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2. 发明申请

WO2008147418A1 METHOD OF TREATING DISEASES WITH PARP INHIBITORS 审中-公开
标题翻译：用PARP抑制剂治疗疾病的方法
公开(公告)号：WO2008147418A1
公开(公告)日：2008-12-04
申请号：PCT/US2007/071053
申请日：2007-06-12
申请人： BIPAR SCIENCES, INC. , OSSOVSKAYA, Valeria, S. , SHERMAN, Barry, M.
发明人： OSSOVSKAYA, Valeria, S. , SHERMAN, Barry, M.
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/57415 , A61K38/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： [00267] The present invention relates to methodsof identifying a disease treatable with PARP modulators by identifying a level of PARP in a sample of a subject, making a decision regarding identifying the disease treatable by the PARP modulators wherein the decision is made based on the level of PARP. The method further comprises of treating the disease in the subject with the PARP modulators. The methods relate to identifying up-regulated PARP in a disease and making a decision regarding the treatment of the disease with PARP inhibitors. The extent of PARP up-regulation in a disease can also help in determining the efficacy of the treatement with PARP inhibitors. [00268] The present invention discloses various diseases that have up-regulated or down-regulated PARP and can be treated with PARP inhibitors or PARP activators, respectively. The examples of the diseases include cancer, inflammation, metabolic disease, CVS disease, CNS disease, disorder of hematolymphoid system, disorder of endocrine and neuroendocrine, disorder of urinary tract, disorder of respiratory system, disorder of female reproductive system, and disorder of male reproductive system.
摘要翻译：本发明涉及通过鉴定受试者样品中的PARP水平来鉴定可用PARP调节剂治疗的疾病的方法，作出关于鉴定由PARP调节剂可治疗的疾病的决定，其中基于水平进行决定的PARP。该方法还包括用PARP调节剂治疗受试者的疾病。该方法涉及鉴定疾病中的上调PARP并且用PARP抑制剂来决定治疗该疾病。疾病中PARP上调的程度也有助于确定PARP抑制剂治疗的疗效。本发明公开了具有上调或下调PARP并可分别用PARP抑制剂或PARP活化剂治疗的各种疾病。疾病的实例包括癌症，炎症，代谢疾病，CVS疾病，CNS疾病，血液系统紊乱，内分泌和神经内分泌紊乱，尿路紊乱，呼吸系统紊乱，女性生殖系统紊乱和男性失调生殖系统。

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