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1. 发明申请

WO2006111716A1 HETEROARYL DERIVATIVES HAVING ANTI-MYCOBACTERIAL ACTIVITY 审中-公开
标题翻译：具有抗真菌活性的异氟烷衍生物
公开(公告)号：WO2006111716A1
公开(公告)日：2006-10-26
申请号：PCT/GB2006/001378
申请日：2006-04-13
申请人： ASTON UNIVERSITY , PARKER, Katy, Jane , RATHBONE, Daniel, Lee , LAMBERT, Peter, Anthony , BILLINGTON, David, Charles
发明人： PARKER, Katy, Jane , RATHBONE, Daniel, Lee , LAMBERT, Peter, Anthony , BILLINGTON, David, Charles
IPC分类号： C07D213/54 , C07D215/12 , C07D241/12 , A61K31/44 , A61K31/47 , A61K31/4965 , A61P31/00
CPC分类号： C07D213/54 , C07D215/12 , C07D241/12
摘要： A compound of formula (I) where Het is selected from (2PY) (3PY) (4PY) (PZ) (QN) and (HD); (A) is formula (1) where X is O or S; R 1 is C 1-6 straight or branched alkyl, C 1-6 straight or branched alkoxy or alkylthio, C 1-6 straight or branched alkylcarbonyloxy, C 1-6 straight or branched alkyloxycarbonyl, phenyl, benzyl or phenyl(C 1-6 )alkyloxy, in each case the phenyl moiety itself being substituted or unsubstituted; and R 2 is H, C 1-6 straight or branched alkyl, C 1-6 alkylcarbonyl, phenyl, benzyl or arylcarbonyl (e.g. benzoyl), in each case the phenyl moiety itself being substituted or unsubstituted, and B is H, hydroxy, C 1-6 straight or branched alkyl, C 1-6 straight or branched alkoxy or alkylthio, C 1-6 straight or branched alkylcarbonyloxy, C 1-6 straight or branched alkyloxycarbonyl, cyano, amino, nitro, halo, phenyl, benzyl or phenyl(C 1-6 )alkyloxy, in each case the phenyl moiety itself being substituted or unsubstituted, and physiologically acceptable salts and complexes (e.g. metal complexes) thereof.
摘要翻译：其中Het选自（2PY）（3PY）（4PY）（PZ）（QN）和（HD））的式（I）化合物; （A）为式（1）其中X为O或S; R 1是C 1-6 - 直链或支链烷基，C 1-6 - 直链或支链烷氧基或烷硫基，C 1〜 6直链或支链烷基羰基氧基，C 1-6直链或支链烷氧基羰基，苯基，苄基或苯基（C 1-6 - ）烷氧基，在每种情况下苯基部分本身是取代或未取代的; 和R 2是H，C 1-6直链或支链烷基，C 1-6烷基羰基，苯基，苄基或芳基羰基（例如苯甲酰基），在每种情况下，苯基部分本身是取代或未取代的，并且B是H，羟基，C 1-16直链或支链烷基，C 1-6直链或支链烷氧基或烷硫基，C 1-6直链或支链烷基羰基氧基，C 1-6直链或支链烷氧基羰基，氰基，氨基，硝基，卤素，苯基，苄基或苯基（C 1-6）烷氧基，在各种情况下，苯基部分本身为取代或未取代的，以及其生理上可接受的盐和络合物（例如金属络合物）。

2. 发明申请

WO9961913A2 IMPROVEMENTS IN OR RELATING TO DIAGNOSIS AND TREATMENT OF BACTERIAL INFECTIONS 审中-公开
标题翻译：细菌感染诊断和治疗方面的改进或相关内容
公开(公告)号：WO9961913A2
公开(公告)日：1999-12-02
申请号：PCT/GB9901650
申请日：1999-05-26
申请人： OXOID LTD , LAMBERT PETER ANTHONY , ELLIOTT THOMAS STUART JACKSON
发明人： LAMBERT PETER ANTHONY , ELLIOTT THOMAS STUART JACKSON
IPC分类号： A61K31/70 , A61K39/085 , C07H3/04 , C07K1/00 , C07K16/12 , C12N1/20 , G01N33/569
CPC分类号： A61K31/70 , A61K39/085 , C07H3/04 , C07K1/00 , C07K16/1271 , C12N1/20
摘要： Disclosed is an isolated compound having the structure shown in Figure 2, wherein n is an integer between 3 and 10 (inclusive) and X may be H, OH, alkyl, aryl, amyl, or an amino acid residue (optionally substituted) or a sugar residue (optionally substituted), and wherein R and R are hydrophobic hydrocarbon or fatty acid chains (R may be the same as R or different), a method of preparing compositions comprising the compound, and a diagnostic method comprising use of the composition.
摘要翻译：公开了具有图2所示结构的分离的化合物，其中n是3至10（包括端值）的整数，X可以是H，OH，烷基，芳基，戊基或氨基酸残基（任选取代的）或糖残基（任选取代的），其中R和R 1是疏水性烃或脂肪酸链（R可以与R 1相同或不同），制备包含该化合物的组合物的方法和诊断方法包括使用该组合物。

3. 发明申请

WO2006075159A1 ANTI-BACTERIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2006075159A1
公开(公告)日：2006-07-20
申请号：PCT/GB2006/000101
申请日：2006-01-12
申请人： ASTON UNIVERSITY , PARKER, Katy, Jane , RATHBONE, Daniel, Lee , LAMBERT, Peter, Anthony , COLEMAN, Michael, Damian , HILTON, Anthony, Craig , WORTHINGTON, Antony , BILLINGTON, David, Charles
发明人： PARKER, Katy, Jane , RATHBONE, Daniel, Lee , LAMBERT, Peter, Anthony , COLEMAN, Michael, Damian , HILTON, Anthony, Craig , WORTHINGTON, Antony , BILLINGTON, David, Charles
IPC分类号： A01N43/40 , A01N43/60 , A01N43/42 , A01N43/50 , C07D213/86 , C07D241/12 , C07D215/48 , A61K31/44 , A01P1/00
CPC分类号： C07D213/53 , A01N43/40 , A01N43/42 , A01N43/50 , A01N43/60 , C07D213/89
摘要： Compounds of formula (I), or salts or solvates thereof, in vitro as inhibitors of growth of Gram-positive bacteria, where A is selected from formula (a).
摘要翻译：式（I）化合物或其盐或溶剂化物，体外为革兰氏阳性菌生长抑制剂，其中A选自式（a）。

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