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1. 发明申请

WO2008030891A2 INHIBITION OF FATTY ACID SYNTHESIS BY PARP INHIBITORS AND METHODS OF TREATMENT THEREOF 审中-公开
标题翻译： PARP抑制剂抑制脂肪酸的合成及其处理方法
公开(公告)号：WO2008030891A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/077662
申请日：2007-09-05
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria , SHERMAN, Barry
发明人： OSSOVSKAYA, Valeria , SHERMAN, Barry
IPC分类号： A61K31/165 , A61P3/04 , A61P9/00
CPC分类号： A61K31/166 , A61K31/197 , A61K31/7012
摘要： The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synthesis related disease is obesity, diabetes, or cardiovascular disease. The present invention also relates to a method of treating a cancer in a subject comprising: (i) identifying a level of fatty acid in a sample from the subject, and (ii) administering an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis in the subject, wherein the administration is based on the level of fatty acid, thereby treating the cancer in the subject. The present invention further relates to a method of treating Her-2 related cancers by administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis.
摘要翻译：本发明涉及一种治疗脂肪酸合成相关疾病的方法，包括向有需要的患者施用有效量的PARP抑制剂或其代谢物以抑制脂肪酸合成，其中所述脂肪酸合成相关疾病是肥胖症，糖尿病，或心血管疾病。本发明还涉及治疗受试者的癌症的方法，包括：（i）鉴定来自受试者的样品中的脂肪酸水平，和（ii）施用有效量的PARP抑制剂或其代谢物以抑制受试者中的脂肪酸合成，其中所述给药基于脂肪酸的水平，从而治疗受试者的癌症。本发明还涉及通过向有需要的患者施用有效量的PARP抑制剂或其代谢物来抑制脂肪酸合成来治疗Her-2相关癌症的方法。

2. 发明申请

WO2008030883A3 TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2008030883A3
公开(公告)日：2008-03-13
申请号：PCT/US2007/077651
申请日：2007-09-05
申请人： BIPAR SCIENCES, INC. , MOORE, Jerome , KEYT, Bruce , BURNIER, John , SHERMAN, Barry , TOTROV, Max , OSSOVSKAYA, Valeria
发明人： MOORE, Jerome , KEYT, Bruce , BURNIER, John , SHERMAN, Barry , TOTROV, Max , OSSOVSKAYA, Valeria
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly- ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.

3. 发明申请

WO2007011962A2 TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症
公开(公告)号：WO2007011962A2
公开(公告)日：2007-01-25
申请号：PCT/US2006027907
申请日：2006-07-18
申请人： BIPAR SCIENCES INC , KUN ERNEST KUN , MENDELEYEV JEROME , BASBAUM CAROL , LEMJABBAR-ALAOUI HASSAN , OSSOVSKAYA VALERIA
发明人： KUN ERNEST KUN , MENDELEYEV JEROME , BASBAUM CAROL , LEMJABBAR-ALAOUI HASSAN , OSSOVSKAYA VALERIA
IPC分类号： A61K31/165
CPC分类号： A61K31/166 , A61K31/165 , A61K31/366 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
摘要翻译：本发明提供了用于治疗癌症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制聚-ADP-核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供施用这种组合物的制剂和模式。

4. 发明申请

WO2010091140A1 TREATMENT OF LUNG CANCER WITH A PARP INHIBITOR IN COMBINATION WITH A GROWTH FACTOR INHIBITOR 审中-公开
标题翻译：用PARP抑制剂与生长因子抑制剂联合治疗肺癌
公开(公告)号：WO2010091140A1
公开(公告)日：2010-08-12
申请号：PCT/US2010/023137
申请日：2010-02-04
申请人： BIPAR SCIENCES, INC. , SHERMAN, Barry, M. , BRADLEY, Charles , OSSOVSKAYA, Valeria, S.
发明人： SHERMAN, Barry, M. , BRADLEY, Charles , OSSOVSKAYA, Valeria, S.
IPC分类号： A01N47/28 , A61K31/17
CPC分类号： A61K45/06 , A61K31/17 , A61K31/404 , A61K31/4375 , A61K31/4709 , A61K31/517 , A61K31/553 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of treating non-small cell lung cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor.
摘要翻译：一方面，本发明提供了一种治疗肺癌的方法，包括给予受试者至少一种PARP抑制剂与至少一种生长因子抑制剂的组合。另一方面，本发明提供了一种治疗非小细胞肺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种生长因子抑制剂的组合。

5. 发明申请

WO2009064738A9 TREATMENT OF BREAST CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗乳腺癌或与抗肿瘤药物联合治疗
公开(公告)号：WO2009064738A9
公开(公告)日：2009-07-16
申请号：PCT/US2008083147
申请日：2008-11-11
申请人： BIPAR SCIENCES INC , SHERMAN BARRY , BRADLEY CHARLES , OSSOVSKAYA VALERIA
发明人： SHERMAN BARRY , BRADLEY CHARLES , OSSOVSKAYA VALERIA
IPC分类号： A61K31/166 , A61P35/00
CPC分类号： A61K31/166 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K41/00 , A61K45/06 , A61K2300/00

6. 发明申请

WO2009064738A2 TREATMENT OF BREAST CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTI-TUMOR AGENTS 审中-公开
标题翻译：用PARP抑制剂治疗乳腺癌或与抗肿瘤药物联合治疗
公开(公告)号：WO2009064738A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083147
申请日：2008-11-11
申请人： BIPAR SCIENCES, INC. , SHERMAN, Barry , BRADLEY, Charles , OSSOVSKAYA, Valeria
发明人： SHERMAN, Barry , BRADLEY, Charles , OSSOVSKAYA, Valeria
IPC分类号： A61K31/166 , A61P35/00
CPC分类号： A61K31/166 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： In one aspect, the present invention provides a method of treating breast cancer that is negative for at least one of ER, PR, or HER2, comprising administering to a subject at least one PARP inhibitor. In another aspect, the present invention provides a method of treating breast cancer comprising administering to a subject at least one PARP inhibitor in combination with at least one anti-tumor agent.
摘要翻译：一方面，本发明提供一种治疗对于ER，PR或HER2中的至少一种呈阴性的乳腺癌的方法，包括向受试者施用至少一种PARP抑制剂。在另一方面，本发明提供了一种治疗乳腺癌的方法，其包括向受试者施用至少一种PARP抑制剂与至少一种抗肿瘤剂的组合。

7. 发明申请

WO2009100159A2 METHODS OF DIAGNOSING AND TREATING PARP-MEDIATED DISEASES 审中-公开
标题翻译：诊断和治疗PARP介导性疾病的方法
公开(公告)号：WO2009100159A2
公开(公告)日：2009-08-13
申请号：PCT/US2009033117
申请日：2009-02-04
申请人： BIPAR SCIENCES INC , OSSOVSKAYA VALERIA S , SHERMAN BARRY M
发明人： OSSOVSKAYA VALERIA S , SHERMAN BARRY M
IPC分类号： C12Q1/68 , A61K48/00 , C07H21/00 , C12N15/11
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , G01N2800/52 , Y02A90/26
摘要： Disclosed are methods of identifying a disease treatable with modulators of differentially expressed genes in a disease, including at least PARP modulators, by identifying the level of expression of differentially expressed genes, including at least PARP, in a plurality of samples from a population, making a decision regarding identifying the disease treatable by modulators to the differentially expressed genes wherein the decision is made based on the level of expression of the differentially expressed genes. The method can further comprise treating the disease in a subject population with modulators of identified differentially expressed genes. The methods relate to identifying up-regulated expression of identified differentially-expressed genes in a disease and making a decision regarding the treatment of the disease. The level of expression of the differentially expressed genes in a disease can also help in determining the efficacy of the treatment with modulators to the differentially expressed genes.
摘要翻译：公开的是通过鉴定来自群体的多个样品中差异表达基因（包括至少PARP）的表达水平，鉴定在疾病中包括至少PARP调节剂的差异表达基因的调节剂可治疗的疾病的方法，使得关于鉴定通过调节剂可治疗的差异表达基因的决定，其中基于差异表达基因的表达水平进行决定。该方法还可以包括用鉴别的差异表达基因的调节剂治疗受试群体中的疾病。该方法涉及鉴定疾病中识别的差异表达基因的上调表达并作出关于疾病治疗的决定。差异表达基因在疾病中的表达水平也有助于确定用调节剂处理差异表达基因的功效。

8. 发明申请

WO2009073869A1 TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS 审中-公开
标题翻译：用TOPOISOMERASE抑制剂和PARP抑制剂联合治疗癌症
公开(公告)号：WO2009073869A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085756
申请日：2008-12-05
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria , BRADLEY, Charles , SHERMAN, Barry
发明人： OSSOVSKAYA, Valeria , BRADLEY, Charles , SHERMAN, Barry
IPC分类号： A01N43/42 , A61K31/47 , G01N33/574
CPC分类号： A61K31/166 , A61K31/337 , A61K31/47 , A61K31/505 , A61K31/513 , A61K45/06 , A61K2300/00
摘要： In one aspect, the present invention provides a composition and a kit comprising a combination of topoisomerase inhibitor and PARP inhibitor for treatment of cancer. In another aspect, the invention provides a method of treating cancer comprising administering to a subject a combination of topoisomerase inhibitor and PARP inhibitor. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase and a topoisomerase, as well as providing formulations and modes of administering such compositions.
摘要翻译：一方面，本发明提供了包含拓扑异构酶抑制剂和PARP抑制剂的组合的组合物和试剂盒，用于治疗癌症。另一方面，本发明提供了一种治疗癌症的方法，包括向受试者施用拓扑异构酶抑制剂和PARP抑制剂的组合。特别地，本发明提供了通过抑制聚-ADP-核糖聚合酶和拓扑异构酶来治疗受试者的癌症的组合物和方法，以及提供施用这种组合物的制剂和模式。

9. 发明申请

WO2009051815A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER USING BENZOPYRONE-TYPE PARP INHIBITORS 审中-公开
标题翻译：使用苯并吡喃型PARP抑制剂治疗癌症的方法和组合物
公开(公告)号：WO2009051815A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/011903
申请日：2008-10-17
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria , SHERMAN, Barry
发明人： OSSOVSKAYA, Valeria , SHERMAN, Barry
IPC分类号： A61K31/35
CPC分类号： A61K31/37 , A61K31/282 , A61K31/4025 , A61K31/4178 , A61K31/4433 , A61K31/453 , A61K31/496 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K38/21 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
摘要翻译：本发明提供了用于治疗癌症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制聚-ADP-核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供施用这种组合物的制剂和模式。

10. 发明申请

WO2008030883A2 TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症
公开(公告)号：WO2008030883A2
公开(公告)日：2008-03-13
申请号：PCT/US2007077651
申请日：2007-09-05
申请人： BIPAR SCIENCES INC , MOORE JEROME , KEYT BRUCE , BURNIER JOHN , SHERMAN BARRY , TOTROV MAX , OSSOVSKAYA VALERIA
发明人： MOORE JEROME , KEYT BRUCE , BURNIER JOHN , SHERMAN BARRY , TOTROV MAX , OSSOVSKAYA VALERIA
IPC分类号： A61K31/166 , A61K31/19 , A61K31/7034 , A61P35/00 , C07C323/42 , C07C323/62
CPC分类号： C07C323/62 , C07C233/65 , C07C235/46 , C07C237/30 , C07C239/18
摘要： The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly- ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
摘要翻译：本发明提供了用于治疗癌症的物质，试剂盒和方法的组合物。特别地，本发明提供了通过抑制多聚-ADP-核糖聚合酶来治疗受试者的癌症的组合物和方法，以及提供施用这种组合物的制剂和方式。

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