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    • 2. 发明申请
    • SYSTEMS AND METHODS FOR DELIVERY OF MATERIALS
    • 用于输送材料的系统和方法
    • WO2009073192A3
    • 2009-10-22
    • PCT/US2008013335
    • 2008-12-03
    • LANDEC CORPTAFT DAVID DBITLER STEVEN PZHENG QIANGTZANNIS STELIOS TBELL ADAM WDAI WEI-GUOOTTENSMANN SANDRA NBALACHANDER NATARAJAN
    • TAFT DAVID DBITLER STEVEN PZHENG QIANGTZANNIS STELIOS TBELL ADAM WDAI WEI-GUOOTTENSMANN SANDRA NBALACHANDER NATARAJAN
    • A61K9/16A61K31/196A61K31/519A61P25/18A61P29/00
    • A61K9/146A61K9/1647A61K31/136A61K31/196A61K31/519A61K31/5513A61K47/34
    • Systems and methods for delivering release materials, for example drugs and other bioactive materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the release materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class of non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. For some uses, particularly the delivery of drugs, a bioerodable CYC carrier is preferably used.
    • 用于输送释放材料的系统和方法,例如药物和其他生物活性材料。 称为CYC载体的结晶聚合体系通过化学键合或通过物理缔合与释放材料相关联。 CYC载体的结晶度来自可结晶侧链的存在,例如长链正烷基部分,这导致相对低的和尖锐的熔融温度。 称为CYSC聚合物的一类CYC载体具有从聚合物主链悬挂的大部分可结晶侧链。 称为ECC聚合物的另一类CYC载体具有连接至聚合物主链末端单元的大部分可结晶侧链。 ECC聚合物可以例如通过改性PLGA聚合物获得。 CYC载体在另一类非聚合物中。 一些称为CYC组件的CYC载体由于存在于不同类型分子中的可结晶部分的物理结合而具有增强的结晶度,例如在含可结晶部分的聚合物和含可结晶部分的单体之间。 对于一些用途,特别是药物的递送,优选使用生物侵蚀性CYC载体。
    • 5. 发明申请
    • SYSTEMS FOR THE ANALYSIS OF GENE EXPRESSION DATA
    • 基因表达数据分析系统
    • WO0028091A9
    • 2002-08-22
    • PCT/US9927072
    • 1999-11-12
    • SCIOS INCZHENG QIANGGARRARD LISA
    • ZHENG QIANGGARRARD LISA
    • G06F19/20C12Q1/68G01N31/00G01N33/48G01N33/50G06F19/00
    • G06F19/20
    • The present invention relates to systems, integrated computer sofwater programs, and related methods for manipualtion and analysis of gene expression data. The methods of the invention are particularly suited for use with gene expression data generated with microarray and genechip technologies. A particular embodiment of the invention relates to systems utilizing clustering algorithms, which may be used to correlate temporal patterns of gene expression. The invention also relates to graphical tools, search and sort functions for viewing both the original and processed gene expression data. The present invention also relates to a graphical user interface for data clustering, graphical viewing, and browsing.
    • 本发明涉及系统,综合计算机软件程序以及用于操作和分析基因表达数据的相关方法。 本发明的方法特别适用于用微阵列和基因技术生成的基因表达数据。 本发明的一个具体实施例涉及利用聚类算法的系统,其可用于相关基因表达的时间模式。 本发明还涉及图形工具,用于查看原始和经处理的基因表达数据的搜索和分类功能。 本发明还涉及用于数据聚类,图形查看和浏览的图形用户界面。