专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006075159A1 ANTI-BACTERIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2006075159A1
公开(公告)日：2006-07-20
申请号：PCT/GB2006/000101
申请日：2006-01-12
申请人： ASTON UNIVERSITY , PARKER, Katy, Jane , RATHBONE, Daniel, Lee , LAMBERT, Peter, Anthony , COLEMAN, Michael, Damian , HILTON, Anthony, Craig , WORTHINGTON, Antony , BILLINGTON, David, Charles
发明人： PARKER, Katy, Jane , RATHBONE, Daniel, Lee , LAMBERT, Peter, Anthony , COLEMAN, Michael, Damian , HILTON, Anthony, Craig , WORTHINGTON, Antony , BILLINGTON, David, Charles
IPC分类号： A01N43/40 , A01N43/60 , A01N43/42 , A01N43/50 , C07D213/86 , C07D241/12 , C07D215/48 , A61K31/44 , A01P1/00
CPC分类号： C07D213/53 , A01N43/40 , A01N43/42 , A01N43/50 , A01N43/60 , C07D213/89
摘要： Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).
摘要翻译：式（I）化合物或其盐或溶剂化物，体外为革兰氏阳性菌生长抑制剂，其中A选自式（a）。

2. 发明申请

WO2002048776A3 OPTICAL SCANNING SYSTEM APPARATUS 审中-公开
公开(公告)号：WO2002048776A3
公开(公告)日：2002-06-20
申请号：PCT/GB2001/005565
申请日：2001-12-14
申请人： THE TECHNOLOGY PARTNERSHIP PLC , WITHERS, Michael , BILLINGTON, David , CASSELLS, John
发明人： WITHERS, Michael , BILLINGTON, David , CASSELLS, John
IPC分类号： G01N351/02
摘要： An apparatus for use with an optical scanning or observation system. The apparatus comprises a drawer for receiving, in use, a sample carrier to be scanned or observed. A first clamp member, engages, in use, with one surface of a sample carrier in the drawer. A second clamp member is arranged to engage, in use, with the side of the sample carrier opposite to that of the first clamp member, the second clamp member having an optical window formed therein to enable viewing, in use, of a sample carrier. The first and second clamping members are arranged in use to move the sample carrier out of engagement with the drawer so that the sample carrier is supported solely on the clamping members.

3. 发明申请

WO2006111716A1 HETEROARYL DERIVATIVES HAVING ANTI-MYCOBACTERIAL ACTIVITY 审中-公开
标题翻译：具有抗真菌活性的异氟烷衍生物
公开(公告)号：WO2006111716A1
公开(公告)日：2006-10-26
申请号：PCT/GB2006/001378
申请日：2006-04-13
申请人： ASTON UNIVERSITY , PARKER, Katy, Jane , RATHBONE, Daniel, Lee , LAMBERT, Peter, Anthony , BILLINGTON, David, Charles
发明人： PARKER, Katy, Jane , RATHBONE, Daniel, Lee , LAMBERT, Peter, Anthony , BILLINGTON, David, Charles
IPC分类号： C07D213/54 , C07D215/12 , C07D241/12 , A61K31/44 , A61K31/47 , A61K31/4965 , A61P31/00
CPC分类号： C07D213/54 , C07D215/12 , C07D241/12
摘要： A compound of formula (I) where Het is selected from (2PY) (3PY) (4PY) (PZ) (QN) and (HD); (A) is formula (1) where X is O or S; R 1 is C 1-6 straight or branched alkyl, C 1-6 straight or branched alkoxy or alkylthio, C 1-6 straight or branched alkylcarbonyloxy, C 1-6 straight or branched alkyloxycarbonyl, phenyl, benzyl or phenyl(C 1-6 )alkyloxy, in each case the phenyl moiety itself being substituted or unsubstituted; and R 2 is H, C 1-6 straight or branched alkyl, C 1-6 alkylcarbonyl, phenyl, benzyl or arylcarbonyl (e.g. benzoyl), in each case the phenyl moiety itself being substituted or unsubstituted, and B is H, hydroxy, C 1-6 straight or branched alkyl, C 1-6 straight or branched alkoxy or alkylthio, C 1-6 straight or branched alkylcarbonyloxy, C 1-6 straight or branched alkyloxycarbonyl, cyano, amino, nitro, halo, phenyl, benzyl or phenyl(C 1-6 )alkyloxy, in each case the phenyl moiety itself being substituted or unsubstituted, and physiologically acceptable salts and complexes (e.g. metal complexes) thereof.
摘要翻译：其中Het选自（2PY）（3PY）（4PY）（PZ）（QN）和（HD））的式（I）化合物; （A）为式（1）其中X为O或S; R 1是C 1-6 - 直链或支链烷基，C 1-6 - 直链或支链烷氧基或烷硫基，C 1〜 6直链或支链烷基羰基氧基，C 1-6直链或支链烷氧基羰基，苯基，苄基或苯基（C 1-6 - ）烷氧基，在每种情况下苯基部分本身是取代或未取代的; 和R 2是H，C 1-6直链或支链烷基，C 1-6烷基羰基，苯基，苄基或芳基羰基（例如苯甲酰基），在每种情况下，苯基部分本身是取代或未取代的，并且B是H，羟基，C 1-16直链或支链烷基，C 1-6直链或支链烷氧基或烷硫基，C 1-6直链或支链烷基羰基氧基，C 1-6直链或支链烷氧基羰基，氰基，氨基，硝基，卤素，苯基，苄基或苯基（C 1-6）烷氧基，在各种情况下，苯基部分本身为取代或未取代的，以及其生理上可接受的盐和络合物（例如金属络合物）。

4. 发明申请

WO2005095002A2 METHOD AND APPARATUS FOR THE APPLICATION OF POWDER MATERIAL TO SUBSTRATES 审中-公开
标题翻译：将粉末材料应用于基材的方法和装置
公开(公告)号：WO2005095002A2
公开(公告)日：2005-10-13
申请号：PCT/GB2005/001247
申请日：2005-03-31
申请人： PHOQUS PHARMACEUTICALS LIMITED , KING, Russell, Stuart , HOLROYD, Michael, John , BILLINGTON, David, Michael
发明人： KING, Russell, Stuart , HOLROYD, Michael, John , BILLINGTON, David, Michael
IPC分类号： B05B5/00
CPC分类号： B05B5/081 , A61J3/005 , B05B5/1683

5. 发明申请

WO0248776A2 OPTICAL SCANNING SYSTEM APPARATUS 审中-公开
标题翻译：光学扫描系统设备
公开(公告)号：WO0248776A2
公开(公告)日：2002-06-20
申请号：PCT/GB0105565
申请日：2001-12-14
申请人： THE TECHNOLOGY PARTNERSHIP PLC , WITHERS MICHAEL , BILLINGTON DAVID , CASSELLS JOHN
发明人： WITHERS MICHAEL , BILLINGTON DAVID , CASSELLS JOHN
IPC分类号： G02B21/26 , B01L3/00 , G02B21/00 , G02B21/34
CPC分类号： B01L3/5085 , G02B21/34
摘要： An apparatus for use with an optical scanning or observation system. The apparatus comprises a drawer for receiving, in use, a sample carrier to be scanned or observed. A first clamp member, engages, in use, with one surface of a sample carrier in the drawer. A second clamp member is arranged to engage, in use, with the side of the sample carrier opposite to that of the first clamp member, the second clamp member having an optical window formed therein to enable viewing, in use, of a sample carrier. The first and second clamping members are arranged in use to move the sample carrier out of engagement with the drawer so that the sample carrier is supported solely on the clamping members.
摘要翻译：一种用于光学扫描或观察系统的设备。该设备包括用于在使用中接收待扫描或观察的样本载体的抽屉。第一夹紧构件在使用中与抽屉中的样品载体的一个表面接合。第二夹紧构件布置成在使用中与样品载体的与第一夹紧构件的侧面相反的侧面接合，第二夹紧构件具有形成在其中的光学窗口，以能够在使用中观察样品载体。第一和第二夹紧构件被设置成在使用中移动样品载体使其脱离与抽屉的接合，使得样品载体仅被支撑在夹紧构件上。

6. 发明申请

WO2005063167A3 METHOD AND APPARATUS FOR THE APPLICATION OF POWDER MATERIAL TO SUBSTRATES 审中-公开
标题翻译：将粉末材料应用于基材的方法和装置
公开(公告)号：WO2005063167A3
公开(公告)日：2005-12-01
申请号：PCT/GB2004005458
申请日：2004-12-30
申请人： PHOQUS PHARMACEUTICALS LTD , TULLETT SIMON , JARVIS ADRIAN , BILLINGTON DAVID , KING RUSSELL , GLEDHILL DAVID , WILLSHER PAUL , HOLROYD MICHAEL JOHN
发明人： TULLETT SIMON , JARVIS ADRIAN , BILLINGTON DAVID , KING RUSSELL , GLEDHILL DAVID , WILLSHER PAUL , HOLROYD MICHAEL JOHN
IPC分类号： A61J3/00 , B05B5/08 , B05B5/16
CPC分类号： B05B5/082 , A61J3/005 , B05B5/1683
摘要： Apparatuses (201) and methods for electrostatically applying a powder material to substrates are described. A plurality of platens (202, 203) are provided, each arranged to hold a plurality of substrates such as solid dosage forms (101, 111). Each platen (202, 203) is driven around an endless path and passes through a loading region (Fig. 3, 4) in which substrates are loaded onto the platens (202, 203), a developing region (Fig. 5, 6) in which the powder material is applied to the substrates, a fusing region (Fig. 7) in which the applied powder material is fused, and an unloading region (Fig. 8) in which substrates are removed from the platens (202, 203).
摘要翻译：描述了用于将粉末材料静电施加到基底的装置（201）和方法。提供多个压板（202,203），每个压板（202,203）各自布置成保持多个基板，例如固体剂型（101,111）。每个压板（202,203）围绕环形路径被驱动并通过其中衬底被加载到压板（202,203）上的负载区域（图3,4），显影区域（图5,6）其中将粉末材料施加到基板上，其中熔化所施加的粉末材料的熔化区域（图7）和其中从压板（202,203）去除衬底的卸载区域（图8）。

7. 发明申请

WO2005063167A2 METHOD AND APPARATUS FOR THE APPLICATION OF POWDER MATERIAL TO SUBSTRATES 审中-公开
标题翻译：将粉末材料应用于基材的方法和装置
公开(公告)号：WO2005063167A2
公开(公告)日：2005-07-14
申请号：PCT/GB2004/005458
申请日：2004-12-30
申请人： PHOQUS PHARMACEUTICALS LIMITED , TULLETT, Simon , JARVIS, Adrian , BILLINGTON, David , KING, Russell , GLEDHILL, David , WILLSHER, Paul , HOLROYD, Michael, John
发明人： TULLETT, Simon , JARVIS, Adrian , BILLINGTON, David , KING, Russell , GLEDHILL, David , WILLSHER, Paul , HOLROYD, Michael, John
IPC分类号： A61J3/00
CPC分类号： B05B5/082 , A61J3/005 , B05B5/1683
摘要： Apparatuses and methods for electrostatically applying a powder material to substrates are described. A plurality of platens are provided, each arranged to hold a plurality of substrates such as solid dosage forms. Each platen is driven around an endless path and passes through a loading region in which substrates are loaded onto the platens, a developing region in which the powder material is applied to the substrates, a fusing region in which the applied powder material is fused, and an unloading region in which substrates are removed from the platens.
摘要翻译：描述了将粉末材料静电施加到基底的装置和方法。提供多个压板，每个压板均布置成保持多个基板，例如固体剂型。每个压板围绕环形路径驱动，并通过其中将基板装载到压板上的加载区域，将粉末材料施加到基板的显影区域，施加的粉末材料熔合的熔合区域，以及卸载区域，其中基板从压板移除。

8. 发明申请

WO0193841A3 BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS 审中-公开
标题翻译：巴比妥酸类似物作为治疗药物
公开(公告)号：WO0193841A3
公开(公告)日：2002-06-06
申请号：PCT/GB0102468
申请日：2001-06-05
申请人： PROLIFIX LTD , BELIN JACKIE Y DE , ROMERO MARTIN MARIA ROSARIO , FINN PAUL W , SAYERS LEE G , LAW NORMAN M , BILLINGTON DAVID C , RYLEY STEPHEN , BHATTACHARYA SHOUMO
发明人： DE BELIN JACKIE Y , ROMERO-MARTIN MARIA-ROSARIO , FINN PAUL W , SAYERS LEE G , LAW NORMAN M , BILLINGTON DAVID C , RYLEY STEPHEN , BHATTACHARYA SHOUMO
IPC分类号： A61K31/506 , A61K31/513 , A61K31/515 , A61K31/519 , A61K31/522 , A61K31/525 , A61P9/00 , A61P35/00 , A61P43/00 , C07D239/62 , C07D239/66 , C07D403/06 , C07D405/06 , C07D409/06 , C07D409/14 , C07D473/06 , C07D473/08 , C07D475/14 , C07D487/04 , A61K31/505 , A61K31/52
CPC分类号： C07D403/06 , A61K31/515 , A61K31/519 , A61K31/522 , A61K31/525 , C07D239/62 , C07D405/06 , C07D409/06 , C07D409/14 , C07D473/06 , C07D473/08 , C07D487/04
摘要： This invention pertains to active barbituric acid analogs which inhibit HIF-1 activity (e.g., the interaction between HIF-1 alpha and p300) and thereby inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HIF-1 activity, and to inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer.
摘要翻译：本发明涉及抑制HIF-1活性的活性巴比妥酸类似物（例如，HIF-1α和p300之间的相互作用），从而抑制血管发生，肿瘤发生和增殖性疾病如癌症。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制HIF-1活性，以及抑制血管发生，肿瘤发生和增殖性疾病如癌症。

9. 发明申请

WO1996033999A1 NOVEL SUBSTITUTED TETRAHYDROPYRANO[3,2-d]OXAZOLONES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型取代的四氢呋喃并[3,2-d]氧杂环己烷，其制备方法及含有它们的药物组合物
公开(公告)号：WO1996033999A1
公开(公告)日：1996-10-31
申请号：PCT/FR1996000629
申请日：1996-04-24
申请人： ADIR ET COMPAGNIE , BILLINGTON, David, C. , PERRON-SIERRA, Françoise , ATASSI, Ghanem , PIERRE, Alain , BURBRIDGE, Michael , GUILBAUD, Nicolas
发明人： ADIR ET COMPAGNIE
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07D498/20
摘要： Compounds of general formula (I), wherein R1, R2, R3, R4, R5, R6, R7, X and Y are as defined in the description, are disclosed and are useful as medicaments.
摘要翻译：公开了通式（I）的化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X和Y如说明书中所定义，并且可用作药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式