
申请日：2010-06-04
申请人： LANDEC CORPORATION , BALACHANDER, Natarajan , TAFT, David , ZHENG, Qiang , BITLER, Steven, P. , HAJDUK, Damian, A.
发明人： BALACHANDER, Natarajan , TAFT, David , ZHENG, Qiang , BITLER, Steven, P. , HAJDUK, Damian, A.
IPC分类号： A61K9/32 , A61K9/22 , A61K9/20 , A61K9/24 , A61K47/30
CPC分类号： A01N25/28 , A01N25/10 , A01N25/12 , A01N51/00
摘要： Compositions for the controlled delivery of active ingredients, for example, drugs, cosmetic materials, and agricultural materials. The compositions include a multiplicity of particles, each of the particles comprising (1) a microstructure comprising a semicrystalline polymer which has a peak melting temperature, Tp, of at least 20°C, and (2) the active ingredient. The microstructure comprises (i) crystalline domains of the semicrystalline polymer, the crystalline domains being separate from each other, and (ii) amorphous domains of the semicrystalline polymer, the amorphous domains providing a multiplicity of tortuous paths between the crystalline domains. At least part of the active ingredient is present in the amorphous domains. One of many valuable uses for the compositions is to provide a coating on a seed, for example a coating containing one or more of an insecticide, a fungicide, a nutrient, a biotic, a growth regulator and an herbicide.
摘要翻译：用于控制递送活性成分的组合物，例如药物，化妆品材料和农业材料。组合物包括多个颗粒，每个颗粒包含（1）包含半结晶聚合物的微结构，其具有至少20℃的峰值熔融温度Tp，和（2）活性成分。微结构包括（i）半结晶聚合物的结晶域，结晶域彼此分离，和（ii）半结晶聚合物的无定形区域，无定形畴在结晶域之间提供多个曲折路径。至少部分活性成分存在于无定形区域中。组合物的许多有价值的用途之一是在种子上提供涂层，例如包含杀虫剂，杀真菌剂，营养物，生物，生长调节剂和除草剂中的一种或多种的涂层。

2. 发明申请

WO2008070118A1 DELIVERY OF DRUGS 审中-公开
标题翻译：药物递送
公开(公告)号：WO2008070118A1
公开(公告)日：2008-06-12
申请号：PCT/US2007/024909
申请日：2007-12-04
申请人： LANDEC CORPORATION , TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, Warwick
发明人： TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, Warwick
IPC分类号： A61K9/52 , A61K9/22
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/146
摘要： Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.
摘要翻译：制备药物和结晶侧链聚合物以提供受控和/或缓释药物制剂。

3. 发明申请

WO2010144755A3 COMPOSITIONS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的组合物和方法
公开(公告)号：WO2010144755A3
公开(公告)日：2011-04-21
申请号：PCT/US2010038239
申请日：2010-06-11
申请人： LANDEC CORP , TAFT DAVID , BALACHANDER NATARAJAN , BITLER STEVEN P , ZHENG QIANG , OTTENSMANN SANDRA
发明人： TAFT DAVID , BALACHANDER NATARAJAN , BITLER STEVEN P , ZHENG QIANG , OTTENSMANN SANDRA
IPC分类号： A61K9/32 , A61K9/20 , A61K9/22 , A61K47/30
CPC分类号： A61K8/416 , A01N25/10 , A61K47/61 , A61K2800/57 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Compositions for delivering release materials, for example drugs, agricultural materials, other bioactive materials, cosmetic materials, organic or inorganic compounds which take part in or catalyse a chemical reaction, a fragrance-emitting material for a vaporizer, or a lubricating material. The release material is associated with a crystalline carrier. The carrier may be a crystalline polymer containing a plurality of crystalline groups or a crystalline monomer which contains a single crystalline group, the crystalline group preferably comprising a straight chain polymethylene radical containing at least 16 carbon atoms. Some of the carriers are obtained by modifying hyaluronic acid, collagen, gelatin, a polysaccharide, a carbohydrate or cyclodextran. The release material may contain a similar crystalline group, for example may be an active compound which has been modified to introduce a crystalline group.
摘要翻译：用于输送释放材料的组合物，例如药物，农业材料，其他生物活性材料，化妆品材料，参与或催化化学反应的有机或无机化合物，用于蒸发器的发泡材料或润滑材料。释放材料与结晶载体结合。载体可以是含有多个结晶基团的结晶聚合物或含有单一结晶基团的结晶单体，该结晶基团优选包含含有至少16个碳原子的直链多亚甲基基团。一些载体通过修饰透明质酸，胶原，明胶，多糖，碳水化合物或环糊精得到。释放材料可以含有相似的结晶基团，例如可以是经修饰以引入结晶基团的活性化合物。

4. 发明申请

WO2009073192A2 SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的系统和方法
公开(公告)号：WO2009073192A2
公开(公告)日：2009-06-11
申请号：PCT/US2008/013335
申请日：2008-12-03
申请人： LANDEC CORPORATION , TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, W , DAI, Wei-guo , OTTENSMANN, Sandra, N , BALACHANDER, Natarajan
发明人： TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, W , DAI, Wei-guo , OTTENSMANN, Sandra, N , BALACHANDER, Natarajan
IPC分类号： A61K47/32 , A61K38/02 , A61K31/136 , A61K31/519 , A61K31/5513
CPC分类号： A61K9/146 , A61K9/1647 , A61K31/136 , A61K31/196 , A61K31/519 , A61K31/5513 , A61K47/34
摘要： Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
摘要翻译：用于递送释放材料的系统和方法，例如药物和其他生物活性材料。被称为CYC载体的结晶聚合物体系通过化学键合或物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，其导致相对低且尖锐的熔化温度。一类CYC载体，被称为CYSC聚合物，其大部分可结晶侧链悬垂在聚合物骨架上。称为ECC聚合物的另一类CYC载体的大部分可结晶侧链连接到聚合物骨架的末端单元。 ECC聚合物可以例如通过改性PLGA聚合物而获得。另一类非聚合物CYC载体。由于存在于不同类型分子中的可结晶部分（例如在含有可结晶部分的聚合物和含有可结晶部分的单体之间）的物理缔合，一些称为CYC组装的CYC载体具有增强的结晶度。对于某些用途，特别是药物的输送，优选使用生物可蚀性CYC载体。

5. 发明申请

WO2008070118A9 DRUG DELIVERY 审中-公开
标题翻译：药物递送
公开(公告)号：WO2008070118A9
公开(公告)日：2008-09-18
申请号：PCT/US2007024909
申请日：2007-12-04
申请人： LANDEC CORP , TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM WARWICK
发明人： TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM WARWICK
IPC分类号： A61K9/52 , A61K9/22
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/146
摘要： Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.
摘要翻译：制备药物和结晶侧链聚合物以提供受控和/或缓释药物制剂。

6. 发明申请

WO9513039A3 ORTHOPEDIC CASTS 审中-公开
公开(公告)号：WO9513039A3
公开(公告)日：1995-07-20
申请号：PCT/US9413007
申请日：1994-11-08
申请人： LANDEC CORP , GREENE LAWRENCE C , DAHLEN BURTON L , LARSON ANDREW W , TAFT DAVID D , BITLER STEVEN P
发明人： GREENE LAWRENCE C , DAHLEN BURTON L , LARSON ANDREW W , TAFT DAVID D , BITLER STEVEN P
IPC分类号： A61F5/058 , A61F13/04 , A61L15/12 , A61F5/04
CPC分类号： A61L15/12 , A61F5/058 , A61F13/04 , A61F13/041 , Y10S264/71 , Y10S428/913 , Y10S524/921 , Y10T428/1314 , Y10T428/1328 , Y10T428/1334 , Y10T428/1362 , Y10T428/1372 , Y10T428/1376 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , Y10T428/24322 , Y10T428/24331 , Y10T442/2811 , C08L67/04
摘要： Heat-recoverable orthopedic casts include a support which is maintained in an elastically deformed condition by a casting polymer, e.g. a polycaprolactone (PCL) or a side chain crystallizable polymer having a relatively low melting point. The cast is placed around the limb and is then heated. The casting polymer softens and the cast recovers around the limb. A liner is preferably placed between the cast and the limb, especially when the casting polymer is PCL or has a comparable or higher melting point. For high strength casts, the support is preferably an open-mesh knitted fabric which, when fully relaxed, contains at most 300 holes per inch2 (at most 45 holes per cm2). Such a fabric, when it is extensible to a maximum of 15 to 40 %, is also useful as casting tape which comprises a curable polymer casting composition, e.g. a water-curable polyurethane prepolymer. As illustrated in Figures 1 and 2, a stockinette liner (2) is preferably placed between the cast (1) and the limb as a thermal barrier. A reinforcing component may be used to strengthen the recovered cast. Suitable reinforcing components include (A) polyurethane precursors which are applied to the cast before or after recovery, and are polymerized during or after recovery, and (B) thermoplastic materials which are applied hot to the recovered cast. Casts made in this way can be divided to make splints which can be easily removed and replaced.

7. 发明申请

WO2010144755A2 COMPOSITIONS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的组合物和方法
公开(公告)号：WO2010144755A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/038239
申请日：2010-06-11
申请人： LANDEC CORPORATION , TAFT, David , BALACHANDER, Natarajan , BITLER, Steven, P. , ZHENG, Qiang , OTTENSMANN, Sandra
发明人： TAFT, David , BALACHANDER, Natarajan , BITLER, Steven, P. , ZHENG, Qiang , OTTENSMANN, Sandra
IPC分类号： A61K9/32 , A61K9/22 , A61K9/20 , A61K47/30
CPC分类号： A61K8/416 , A01N25/10 , A61K47/61 , A61K2800/57 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Compositions for delivering release materials, for example drugs, agricultural materials, other bioactive materials, cosmetic materials, organic or inorganic compounds which take part in or catalyse a chemical reaction, a fragrance-emitting material for a vaporizer, or a lubricating material. The release material is associated with a crystalline carrier. The carrier may be a crystalline polymer containing a plurality of crystalline groups or a crystalline monomer which contains a single crystalline group, the crystalline group preferably comprising a straight chain polymethylene radical containing at least 16 carbon atoms. Some of the carriers are obtained by modifying hyaluronic acid, collagen, gelatin, a polysaccharide, a carbohydrate or cyclodextran. The release material may contain a similar crystalline group, for example may be an active compound which has been modified to introduce a crystalline group.
摘要翻译：用于输送释放材料的组合物，例如药物，农业材料，其他生物活性材料，化妆品材料，参与或催化化学反应的有机或无机化合物，用于蒸发器的发泡材料或润滑材料。释放材料与结晶载体结合。载体可以是含有多个结晶基团的结晶聚合物或含有单一结晶基团的结晶单体，该结晶基团优选包含含有至少16个碳原子的直链多亚甲基基团。一些载体通过修饰透明质酸，胶原，明胶，多糖，碳水化合物或环糊精得到。释放材料可以含有相似的结晶基团，例如可以是经修饰以引入结晶基团的活性化合物。

8. 发明申请

WO2010068279A1 THERMOCHROMIC INDICATOR 审中-公开
标题翻译：热电偶指示剂
公开(公告)号：WO2010068279A1
公开(公告)日：2010-06-17
申请号：PCT/US2009/006503
申请日：2009-12-11
申请人： LANDEC CORPORATION , PARKER, Robert , SCHAFER, Julian, E. , BITLER, Steven, P.
发明人： PARKER, Robert , SCHAFER, Julian, E. , BITLER, Steven, P.
IPC分类号： G01K11/12 , G01N31/00 , G01N33/00 , C09K3/00
CPC分类号： G01K11/16 , B05D5/06 , G01K11/165 , Y10T428/249986 , Y10T428/25 , Y10T428/254 , Y10T428/269 , Y10T442/2139
摘要： A thermochromic indicator includes a coating on the substrate. The coating comprising a solid crystalline particles having a melting point of 0-130°C. At temperatures below the melting point, the coating is opaque. At temperatures above the melting point, the coating becomes translucent. The change in opacity can be reversible or irreversible.
摘要翻译：热变色指示剂包括在基底上的涂层。该涂层包含熔点为0-130℃的固体结晶颗粒。在低于熔点的温度下，涂层是不透明的。在高于熔点的温度下，涂层变得透明。不透明度的变化可以是可逆的或不可逆的。

9. 发明申请

WO2009073192A3 SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS 审中-公开
标题翻译：用于输送材料的系统和方法
公开(公告)号：WO2009073192A3
公开(公告)日：2009-10-22
申请号：PCT/US2008013335
申请日：2008-12-03
申请人： LANDEC CORP , TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM W , DAI WEI-GUO , OTTENSMANN SANDRA N , BALACHANDER NATARAJAN
发明人： TAFT DAVID D , BITLER STEVEN P , ZHENG QIANG , TZANNIS STELIOS T , BELL ADAM W , DAI WEI-GUO , OTTENSMANN SANDRA N , BALACHANDER NATARAJAN
IPC分类号： A61K9/16 , A61K31/196 , A61K31/519 , A61P25/18 , A61P29/00
CPC分类号： A61K9/146 , A61K9/1647 , A61K31/136 , A61K31/196 , A61K31/519 , A61K31/5513 , A61K47/34
摘要： Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
摘要翻译：用于输送释放材料的系统和方法，例如药物和其他生物活性材料。称为CYC载体的结晶聚合体系通过化学键合或通过物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在，例如长链正烷基部分，这导致相对低的和尖锐的熔融温度。称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 CYC载体在另一类非聚合物中。一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度，例如在含可结晶部分的聚合物和含可结晶部分的单体之间。对于一些用途，特别是药物的递送，优选使用生物侵蚀性CYC载体。

10. 发明申请

WO2008070165A1 DRUG-CONTAINING COMPOSITIONS AND THEIR USE 审中-公开
标题翻译：含药组合物及其使用
公开(公告)号：WO2008070165A1
公开(公告)日：2008-06-12
申请号：PCT/US2007/025032
申请日：2007-12-05
申请人： LANDEC CORPORATION , TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, Warwick
发明人： TAFT, David, D. , BITLER, Steven, P. , ZHENG, Qiang , TZANNIS, Stelios, T. , BELL, Adam, Warwick
IPC分类号： A61K47/30 , A61K47/32 , A61K9/10 , A61K9/20 , A61K9/32
CPC分类号： A61K9/0024 , A61K9/0019 , A61K9/146
摘要： Formulations of drugs and crystalline side chain polymers to provide controlled and/or sustained release drug formulations.
摘要翻译：制备药物和结晶侧链聚合物以提供受控和/或缓释药物制剂。

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