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1. 发明申请

WO2008030891A2 INHIBITION OF FATTY ACID SYNTHESIS BY PARP INHIBITORS AND METHODS OF TREATMENT THEREOF 审中-公开
标题翻译： PARP抑制剂抑制脂肪酸的合成及其处理方法
公开(公告)号：WO2008030891A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/077662
申请日：2007-09-05
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria , SHERMAN, Barry
发明人： OSSOVSKAYA, Valeria , SHERMAN, Barry
IPC分类号： A61K31/165 , A61P3/04 , A61P9/00
CPC分类号： A61K31/166 , A61K31/197 , A61K31/7012
摘要： The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.
摘要翻译：本发明涉及一种治疗脂肪酸合成相关疾病的方法，包括向有需要的患者施用有效量的PARP抑制剂或其代谢物以抑制脂肪酸合成，其中所述脂肪酸合成相关疾病是肥胖症，糖尿病，或心血管疾病。本发明还涉及治疗受试者的癌症的方法，包括：（i）鉴定来自受试者的样品中的脂肪酸水平，和（ii）施用有效量的PARP抑制剂或其代谢物以抑制受试者中的脂肪酸合成，其中所述给药基于脂肪酸的水平，从而治疗受试者的癌症。本发明还涉及通过向有需要的患者施用有效量的PARP抑制剂或其代谢物来抑制脂肪酸合成来治疗Her-2相关癌症的方法。

2. 发明申请

WO2008030883A3 TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2008030883A3
公开(公告)日：2008-03-13
申请号：PCT/US2007/077651
申请日：2007-09-05
申请人： BIPAR SCIENCES, INC. , MOORE, Jerome , KEYT, Bruce , BURNIER, John , SHERMAN, Barry , TOTROV, Max , OSSOVSKAYA, Valeria
发明人： MOORE, Jerome , KEYT, Bruce , BURNIER, John , SHERMAN, Barry , TOTROV, Max , OSSOVSKAYA, Valeria
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly- ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.

3. 发明申请

WO2007011962A2 TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症
公开(公告)号：WO2007011962A2
公开(公告)日：2007-01-25
申请号：PCT/US2006027907
申请日：2006-07-18
申请人： BIPAR SCIENCES INC , KUN ERNEST KUN , MENDELEYEV JEROME , BASBAUM CAROL , LEMJABBAR-ALAOUI HASSAN , OSSOVSKAYA VALERIA
发明人： KUN ERNEST KUN , MENDELEYEV JEROME , BASBAUM CAROL , LEMJABBAR-ALAOUI HASSAN , OSSOVSKAYA VALERIA
IPC分类号： A61K31/165
CPC分类号： A61K31/166 , A61K31/165 , A61K31/366 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
摘要翻译：本发明提供了用于治疗癌症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制聚-ADP-核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供施用这种组合物的制剂和模式。

4. 发明申请

WO2010091140A1 TREATMENT OF LUNG CANCER WITH A PARP INHIBITOR IN COMBINATION WITH A GROWTH FACTOR INHIBITOR 审中-公开
标题翻译：用PARP抑制剂与生长因子抑制剂联合治疗肺癌
公开(公告)号：WO2010091140A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023137
申请日：2010-02-04
申请人： BIPAR SCIENCES, INC. , SHERMAN, Barry, M. , BRADLEY, Charles , OSSOVSKAYA, Valeria, S.
发明人： SHERMAN, Barry, M. , BRADLEY, Charles , OSSOVSKAYA, Valeria, S.
IPC分类号： A01N47/28 , A61K31/17
CPC分类号： A61K45/06 , A61K31/17 , A61K31/404 , A61K31/4375 , A61K31/4709 , A61K31/517 , A61K31/553 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of treating non-small cell lung cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor.
摘要翻译：一方面，本发明提供了一种治疗肺癌的方法，包括给予受试者至少一种PARP抑制剂与至少一种生长因子抑制剂的组合。另一方面，本发明提供了一种治疗非小细胞肺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种生长因子抑制剂的组合。

5. 发明申请

WO2009064738A9 TREATMENT OF BREAST CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗乳腺癌或与抗肿瘤药物联合治疗
公开(公告)号：WO2009064738A9
公开(公告)日：2009-07-16
申请号：PCT/US2008083147
申请日：2008-11-11
申请人： BIPAR SCIENCES INC , SHERMAN BARRY , BRADLEY CHARLES , OSSOVSKAYA VALERIA
发明人： SHERMAN BARRY , BRADLEY CHARLES , OSSOVSKAYA VALERIA
IPC分类号： A61K31/166 , A61P35/00
CPC分类号： A61K31/166 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K41/00 , A61K45/06 , A61K2300/00

6. 发明申请

WO2009064738A2 TREATMENT OF BREAST CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗乳腺癌或与抗肿瘤药物联合治疗
公开(公告)号：WO2009064738A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083147
申请日：2008-11-11
申请人： BIPAR SCIENCES, INC. , SHERMAN, Barry , BRADLEY, Charles , OSSOVSKAYA, Valeria
发明人： SHERMAN, Barry , BRADLEY, Charles , OSSOVSKAYA, Valeria
IPC分类号： A61K31/166 , A61P35/00
CPC分类号： A61K31/166 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗对于ER，PR或HER2中的至少一种呈阴性的乳腺癌的方法，包括向受试者施用至少一种PARP抑制剂。在另一方面，本发明提供了一种治疗乳腺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂的组合。

7. 发明申请

WO2009100159A3 METHODS OF DIAGNOSING AND TREATING PARP-MEDIATED DISEASES 审中-公开
公开(公告)号：WO2009100159A3
公开(公告)日：2009-08-13
申请号：PCT/US2009/033117
申请日：2009-02-04
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria S. , SHERMAN, Barry M.
发明人： OSSOVSKAYA, Valeria S. , SHERMAN, Barry M.
IPC分类号： C12Q1/68 , C12N15/11 , C07H21/00 , A61K48/00
摘要： Disclosed are methods of identifying a disease treatable with modulators of differentially expressed genes in a disease, including at least PARP modulators, by identifying the level of expression of differentially expressed genes, including at least PARP, in a plurality of samples from a population, making a decision regarding identifying the disease treatable by modulators to the differentially expressed genes wherein the decision is made based on the level of expression of the differentially expressed genes. The method can further comprise treating the disease in a subject population with modulators of identified differentially expressed genes. The methods relate to identifying up-regulated expression of identified differentially-expressed genes in a disease and making a decision regarding the treatment of the disease. The level of expression of the differentially expressed genes in a disease can also help in determining the efficacy of the treatment with modulators to the differentially expressed genes.

8. 发明申请

WO2008147418A1 METHOD OF TREATING DISEASES WITH PARP INHIBITORS 审中-公开
标题翻译：用PARP抑制剂治疗疾病的方法
公开(公告)号：WO2008147418A1
公开(公告)日：2008-12-04
申请号：PCT/US2007/071053
申请日：2007-06-12
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria, S. , SHERMAN, Barry, M.
发明人： OSSOVSKAYA, Valeria, S. , SHERMAN, Barry, M.
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/57415 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： [00267] The present invention relates to methodsof identifying a disease treatable with PARP modulators by identifying a level of PARP in a sample of a subject, making a decision regarding identifying the disease treatable by the PARP modulators wherein the decision is made based on the level of PARP. The method further comprises of treating the disease in the subject with the PARP modulators. The methods relate to identifying up-regulated PARP in a disease and making a decision regarding the treatment of the disease with PARP inhibitors. The extent of PARP up-regulation in a disease can also help in determining the efficacy of the treatement with PARP inhibitors. [00268] The present invention discloses various diseases that have up-regulated or down-regulated PARP and can be treated with PARP inhibitors or PARP activators, respectively. The examples of the diseases include cancer, inflammation, metabolic disease, CVS disease, CNS disease, disorder of hematolymphoid system, disorder of endocrine and neuroendocrine, disorder of urinary tract, disorder of respiratory system, disorder of female reproductive system, and disorder of male reproductive system.
摘要翻译：本发明涉及通过鉴定受试者样品中的PARP水平来鉴定可用PARP调节剂治疗的疾病的方法，作出关于鉴定由PARP调节剂可治疗的疾病的决定，其中基于水平进行决定的PARP。该方法还包括用PARP调节剂治疗受试者的疾病。该方法涉及鉴定疾病中的上调PARP并且用PARP抑制剂来决定治疗该疾病。疾病中PARP上调的程度也有助于确定PARP抑制剂治疗的疗效。本发明公开了具有上调或下调PARP并可分别用PARP抑制剂或PARP活化剂治疗的各种疾病。疾病的实例包括癌症，炎症，代谢疾病，CVS疾病，CNS疾病，血液系统紊乱，内分泌和神经内分泌紊乱，尿路紊乱，呼吸系统紊乱，女性生殖系统紊乱和男性失调生殖系统。

9. 发明申请

WO2008089272A1 FORMULATIONS FOR CANCER TREATMENT 审中-公开
标题翻译：癌症治疗配方
公开(公告)号：WO2008089272A1
公开(公告)日：2008-07-24
申请号：PCT/US2008/051214
申请日：2008-01-16
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria , LI, Lingyun , SHERMAN, Barry
发明人： OSSOVSKAYA, Valeria , LI, Lingyun , SHERMAN, Barry
IPC分类号： A61P35/00 , A61K9/48 , A61K31/166 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/26
CPC分类号： B82Y5/00 , A61K9/0019 , A61K9/1075 , A61K9/1635 , A61K9/1652 , A61K31/166 , A61K47/6951
摘要： The present invention provides compositions of matter, kits, and methods for use in treating cancer and viral conditions. In particular the invention provides for pharmaceutical compositions containing nitrobenzamide compounds that have enhanced solubility in aqueous solutions.
摘要翻译：本发明提供了用于治疗癌症和病毒病症的物质，试剂盒和方法的组合物。特别地，本发明提供含有在水溶液中具有增强的溶解度的硝基苯甲酰胺化合物的药物组合物。

10. 发明申请

WO2008030892A2 DRUG DESIGN FOR TUBULIN INHIBITORS, COMPOSITIONS, AND METHODS OF TREATMENT THEREOF 审中-公开
标题翻译：用于管状体抑制剂的药物设计，组合物及其处理方法
公开(公告)号：WO2008030892A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/077663
申请日：2007-09-05
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria , BURNIER, John , SHERMAN, Barry , TOTROV, Max
发明人： OSSOVSKAYA, Valeria , BURNIER, John , SHERMAN, Barry , TOTROV, Max
IPC分类号： A61K31/12 , A61K31/135 , A61K31/497 , A61K31/66 , A61P43/00 , G06G7/48
CPC分类号： A61K31/12 , A61K31/135 , A61K31/497 , A61K31/66 , G06F19/16 , G06F19/706
摘要： The present invention relates to a computer-assisted method of a designing of a tubulin inhibitor comprising: a) determining an interaction between a tubulin protein and a chemical known to bind the tubulin protein by evaluating a binding of the tubulin protein to the chemical known to bind the tubulin protein; b) based on the interaction, designing a candidate tubulin inhibitor; c) determining an interaction between the tubulin protein and the candidate tubulin inhibitor by evaluating a binding of the tubulin protein to the candidate tubulin inhibitor; and d) concluding that the candidate tubulin inhibitor inhibits the tubulin protein wherein the conclusion is based on the interaction of step c). The invention also provides compositions and methods of treatment of diseases with the candidate tubulin inhibitors.
摘要翻译：本发明涉及一种设计微管蛋白抑制剂的计算机辅助方法，包括：a）通过评估微管蛋白与已知的化学物质的结合来确定微管蛋白与已知结合微管蛋白的化学物质之间的相互作用结合微管蛋白; b）基于相互作用，设计候选微管蛋白抑制剂; c）通过评估微管蛋白与候选微管蛋白抑制剂的结合来确定微管蛋白和候选微管蛋白抑制剂之间的相互作用; 和d）得出结论，候选微管蛋白抑制剂抑制微管蛋白，其中结论基于步骤c）的相互作用。本发明还提供了用候选微管蛋白抑制剂治疗疾病的组合物和方法。

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